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1. 发明申请

WO2014186461A1 SCANNING IMAGE FLOW CYTOMETER 审中-公开
标题翻译：扫描图像流量计
公开(公告)号：WO2014186461A1
公开(公告)日：2014-11-20
申请号：PCT/US2014/037995
申请日：2014-05-14
申请人： CAPTL LLC
发明人： YAMAMOTO, Masanobu , ROBINSON, J., Paul
IPC分类号： G01N15/14
CPC分类号： G01N15/1434 , G01N15/1429 , G01N15/1459
摘要： An image flow cytometer has a flow chamber with a flow channel formed therein to permit a microparticulate sample to flow through the flow channel. An irradiation optical system irradiates the sample in the channel with incident light in an irradiation spot smaller than a selected representative size, e.g., smaller than the sample. The system scans an irradiation position perpendicular to the flow direction of the sample. A detection optical system is opposed to the irradiation optical system through the flow chamber, or is off the optical axis of the incident light. The detection system detects a light intensity of resultant light from the flow chamber. A control unit detects the microparticulate sample according to a change of the light intensity of the resultant light detected by the detection optical system.
摘要翻译：图像流式细胞仪具有流动室，其中形成有流动通道，以允许微粒样品流过流动通道。照射光学系统在入射光中照射具有小于所选代表尺寸的照射点的样品，例如小于样品。系统扫描垂直于样品流动方向的照射位置。检测光学系统与通过流动室的照射光学系统相对，或者离开入射光的光轴。检测系统检测来自流动室的合成光的光强度。控制单元根据由检测光学系统检测到的所得光的光强度的变化来检测微粒样品。

2. 发明申请

WO2018191497A2 PHOTON COUNTING AND SPECTROSCOPY 审中-公开
公开(公告)号：WO2018191497A2
公开(公告)日：2018-10-18
申请号：PCT/US2018/027302
申请日：2018-04-12
申请人： CAPTL LLC
发明人： YAMAMOTO, Masanobu , HERNANDEZ, Keegan , ROBINSON, J., Paul
IPC分类号： G01J3/02 , G01J3/18 , G01J3/44
CPC分类号： G01J3/44 , G01J3/0208 , G01J3/0221 , G01J3/0227 , G01J3/18 , G01J3/4406 , G01J2001/442 , G01N15/1429 , G01N15/1459 , G01N21/645 , G01N2015/1006
摘要： A measurement system includes an optical source (e.g., laser) to irradiate a sample (e.g., a cell); a solid-state photon detector (SSPD) to receive resultant light from the sample; and a photon counter to count photons received by the SSPD. The photon counter can include a differentiator to provide a differentiated photon signal and a crossing detector configured to count photons based on a number of times the differentiated photon signal crosses a predetermined threshold level. In some examples, a pulse detector can provide a pulse-width signal from the SSPD output photon signal, and a pulse counter can count based on both a number of pulses and widths of the pulses. The SSPD can include a silicon photomultiplier (SiPM) array or a solid-state photomultiplier. Some examples use the measurement system to measure samples in fluids, e.g., in flow cytometers or multi-well plates.

3. 发明申请

WO2020131754A3 PHOTON COUNTING AND MULTI-SPOT SPECTROSCOPY 审中-公开
公开(公告)号：WO2020131754A3
公开(公告)日：2020-06-25
申请号：PCT/US2019/066652
申请日：2019-12-16
申请人： CAPTL LLC
发明人： YAMAMOTO, Masanobu , ROBINSON, J., Paul , HERNANDEZ, Keegan
IPC分类号： G01J3/02 , G01J3/18 , G01N15/14 , G01J1/46
摘要： An example system can include a support and two or more sensor elements mounted to the support. Each sensor element can be electrically connected to a common electrical node and may include: a respective quench resistor connected to a respective internal node; and a respective photodiode (PD) connected to the respective internal node; a differentiating element fed by at least one of the photodiodes; a first readout electrode fed by the common electrical node; and a second readout electrode fed by the differentiating element. The common electrical node may be connected to at least one of the quench resistors or at least one of the photodiodes.

