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1. 发明申请

US20040126440A1 Periodontal treatment compound and method of use 失效
标题翻译：牙周治疗化合物及使用方法
公开(公告)号：US20040126440A1
公开(公告)日：2004-07-01
申请号：US10334373
申请日：2002-12-30
发明人： Marvin B. Frager , R. Douglas Gaynor , John R. Taylor
IPC分类号： A61K035/78 , A61K031/716
CPC分类号： A61K36/45 , A61K31/047 , A61K31/716 , A61K36/61 , A61K2300/00
摘要： An oral compound of water; glycerin; a cranberry source; methylsulfonylmethane; melaleuca alternifolia oil; hydroxyethylcellulose; and a surfactant, in proper combination for use by injecting the compound around a person's gum line followed by its use in a dental tray over a person's teeth and gums for a specified period of time. The next phase to the overall treatment regimen is a daily health care regimen involving: a systemic immune defense compound having colostrum beta 1,3 Glucans; fructo-oligosaccharides; amla fruit 4:1; inositol hexaphosphate; selected minerals; selected enzymes; selected probiotics; and methylsulfonylmethane; an antimicrobial compound having sodium bicarbonate, silicone dioxide, and a cranberry source; and an oral probiotic compound having selected probiotics; vitamin C; and colostrum.
摘要翻译：水的口服化合物甘油; 蔓越莓来源; 甲基磺酰甲烷; 黄花菜油羟乙基纤维素; 和表面活性剂，其适当组合用于通过将化合物注射在人的牙龈线周围，随后在牙齿托盘上将其用于牙齿和牙龈一段指定的时间段。总体治疗方案的下一个阶段是每日保健方案，涉及：具有初乳β1,3葡聚糖的全身免疫防御化合物; 果寡糖; amla水果4：1; 肌醇六磷酸选矿; 选择的酶; 选择益生菌; 和甲磺酰甲烷; 具有碳酸氢钠，二氧化硅和蔓越莓来源的抗微生物化合物; 和具有选择的益生菌的口服益生菌化合物; 维生素C; 和初乳

2. 发明申请

US20040120916A1 Contact lens care compositions, methods of use and preparation which protect ocular tissue membrane integrity 审中-公开
标题翻译：隐形眼镜护理组合物，保护眼组织膜完整性的使用和制备方法
公开(公告)号：US20040120916A1
公开(公告)日：2004-06-24
申请号：US10328641
申请日：2002-12-23
申请人： ADVANCED MEDICAL OPTICS, INC.
发明人： Stan Huth
IPC分类号： A61K031/716 , A61K031/185
CPC分类号： C11D3/48 , C11D3/0078 , C11D3/06 , C11D3/349
摘要： A multi-purpose contact lens care solution comprising taurine, a liquid aqueous medium, an antimicrobial component, a surfactant and a buffer. This solution prevents losses in ocular tissue membrane integrity during contact lens wear.
摘要翻译：一种多用途隐形眼镜护理溶液，其包含牛磺酸，液体水性介质，抗微生物组分，表面活性剂和缓冲剂。该解决方案防止隐形眼镜佩戴期间眼组织膜完整性的损失。

3. 发明申请

US20040101546A1 Hemostatic wound dressing containing aldehyde-modified polysaccharide and hemostatic agents 审中-公开
标题翻译：含有醛修饰多糖和止血剂的止血伤口敷料
公开(公告)号：US20040101546A1
公开(公告)日：2004-05-27
申请号：US10304472
申请日：2002-11-26
发明人： Anne Jessica Gorman , Sanyog Manohar Pendharkar
IPC分类号： A61K031/737 , A61K031/728 , A61K031/716 , A61K031/715 , A61K009/70
CPC分类号： A61L15/28 , A61K31/715 , A61K31/717 , A61K38/095 , A61K38/363 , A61K38/38 , A61K38/39 , A61K38/4833 , A61K38/4846 , A61L15/44 , A61L2300/418 , A61L2400/04 , C08L1/04 , C08L5/00 , C08L1/00
摘要： The present invention is directed to hemostatic wound dressings that contain a substrate for contacting a wound, wherein the substrate includes a wound-contacting surface and is fabricated at least in part from a biocompatible aldehyde-modified polysaccharide having covalently conjugated there with a hemostatic agent, and to methods of providing hemostasis to a wound that include applying the wound dressing described herein to a wound.
摘要翻译：本发明涉及含有用于接触伤口的基底的止血伤口敷料，其中所述基底包括伤口接触表面，并且至少部分地由与止血剂共价结合的生物相容性醛修饰多糖制成，以及向伤口提供止血的方法，包括将本文所述的伤口敷料施用于伤口。

