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1. 发明专利

AT374255T 未知
公开(公告)号：AT374255T
公开(公告)日：2007-10-15
申请号：AT03726328
申请日：2003-04-16
申请人： BIOREN INC , CAPPUCCILLI GUIDO
发明人： CREA ROBERTO , CAPPUCCILLI GUIDO
IPC分类号： C12N15/09 , C12N15/63 , C07K14/47 , C07K16/18 , C12N15/10 , C12P21/00 , C12Q1/68

2. 发明公开

EP1495142A4 "DOPING" IN WALK-THROUGH MUTAGENESIS 有权
标题翻译： DOPING BEI DER WALK-THROUGH-MUTAGENESE
公开(公告)号：EP1495142A4
公开(公告)日：2005-06-29
申请号：EP03726328
申请日：2003-04-16
申请人： CREA ROBERTO , CAPPUCCILLI GUIDO
发明人： CREA ROBERTO , CAPPUCCILLI GUIDO
IPC分类号： C12N15/09 , C07K14/47 , C12N15/10 , C12Q1/68 , C12N15/63 , C07K16/18 , C12P21/00
CPC分类号： C12N15/1089 , C12N15/102 , C12Q1/6883 , C12Q1/6897
摘要： A method of walk-through mutagenesis of a nucleic acid encoding a prototype polypeptide of interest, is described, the method comprising selecting a predetermined amino acid and one or more target regions of the polypeptide, and synthesizing a mixture of oligonucleotides containing at each sequence position in the target region, either a prototype nucleotide that is required for synthesis of the prototype amino acid of the polypeptide, or a predetermined nucleotide that is required for synthesis of the predetermined amino acid, in which during the synthesis, the ratio of available prototype nucleotides, to available predetermined nucleotides, is greater than 1:1.
摘要翻译：描述了编码感兴趣的原型多肽的核酸的步骤突变的方法，所述方法包括选择预定的氨基酸和多肽的一个或多个靶区域，并且合成含有在每个序列位置处的寡核苷酸的混合物在目标区域中，或者是合成多肽的原型氨基酸所需的原型核苷酸，或者是合成预定氨基酸所需的预定核苷酸，其中合成期间可用原型核苷酸的比例，到可用的预定核苷酸，大于1：1。

3. 发明授权

EP1495142B1 "DOPING" IN WALK-THROUGH MUTAGENESIS 有权
标题翻译：兴奋剂步行通过诱变
公开(公告)号：EP1495142B1
公开(公告)日：2007-09-26
申请号：EP03726328.2
申请日：2003-04-16
申请人： Bioren, Inc. , Cappuccilli, Guido
发明人： Crea, Roberto , Cappuccilli, Guido
IPC分类号： C12N15/63 , C12N15/10 , C07K16/18 , C12Q1/68 , C12P21/00
CPC分类号： C12N15/1089 , C12N15/102 , C12Q1/6883 , C12Q1/6897
摘要： A method of walk-through mutagenesis of a nucleic acid encoding a prototype polypeptide of interest, is described, the method comprising selecting a predetermined amino acid and one or more target regions of the polypeptide, and synthesizing a mixture of oligonucleotides containing at each sequence position in the target region, either a prototype nucleotide that is required for synthesis of the prototype amino acid of the polypeptide, or a predetermined nucleotide that is required for synthesis of the predetermined amino acid, in which during the synthesis, the ratio of available prototype nucleotides, to available predetermined nucleotides, is greater than 1:1.

4. 发明专利

CA2482769C "DOPING" IN WALK-THROUGH MUTAGENESIS 未知
公开(公告)号：CA2482769C
公开(公告)日：2013-10-08
申请号：CA2482769
申请日：2003-04-16
申请人： CREA ROBERTO , CAPPUCCILLI GUIDO
发明人： CREA ROBERTO , CAPPUCCILLI GUIDO
IPC分类号： C12N15/09 , C12Q1/68 , C07K14/47 , C12N15/10 , C12N15/63 , C12P21/00
摘要： A method of walk-through mutagenesis of a nucleic acid encoding a prototype polypeptide of interest, is described, the method comprising selecting a predetermined amino acid and one or more target regions of the polypeptide, and synthesizing a mixture of oligonucleotides containing at each sequence position in the target region, either a prototype nucleotide that is required for synthesis of the prototype amino acid of the polypeptide, or a predetermined nucleotide that is required for synthesis of the predetermined amino acid, in which during the synthesis, the ratio of available prototype nucleotides, to available predetermined nucleotides, is greater than 1:1.