4. 发明申请

WO2016161337A1 PARTICLE DETECTION USING REFLECTIVE SURFACE 审中-公开
标题翻译：使用反射表面的颗粒检测
公开(公告)号：WO2016161337A1
公开(公告)日：2016-10-06
申请号：PCT/US2016/025650
申请日：2016-04-01
申请人： CAPTL LLC
发明人： YAMAMOTO, Masanobu , ROBINSON, J., Paul
IPC分类号： G01N15/14 , G01N21/25 , G01N21/55
CPC分类号： G01N21/47 , B01L3/502715 , B01L2300/0654 , B01L2300/0806 , B01L2300/168 , B01L2400/0406 , B01L2400/0409 , B01L2400/049 , G01N15/1425 , G01N15/1429 , G01N15/1434 , G01N15/147 , G01N15/1484 , G01N21/4788 , G01N21/55 , G01N21/645 , G01N2015/1006 , G01N2021/6439 , G01N2021/6463
摘要： An example assembly includes a target holder that retains a target in a detection region. A reflective surface reflects at least part of a focused spot of light to provide resultant light. An irradiation system irradiates at least part of the detection region with the focused spot of light. A motion system causes motion of the focused spot of light relative to the reflective surface. A detection system detects the resultant light. An example device, e.g., a lab-on-chip, includes a substrate, a sample inlet, and a reflective grating. The grating is retains a fluidic sample in a detection region fluidically connected to the sample inlet. The detection region is operatively arranged with respect to the reflective grating so that at least a portion of light passing through the detection region towards the reflective grating also passes through the detection region after reflecting off the reflective grating.
摘要翻译：示例性组件包括将目标保持在检测区域中的目标保持器。反射表面反射聚焦光点的至少一部分以提供合成的光。照射系统用聚焦光照射至少部分检测区域。运动系统引起聚焦光点相对于反射表面的运动。检测系统检测合成的光。示例性器件，例如片上实验室，包括衬底，样品入口和反射光栅。光栅将流体样品保持在与样品入口流体连接的检测区域中。检测区域相对于反射光栅可操作地布置，使得在反射光栅反射之后，通过检测区域的至少一部分光朝反射光栅也通过检测区域。

5. 发明申请

WO2016100954A1 FLOW CYTOMETRY USING HYDRODYNAMICALLY PLANAR FLOW 审中-公开
标题翻译：使用水动力平面流动的流动细胞计数
公开(公告)号：WO2016100954A1
公开(公告)日：2016-06-23
申请号：PCT/US2015/066947
申请日：2015-12-19
申请人： CAPTL LLC , HAMAMATSU PHOTONICS K.K.
发明人： YAMAMOTO, Masanobu , ROBINSON, J., Paul , MASUDA, Yuji , KAYOU, Tsukasa
IPC分类号： G01N15/14 , B01F13/00 , B01L3/00
CPC分类号： G01N15/1404 , B01L3/502761 , B01L3/502776 , B01L2300/0654 , B01L2300/0816 , B01L2300/0867 , B01L2300/0874 , B01L2300/0877 , B01L2300/0887 , B01L2400/0487 , G01N15/1434 , G01N15/1459 , G01N15/147 , G01N15/1484 , G01N2015/1409 , G01N2015/1413 , G01N2015/144
摘要： According to various aspects, a flow system for transporting mi crop articulate samples in a hydrodynamically planar flow in a selected flow direction includes a flow chamber extending in the flow direction, having first and second apertures on opposed surfaces of the flow chamber. A sheath-fluid channel has first and second branches to carry the sheath fluid into the flow chamber through the first aperture and having orientations separated by less than about 15° at the first aperture; and third and fourth branches to carry the sheath fluid through the second aperture and having orientations separated by less than about 15° at the second aperture. In some examples, guide channels extend from the apertures substantially perpendicular to the flow chamber at the apertures, and sheath-fluid channel supply sheath fluid to the guide channels. Flow systems can be used in image flow cytometers for observing microparticulate samples, e.g., using scanning irradiation.
摘要翻译：根据各个方面，用于在所选择的流动方向上以流体动力学平面的流动方式输送mi crop crop ulate样品的流动系统包括在流动方向上延伸的流动室，在流动室的相对表面上具有第一和第二孔。皮 - 液流体通道具有第一和第二分支，以将护套流体通过第一孔携带到流动室中，并且在第一孔处具有分开小于约15°的取向; 以及第三和第四分支，以通过第二孔承载鞘液，并且在第二孔处具有分开小于约15°的取向。在一些示例中，引导通道从孔处基本垂直于流动室的孔延伸，并且鞘液流体通道将护套流体供应到引导通道。流式系统可用于图像流式细胞仪，用于观察微粒样品，例如使用扫描照射。

