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1. 发明申请

WO2006086343A2 CHEMICAL EXCHANGE SATURATION TRANSFER BASED MRI USING REPORTER GENES AND MRI METHODS RELATED THERETO 审中-公开
标题翻译：使用报告基因的化学交换饱和转移性MRI和与之相关的MRI方法
公开(公告)号：WO2006086343A2
公开(公告)日：2006-08-17
申请号：PCT/US2006/004187
申请日：2006-02-07
申请人： THE JOHNS HOPKINS UNIVERSITY , VAN ZIJL, Peter, C., M. , GILAD, Assaf, A. , BULTE, Jeff , MCMAHON, Michael, T. , VENU, Raman , WINNARD, Paul, T., Jr.
发明人： VAN ZIJL, Peter, C., M. , GILAD, Assaf, A. , BULTE, Jeff , MCMAHON, Michael, T. , VENU, Raman , WINNARD, Paul, T., Jr.
IPC分类号： A61K49/12
CPC分类号： A61K49/14 , A61B5/055 , A61B6/481 , Y10T436/24
摘要： Featured are a new class of reporter genes including reporter compositions as well as methods, MRI systems and MRI imaging kits related thereto. The genes according to the present invention provide MR contrast when the sample/subject is irradiated at a specific off-resonance radio-frequency (RF frequency), where the contrast mechanism utilizes chemical exchange saturation transfer (CEST) technique for imaging.
摘要翻译：特色是一类新的报道基因，包括报道组合物，以及与之相关的方法，MRI系统和MRI成像试剂盒。当以特定的非共振频率（RF频率）照射样品/受试者时，根据本发明的基因提供MR对比度，其中造影机构利用化学交换饱和转移（CEST）技术进行成像。

2. 发明申请

WO2002100269A1 COMPOSITIONS AND METHODS FOR MAGNETICALLY LABELING CELLS 审中-公开
标题翻译：用于磁性标记细胞的组合物和方法
公开(公告)号：WO2002100269A1
公开(公告)日：2002-12-19
申请号：PCT/US2002/015597
申请日：2002-05-17
申请人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY OF THE DEPARTMENT OF HEALTH & HUMAN SERVICES , FRANK, Joseph, A. , BULTE, Jeff, W., M.
发明人： FRANK, Joseph, A. , BULTE, Jeff, W., M.
IPC分类号： A61B5/055
CPC分类号： A61K49/1866 , A61K49/1851
摘要： A composition that includes magnetic-responsive coated metal oxide particles mixed with at least one transfection agent. According to one particular embodiment, the mixing is done in the presence of a cell culture medium. There is also provided a method of labeling living cells to render the cells magnetic resonance sensitive that involves contacting the cells to be labeled with a mixture of (i) magnetic-responsive coated metal oxide particles and (ii) at least one transfection agent, and allowing the mixture to be internalized by the cells.
摘要翻译：包含与至少一种转染剂混合的磁响应性包被金属氧化物颗粒的组合物。根据一个具体实施方案，混合在细胞培养基存在下进行。还提供了一种标记活细胞以使细胞磁共振敏感的方法，其涉及使被标记的细胞与（i）磁响应的包被的金属氧化物颗粒和（ii）至少一种转染剂的混合物接触，以及允许混合物被细胞内化。

3. 发明申请

WO2011103182A3 IMAGING METHODS FOR ASSESSMENT AND QUANTIFICATION OF VACCINATION AND IN VIVO ANTIGEN CAPTURE 审中-公开
标题翻译：成像方法评估和量化接种和体内抗原捕获
公开(公告)号：WO2011103182A3
公开(公告)日：2011-12-29
申请号：PCT/US2011025072
申请日：2011-02-16
申请人： UNIV JOHNS HOPKINS , BULTE JEFF , LONG CHRISTOPHER , LEVITSKY HYAM
发明人： BULTE JEFF , LONG CHRISTOPHER , LEVITSKY HYAM
IPC分类号： G01N33/53 , G01N33/532 , G01N33/574 , G01N33/58
CPC分类号： G01N33/586 , G01N33/574 , G01R33/1269
摘要： The invention provides for labeling, imaging, and quantifying an antigen presenting cell in vivo.
摘要翻译：本发明提供了体内抗原呈递细胞的标记，成像和定量。

