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1. 发明申请

US20020143174A1 Very high molecular weight beta-glucans 有权
公开(公告)号：US20020143174A1
公开(公告)日：2002-10-03
申请号：US10094686
申请日：2002-03-07
申请人： Biopolymer Engineering, Inc.
发明人： Myra L. Patchen , Spiros Jamas , D. Davidson Easson JR. , Gary R. Ostroff
IPC分类号： A61K031/716 , C07H001/00
CPC分类号： A61K31/716 , C08B37/0024 , C08L5/00 , Y10S514/885 , Y10S514/944 , Y10S514/951 , Y10S514/959 , Y10S514/962
摘要： The invention pertains to compositions and therapeutic and prophylatic methods for treating/preventing infections in an animal or human by administering a soluble null-glucan composition comprising null-glucan molecules having an average molecular weight of at least 1,000,000 daltons, as determined by multi-angle laser light scattering (VHMW-glucan).

2. 发明申请

WO2009042230A1 ß-GLUCAN TREATMENT OF UPPER RESPIRATORY TRACT INFECTION SYMPTOMS AND PSYCHOLOGICAL WELL-BEING 审中-公开
标题翻译： ß-GLUCAN治疗上呼吸道感染症状和心理健康
公开(公告)号：WO2009042230A1
公开(公告)日：2009-04-02
申请号：PCT/US2008/011249
申请日：2008-09-29
申请人： BIOPOLYMER ENGINEERING, INC. DBA BIOTHERA, INC , COX, Donald , TALBOT, Steven
发明人： COX, Donald , TALBOT, Steven
IPC分类号： A61K31/716
CPC分类号： A61K31/716
摘要： Studies involving placebo-controlled, double-blinded designs to evaluate the effect of beta-glucan compositions on upper-respiratory tract infections and psychological wellness were carried out. During the course of the reporting periods of these studies, subjects in the treatment groups reported fewer URTI symptoms, better overall health and a more positive psychological assessment based on a POMS survey.
摘要翻译：进行了涉及安慰剂对照，双盲设计以评估β-葡聚糖组合物对上呼吸道感染和心理健康的影响的研究。在这些研究的报告期间，治疗组中的受试者报告了基于POMS调查的URTI症状较少，总体健康状况更好，心理评估更积极。

3. 发明申请

WO2006085895A3 WHOLE GLUCAN PARTICLES IN COMBINATION WITH ANTIBIOTICS, VACCINES AND VIRAL MONOCLONAL ANTIBODIES 审中-公开
标题翻译：整体葡聚糖颗粒与抗生素，疫苗和病毒单克隆抗体的组合
公开(公告)号：WO2006085895A3
公开(公告)日：2006-10-19
申请号：PCT/US2005016229
申请日：2005-05-10
申请人： BIOPOLYMER ENGINEERING INC , UNIV LOUISVILLE RES FOUND , KOURNIKAKIS BILL , ROSS TRUNETTA JO DOCKTER , KAREL STEVEN J , CONNERS DANIEL K
发明人： KOURNIKAKIS BILL , ROSS TRUNETTA JO DOCKTER , KAREL STEVEN J , CONNERS DANIEL K
IPC分类号： A61K31/715 , C07H1/00
CPC分类号： A61K31/716 , A61K39/42 , A61K2300/00
摘要： The present invention relates to compositions and methods of using whole glucan particles and agents. Whole glucan particles enhance the tumoricidal activity of the innate immune system by binding to the C3 complement protein receptor CR3. This binding enhances innate immune system cytotoxicity, as well as stimulating the release of activatingcytokines and enhances the bodies response to the agent.
摘要翻译：本发明涉及使用全葡聚糖颗粒和试剂的组合物和方法。全葡聚糖颗粒通过与C3补体蛋白受体CR3结合来增强先天性免疫系统的杀肿瘤活性。这种结合增强先天性免疫系统的细胞毒性，以及刺激活化细胞因子的释放并增强机体对药物的反应。

4. 发明申请

WO2006085895A2 WHOLE GLUCAN PARTICLES IN COMBINATION WITH ANTIBIOTICS, VACCINES AND VIRAL MONOCLONAL ANTIBODIES 审中-公开
标题翻译：与抗生素，疫苗和病毒性单克隆抗体联合使用的全部GLUCAN颗粒
公开(公告)号：WO2006085895A2
公开(公告)日：2006-08-17
申请号：PCT/US2005/016229
申请日：2005-05-10
申请人： BIOPOLYMER ENGINEERING, INC. , UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC. , KOURNIKAKIS, Bill , ROSS, Trunetta, Jo, Dockter , KAREL, Steven, J. , CONNERS, Daniel, K.
发明人： KOURNIKAKIS, Bill , ROSS, Trunetta, Jo, Dockter , KAREL, Steven, J. , CONNERS, Daniel, K.
IPC分类号： A61K31/716
CPC分类号： A61K31/716 , A61K39/42 , A61K2300/00
摘要： The present invention relates to compositions and methods of using whole glucan particles and agents. Whole glucan particles enhance the tumoricidal activity of the innate immune system by binding to the C3 complement protein receptor CR3. This binding enhances innate immune system cytotoxicity, as well as stimulating the release of activatingcytokines and enhances the bodies response to the agent.
摘要翻译：本发明涉及使用全葡聚糖颗粒和试剂的组合物和方法。全葡聚糖颗粒通过结合C3补体蛋白受体CR3增强先天免疫系统的杀肿瘤活性。这种结合增强先天免疫系统的细胞毒性，以及刺激活化细胞因子的释放并增强身体对药剂的反应。