4. 发明申请

US20040096503A1 Dry-powder film coating composition and method of preparation 失效
标题翻译：干粉薄膜涂料组合物及其制备方法
公开(公告)号：US20040096503A1
公开(公告)日：2004-05-20
申请号：US10706194
申请日：2003-11-12
申请人： Chr. Hansen, Inc.
发明人： Charles W. Gayser JR. , Jean-Paul Goyette
IPC分类号： A61K009/24 , A61K031/716
CPC分类号： A61K9/2866 , A23G3/343 , A23G3/54 , A23G2220/20 , A23P20/105 , A23V2002/00 , A61K9/282 , A61K9/2853 , A61K9/286 , A23V2200/22 , A23V2250/5022 , A23V2250/51086 , A23V2250/6406
摘要： An edible dry-powder formulation of a film coating for pharmaceuticals and confectioneries using gum acacia as a low-cost film former is provided. A cellulosic polymer such as hydroxypropyl methylcellulose is used in addition to the gum acacia. A plasticizer such as propylene glycol is also added. The resulting formulation is a dry, free flowing powder that can be put into solution and applied to a tablet or other substrate without an extended waiting period. The resulting film coating is clear, shiny, durable and extremely economical. Because the formulation is a dry powder, it has along shelf life and low shipping costs.
摘要翻译：提供了使用阿拉伯胶作为低成本成膜剂的用于药物和糖果的薄膜包衣的可食用干粉配方。除了阿拉伯胶之外，还使用纤维素聚合物如羟丙基甲基纤维素。还加入增塑剂如丙二醇。所得制剂是干燥，自由流动的粉末，其可以放入溶液中并施加到片剂或其它基材上，而不延长等待期。所得薄膜包衣透明，有光泽，耐用且极为经济。因为制剂是干粉，它具有保质期和低运输成本。

5. 发明申请

US20040087612A1 Method of increasing lacrimal gland tearing by topical administration of tacrolimus 审中-公开
标题翻译：通过局部施用他克莫司增加泪腺撕裂的方法
公开(公告)号：US20040087612A1
公开(公告)日：2004-05-06
申请号：US10287052
申请日：2002-11-04
发明人： Robert V. English , Bradley Nadelstein
IPC分类号： A61K031/4745 , A61K031/7012 , A61K031/716
CPC分类号： A61K31/7012 , A61K9/0048 , A61K31/4745 , A61K31/716
摘要： A method is provided for increasing lacrimal gland tearing in a patient's eye. Specifically, tacrolimus in a pharmaceutically acceptable vehicle is topically administered to the patient's eye.
摘要翻译：提供了一种增加患者眼睛泪腺撕裂的方法。具体地说，将药物可接受的媒介物中的他克莫司局部施用于患者的眼睛。

6. 发明申请

US20040077593A1 Numbing gel for hair removal 审中-公开
标题翻译：用于脱毛的数字凝胶
公开(公告)号：US20040077593A1
公开(公告)日：2004-04-22
申请号：US10274131
申请日：2002-10-21
发明人： Susan M. Marron
IPC分类号： A61K031/716 , A61K031/24
CPC分类号： A61Q9/04 , A61K8/42 , A61K8/44 , A61K8/731 , A61K31/24 , A61K31/716 , A61K2300/00
摘要： A numbing gel composition used in preparation for a body hair removal procedure such as the hot wax method. The gel composition contains lidocaine, tetracaine, methycellulose, and normal saline. The composition renders the skin substantially non-painful for the subsequent depilatory hot wax method.
摘要翻译：用于制备身体脱毛程序（例如热蜡法）的麻木凝胶组合物。凝胶组合物含有利多卡因，丁卡因，甲基纤维素和生理盐水。组合物使皮肤对于随后的脱毛热蜡方法基本上不疼痛。

7. 发明申请

US20040076675A1 Composition improved in solubility or oral absorbability 失效
标题翻译：组合物的溶解度或口服吸收性提高
公开(公告)号：US20040076675A1
公开(公告)日：2004-04-22
申请号：US10433515
申请日：2003-11-24
发明人： Jun Sugishita , Makoto Kigoshi , Setsuko Yano , Hideki Morita , Yasuki Kato
IPC分类号： A61K009/14 , A61K031/716
CPC分类号： A61K31/56 , A61K9/145 , A61K9/146 , A61K9/1617 , A61K9/1623 , A61K9/1652 , A61K9/1682 , A61K31/122 , A61K31/335 , A61K31/522
摘要： An object of the present invention is to provide a composition improved in the solubility or oral absorbability. The present invention provides a composition which comprises three components of a slightly water-soluble component, a surfactant and a hydrophilic polymer, and is obtainable by wet granulation in the presence of water.
摘要翻译：本发明的目的是提供改善溶解性或口服吸收性的组合物。本发明提供一种组合物，其包含微溶于水的组分，表面活性剂和亲水性聚合物的三种组分，并且可通过在水存在下通过湿法制粒获得。

