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1. 发明授权

US06713464B1 Derivatives of 3,3-diphenylpropylamines 有权
标题翻译： 3,3-二苯基丙胺的衍生物
公开(公告)号：US06713464B1
公开(公告)日：2004-03-30
申请号：US09700094
申请日：2001-01-02
申请人： Claus Meese , Bengt Sparf
发明人： Claus Meese , Bengt Sparf
IPC分类号： A61K31215
CPC分类号： C07C217/48 , C07C217/62 , C07C219/28 , C07C229/34 , C07C271/44 , C07C271/52 , C07C307/02
摘要： The invention concerns novel derivatives of 3,3-diphenylpropylamines, methods for their preparation, pharmaceutical compositions containing the novel compounds, and the use of the compounds for preparing drugs. More particularly, the invention relates to novel prodrugs of antimuscarinic agents with superior pharmacokinetic properties compared to existing drugs such as oxybutynin and tolterodine, methods for their preparation, pharmaceutical compositions containing them, a method of using said compounds and compositions for the treatment of urinary incontinence, gastrointestinal hyperactivity (irritable bowel syndrome) and other smooth muscle contractile conditions.
摘要翻译：本发明涉及3,3-二苯基丙胺的新衍生物，其制备方法，含有新化合物的药物组合物，以及该化合物用于制备药物的用途。更具体地，本发明涉及与现有药物如奥昔布宁和托特罗定相比具有优异药代动力学性质的抗毒蕈碱剂的新型前药，其制备方法，含有它们的药物组合物，使用所述化合物和组合物治疗尿失禁的方法，胃肠道多动症（肠易激综合征）等平滑肌收缩状况。

2. 发明申请

US20090042981A1 NOVEL DERIVATIVES OF 3,3-DIPHENYLPROPYLAMINES 有权
标题翻译： 3,3-二苯基丙烯酸的新型衍生物
公开(公告)号：US20090042981A1
公开(公告)日：2009-02-12
申请号：US12105016
申请日：2008-04-17
申请人： Claus Meese , Bengt Sparf
发明人： Claus Meese , Bengt Sparf
IPC分类号： A61K31/235
CPC分类号： C07C217/48 , C07C217/62 , C07C219/28 , C07C229/34 , C07C271/44 , C07C271/52 , C07C307/02
摘要： The invention concerns novel derivatives of 3,3-diphenylpropylamines, methods for their preparation, pharmaceutical compositions containing the novel compounds, and the use of the compounds for preparing drugs. More particularly, the invention relates to novel prodrugs of antimuscarinic agents with superior pharmacokinetic properties compared to existing drugs such as oxybutynin and tolterodine, methods for their preparation, pharmaceutical compositions containing them, a method of using said compounds and compositions for the treatment of urinary incontinence, gastrointestinal hyperactivity (irritable bowel syndrome) and other smooth muscle contractile conditions.
摘要翻译：本发明涉及3,3-二苯基丙胺的新衍生物，其制备方法，含有新化合物的药物组合物，以及该化合物用于制备药物的用途。更具体地，本发明涉及与现有药物如奥昔布宁和托特罗定相比具有优异药代动力学性质的抗毒蕈碱剂的新型前药，其制备方法，含有它们的药物组合物，使用所述化合物和组合物治疗尿失禁的方法，胃肠道多动症（肠易激综合征）等平滑肌收缩状况。

3. 发明申请

US20100256231A1 NOVEL DERIVATIVES OF 3,3-DIPHENYLPROPYLAMINES 有权
标题翻译： 3,3-二苯基丙烯酸的新型衍生物
公开(公告)号：US20100256231A1
公开(公告)日：2010-10-07
申请号：US12814982
申请日：2010-06-14
申请人： Claus MEESE , Bengt SPARF
发明人： Claus MEESE , Bengt SPARF
IPC分类号： A61K31/222 , C07C69/017 , A61P13/00
CPC分类号： C07C217/48 , C07C217/62 , C07C219/28 , C07C229/34 , C07C271/44 , C07C271/52 , C07C307/02
摘要： The invention concerns novel derivatives of 3,3-diphenylpropylamines, methods for their preparation, pharmaceutical compositions containing the novel compounds, and the use of the compounds for preparing drugs. More particularly, the invention relates to novel prodrugs of antimuscarinic agents with superior pharmacokinetic properties compared to existing drugs such as oxybutynin and tolterodine, methods for their preparation, pharmaceutical compositions containing them, a method of using said compounds and compositions for the treatment of urinary incontinence, gastrointestinal hyperactivity (irritable bowel syndrome) and other smooth muscle contractile conditions.
摘要翻译：本发明涉及3,3-二苯基丙胺的新衍生物，其制备方法，含有新化合物的药物组合物，以及该化合物用于制备药物的用途。更具体地，本发明涉及与现有药物如奥昔布宁和托特罗定相比具有优异药代动力学性质的抗毒蕈碱剂的新型前药，其制备方法，含有它们的药物组合物，使用所述化合物和组合物治疗尿失禁的方法，胃肠道多动症（肠易激综合征）等平滑肌收缩状况。

