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1. 发明申请

WO2008008827A2 METHODS AND FORMULATIONS FOR OPTIMAL LOCAL DELIVERY OF CELL THERAPY VIA MINIMALLY INVASIVE PROCEDURES 审中-公开
标题翻译：通过微创手术最佳局部输送细胞疗法的方法和制剂
公开(公告)号：WO2008008827A2
公开(公告)日：2008-01-17
申请号：PCT/US2007/073245
申请日：2007-07-11
申请人： MEDTRONIC, INC. , CASAS, Jesus, W. , BLAKSTVEDT, Adam, A. , SCHILTGEN, Molly, B. , WIKA, Kent, E. , MOLNAR, Gyongike, M.
发明人： CASAS, Jesus, W. , BLAKSTVEDT, Adam, A. , SCHILTGEN, Molly, B. , WIKA, Kent, E. , MOLNAR, Gyongike, M.
IPC分类号： A61M31/00
CPC分类号： A61K9/0019 , A61B5/0515 , A61B5/416 , A61K9/10 , A61K9/127 , A61K35/12 , A61K49/0461 , A61K49/0471 , A61K49/1896 , A61K51/1203 , A61K51/1234
摘要： The present invention relates to methods, kits, and compositions for safe and efficient delivery of a bioagent to a targeted area of an organ. The method comprises preparing a suspension comprising the bioagent, a contrast agent, and a vehicle, wherein said suspension has an osmolarity from about 270 mOsm to about 440 mOsm; and dispensing at least a portion of said suspension into the targeted area. The invention further provides a kit for delivering a bioagent into a targeted area of an organ comprising: a delivery device; a contrast agent; and a vehicle.
摘要翻译：本发明涉及用于将生物试剂安全有效地递送至器官靶向区域的方法，试剂盒和组合物。该方法包括制备包含生物试剂，造影剂和载体的混悬液，其中所述混悬液具有约270mOsm至约440mOsm的同渗容摩; 并且将所述悬浮液的至少一部分分配到目标区域中。本发明进一步提供了用于将生物试剂递送至器官的靶向区域的试剂盒，其包括：递送装置; 造影剂; 和一辆车。

2. 发明申请

WO2006050396A2 INTRODUCTION OF AGENT WITH MEDICAL DEVICE 审中-公开
标题翻译：医疗器械代理人简介
公开(公告)号：WO2006050396A2
公开(公告)日：2006-05-11
申请号：PCT/US2005/039562
申请日：2005-10-31
申请人： MEDTRONIC, INC. , CASAS, Jesus , CHRISTOFERSON, Laura, J. , BLAKSTVEDT, Adam, A.
发明人： CASAS, Jesus , CHRISTOFERSON, Laura, J. , BLAKSTVEDT, Adam, A.
IPC分类号： A61M25/00 , A61M25/10
CPC分类号： A61M5/14276 , A61L29/16 , A61L2300/404 , A61L2300/45 , A61M25/00 , A61M25/10 , A61M39/0208 , A61M2025/0057 , A61M2025/105
摘要： The disclosure is directed to apparatus and techniques that deliver an antibiotic or loosening agent to a patient by diffusion. An element of the medical device deployed proximate to the living cells includes a diffusible material, which comprises a lumen. An agent introduced into the lumen diffuses through the diffusible material to the living cells or tissues. The invention can be applied to medical devices that are placed partially inside a patient, as well as those that are fully implanted. Some embodiments support moving the internal element of a medical device proximate to targeted cells, such as a tumor, and administering an antibiotic agent to the targeted cells by diffusion. The disclosure also encompasses a testing system that helps test and develop apparatus and techniques for delivering an agent by diffusion.
摘要翻译：本公开涉及通过扩散将抗生素或松散剂递送给患者的设备和技术。靠近活细胞布置的医疗装置的元件包括可扩散材料，其包括内腔。引入腔中的药剂通过可扩散材料扩散到活细胞或组织。本发明可以应用于部分放置在患者体内的医疗装置以及完全植入的医疗装置。一些实施例支持移动医疗设备的内部元件接近靶向细胞（例如肿瘤），并且通过扩散将抗生素剂施用至靶细胞。本公开还包括测试系统，其帮助测试和开发通过扩散传递代理的装置和技术。