5. 发明公开

EP1495142A1 "DOPING" IN WALK-THROUGH MUTAGENESIS 有权
标题翻译：兴奋剂步行通过诱变
公开(公告)号：EP1495142A1
公开(公告)日：2005-01-12
申请号：EP03726328.2
申请日：2003-04-16
申请人： Crea, Roberto , Cappuccilli, Guido
发明人： Crea, Roberto , Cappuccilli, Guido
IPC分类号： C12Q1/68 , C12P21/00 , C12N15/63
CPC分类号： C12N15/1089 , C12N15/102 , C12Q1/6883 , C12Q1/6897
摘要： A method of walk-through mutagenesis of a nucleic acid encoding a prototype polypeptide of interest, is described, the method comprising selecting a predetermined amino acid and one or more target regions of the polypeptide, and synthesizing a mixture of oligonucleotides containing at each sequence position in the target region, either a prototype nucleotide that is required for synthesis of the prototype amino acid of the polypeptide, or a predetermined nucleotide that is required for synthesis of the predetermined amino acid, in which during the synthesis, the ratio of available prototype nucleotides, to available predetermined nucleotides, is greater than 1:1.

6. 发明申请

WO2009023184A3 UNIVERSAL FIBRONECTIN TYPE III BINDING-DOMAIN LIBRARIES 审中-公开
标题翻译：通用纤连蛋白III型结合域文库
公开(公告)号：WO2009023184A3
公开(公告)日：2009-07-09
申请号：PCT/US2008009617
申请日：2008-08-11
申请人： PROTELIX INC , CAPPUCCILLI GUIDO , CREA ROBERTO , SHEN RANDY , HOKANSON CRAIG A , KIRK PETER B , LISTON DAVID R
发明人： CAPPUCCILLI GUIDO , CREA ROBERTO , SHEN RANDY , HOKANSON CRAIG A , KIRK PETER B , LISTON DAVID R
IPC分类号： C12N15/10 , C07K14/78 , C07K16/18 , C07K16/22 , C07K16/24 , C12N9/00
CPC分类号： C07K16/241 , C07K14/78 , C07K16/18 , C07K16/22 , C07K2317/21 , C07K2317/52 , C07K2318/20 , C07K2319/30 , C12N15/1044
摘要： Walk-through mutagenesis and natural-variant combinatorial fibronectin Type III (FN3) polypeptide libraries are described, along with their method of construction and use. Also disclosed are a number of high binding affinity polypeptides selected by screening the libraries against a variety of selected antigens.
摘要翻译：描述了步行诱变和天然变体组合型纤连蛋白III型（FN3）多肽文库以及它们的构建和使用方法。还公开了通过筛选文库针对各种选择的抗原选择的许多高结合亲和性多肽。

7. 发明申请

WO2008027452A3 SELF-ASSEMBLING OLIGONUCLEOTIDES AND METHODS 审中-公开
标题翻译：自组装寡核苷酸和方法
公开(公告)号：WO2008027452A3
公开(公告)日：2008-05-08
申请号：PCT/US2007019036
申请日：2007-08-29
申请人： CREA AND COMPANY R , CREA ROBERTO , CAPPUCCILLI GUIDO
发明人： CREA ROBERTO , CAPPUCCILLI GUIDO
IPC分类号： C07H21/00
CPC分类号： C07H21/04 , C07H21/00
摘要： A composition comprising individual single-stranded oligonucleotides capable of self assembling to form a pair of complementary, substantially contiguous single strands of a double-stranded nucleic acid filament, and a method for forming such filaments are disclosed.
摘要翻译：公开了包含能够自组装以形成双链核酸丝的一对互补的，基本相邻的单链的单个单链寡核苷酸的组合物和形成这种细丝的方法。