4. 发明申请

US20060270738A1 Novel derivatives of 3,3-diphenylpropylamines 有权
标题翻译： 3,3-二苯基丙胺的新型衍生物
公开(公告)号：US20060270738A1
公开(公告)日：2006-11-30
申请号：US11201756
申请日：2005-08-10
申请人： Claus Meese , Bengt Sparf
发明人： Claus Meese , Bengt Sparf
IPC分类号： A61K31/225 , A61K31/365
CPC分类号： C07C217/48 , C07C217/62 , C07C219/28 , C07C229/34 , C07C271/44 , C07C271/52 , C07C307/02
摘要： The invention concerns novel derivatives of 3,3-diphenylpropylamines, methods for their preparation, pharmaceutical compositions containing the novel compounds, and the use of the compounds for preparing drugs. More particularly, the invention relates to novel prodrugs of antimuscarinic agents with superior pharmacokinetic properties compared to existing drugs such as oxybutynin and tolterodine, methods for their preparation, pharmaceutical compositions containing them, a method of using said compouds and compositions for the treatment of urinary incontinence, gastrointestinal hyperactivity (irritable bowel syndrome) and other smooth muscle contractile conditions.
摘要翻译：本发明涉及3,3-二苯基丙胺的新衍生物，其制备方法，含有新化合物的药物组合物，以及该化合物用于制备药物的用途。更具体地，本发明涉及与现有药物如奥昔布宁和托特罗定相比具有优异药代动力学性质的抗毒蕈碱剂的新型前药，其制备方法，含有它们的药物组合物，使用所述组合物和组合物治疗尿失禁的方法，胃肠道多动症（肠易激综合征）等平滑肌收缩状况。

5. 发明授权

US08338478B2 Derivatives of 3,3-diphenylpropylamines 有权
标题翻译： 3,3-二苯基丙胺的衍生物
公开(公告)号：US08338478B2
公开(公告)日：2012-12-25
申请号：US13161049
申请日：2011-06-15
申请人： Claus Meese , Bengt Sparf
发明人： Claus Meese , Bengt Sparf
IPC分类号： A61K31/21 , C07C229/00
CPC分类号： C07C217/48 , C07C217/62 , C07C219/28 , C07C229/34 , C07C271/44 , C07C271/52 , C07C307/02
摘要： The invention concerns novel derivatives of 3,3-diphenyl-propylamines, methods for their preparation, pharmaceutical compositions containing the novel compounds, and the use of the compounds for preparing drugs. More particularly, the invention relates to novel prodrugs of antimuscarinic agents with superior pharmacokinetic properties compared to existing drugs such as oxybutynin and tolterodine, methods for their preparation, pharmaceutical compositions containing them, a method of using said compounds and compositions for the treatment of urinary incontinence, gastrointestinal hyperactivity (irritable bowel syndrome) and other smooth muscle contractile conditions.
摘要翻译：本发明涉及3,3-二苯基 - 丙胺的新衍生物，其制备方法，含有新化合物的药物组合物，以及该化合物用于制备药物的用途。更具体地，本发明涉及与现有药物如奥昔布宁和托特罗定相比具有优异药代动力学性质的抗毒蕈碱剂的新型前药，其制备方法，含有它们的药物组合物，使用所述化合物和组合物治疗尿失禁的方法，胃肠道多动症（肠易激综合征）等平滑肌收缩状况。