3. 发明申请

WO2008008827A3 METHODS AND FORMULATIONS FOR OPTIMAL LOCAL DELIVERY OF CELL THERAPY VIA MINIMALLY INVASIVE PROCEDURES 审中-公开
标题翻译：通过微型入侵程序进行细胞治疗的最佳地方交付方法和制剂
公开(公告)号：WO2008008827A3
公开(公告)日：2008-03-20
申请号：PCT/US2007073245
申请日：2007-07-11
申请人： MEDTRONIC INC , CASAS JESUS W , BLAKSTVEDT ADAM A , SCHILTGEN MOLLY B , WIKA KENT E , MOLNAR GYONGIKE M
发明人： CASAS JESUS W , BLAKSTVEDT ADAM A , SCHILTGEN MOLLY B , WIKA KENT E , MOLNAR GYONGIKE M
IPC分类号： A61M31/00
CPC分类号： A61K9/0019 , A61B5/0515 , A61B5/416 , A61K9/10 , A61K9/127 , A61K35/12 , A61K49/0461 , A61K49/0471 , A61K49/1896 , A61K51/1203 , A61K51/1234
摘要： The present invention relates to methods, kits, and compositions for safe and efficient delivery of a bioagent to a targeted area of an organ. The method comprises preparing a suspension comprising the bioagent, a contrast agent, and a vehicle, wherein said suspension has an osmolarity from about 270 mOsm to about 440 mOsm; and dispensing at least a portion of said suspension into the targeted area. The invention further provides a kit for delivering a bioagent into a targeted area of an organ comprising: a delivery device; a contrast agent; and a vehicle.
摘要翻译：本发明涉及用于将生物剂安全有效地递送至器官的目标区域的方法，试剂盒和组合物。该方法包括制备包含生物剂，造影剂和载体的悬浮液，其中所述悬浮液具有约270mOsm至约440mOsm的渗透压浓度; 以及将所述悬架的至少一部分分配到所述目标区域中。本发明还提供了用于将生物体递送到器官的目标区域的试剂盒，其包括：递送装置; 造影剂和车辆。

4. 发明申请

WO2009114324A2 GUIDEWIRES AND DELIVERY CATHETERS HAVING FIBER OPTIC SENSING COMPONENT AND RELATED SYSTEMS AND METHODS 审中-公开
标题翻译：具有光纤感光元件的导板和传送导管及相关系统和方法
公开(公告)号：WO2009114324A2
公开(公告)日：2009-09-17
申请号：PCT/US2009035751
申请日：2009-03-02
申请人： MEDTRONIC VASCULAR INC , BLAKSTVEDT ADAM , CASAS JESUS , ROBINSON TIMOTHY
发明人： BLAKSTVEDT ADAM , CASAS JESUS , ROBINSON TIMOTHY
IPC分类号： A61M25/09 , A61M25/16 , A61M31/00
CPC分类号： A61B5/0084 , A61B5/0075 , A61B5/0086 , A61B5/1459 , A61B5/6848 , A61B8/0833 , A61M2025/018
摘要： Methods, systems and devices for delivering a diagnostic or therapeutic treatment, substance or device to a target area located within the body of a human or animal subject. A tissue penetrating catheter is positioned within a body lumen near the target area. A hollow penetrator is then advanced from the tissue penetrating catheter and penetrated from the body lumen in which the penetrating catheter is positioned into tissue in the direction of the target area. Thereafter, an elongate optical device (e.g., an optically equipped guidewire or catheter) is advanced through the hollow penetrator and continues to advance through tissue, in the direction of the target area. The elongate optical device is connected to an optical processing device (e.g., a spectrometer) which provides optically determined data (e.g., spectral reflectance, pH, oxygen concentration, temperature) indicating when the elongate optical device has entered the target area. The elongate optical device is then used to facilitate delivery of a diagnostic or therapeutic modality, substance or device into the target area.
摘要翻译：用于将诊断或治疗性治疗物质或装置递送到位于人或动物受试者身体内的目标区域的方法，系统和装置。组织穿透导管位于目标区域附近的体腔内。然后，中空穿透器从组织穿透导管前进，并从其中穿透导管位于组织中的目标区域的方向穿透其中。此后，细长的光学装置（例如，光学配置的导丝或导管）通过中空穿透器前进并且继续沿目标区域的方向前进穿过组织。细长光学装置连接到光学处理装置（例如，光谱仪），其提供光学确定的数据（例如，光谱反射率，pH，氧浓度，温度），指示细长光学装置何时已经进入目标区域。然后将细长光学装置用于促进将诊断或治疗方式，物质或装置输送到目标区域中。

