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1. 发明授权

US07892576B2 Tablets comprising a biologically active substance and an excipient containing calcium carbonate 失效
标题翻译：包含生物活性物质和含有碳酸钙的赋形剂的片剂
公开(公告)号：US07892576B2
公开(公告)日：2011-02-22
申请号：US11816326
申请日：2006-02-13
申请人： Karine Cavalier , Didier Sy , Roberto Rosa , Bernard Bataille , Michele Delalonde , Gilles Baylac , Alberto Galasco
发明人： Karine Cavalier , Didier Sy , Roberto Rosa , Bernard Bataille , Michele Delalonde , Gilles Baylac , Alberto Galasco
IPC分类号： A61K9/20 , A61K47/04
CPC分类号： A61K9/2009 , A61K9/2027 , A61K9/2054 , A61K9/2077 , A61K31/00
摘要： Tablet comprising at least one biologically active substance and an excipient, in which the excipient contains calcium carbonate and at least one additive selected from fatty acids, their salts, their esters, lipid materials, polysaccharides, polyvinylpyrrolidone and polyvinylpyrrolidone derivatives, acrylic compounds, mono-, di- or triglyceride esters, animal proteins, and mixtures of at least two of these. Method for producing these tablets. Use of calcium carbonate in tablets containing at least one biologically active substance, for the prolonged release of this substance.
摘要翻译：包含至少一种生物活性物质和赋形剂的片剂，其中所述赋形剂含有碳酸钙和至少一种选自脂肪酸，其盐，其酯，脂质材料，多糖，聚乙烯吡咯烷酮和聚乙烯吡咯烷酮衍生物的添加剂，丙烯酸类化合物，，甘油二酯或甘油三酸酯，动物蛋白质，以及这些中的至少两种的混合物。生产这些片剂的方法。在含有至少一种生物活性物质的片剂中使用碳酸钙，以延长该物质的释放。

2. 发明申请

US20100113619A1 HIGH-AMYLOSE SODIUM CARBOXYMETHYL STARCH SUSTAINED RELEASE EXCIPIENT AND PROCESS FOR PREPARING THE SAME 审中-公开
标题翻译：高分子量的羧甲基纤维素淀粉保留释放专利及其制备方法
公开(公告)号：US20100113619A1
公开(公告)日：2010-05-06
申请号：US12451907
申请日：2008-06-05
申请人： Fabien Brouillet , Bernard Bataille , Gilles Baylac , Louis Cartilier
发明人： Fabien Brouillet , Bernard Bataille , Gilles Baylac , Louis Cartilier
IPC分类号： A61K47/36 , C08B31/00 , A61K9/20
CPC分类号： A61K9/2059 , A61K47/36 , C08B31/12 , C08J3/122 , C08J2303/02 , C08J2303/08 , C08J2305/04 , C08L3/02 , C08L3/08 , C08L5/04
摘要： A process for obtaining a spray-dried high amylose sodium carboxymethyl starch comprising a major fraction of amorphous form and optionally a minor fraction of crystalline V form, is provided. The process comprises providing an amorphous pregelatinized high amylose sodium carboxymethyl starch (HASCA); dispersing the amorphous pregelatinized HASCA in a solution comprising water and at least one first pharmaceutically acceptable organic solvent miscible with water and suitable for spray-drying; and spray-drying the dispersion to obtain the spray-dried HASCA comprising a major fraction of amorphous form and optionally a minor fraction of crystalline V form, in the form of a powder. Also provided is a spray-dried HASCA sustained-release excipient. This excipient is useful for preparing a tablet for the sustained-release of at least one drug.
摘要翻译：提供了一种获得喷雾干燥的高直链淀粉钠羧甲基淀粉的方法，该方法包括非晶形式的主要部分和任选的微结晶V形式的少部分。该方法包括提供无定形预胶化的高直链淀粉钠羧甲基淀粉（HASCA）; 将无定形预胶化的HASCA分散在包含水和至少一种可与水混溶并适于喷雾干燥的至少一种药学上可接受的有机溶剂的溶液中; 并喷雾干燥该分散体以获得喷雾干燥的HASCA，其包含粉末形式的非晶形式的主要部分和任选的微晶V型的少部分。还提供喷雾干燥的HASCA持续释放赋形剂。该赋形剂可用于制备用于缓释至少一种药物的片剂。