6. 发明授权

US07985772B2 Derivatives of 3,3-diphenylpropylamines 有权
标题翻译： 3,3-二苯基丙胺的衍生物
公开(公告)号：US07985772B2
公开(公告)日：2011-07-26
申请号：US12814982
申请日：2010-06-14
申请人： Claus Meese , Bengt Sparf
发明人： Claus Meese , Bengt Sparf
IPC分类号： A61K31/21 , A61K31/215 , A61K31/315 , C07C69/76 , C07C211/00
CPC分类号： C07C217/48 , C07C217/62 , C07C219/28 , C07C229/34 , C07C271/44 , C07C271/52 , C07C307/02
摘要： The invention concerns novel derivatives of 3,3-diphenylpropylamines, methods for their preparation, pharmaceutical compositions containing the novel compounds, and the use of the compounds for preparing drugs. More particularly, the invention relates to novel prodrugs of antimuscarinic agents with superior pharmacokinetic properties compared to existing drugs such as oxybutynin and tolterodine, methods for their preparation, pharmaceutical compositions containing them, a method of using said compounds and compositions for the treatment of urinary incontinence, gastrointestinal hyperactivity (irritable bowel syndrome) and other smooth muscle contractile conditions.
摘要翻译：本发明涉及3,3-二苯基丙胺的新衍生物，其制备方法，含有新化合物的药物组合物，以及该化合物用于制备药物的用途。更具体地，本发明涉及与现有药物如奥昔布宁和托特罗定相比具有优异药代动力学性质的抗毒蕈碱剂的新型前药，其制备方法，含有它们的药物组合物，使用所述化合物和组合物治疗尿失禁的方法，胃肠道多动症（肠易激综合征）等平滑肌收缩状况。

7. 发明授权

US07384980B2 Derivatives of 3,3-diphenylpropylamines 有权
标题翻译： 3,3-二苯基丙胺的衍生物
公开(公告)号：US07384980B2
公开(公告)日：2008-06-10
申请号：US11201756
申请日：2005-08-10
申请人： Claus Meese , Bengt Sparf
发明人： Claus Meese , Bengt Sparf
IPC分类号： A01N37/12 , A01N37/44 , A61K31/22 , C07D69/00
CPC分类号： C07C217/48 , C07C217/62 , C07C219/28 , C07C229/34 , C07C271/44 , C07C271/52 , C07C307/02
摘要： The invention concerns novel derivatives of 3,3-diphenylpropylamines, methods for their preparation, pharmaceutical compositions containing the novel compounds, and the use of the compounds for preparing drugs. More particularly, the invention relates to novel prodrugs of antimuscarinic agents with superior pharmacokinetic properties compared to existing drugs such as oxybutynin and tolterodine, methods for their preparation, pharmaceutical compositions containing them, a method of using said compounds and compositions for the treatment of urinary incontinence, gastrointestinal hyperactivity (irritable bowel syndrome) and other smooth muscle contractile conditions.
摘要翻译：本发明涉及3,3-二苯基丙胺的新衍生物，其制备方法，含有新化合物的药物组合物，以及该化合物用于制备药物的用途。更具体地，本发明涉及与现有药物如奥昔布宁和托特罗定相比具有优异药代动力学性质的抗毒蕈碱剂的新型前药，其制备方法，含有它们的药物组合物，使用所述化合物和组合物治疗尿失禁的方法，胃肠道多动症（肠易激综合征）等平滑肌收缩状况。

8. 发明授权

US07230030B2 Derivatives of 3,3-diphenylpropylamines 有权
标题翻译： 3,3-二苯基丙胺的衍生物
公开(公告)号：US07230030B2
公开(公告)日：2007-06-12
申请号：US10766263
申请日：2004-01-27
申请人： Claus Meese , Bengt Sparf
发明人： Claus Meese , Bengt Sparf
IPC分类号： A01N37/02 , A01N37/06 , A61K31/225 , C07C69/34 , C07C211/00
CPC分类号： C07C217/48 , C07C217/62 , C07C219/28 , C07C229/34 , C07C271/44 , C07C271/52 , C07C307/02
摘要： The invention concerns novel derivatives of 3,3-diphenylpropylamines, methods for their preparation, pharmaceutical compositions containing the novel compounds, and the use of the compounds for preparing drugs. More particularly, the invention relates to novel prodrugs of antimuscarinic agents with superior pharmacokinetic properties compared to existing drugs such as oxybutynin and tolterodine, methods for their preparation, pharmaceutical compositions containing them, a method of using said compounds and compositions for the treatment of urinary incontinence, gastrointestinal hyperactivity (irritable bowel syndrome) and other smooth muscle contractile conditions.
摘要翻译：本发明涉及3,3-二苯基丙胺的新衍生物，其制备方法，含有新化合物的药物组合物，以及该化合物用于制备药物的用途。更具体地，本发明涉及与现有药物如奥昔布宁和托特罗定相比具有优异药代动力学性质的抗毒蕈碱剂的新型前药，其制备方法，含有它们的药物组合物，使用所述化合物和组合物治疗尿失禁的方法，胃肠道多动症（肠易激综合征）等平滑肌收缩状况。