6. 发明申请

WO2020131754A2 PHOTON COUNTING AND MULTI-SPOT SPECTROSCOPY 审中-公开
公开(公告)号：WO2020131754A2
公开(公告)日：2020-06-25
申请号：PCT/US2019/066652
申请日：2019-12-16
申请人： CAPTL LLC
发明人： YAMAMOTO, Masanobu , ROBINSON, J., Paul , HERNANDEZ, Keegan
IPC分类号： G01J3/02 , G01J3/18 , G01N15/14 , G01J1/46
摘要： An example system can include a support and two or more sensor elements mounted to the support. Each sensor element can be electrically connected to a common electrical node and may include: a respective quench resistor connected to a respective internal node; and a respective photodiode (PD) connected to the respective internal node; a differentiating element fed by at least one of the photodiodes; a first readout electrode fed by the common electrical node; and a second readout electrode fed by the differentiating element. The common electrical node may be connected to at least one of the quench resistors or at least one of the photodiodes.

7. 发明申请

WO2018191497A3 PHOTON COUNTING AND SPECTROSCOPY 审中-公开
公开(公告)号：WO2018191497A3
公开(公告)日：2018-10-18
申请号：PCT/US2018/027302
申请日：2018-04-12
申请人： CAPTL LLC
发明人： YAMAMOTO, Masanobu , HERNANDEZ, Keegan , ROBINSON, J., Paul
IPC分类号： G01J3/02 , G01J3/18 , G01J3/44 , G01N21/64
摘要： A measurement system includes an optical source (e.g., laser) to irradiate a sample (e.g., a cell); a solid-state photon detector (SSPD) to receive resultant light from the sample; and a photon counter to count photons received by the SSPD. The photon counter can include a differentiator to provide a differentiated photon signal and a crossing detector configured to count photons based on a number of times the differentiated photon signal crosses a predetermined threshold level. In some examples, a pulse detector can provide a pulse-width signal from the SSPD output photon signal, and a pulse counter can count based on both a number of pulses and widths of the pulses. The SSPD can include a silicon photomultiplier (SiPM) array or a solid-state photomultiplier. Some examples use the measurement system to measure samples in fluids, e.g., in flow cytometers or multi-well plates.

