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    • 3. 发明申请
    • COMPOSITIONS AND METHODS RELATING TO PROSTATE SPECIFIC GENES AND PROTEINS
    • 与前列腺特异性基因和蛋白质相关的组合物和方法
    • WO0242499A2
    • 2002-05-30
    • PCT/US0145179
    • 2001-11-20
    • DIADEXUS INCSALCEDA SUSANAMACINA ROBERTO ARECIPON HERVECAFFERKEY ROBERTALI SHUJATHSUN YONGMINGLIU CHENGHUA
    • SALCEDA SUSANAMACINA ROBERTO ARECIPON HERVECAFFERKEY ROBERTALI SHUJATHSUN YONGMINGLIU CHENGHUA
    • C07K14/47C12N15/12C12Q1/68
    • C07K14/47
    • The present invention relates to newly identified nucleic acids and polypeptides present in normal and neoplastic prostate cells, including fragments, variants and derivatives of the nucleic acids and polypeptides. The present invention also relates to antibodies to the polypeptides of the invention, as well as agonists and antagonists of the polypeptides of the invention. The invention also relates to compositions comprising the nucleic acids, polypeptides, antibodies, variants, derivatives, agonists and antagonists of the invention and methods for the use of these compositions. These uses includes identifying, diagnosing, monitoring, staging, imaging and treating prostate cancer and non-cancerous disease states in prostate tissue, identifying prostate tissue, monitoring and identifying and/or designing agonists and antagonists of polypeptides of the invention. The uses also include gene therapy, production of transgenic animals and cells, and production of engineered prostate tissue for treatment and research.
    • 本发明涉及存在于正常和肿瘤前列腺细胞中的新鉴定的核酸和多肽,包括核酸和多肽的片段,变体和衍生物。 本发明还涉及本发明多肽的抗体,以及本发明多肽的激动剂和拮抗剂。 本发明还涉及包含本发明的核酸,多肽,抗体,变体,衍生物,激动剂和拮抗剂以及使用这些组合物的方法的组合物。 这些用途包括识别,诊断,监测,分期,成像和治疗前列腺组织中的前列腺癌和非癌性疾病状态,鉴定前列腺组织,监测和/或设计本发明多肽的激动剂和拮抗剂。 用途还包括基因治疗,转基因动物和细胞的生产,以及用于治疗和研究的工程前列腺组织的生产。