8. 发明专利

ES2295584T3 "DOPAJE" EN MUTAGENESIS DE PASO. 未知
公开(公告)号：ES2295584T3
公开(公告)日：2008-04-16
申请号：ES03726328
申请日：2003-04-16
申请人： BIOREN INC , CAPPUCCILLI GUIDO
发明人： CREA ROBERTO , CAPPUCCILLI GUIDO
IPC分类号： C12N15/09 , C12N15/63 , C07K14/47 , C07K16/18 , C12N15/10 , C12P21/00 , C12Q1/68
摘要： Un método de mutagénesis de paso a través de un ácido nucleico que codifica un polipéptido prototipo de interés, que comprende: a) seleccionar una o más regiones diana de aminoácidos prototipo en el polipéptido prototipo de interés, codificado por el ácido nucleico; b) para cada una de las regiones diana, predeterminar un aminoácido para que se incorpore a la región diana, en lugar de los aminoácidos prototipos; y c) sintetizar una mezcla de oligonucleótidos que contiene una secuencia de nucleótidos para cada región diana, donde cada oligonucleótido contiene, en cada posición de secuencia en la región diana, un nucleótido que se requiere para la síntesis del aminoácido prototipo del polipéptido, o un nucleótido predeterminado que se requiere para la síntesis del aminoácido predeterminado, donde, durante la síntesis, la relación entre nucleótidos prototipo disponibles y nucleótidos predeterminados disponibles, es igual o mayor que 4:1, donde dicha relación se determina mediante el uso de ladistribución binomial y donde dicha distribución de probabilidad tiene en consideración el número (N) de aminoácidos en la región o regiones diana, y la probabilidad (P) de éxito en incorporar los nucleótidos que codifican el aminoácido predeterminado, y donde X (número total de aminoácidos mutados en una secuencia de longitud N), es menor que N.

9. 发明专利

AU2003228568A1 "DOPING" IN WALK-THROUGH MUTAGENESIS 未知
公开(公告)号：AU2003228568A1
公开(公告)日：2003-11-03
申请号：AU2003228568
申请日：2003-04-16
申请人： CAPPUCCILLI GUIDO , CREA ROBERTO
发明人： CREA ROBERTO , CAPPUCCILLI GUIDO
IPC分类号： C12N15/09 , C07K14/47 , C12N15/10 , C12Q1/68 , C12N15/63 , C12P21/00

10. 发明申请

WO2011035202A3 UNIVERSAL FIBRONECTIN TYPE III BINDING-DOMAIN LIBRARIES 审中-公开
标题翻译：通用FIBRONECTIN III型绑定库
公开(公告)号：WO2011035202A3
公开(公告)日：2011-05-12
申请号：PCT/US2010049391
申请日：2010-09-17
申请人： PROTELIX INC , CAPPUCCILLI GUIDO , CREA ROBERTO , SHEN RANDY , HOKANSON CRAIG A , KIRK PETER B , LISTON DAVID R
发明人： CAPPUCCILLI GUIDO , CREA ROBERTO , SHEN RANDY , HOKANSON CRAIG A , KIRK PETER B , LISTON DAVID R
IPC分类号： C07K14/00 , G01N33/53
CPC分类号： C07K14/78 , C07K16/18 , C07K16/22 , C07K16/241 , C07K2317/21 , C07K2317/52 , C07K2318/20 , C12N15/1044 , C40B40/10
摘要： Fibronectin Type III (FN3) polypeptide libraries are described, along with their use in identifying fibronectin-type binding peptides having hign binding affinities, e.g., greater than 300 nM, for VEGFR2 or AxI proteins.
摘要翻译：描述了纤连蛋白III型（FN3）多肽文库，以及它们用于鉴定对于VEGFR2或AxI蛋白具有hign结合亲和力（例如大于300nM）的纤连蛋白型结合肽。

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