5. 发明申请

WO2006050396A8 INTRODUCTION OF AGENT WITH MEDICAL DEVICE 审中-公开
标题翻译：介绍与医疗设备的代理
公开(公告)号：WO2006050396A8
公开(公告)日：2007-01-25
申请号：PCT/US2005039562
申请日：2005-10-31
申请人： MEDTRONIC INC , CASAS JESUS , CHRISTOFERSON LAURA J , BLAKSTVEDT ADAM A
发明人： CASAS JESUS , CHRISTOFERSON LAURA J , BLAKSTVEDT ADAM A
IPC分类号： A61M25/00 , A61F2/958 , C12M1/12 , C12M1/18
CPC分类号： A61M5/14276 , A61L29/16 , A61L2300/404 , A61L2300/45 , A61M25/00 , A61M25/10 , A61M39/0208 , A61M2025/0057 , A61M2025/105
摘要： The disclosure is directed to apparatus and techniques that deliver an antibiotic or loosening agent to a patient by diffusion. An element of the medical device deployed proximate to the living cells includes a diffusible material, which comprises a lumen. An agent introduced into the lumen diffuses through the diffusible material to the living cells or tissues. The invention can be applied to medical devices that are placed partially inside a patient, as well as those that are fully implanted. Some embodiments support moving the internal element of a medical device proximate to targeted cells, such as a tumor, and administering an antibiotic agent to the targeted cells by diffusion. The disclosure also encompasses a testing system that helps test and develop apparatus and techniques for delivering an agent by diffusion.
摘要翻译：本公开涉及通过扩散将抗生素或松动剂递送至患者的装置和技术。靠近活细胞部署的医疗装置的元件包括可扩散材料，其包括管腔。引入腔的药剂通过可扩散材料扩散到活细胞或组织。本发明可以应用于部分放置在患者体内的医疗装置以及完全植入的医疗装置。一些实施方案支持将医疗装置的内部元件移动到接近靶细胞（例如肿瘤），并通过扩散向靶细胞施用抗生素。本公开还包括一种测试系统，其有助于测试和开发用于通过扩散递送代理的设备和技术。

6. 发明申请

WO2006050396A3 INTRODUCTION OF AGENT WITH MEDICAL DEVICE 审中-公开
标题翻译：介绍与医疗设备的代理
公开(公告)号：WO2006050396A3
公开(公告)日：2006-08-31
申请号：PCT/US2005039562
申请日：2005-10-31
申请人： MEDTRONIC INC , CASAS JESUS , CHRISTOFERSON LAURA J , BLAKSTVEDT ADAM A
发明人： CASAS JESUS , CHRISTOFERSON LAURA J , BLAKSTVEDT ADAM A
IPC分类号： A61M25/00 , A61F2/958 , C12M1/12 , C12M1/18
CPC分类号： A61M5/14276 , A61L29/16 , A61L2300/404 , A61L2300/45 , A61M25/00 , A61M25/10 , A61M39/0208 , A61M2025/0057 , A61M2025/105
摘要： The disclosure is directed to apparatus and techniques that deliver an antibiotic or loosening agent to a patient by diffusion. An element of the medical device deployed proximate to the living cells includes a diffusible material, which comprises a lumen. An agent introduced into the lumen diffuses through the diffusible material to the living cells or tissues. The invention can be applied to medical devices that are placed partially inside a patient, as well as those that are fully implanted. Some embodiments support moving the internal element of a medical device proximate to targeted cells, such as a tumor, and administering an antibiotic agent to the targeted cells by diffusion. The disclosure also encompasses a testing system that helps test and develop apparatus and techniques for delivering an agent by diffusion.
摘要翻译：本公开涉及通过扩散将抗生素或松动剂递送给患者的装置和技术。靠近活细胞部署的医疗装置的元件包括可扩散材料，其包括管腔。引入内腔的药剂通过可扩散材料扩散到活细胞或组织。本发明可以应用于部分放置在患者体内的医疗装置以及完全植入的医疗装置。一些实施方案支持将医疗装置的内部元件移动到接近靶细胞（例如肿瘤），并通过扩散向靶细胞施用抗生素。本公开还包括一种测试系统，其帮助测试和开发用于通过扩散递送代理的设备和技术。

7. 发明申请

WO2010062492A1 ENDOLUMINAL IMPLANTS FOR BIOACTIVE MATERIAL DELIVERY 审中-公开
标题翻译：用于生物材料输送的内膜植入物
公开(公告)号：WO2010062492A1
公开(公告)日：2010-06-03
申请号：PCT/US2009/060998
申请日：2009-10-16
申请人： MEDTRONIC, INC. , CASAS, Jesus, W. , DEARKING, Amy , PADUA, Rodolfo , SCHILTGEN, Molly , WALKER, Jeffrey
发明人： CASAS, Jesus, W. , DEARKING, Amy , PADUA, Rodolfo , SCHILTGEN, Molly , WALKER, Jeffrey
IPC分类号： A61F2/06 , A61F2/00
CPC分类号： A61M31/002 , A61L29/146 , A61L29/16 , A61L31/146 , A61L31/16 , A61L2300/00 , A61M2025/0681
摘要： Disclosed herein are endoluminal implants for bioactive material delivery. The disclosed endoluminal implants come in the general forms of patches and sleeves and can deliver bioactive materials independently of other implantable medical devices such as stents.
摘要翻译：本文公开了用于生物活性物质输送的腔内植入物。所公开的腔内植入物具有贴片和袖子的一般形式，并且可以独立于其他可植入医疗装置（例如支架）递送生物活性材料。