8. 发明申请

WO2016099538A1 FLOW CYTOMETRY USING HYDRODYNAMICALLY PLANAR FLOW 审中-公开
标题翻译：使用水动力平面流动的流动细胞计数
公开(公告)号：WO2016099538A1
公开(公告)日：2016-06-23
申请号：PCT/US2014/071391
申请日：2014-12-19
申请人： CAPTL LLC , HAMAMATSU PHOTONICS K.K.
发明人： YAMAMOTO, Masanobu , ROBINSON, J., Paul , MASUDA, Yuji , KAYOU, Tsukasa
IPC分类号： G01N15/14
CPC分类号： G01N15/1404 , G01N15/1459 , G01N15/1463 , G01N15/147 , G01N15/1475 , G01N15/1484 , G01N2015/1006 , G01N2015/1409 , G01N2015/1413 , G01N2015/1493 , G01N2015/1497
摘要： An image flow cytometer for observing microparticulate samples includes a flow system directing a carrier fluid including the samples through a sensing area in a hydrodynamically planar flow. The flow system includes an elongated flow chamber having opposed first and second apertures and the sensing area downstream of the apertures, and receiving the carrier fluid upstream of the first and second apertures. A sheath- fluid channel includes two branches configured to carry the sheath fluid from opposite directions into the flow chamber through the first aperture, and likewise third and fourth branches through the second aperture. An irradiation spot smaller than the flow thickness is scanned across the sensing area across the flow direction. A detection optical system detects a time -varying light intensity of resultant light from the flow chamber. A processor detects two or more of the microparticulate samples according to the detected intensity.
摘要翻译：用于观察微粒样品的图像流式细胞仪包括流动系统，其将包含样品的载体流体通过流体动力学平面流中的感测区域引导。流动系统包括细长的流动室，其具有相对的第一和第二孔以及孔的下游的感测区域，并且在第一和第二孔的上游接收载体流体。护套流体通道包括两个分支，其构造成将护套流体从相反方向通过第一孔携带到流动室中，同样第三和第四分支穿过第二孔。在流动方向上跨越感测区域扫描小于流动厚度的照射点。检测光学系统检测来自流动室的合成光的时间变化的光强度。处理器根据检测到的强度来检测两个或更多个微粒样品。

9. 发明授权

US10900885B2 Flow cytometry using hydrodynamically planar flow 有权
公开(公告)号：US10900885B2
公开(公告)日：2021-01-26
申请号：US15537744
申请日：2015-12-19
申请人： CAPTL LLC , Hamamatsu Photonics K.K.
发明人： Masanobu Yamamoto , J. Paul Robinson , Yuji Masuda , Tsukasa Kayou
IPC分类号： G01N15/14 , B01L3/00
摘要： According to various aspects, a flow system for transporting microparticulate samples in a hydrodynamically planar flow in a selected flow direction includes a flow chamber extending in the flow direction, having first and second apertures on opposed surfaces of the flow chamber. A sheath-fluid channel has first and second branches to carry the sheath fluid into the flow chamber through the first aperture and having orientations separated by less than about 15° at the first aperture; and third and fourth branches to carry the sheath fluid through the second aperture and having orientations separated by less than about 15° at the second aperture. In some examples, guide channels extend from the apertures substantially perpendicular to the flow chamber at the apertures, and sheath-fluid channel supply sheath fluid to the guide channels. Flow systems can be used in image flow cytometers for observing microparticulate samples, e.g., using scanning irradiation.

10. 发明申请

US20190049356A1 Multiple-Spot Time-Sequential Cytometry 审中-公开
公开(公告)号：US20190049356A1
公开(公告)日：2019-02-14
申请号：US16045094
申请日：2018-07-25
申请人： CAPTL LLC
发明人： Masanobu Yamamoto , J. Paul Robinson
IPC分类号： G01N15/14 , G01N15/10
CPC分类号： G01N15/1427 , G01N15/1404 , G01N15/1434 , G01N15/147 , G01N15/1475 , G01N2015/1006 , G01N2015/1409 , G01N2015/1413 , G01N2015/144 , G01N2015/1452
摘要： An image flow cytometer for observing a microparticulate sample includes a flow chamber having a flow channel that permits the microparticulate sample to travel in a flow direction. An irradiation system scans an irradiation spot across a sensing area of the flow channel in a scan direction different from the flow direction. A detection system detects resultant light from the sensing area and provides a detection signal. An alignment system alters a location of the sensing area with respect to the flow chamber. A control unit causes the irradiation system to scan the irradiation spot during a first measurement interval and operates the alignment system to translate the location of the sensing area along the flow direction. The flow chamber can be mounted to a movable stage in some examples, and the alignment system can move the flow chamber substantially opposite the flow direction using the stage.

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