5. 发明申请

WO2007146417A3 GLUCAN COMPOSITIONS AND METHODS OF ENHANCING CR3 DEPENDENT NEUTROPHIL-MEDIATED CYTOTOXICITY 审中-公开
标题翻译：葡萄糖组合物和增强CR3依赖性中性粒细胞毒性的方法
公开(公告)号：WO2007146417A3
公开(公告)日：2008-05-15
申请号：PCT/US2007014056
申请日：2007-06-15
申请人： BIOPOLYMER ENGINEERING INC DBA , YAN JUN
发明人： YAN JUN
IPC分类号： C07H3/06 , A61K31/715
CPC分类号： C07K16/2845 , A61K31/716 , A61K39/395 , A61K45/06 , A61K2300/00
摘要： A 25 kD ß-glucan composition is described herein that effects the CR3-dependent priming of neutrophils and can promote neutrophil killing of iC3b-opsonized targets. Also described herein are methods of enhancing neutrophil cytotoxicity locally at the site of the tumor.
摘要翻译：本文描述了25kDβ-葡聚糖组合物，其影响中性粒细胞的CR3依赖性引发并且可以促进iC3b调理的靶标的嗜中性粒细胞杀伤。本文还描述了在肿瘤部位局部增强嗜中性粒细胞毒性的方法。

6. 发明申请

WO2005014776A2 USE OF BETA-GLUCANS AGAINST BIOLOGICAL WARFARE WEAPONS AND PATHOGENS INCLUDING ANTHRAX 审中-公开
标题翻译：使用抗生素威胁武器和病毒包括ANTHRAX的BETA-GLUCANS
公开(公告)号：WO2005014776A2
公开(公告)日：2005-02-17
申请号：PCT/US0332196
申请日：2003-10-09
申请人： BIOPOLYMER ENGINEERING INC , OSTROFF GARY R
发明人： OSTROFF GARY R
IPC分类号： A61K31/715 , A61K39/395 , A61K45/06 , C12N
CPC分类号： A61K31/715 , A61K31/716 , A61K39/395 , A61K45/06 , C08B37/0024 , A61K2300/00
摘要： The present invention provides a means to broadly protect the military and the public from injury from biological warfare weapons, particularly infective agents such as anthrax. Beta (1,3)-glucans, particularly whole glucan particles, PGG-Glucan, and microparticulate glucan, provide general immune enhancement, thereby increasing the body's ability to defend against a wide variety of biological threats. Beta (1,3)-glucans have been shown to increase the resistance to infection by anthrax and other infectious organisms when administered before and after infection. The anti-infective mechanism of 3 (1,3)-glucan appears to involve stimulation of the innate immune system through increased cytokine release and CR3 receptor activation. Beta (1,3)-glucan is pharmaceutically stable, relatively compact, and can also be used without significant side effects. Beta (1,3)-glucan can also enhance the effectiveness of other medical countermeasures such as antibiotics, vaccines, and immune antibodies.
摘要翻译：本发明提供了广泛保护军事和公众免受生物武器武器特别是炭疽等感染因素的伤害的手段。 β（1,3）葡聚糖，特别是全葡聚糖颗粒，PGG-葡聚糖和微粒葡聚糖，提供一般的免疫增强，从而增加身体防御各种生物威胁的能力。已证明β（1,3） - 葡聚糖在感染前后施用时可以增加炭疽病和其他感染性生物体对感染的抵抗力。 3（1,3） - 葡聚糖的抗感染机制似乎涉及通过增加细胞因子释放和CR3受体激活来刺激先天免疫系统。 β（1,3） - 葡聚糖是药学上稳定的，相对紧凑的，也可以没有显着的副作用使用。 β（1,3） - 葡聚糖还可以提高其他医疗对策如抗生素，疫苗和免疫抗体的有效性。