4. 发明申请

WO2007127231A2 MAGNETIC RESONANCE-DETECTABLE, ULTRASOUND-DETECTABLE AND/OR RADIOPAQUE MICROCAPSULES AND USES THEREOF 审中-公开
标题翻译：磁共振检测，超声检测和/或放射性微球及其用途
公开(公告)号：WO2007127231A2
公开(公告)日：2007-11-08
申请号：PCT/US2007/009992
申请日：2007-04-24
申请人： THE JOHNS HOPKINS UNIVERSITY , BULTE, Jeff , BARNETT, Bradley, Powers , AREPALLY, Aravind , KRAITCHMAN, Dara, Lee
发明人： BULTE, Jeff , BARNETT, Bradley, Powers , AREPALLY, Aravind , KRAITCHMAN, Dara, Lee
IPC分类号： A61K38/19
CPC分类号： A61K35/39 , A61B6/507 , A61K49/0002 , A61K49/1818 , A61K49/1887 , A61K49/1896 , A61L31/022 , A61L31/042 , A61L31/047 , A61L31/16 , A61L31/18 , A61L2300/45 , C08L5/04
摘要： The present invention provides a microcapsule for implantation into a mammalian body, comprising: a) at least one cell and/or bioactive agent; and b) a biocompatible semi-permeable membrane encapsulating the at least one cell, wherein the biocompatible semi-permeable membrane comprises: at least one polycationic polymer region, at least one alginate polymer region, and a paramagnetic or superparamagnetic metal that does not participate in the crosslinking of the alginate polymer. The present invention further provides methods of making the microcapsules of this invention and use of the microcapsules of this invention in methods of delivering cells and/or therapeutic agents to a subject and in methods of embolization.
摘要翻译：本发明提供一种用于植入哺乳动物体内的微胶囊，包括：a）至少一种细胞和/或生物活性剂; 以及b）包封所述至少一个细胞的生物相容性半透膜，其中所述生物相容性半透膜包括：至少一个聚阳离子聚合物区域，至少一个藻酸盐聚合物区域和不参与的顺磁性或超顺磁性金属藻酸盐聚合物的交联。本发明进一步提供了制备本发明的微胶囊的方法以及本发明的微胶囊在对受试者和栓塞方法中递送细胞和/或治疗剂的方法中的用途。

5. 发明申请

WO0071169A3 MAGNETIC RESONANCE TRACKING OF MAGNETICALLY LABELED CELLS 审中-公开
标题翻译：磁性标记细胞的磁共振跟踪
公开(公告)号：WO0071169A3
公开(公告)日：2001-08-02
申请号：PCT/US0013826
申请日：2000-05-19
申请人： US GOV HEALTH & HUMAN SERV , BULTE JEFF W , DUNCAN IAN D , FRANK JOSEPH A
发明人： BULTE JEFF W , DUNCAN IAN D , FRANK JOSEPH A
IPC分类号： A61K49/00
CPC分类号： A61K49/00
摘要： The method of the present invention is to label living cells so as to render them detectable in MRI. The invention relates to the use of magnetic resonance (MR) sensitive agents to render treated living cells identifiable and distinguishable in MR Imaging (MRI). MR sensitive agents can be bound to a targeting compound such as a protein or antibody. The targeting compound reacts with living cells in a way that the MR sensitive agent is incorporated into the or onto the cell surface. The MR sensitive agents can also be coated with agents that render the magnetic resonance sensitive agent able to bind to or be internalized by cells. The treated cells of the invention can be applied to patient for any therapeutic, diagnostic, or experimental purpose. The invention also encompasses imaging the host with MRI to locate MR labeled cells, to track their migration or bio-distribution non-invasively, and to establish to survival characteristics of such cells.
摘要翻译：本发明的方法是标记活细胞以使其在MRI中可检测。本发明涉及使用磁共振（MR）敏感剂来在MR成像（MRI）中鉴定和区分经处理的活细胞。 MR敏感剂可以与靶向化合物如蛋白质或抗体结合。靶向化合物以活性细胞与MR敏感剂并入细胞表面或细胞表面的方式反应。 MR敏感剂还可以涂覆有使磁共振敏感剂能够结合或被细胞内化的试剂。本发明的治疗细胞可以用于患者任何治疗，诊断或实验目的。本发明还包括用MRI对宿主进行成像以定位MR标记的细胞，以非侵入性的方式追踪其迁移或生物分布，并确定这些细胞的存活特征。