8. 发明申请

US20040071727A1 Method of vaccinating vertebrates 失效
标题翻译：接种脊椎动物的方法
公开(公告)号：US20040071727A1
公开(公告)日：2004-04-15
申请号：US10705660
申请日：2003-11-10
申请人： Pharmacia & Upjohn Company
发明人： Terry L. Bowersock , Paul Guimond , Tzu-Chi R. Ju , Argaw Kidane
IPC分类号： A61K039/00 , A61K031/716 , A61K031/715
CPC分类号： A61K39/39 , A61K9/1641 , A61K9/1652 , A61K38/00 , A61K2039/541 , A61K2039/542 , A61K2039/55555 , A61K2039/55566
摘要： The invention provides a vaccine composition and a method of preparation including the steps of: forming a water-in-oil emulsion including an alginate in water, an oil, an antigen, and either (a) a cellulose ether and at least one nonionic surfactant or (b) a PEO-PPO-PEO triblock copolymer surfactant and at least one nonionic surfactant; followed by crosslinking the alginate in the emulsion with at least two cations selected from the group consisting of aluminum, barium, calcium, lithium, manganese, strontium, and zinc, to form antigen-containing, crosslinked alginate microparticles; and harvesting the microparticles. Another aspect of the invention is a method of vaccinating a vertebrate species including the step of administering to the species a vaccine composition prepared according to the method of the invention. The compositions of the invention have improved antigen loading, reduced microparticle size, increased hydrophobicity, improved uptake by antigen sampling cells, controlled antigen release characteristics, and improved immunogenicity.
摘要翻译：本发明提供疫苗组合物和制备方法，包括以下步骤：在水，油，抗原中形成包含藻酸盐的油包水乳液，和（a）纤维素醚和至少一种非离子表面活性剂或（b）PEO-PPO-PEO三嵌段共聚物表面活性剂和至少一种非离子表面活性剂; 然后用选自铝，钡，钙，锂，锰，锶和锌的至少两种阳离子将乳液中的藻酸盐交联，以形成含抗原的交联的藻酸盐微粒; 并收获微粒。本发明的另一方面是疫苗接种脊椎动物物种的方法，包括向物种施用根据本发明方法制备的疫苗组合物的步骤。本发明的组合物具有改善的抗原负载，降低的微粒尺寸，增加的疏水性，改善抗原取样细胞的摄取，受控的抗原释放特征和改善的免疫原性。

9. 发明申请

US20040006140A1 Controlled release arginine formulations 审中-公开
标题翻译：控制释放精氨酸制剂
公开(公告)号：US20040006140A1
公开(公告)日：2004-01-08
申请号：US10258633
申请日：2003-05-06
发明人： Wayne H Kaesemeyer
IPC分类号： A61K031/198 , A61K031/716 , B27N003/00
CPC分类号： A61K9/2027 , A61K9/2054 , A61K9/2866 , A61K31/198 , A61K31/716
摘要： A sustained release formulation of L-arginine alone or in combination with an agent which enhances the biotransformation of L-arginine into NO is described herein. FIG. 1A shows a schematic representation of proposed L-arginine dependent and independent pahtways.
摘要翻译：本文描述了L-精氨酸单独或与增强L-精氨酸生成转化为NO的试剂组合的持续释放制剂。图。图1A显示了所提出的L-精氨酸依赖和独立通路的示意图。

10. 发明申请

US20030228363A1 Stabilized pharmaceutical compositons containing benzimidazole compounds 审中-公开
标题翻译：含有苯并咪唑化合物的稳定药物组合物
公开(公告)号：US20030228363A1
公开(公告)日：2003-12-11
申请号：US10164744
申请日：2002-06-07
发明人： Mahendra R. Patel , Amol Singh Matharu , Chuanbin Wu , Ashish Anilbhai Patel
IPC分类号： A61K031/4439 , A61K031/716 , A61K009/24 , A61K009/36
CPC分类号： A61K31/716 , A61K9/2826 , A61K9/2846 , A61K9/2866 , A61K9/2886 , A61K31/4439
摘要： Thus, the present invention is directed toward an oral pharmaceutical composition in the form of a tablet comprising: a) single tablet core comprising, as an active ingredient, a labile PPI, wherein said single tablet core has an exterior surface; b) an enteric coating that is compression-coated onto the exterior surface of said single tablet core containing said PPI, without a separating layer between said single tablet core and said enteric coating; and c) optionally, a polymer over-coating on said enteric coating.
摘要翻译：因此，本发明涉及片剂形式的口服药物组合物，其包含：a）单片芯，其包含作为活性成分的不稳定PPI，其中所述单片芯具有外表面; b）在包含所述PPI的所述单个片芯的外表面上被压缩涂覆的肠溶衣，而在所述单个片芯和所述肠溶包衣之间没有分离层; 和c）任选地，所述肠溶衣上涂覆的聚合物。

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