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1. 发明授权

US5488854A Pipetting apparatus 失效
标题翻译：移液器
公开(公告)号：US5488854A
公开(公告)日：1996-02-06
申请号：US295691
申请日：1994-10-17
申请人： Junichi Kawanabe , Masaaki Takeda , Hitomi Katagi , Yuko Kato , Brent A. Pelletier
发明人： Junichi Kawanabe , Masaaki Takeda , Hitomi Katagi , Yuko Kato , Brent A. Pelletier
IPC分类号： G01F23/14 , G01N35/10 , G01N7/00
CPC分类号： G01N35/1016 , G01F23/14 , G01N2035/1018
摘要： The presence of air bubbles is detected during a dispensing of samples for determining if the volume of the sample dispensed is insufficient.The characteristic of a presence-of-bubbles curve (101) has a difference in a pressure inside a nozzle from the characteristic of a curve (100) under a normal condition in which no bubbles exist, at the time just before the dispensing of the sample is completed. Accordingly, it is possible to determine whether or not bubbles exist by detecting the pressure inside the nozzle at the determination time (105) and comparing the detected value with an established threshold value, and it is determined that an insufficient volume of sample has been dispensed, thereby a warning is generated.
摘要翻译： PCT No.PCT / JP92 / 01681 Sec。 371日期：1994年10月17日 102（e）日期1994年10月17日PCT提交1992年12月22日PCT公布。公开号WO93 / 18409 日期为1993年9月16日。在分配样品期间检测到气泡的存在，以确定分配的样品的体积是否不足。存在气泡曲线（101）的特征在正好在没有气泡存在的正常条件下，喷嘴内部的压力与曲线（100）的特性之间在分配前样品完成。因此，可以通过在确定时间（105）检测喷嘴内部的压力并将检测值与建立的阈值进行比较来确定是否存在气泡，并且确定已经分配了不足的样本体积，从而产生警告。

2. 发明授权

US5537880A Automatic pipetting apparatus with leak detection and method of detecting a leak 失效
标题翻译：具有泄漏检测的自动移液装置和检测泄漏的方法
公开(公告)号：US5537880A
公开(公告)日：1996-07-23
申请号：US481677
申请日：1995-06-07
申请人： Masaaki Takeda , Yuko Kato , Brent A. Pelletier
发明人： Masaaki Takeda , Yuko Kato , Brent A. Pelletier
IPC分类号： G01M3/26 , G01N35/10
CPC分类号： G01N35/1016 , G01M3/26 , G01N2035/102
摘要： Embodiments described herein provide a pipetting apparatus with leak detection and a method for detecting a leak. In one embodiment, an automatic pipetting apparatus comprises a nozzle having a lower end portion through which a fluid sample is aspirated and dispensed by changes in air pressure supplied to the nozzle. A piping system operatively connects the nozzle to a pump for supplying the air pressure to the nozzle. A pressure sensor is operatively connected with the piping system for measuring internal pressure in the piping system. An XYZ robot is operatively connected with the nozzle for three-dimensionally moving the nozzle between an aspirating position of the fluid sample and a dispensing position. A leak detector is operatively connected with the pressure sensor for detecting a leak in the piping system based upon a measured result obtained by measuring the internal pressure in the piping system with the pressure sensor while the nozzle, which has aspirated a predetermined volume of the fluid sample, is being moved between the aspirating position and the dispensing position by the robot.
摘要翻译：本文所述的实施例提供了具有泄漏检测的移液装置和用于检测泄漏的方法。在一个实施例中，自动移液装置包括具有下端部分的喷嘴，通过该下端部抽吸流体样品并通过供给喷嘴的空气压力的变化来分配。管道系统将喷嘴可操作地连接到泵，以将空气压力提供给喷嘴。压力传感器与管道系统可操作地连接，用于测量管道系统中的内部压力。 XYZ机器人与喷嘴可操作地连接，用于在流体样品的抽吸位置和分配位置之间三维地移动喷嘴。泄漏检测器与压力传感器可操作地连接，用于基于通过用压力传感器测量管道系统中的内部压力而获得的测量结果来检测管道系统中的泄漏，同时吸入预定体积的流体样品由机器人在抽吸位置和分配位置之间移动。

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