6. 发明申请

WO2013158719A1 USE OF NON-METALLIC CEST AGENTS FOR MRI MONITORING OF NANOPARTICLE DELIVERY 审中-公开
标题翻译：使用非金属化学试剂进行纳米材料交付的MRI监测
公开(公告)号：WO2013158719A1
公开(公告)日：2013-10-24
申请号：PCT/US2013/036904
申请日：2013-04-17
申请人： THE JOHNS HOPKINS UNIVERSITY , KENNEDY KRIEGER INSTITUTE, INC. , MCMAHON, Michael T. , CHAN, Kannie W., Y. , LIU, Guanshu , BULTE, Jeff W., M. , OSKOLKOV, Nikita
发明人： MCMAHON, Michael T. , CHAN, Kannie W., Y. , LIU, Guanshu , BULTE, Jeff W., M. , OSKOLKOV, Nikita
IPC分类号： A61K49/06 , A61K49/08 , A61K9/16 , A61K47/48
CPC分类号： A61K49/1818 , A61B5/055 , A61K31/337 , A61K31/704 , A61K49/1812 , A61K49/1857
摘要： The present invention includes drug-loaded, polymer nanoparticles and liposomes further incorporating a non-paramagnetic, bioorganic CEST agent. The CEST agent allows for an alternative approach to accomplish MR-compatible in vivo tracking of drug-loaded polymer nanoparticles and liposomes, including simultaneous multi-color mapping of more than one particle type, or of the same particle type delivered via two different routes (e.g., systemic versus local). Additionally, the present invention can include a library of biodegradable diamagnetic (DIA)CEST agents. These DIACEST agents can be incorporated into nanoparticle-based delivery systems, such as stealth liposomes loaded with doxorubicin and stealth polymer nanoparticles loaded with paclitaxel. These systems can be tracked, according to an embodiment of the present invention using CEST-based MRI (compared to SPECT/CT) as a method to monitor the efficiency with which the nanoparticles reach the targeted tumors and how long they persist. Measured particle persistence times are also used to guide the spacing between doses.
摘要翻译：本发明包括进一步掺入非顺磁性生物有机CEST试剂的载药聚合物纳米颗粒和脂质体。 CEST代理允许替代方法来实现载药聚合物纳米颗粒和脂质体的MR兼容的体内跟踪，包括多于一种颗粒类型的同时多色映射或通过两种不同途径递送的相同颗粒类型例如，系统性与局部性）。此外，本发明可以包括可生物降解的抗磁性（DIA）CEST试剂的文库。这些DIACEST试剂可以并入基于纳米颗粒的递送系统中，例如装载多柔比星的隐形脂质体和负载紫杉醇的隐形聚合物纳米颗粒。根据使用基于CEST的MRI（与SPECT / CT相比）的本发明的实施例，可以跟踪这些系统作为监测纳米颗粒达到靶向肿瘤的效率以及持续时间的方法。测量的颗粒持续时间也用于指导剂量间隔。

7. 发明申请

WO2007127231A3 MAGNETIC RESONANCE-DETECTABLE, ULTRASOUND-DETECTABLE AND/OR RADIOPAQUE MICROCAPSULES AND USES THEREOF 审中-公开
标题翻译：磁共振检测，超声检测和/或放射性微球及其用途
公开(公告)号：WO2007127231A3
公开(公告)日：2008-12-04
申请号：PCT/US2007009992
申请日：2007-04-24
申请人： UNIV JOHNS HOPKINS , BULTE JEFF , BARNETT BRADLEY POWERS , AREPALLY ARAVIND , KRAITCHMAN DARA LEE
发明人： BULTE JEFF , BARNETT BRADLEY POWERS , AREPALLY ARAVIND , KRAITCHMAN DARA LEE
IPC分类号： A61K9/14 , A61B5/05 , A61B6/00 , A61K9/16 , A61K9/50 , A61K49/04
CPC分类号： A61K35/39 , A61B6/507 , A61K49/0002 , A61K49/1818 , A61K49/1887 , A61K49/1896 , A61L31/022 , A61L31/042 , A61L31/047 , A61L31/16 , A61L31/18 , A61L2300/45 , C08L5/04
摘要： The present invention provides a microcapsule for implantation into a mammalian body, comprising: a) at least one cell and/or bioactive agent; and b) a biocompatible semi-permeable membrane encapsulating the at least one cell, wherein the biocompatible semi-permeable membrane comprises: at least one polycationic polymer region, at least one alginate polymer region, and a paramagnetic or superparamagnetic metal that does not participate in the crosslinking of the alginate polymer. The present invention further provides methods of making the microcapsules of this invention and use of the microcapsules of this invention in methods of delivering cells and/or therapeutic agents to a subject and in methods of embolization.
摘要翻译：本发明提供一种用于植入哺乳动物体内的微胶囊，其包含：a）至少一种细胞和/或生物活性剂; 以及b）包封所述至少一个细胞的生物相容性半透膜，其中所述生物相容性半透膜包括：至少一个聚阳离子聚合物区域，至少一个藻酸盐聚合物区域和不参与所述至少一个藻酸盐聚合物区域的顺磁性或超顺磁性金属藻酸盐聚合物的交联。本发明进一步提供了制备本发明的微胶囊的方法以及本发明的微胶囊在对受试者和栓塞方法中递送细胞和/或治疗剂的方法中的用途。