3. 发明申请

US20080131506A1 Tablets Comprising a Biologically Active Substance and an Excipient Containing Calcium Carbonate 失效
标题翻译：包含生物活性物质的片剂和含碳酸钙的赋形剂
公开(公告)号：US20080131506A1
公开(公告)日：2008-06-05
申请号：US11816326
申请日：2006-02-13
申请人： Karine Cavalier , Didier Sy , Roberto Rosa , Bernard Bataille , Michele Delalonde , Gilles Baylac , Alberto Galasco
发明人： Karine Cavalier , Didier Sy , Roberto Rosa , Bernard Bataille , Michele Delalonde , Gilles Baylac , Alberto Galasco
IPC分类号： A61K9/20 , A61K47/04
CPC分类号： A61K9/2009 , A61K9/2027 , A61K9/2054 , A61K9/2077 , A61K31/00
摘要： Tablet comprising at least one biologically active substance and an excipient, in which the excipient contains calcium carbonate and at least one additive selected from fatty acids, their salts, their esters, lipid materials, polysaccharides, polyvinylpyrrolidone and polyvinylpyrrolidone derivatives, acrylic compounds, mono-, di- or triglyceride esters, animal proteins, and mixtures of at least two of these. Method for producing these tablets. Use of calcium carbonate in tablets containing at least one biologically active substance, for the prolonged release of this substance.
摘要翻译：包含至少一种生物活性物质和赋形剂的片剂，其中所述赋形剂含有碳酸钙和至少一种选自脂肪酸，其盐，其酯，脂质材料，多糖，聚乙烯吡咯烷酮和聚乙烯吡咯烷酮衍生物的添加剂，丙烯酸类化合物，，甘油二酯或甘油三酸酯，动物蛋白质，以及这些中的至少两种的混合物。生产这些片剂的方法。在含有至少一种生物活性物质的片剂中使用碳酸钙，以延长该物质的释放。

4. 发明授权

US5733551A Process for preparing spheroids of plant origin 失效
标题翻译：制备植物来源的球体的方法
公开(公告)号：US5733551A
公开(公告)日：1998-03-31
申请号：US495964
申请日：1995-06-28
申请人： Maurice Jacob , Bernard Bataille , Olivier Jacob , Michel Iderne
发明人： Maurice Jacob , Bernard Bataille , Olivier Jacob , Michel Iderne
IPC分类号： A61K9/16 , A61K35/78
CPC分类号： A61K9/1652
摘要： Compositions of natural, especially plant, constituents in the form of spheroids in particular of the medicinal type and formulations necessary to their preparation by a technical extrusion and spheronization system. Compositions characterized by the direct use of large quantities of solutions of natural, especially plant, origin such as liquid extracts adsorbed by natural or synthetic polymer-type substances. These various components are selected so that their combination permits the obtainment of a mass of a plasticity compatible with the technical extrusion and spheronization system. According to the process, liquid extract is prepared, this extract is incorporated in a substance of a polymeric type, the correctly moistened mass is extruded by micro-extrusion techniques and the extrudates are spheronized and then dried and calibrated.
摘要翻译：天然的，特别是植物的组成成分的球形，特别是药物类型和通过技术挤出和滚圆系统制备所需的配方。组合物的特征在于直接使用大量天然的，特别是植物来源的溶液，例如由天然或合成聚合物型物质吸附的液体提取物。选择这些各种组分使得它们的组合允许获得与技术挤出和滚圆系统相容的塑性质量。根据该方法，制备液体提取物，将该提取物加入到聚合物类型中，通过微挤出技术挤出正确润湿的物质，并将挤出物滚圆，然后干燥和校准。

5. 发明专利

IL202576D0 HIGH-AMYLOSE SODIUM CARBOXYMETHYL STARCH SUSTAINED RELEASE EXCIPIENT AND PROCESS FOR PREPARING THE SAME 未知
公开(公告)号：IL202576D0
公开(公告)日：2010-06-30
申请号：IL20257609
申请日：2009-12-07
申请人： BERNARD BATAILLE , UNIV MONTREAL , LOUIS CARTILIER , FABIEN BROUILLET , GILLES BAYLAC
IPC分类号： C08B20100101
摘要： A process for obtaining a spray-dried high amylose sodium carboxymethyl starch comprising a major fraction of amorphous form and optionally a minor fraction of crystalline V form, is provided. The process comprises providing an amorphous pregelatinized high amylose sodium carboxymethyl starch (HASCA); dispersing the amorphous pregelatinized HASCA in a solution comprising water and at least one first pharmaceutically acceptable organic solvent miscible with water and suitable for spray-drying; and spray-drying the dispersion to obtain the spray-dried HASCA comprising a major fraction of amorphous form and optionally a minor fraction of crystalline V form, in the form of a powder. Also provided is a spray-dried HASCA sustained-release excipient. This excipient is useful for preparing a tablet for the sustained-release of at least one drug.

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