7. 发明申请

WO2004021994A3 CANCER THERAPY USING WHOLE GLUCAN PARTICLES AND ANTIBODIES 审中-公开
标题翻译：使用全部葡聚糖颗粒和抗体的癌症治疗
公开(公告)号：WO2004021994A3
公开(公告)日：2004-08-12
申请号：PCT/US0327841
申请日：2003-09-04
申请人： BIOPOLYMER ENGINEERING INC , UNIV LOUISVILLE RES FOUND , OSTROFF GARY R , ROSS GORDON D
发明人： OSTROFF GARY R , ROSS GORDON D
IPC分类号： A61K39/395 , A61K38/16 , A61K31/715 , C07K16/00
CPC分类号： A61K31/716 , A61K31/47 , A61K31/715 , A61K39/39558 , A61K2039/505 , A61K2039/545 , C07K16/18 , C07K2317/732 , C07K2317/75 , C07K2317/76 , A61K2300/00
摘要： The present invention relates to methods of using whole glucan particles and complement activating antibodies for antitumor therapy. Whole glucan particles enhance the tumoricidal activity of the innate immune system by binding to the C3 complement protein receptor CR3. This binding enhances innate immune system cytotoxicity, as well as stimulating the release of activating cytokines.
摘要翻译：本发明涉及使用全葡聚糖颗粒和补体活化抗体进行抗肿瘤治疗的方法。全葡聚糖颗粒通过与C3补体蛋白受体CR3结合来增强先天性免疫系统的杀肿瘤活性。这种结合增强了先天性免疫系统的细胞毒性，并刺激了活化细胞因子的释放。

8. 发明申请

WO2004021994A2 CANCER THERAPY USING WHOLE GLUCAN PARTICLES AND ANTIBODIES 审中-公开
标题翻译：使用全球葡萄糖颗粒和抗体的癌症治疗
公开(公告)号：WO2004021994A2
公开(公告)日：2004-03-18
申请号：PCT/US2003/027841
申请日：2003-09-04
申请人： BIOPOLYMER ENGINEERING, INC. , UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC. , OSTROFF, Gary, R. , ROSS, Gordon, D.
发明人： OSTROFF, Gary, R. , ROSS, Gordon, D.
IPC分类号： A61K
CPC分类号： A61K31/716 , A61K31/47 , A61K31/715 , A61K39/39558 , A61K2039/505 , A61K2039/545 , C07K16/18 , C07K2317/732 , C07K2317/75 , C07K2317/76 , A61K2300/00
摘要： The present invention relates to methods of using whole glucan particles and complement activating antibodies for antitumor therapy. Whole glucan particles enhance the tumoricidal activity of the innate immune system by binding to the C3 complement protein receptor CR3. This binding enhances innate immune system cytotoxicity, as well as stimulating the release of activating cytokines.
摘要翻译：本发明涉及使用全葡聚糖颗粒和补体活化抗体进行抗肿瘤治疗的方法。全葡聚糖颗粒通过结合C3补体蛋白受体CR3增强先天免疫系统的杀肿瘤活性。这种结合增强先天免疫系统的细胞毒性，以及刺激激活细胞因子的释放。

9. 发明申请

WO2007146417A2 GLUCAN COMPOSITIONS AND METHODS OF ENHANCING CR3 DEPENDENT NEUTROPHIL-MEDIATED CYTOTOXICITY 审中-公开
标题翻译：葡萄糖组合物和增强CR3依赖性中性粒细胞毒性的方法
公开(公告)号：WO2007146417A2
公开(公告)日：2007-12-21
申请号：PCT/US2007/014056
申请日：2007-06-15
申请人： BIOPOLYMER ENGINEERING, INC. DBA BIOTHERA, INC. , YAN, Jun
发明人： YAN, Jun
IPC分类号： A61K31/716 , A61K39/395
CPC分类号： C07K16/2845 , A61K31/716 , A61K39/395 , A61K45/06 , A61K2300/00
摘要： A 25 kD β-glucan composition is described herein that effects the CR3-dependent priming of neutrophils and can promote neutrophil killing of iC3b-opsonized targets. Also described herein are methods of enhancing neutrophil cytotoxicity locally at the site of the tumor.
摘要翻译：本文描述了25kDβ-葡聚糖组合物，其影响中性粒细胞的CR3依赖性引发并且可以促进iC3b调理的靶标的嗜中性粒细胞杀伤。本文还描述了在肿瘤部位局部增强嗜中性粒细胞毒性的方法。

10. 发明申请

WO2007146416A3 GLUCAN PREPARATIONS 审中-公开
公开(公告)号：WO2007146416A3
公开(公告)日：2007-12-21
申请号：PCT/US2007/014055
申请日：2007-06-15
申请人： BIOPOLYMER ENGINEERING, INC. DBA BIOTHERA, INC. , MAGEE, Andrew , ROLKE, James , YANG, Ren-der
发明人： MAGEE, Andrew , ROLKE, James , YANG, Ren-der
IPC分类号： A61L26/00 , C12P19/04 , A61K31/716 , C08B37/00
摘要： The present invention relates to compositions that include β-glucan. More particularly, the present invention relates to a process for producing soluble β-glucan.

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