8. 发明申请

WO2009114324A3 GUIDEWIRES AND DELIVERY CATHETERS HAVING FIBER OPTIC SENSING COMPONENT AND RELATED SYSTEMS AND METHODS 审中-公开
公开(公告)号：WO2009114324A3
公开(公告)日：2009-09-17
申请号：PCT/US2009/035751
申请日：2009-03-02
申请人： MEDTRONIC VASCULAR INC. , BLAKSTVEDT, Adam , CASAS, Jesus , ROBINSON, Timothy
发明人： BLAKSTVEDT, Adam , CASAS, Jesus , ROBINSON, Timothy
IPC分类号： A61M25/09 , A61M25/16 , A61M31/00
摘要： Methods, systems and devices for delivering a diagnostic or therapeutic treatment, substance or device to a target area located within the body of a human or animal subject. A tissue penetrating catheter is positioned within a body lumen near the target area. A hollow penetrator is then advanced from the tissue penetrating catheter and penetrated from the body lumen in which the penetrating catheter is positioned into tissue in the direction of the target area. Thereafter, an elongate optical device (e.g., an optically equipped guidewire or catheter) is advanced through the hollow penetrator and continues to advance through tissue, in the direction of the target area. The elongate optical device is connected to an optical processing device (e.g., a spectrometer) which provides optically determined data (e.g., spectral reflectance, pH, oxygen concentration, temperature) indicating when the elongate optical device has entered the target area. The elongate optical device is then used to facilitate delivery of a diagnostic or therapeutic modality, substance or device into the target area.

9. 发明申请

WO2008008827B1 METHODS AND FORMULATIONS FOR OPTIMAL LOCAL DELIVERY OF CELL THERAPY VIA MINIMALLY INVASIVE PROCEDURES 审中-公开
标题翻译：通过微创手术最佳局部输送细胞疗法的方法和制剂
公开(公告)号：WO2008008827B1
公开(公告)日：2008-05-02
申请号：PCT/US2007073245
申请日：2007-07-11
申请人： MEDTRONIC INC , CASAS JESUS W , BLAKSTVEDT ADAM A , SCHILTGEN MOLLY B , WIKA KENT E , MOLNAR GYONGIKE M
发明人： CASAS JESUS W , BLAKSTVEDT ADAM A , SCHILTGEN MOLLY B , WIKA KENT E , MOLNAR GYONGIKE M
IPC分类号： A61M31/00
CPC分类号： A61K9/0019 , A61B5/0515 , A61B5/416 , A61K9/10 , A61K9/127 , A61K35/12 , A61K49/0461 , A61K49/0471 , A61K49/1896 , A61K51/1203 , A61K51/1234
摘要： The present invention relates to methods, kits, and compositions for safe and efficient delivery of a bioagent to a targeted area of an organ. The method comprises preparing a suspension comprising the bioagent, a contrast agent, and a vehicle, wherein said suspension has an osmolarity from about 270 mOsm to about 440 mOsm; and dispensing at least a portion of said suspension into the targeted area. The invention further provides a kit for delivering a bioagent into a targeted area of an organ comprising: a delivery device; a contrast agent; and a vehicle.
摘要翻译：本发明涉及用于将生物试剂安全有效地递送至器官的靶向区域的方法，试剂盒和组合物。该方法包括制备包含生物试剂，造影剂和载体的混悬液，其中所述混悬液具有约270mOsm至约440mOsm的同渗容摩; 并且将所述悬浮液的至少一部分分配到目标区域中。本发明进一步提供了用于将生物试剂递送至器官的靶向区域的试剂盒，其包括：递送装置; 造影剂; 和车辆。

10. 发明专利

ES1155083Y RUEDA MEJORADA PARA CESTAS Y CARROS DE LA COMPRA 未知
公开(公告)号：ES1155083Y
公开(公告)日：2016-07-18
申请号：ES201630398
申请日：2016-04-01
申请人： SIMON CASAS OSCAR , SIMON CASAS JESUS
发明人： SIMON CASAS OSCAR , SIMON CASAS JESUS
IPC分类号： B60B33/00

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