9. 发明申请

US20110294882A1 NOVEL DERIVATIVES OF 3,3-DIPHENYLPROPYLAMINES 有权
标题翻译： 3,3-二苯基丙烯酸的新型衍生物
公开(公告)号：US20110294882A1
公开(公告)日：2011-12-01
申请号：US13161049
申请日：2011-06-15
申请人： Claus Meese , Bengt Sparf
发明人： Claus Meese , Bengt Sparf
IPC分类号： A61K31/24 , A61P13/00 , C07C69/78
CPC分类号： C07C217/48 , C07C217/62 , C07C219/28 , C07C229/34 , C07C271/44 , C07C271/52 , C07C307/02
摘要： The invention concerns novel derivatives of 3,3-diphenylpropylamines, methods for their preparation, pharmaceutical compositions containing the novel compounds, and the use of the compounds for preparing drugs. More particularly, the invention relates to novel prodrugs of antimuscarinic agents with superior pharmacokinetic properties compared to existing drugs such as oxybutynin and tolterodine, methods for their preparation, pharmaceutical compositions containing them, a method of using said compounds and compositions for the treatment of urinary incontinence, gastrointestinal hyperactivity (irritable bowel syndrome) and other smooth muscle contractile conditions.
摘要翻译：本发明涉及3,3-二苯基丙胺的新衍生物，其制备方法，含有新化合物的药物组合物，以及该化合物用于制备药物的用途。更具体地，本发明涉及与现有药物如奥昔布宁和托特罗定相比具有优异药代动力学性质的抗毒蕈碱剂的新型前药，其制备方法，含有它们的药物组合物，使用所述化合物和组合物治疗尿失禁的方法，胃肠道多动症（肠易激综合征）等平滑肌收缩状况。

10. 发明授权

US07855230B2 Derivatives of 3,3-diphenylpropylamines 有权
标题翻译： 3,3-二苯基丙胺的衍生物
公开(公告)号：US07855230B2
公开(公告)日：2010-12-21
申请号：US12105016
申请日：2008-04-17
申请人： Claus Meese , Bengt Sparf
发明人： Claus Meese , Bengt Sparf
IPC分类号： A61K31/24 , A01N37/10 , C07C69/22
CPC分类号： C07C217/48 , C07C217/62 , C07C219/28 , C07C229/34 , C07C271/44 , C07C271/52 , C07C307/02
摘要： The invention concerns novel derivatives of 3,3-diphenylpropylamines, methods for their preparation, pharmaceutical compositions containing the novel compounds, and the use of the compounds for preparing drugs. More particularly, the invention relates to novel prodrugs of antimuscarinic agents with superior pharmacokinetic properties compared to existing drugs such as oxybutynin and tolterodine, methods for their preparation, pharmaceutical compositions containing them, a method of using said compounds and compositions for the treatment of urinary incontinence, gastrointestinal hyperactivity (irritable bowel syndrome) and other smooth muscle contractile conditions.
摘要翻译：本发明涉及3,3-二苯基丙胺的新衍生物，其制备方法，含有新化合物的药物组合物，以及该化合物用于制备药物的用途。更具体地，本发明涉及与现有药物如奥昔布宁和托特罗定相比具有优异药代动力学性质的抗毒蕈碱剂的新型前药，其制备方法，含有它们的药物组合物，使用所述化合物和组合物治疗尿失禁的方法，胃肠道多动症（肠易激综合征）等平滑肌收缩状况。

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