8. 发明申请

WO2008144028A1 METHODS FOR IN VIVO IMAGING OF CELLS 审中-公开
标题翻译：用于细胞成像的方法
公开(公告)号：WO2008144028A1
公开(公告)日：2008-11-27
申请号：PCT/US2008/006380
申请日：2008-05-14
申请人： THE JOHNS HOPKINS UNIVERSITY , BULTE, Jeff , BARNETT, Bradley, Powers , AREPALLY, Aravind
发明人： BULTE, Jeff , BARNETT, Bradley, Powers , AREPALLY, Aravind
IPC分类号： A61B6/00
CPC分类号： A61K49/0002 , A61K49/0409 , A61K49/222
摘要： The instant invention provides methods for the in vivo imaging of cells using one or more imaging modalities.
摘要翻译：本发明提供使用一种或多种成像模态进行细胞体内成像的方法。

9. 发明申请

WO2011103182A2 IMAGING METHODS FOR ASSESSMENT AND QUANTIFICATION OF VACCINATION AND IN VIVO ANTIGEN CAPTURE 审中-公开
标题翻译：成像方法用于评估和定量疫苗接种和体内抗原检测
公开(公告)号：WO2011103182A2
公开(公告)日：2011-08-25
申请号：PCT/US2011/025072
申请日：2011-02-16
申请人： THE JOHNS HOPKINS UNIVERSITY , BULTE, Jeff , LONG, Christopher , LEVITSKY, Hyam
发明人： BULTE, Jeff , LONG, Christopher , LEVITSKY, Hyam
IPC分类号： G01N33/53 , G01N33/532 , G01N33/58 , G01N33/574
CPC分类号： G01N33/586 , G01N33/574 , G01R33/1269
摘要： The invention provides for labeling, imaging, and quantifying an antigen presenting cell in vivo.
摘要翻译：本发明提供了体内抗原呈递细胞的标记，成像和定量。

10. 发明申请

WO2006086343A3 CHEMICAL EXCHANGE SATURATION TRANSFER BASED MRI USING REPORTER GENES AND MRI METHODS RELATED THERETO 审中-公开
标题翻译：基于化学交换饱和度转移的MRI使用报告基因和MRI相关方法
公开(公告)号：WO2006086343A3
公开(公告)日：2006-12-28
申请号：PCT/US2006004187
申请日：2006-02-07
申请人： UNIV JOHNS HOPKINS , VAN ZIJL PETER C M , GILAD ASSAF A , BULTE JEFF , MCMAHON MICHAEL T , VENU RAMAN , WINNARD PAUL T JR
发明人： VAN ZIJL PETER C M , GILAD ASSAF A , BULTE JEFF , MCMAHON MICHAEL T , VENU RAMAN , WINNARD PAUL T JR
IPC分类号： A61B5/055
CPC分类号： A61K49/14 , A61B5/055 , A61B6/481 , Y10T436/24
摘要： Featured are a new class of reporter genes including reporter compositions as well as methods, MRI systems and MRI imaging kits related thereto. The genes according to the present invention provide MR contrast when the sample/subject is irradiated at a specific off-resonance radio-frequency (RF frequency), where the contrast mechanism utilizes chemical exchange saturation transfer (CEST) technique for imaging.
摘要翻译：特色是一类新的报告基因，包括报告组合物以及与之相关的方法，MRI系统和MRI成像套件。当对比机制利用化学交换饱和转移（CEST）技术进行成像时，根据本发明的基因提供MR对比，当样品/对象以特定的非共振射频（RF频率）照射时。

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