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1. 发明公开

EP1495142A1 "DOPING" IN WALK-THROUGH MUTAGENESIS 有权
标题翻译：兴奋剂步行通过诱变
公开(公告)号：EP1495142A1
公开(公告)日：2005-01-12
申请号：EP03726328.2
申请日：2003-04-16
申请人： Crea, Roberto , Cappuccilli, Guido
发明人： Crea, Roberto , Cappuccilli, Guido
IPC分类号： C12Q1/68 , C12P21/00 , C12N15/63
CPC分类号： C12N15/1089 , C12N15/102 , C12Q1/6883 , C12Q1/6897
摘要： A method of walk-through mutagenesis of a nucleic acid encoding a prototype polypeptide of interest, is described, the method comprising selecting a predetermined amino acid and one or more target regions of the polypeptide, and synthesizing a mixture of oligonucleotides containing at each sequence position in the target region, either a prototype nucleotide that is required for synthesis of the prototype amino acid of the polypeptide, or a predetermined nucleotide that is required for synthesis of the predetermined amino acid, in which during the synthesis, the ratio of available prototype nucleotides, to available predetermined nucleotides, is greater than 1:1.

2. 发明授权

EP1495142B1 "DOPING" IN WALK-THROUGH MUTAGENESIS 有权
标题翻译：兴奋剂步行通过诱变
公开(公告)号：EP1495142B1
公开(公告)日：2007-09-26
申请号：EP03726328.2
申请日：2003-04-16
申请人： Bioren, Inc. , Cappuccilli, Guido
发明人： Crea, Roberto , Cappuccilli, Guido
IPC分类号： C12N15/63 , C12N15/10 , C07K16/18 , C12Q1/68 , C12P21/00
CPC分类号： C12N15/1089 , C12N15/102 , C12Q1/6883 , C12Q1/6897
摘要： A method of walk-through mutagenesis of a nucleic acid encoding a prototype polypeptide of interest, is described, the method comprising selecting a predetermined amino acid and one or more target regions of the polypeptide, and synthesizing a mixture of oligonucleotides containing at each sequence position in the target region, either a prototype nucleotide that is required for synthesis of the prototype amino acid of the polypeptide, or a predetermined nucleotide that is required for synthesis of the predetermined amino acid, in which during the synthesis, the ratio of available prototype nucleotides, to available predetermined nucleotides, is greater than 1:1.

3. 发明公开

EP2632278A2 JATROPHA CURCAS PROCESSING METHODS AND PRODUCTS 审中-公开
标题翻译：麻风树树，加工及制品
公开(公告)号：EP2632278A2
公开(公告)日：2013-09-04
申请号：EP11837023.8
申请日：2011-10-26
申请人： Crea, Roberto
发明人： Crea, Roberto
IPC分类号： A23K1/14 , A23L1/29
CPC分类号： A23K50/80 , A23D9/007 , A23D9/02 , A23K10/30 , A23K10/37 , A23K20/158 , A23K50/10 , A23K50/30 , A23K50/75 , A23L33/105 , A23L33/115 , A61K36/47 , C11B1/06 , C11B1/10 , C11B5/0035 , Y02P60/877
摘要： A process for preparing a food or feed composition from J. curcas is disclosed. The method involves adding an acidified aqueous solution to J. curcas components, to a final pH of between 1 and 5, incubating the acidified mixture for a period for a period of at least 1 hour, and centrifuging the incubated mixture to separate the mixture into three physically distinct fractions: (i) a light, upper fraction containing oil, (ii) an aqueous fraction containing soluble acid-extracted components and breakdown products, and (iii) a substantially detoxified solid cake which forms or is used in forming the food or feed composition. The acidified aqueous solution added may be acidified olive vegetation water having a ratio of hydroxytyrosol to oleuropein of between 5:1 to 100:1. Also disclosed are a food or feed composition, and oil and aqueous fractions formed by the method.

4. 发明公开

EP1499887A2 UNIVERSAL LIBRARIES FOR IMMUNOGLOBULINS 有权
标题翻译：全能银行免疫球蛋白
公开(公告)号：EP1499887A2
公开(公告)日：2005-01-26
申请号：EP03726329.0
申请日：2003-04-16
申请人： Crea, Roberto
发明人： Crea, Roberto
IPC分类号： G01N33/53
CPC分类号： C07K16/1063 , C07K2317/21 , C07K2317/565 , C07K2317/622
摘要： Libraries of immunoglobulins of interest are described, the libraries containing mutated immunoglobulins of interest in which a single predetermined amino acid has been substituted in one or more positions in one or more complementarity-determining regions of the immunoglobulin of interest. The libraries comprise a series of subset libraries, in which the predetermined amino acid is 'walked through' each of the six complementarity-determining regions (CDRs) of the immunoglobulin of interest not only individually but also for each of the possible combinatorial variations of the CDRs, resulting in subset libraries that include mutated immunoglobulins having the predetermined amino acid at one or more positions in each CDR, and collectively having the predetermined amino acid at each position in each CDR. The invention is further drawn to universal libraries containing one such library for each naturally-occurring amino acid as the single predetermined amino acid, totaling twenty libraries; and also to libraries of nucleic acids encoding the described libraries.

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