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1. 发明专利

IL292814A Modified adeno-associated virus vectors and delivery thereof into the central nervous system 未知
公开(公告)号：IL292814A
公开(公告)日：2022-07-01
申请号：IL29281422
申请日：2022-05-07
申请人： COAVE THERAPEUTICS , MOULLIER PHILIPPE , BROEKAERT WILLEM
发明人： MOULLIER PHILIPPE , BROEKAERT WILLEM
IPC分类号： A61K48/00 , A61P25/00 , C12N15/86
摘要： The present invention relates to modified adeno-associated virus (AAV) vectors for use in transducing a cell in the central nervous system (CNS) of a subject, and for use in the prevention or treatment of a CNS disease. In particular, the modified AAV vectors according to the present invention comprise at least one surface-bound saccharide, and are to be administered directly to the CNS but not intracerebroventricularly.

2. 发明专利

GB9613753D0 Plant protection method 未知
公开(公告)号：GB9613753D0
公开(公告)日：1996-09-04
申请号：GB9613753
申请日：1996-07-01
申请人： BROEKAERT WILLEM F
IPC分类号： A01G7/00 , A01N27/00 , A01N37/42 , A01N61/00 , C07K14/415 , C12N15/09 , C12N15/82 , C12Q1/68 , G01N33/15 , G01N33/48 , G01N33/50
摘要： A method of protecting a plant against a pathogen is described, the method comprising inducing expression of a plant defensin gene by stimulating the jasmonate and/or ethylenc pathways. Also deseribed is a method of inducing expression of a plant defensin gene, a composition which is capable of inducing expression of a plant defensin gene and a method for screening compounds giving resistance-inducing activity. Preferably, the pathogen is a necrotrophic pathogen.

3. 发明申请

WO2010088744A2 METHOD FOR MAKING PENTOSES AND PENTOSE-BASED SOLUBLE OLIGO/POLYSACCHARIDES FROM CEREALS 审中-公开
标题翻译：从谷物制备糖果和基于戊糖的可溶性低聚果糖/多糖的方法
公开(公告)号：WO2010088744A2
公开(公告)日：2010-08-12
申请号：PCT/BE2010/000008
申请日：2010-02-09
申请人： FUGEIA NV , BROEKAERT, Willem
发明人： BROEKAERT, Willem
CPC分类号： C13K13/002 , A23L29/30 , C08B37/0057 , C13K13/007
摘要： The present invention provides a method for the extraction and isolation of solubilised arabinoxylan depolymerisation products, using arabinoxylan-containing plant material as a starting material. Preferably, such solubilised arabinoxylan depolymerisation product is any one of soluble arabinoxylan, arabinoxylan-oligosaccharides, xylose and arabinose. Said method comprises the mashing of said arabinoxylan-containing plant material in water and treating it with an appropriate concentration of an endoxylanase enzyme preparation in order to enzymatically depolymerise and solubilise a fraction of the arabinoxylans comprised in said plant material, wherein said endoxylanase treatment is followed or preceded by an acid treatment. This acid treatment comprising the incubation of said plant material in an acidified aqueous mash in order to obtain a depolymerisation and solubilisation of another fraction of the arabinoxylans comprised in said plant material. Preferably, said acidified mash is obtained by adding to said mash a strong acid to a final concentration between 0.02 and 0.4 N. The method further comprises the separation from said mashed plant material of a water-solubilised fraction, which comprises at least part of the solubilised arabinoxylan depolymerisation products.
摘要翻译：本发明提供了一种使用含有阿拉伯木聚糖的植物材料作为起始材料来提取和分离溶解的阿拉伯木聚糖解聚产物的方法。优选地，这种增溶的阿拉伯糖基木聚糖解聚产物是可溶性阿拉伯木聚糖，阿拉伯木聚糖 - 寡糖，木糖和阿拉伯糖中的任一种。所述方法包括将所述含阿拉伯木聚糖的植物材料在水中糖化并用合适浓度的木聚糖内切酶酶制剂处理，以便酶解解和溶解包含在所述植物材料中的阿拉伯木聚糖部分，其中遵循所述木聚糖内切酶处理或者先进行酸处理。该酸处理包括将所述植物材料在酸化的含水ma液中温育以获得包含在所述植物材料中的另一部分阿糖基木聚糖的解聚和增溶。优选地，所述酸化ma液通过向所述ma液中加入强酸来达到0.02至0.4N的最终浓度而获得。所述方法还包括从所述捣碎的植物材料中分离水溶解部分，所述水溶解部分包含至少部分溶解的阿拉伯木聚糖解聚产物。

4. 发明申请

WO2010066012A2 NUTRIMENT CONTAINING ARABINOXYLAN AND OLIGOSACCHARIDES 审中-公开
标题翻译：含有阿拉伯糖和低聚糖的营养素
公开(公告)号：WO2010066012A2
公开(公告)日：2010-06-17
申请号：PCT/BE2009000062
申请日：2009-12-10
申请人： UNIV LEUVEN KATH , FUGEIA NV , BROEKAERT WILLEM , COURTIN CHRISTOPHE , DAMEN BRAM , DELCOUR JAN
发明人： BROEKAERT WILLEM , COURTIN CHRISTOPHE , DAMEN BRAM , DELCOUR JAN
IPC分类号： A23L1/308 , A23L1/10 , A23L1/16 , A23L1/30
CPC分类号： A23L2/02 , A21D2/181 , A21D2/36 , A23L7/109 , A23L7/115 , A23L7/122 , A23L33/22
摘要： The present invention provides nutritional compositions, more particularly food supplement and processed food products, enriched with arabinoxylan-oligosaccharides and further comprising either or both water-unextractable arabinoxylans or water-soluble arabinoxylans Preferably said nutritional compositions comprises both arabinoxylan-oligosaccharides an water-unextractable arabinoxylans.
摘要翻译：本发明提供富含阿拉伯木聚寡糖的营养组合物，更特别是食物补充剂和加工食品，还包含水不可提取的阿拉伯木聚糖或水溶性阿拉伯木聚糖中的一种或两种。优选地，所述营养组合物包含阿拉伯木聚寡糖，水不可提取的阿拉伯木聚糖。

5. 发明申请

WO2009117790A3 (ARABINO)XYLAN OLIGOSACCHARIDE PREPARATION 审中-公开
公开(公告)号：WO2009117790A3
公开(公告)日：2009-10-01
申请号：PCT/BE2009/000020
申请日：2009-03-25
申请人： KATHOLIEKE UNIVERSITEIT LEUVEN , BROEKAERT, Willem , COURTIN, Christophe , DELCOUR, Jan
发明人： BROEKAERT, Willem , COURTIN, Christophe , DELCOUR, Jan
IPC分类号： A21D2/18 , A23L1/30 , A23L2/52
摘要： The present invention relates to preparations comprising (arabino)xylan oligosaccharides with average degree of polymerisation between 4 and 10 and average degree of arabinose substitution between 0.15 and 0.35, which beneficially modulate the intestinal flora, such preparation comprising both xylo- and arabinoxylo-oligosaccharides. Preferably, the arabinoxylo-oligosaccharides are substituted in part by hydroxycinnamic acids and exert antioxidant effects. Furthermore, it is preferred that the preparations according to the present invention have a nitrogen content below 0.16% (w/w) in order to ensure good organoleptic and colour properties, particularly upon heating said preparations. In addition, food, beverage and nutritional supplement products comprising the preparations are provided as well as methods to prepare the said preparations.

6. 发明申请

WO2009049385A1 METHOD FOR BREWING BEER 审中-公开
标题翻译：酿造啤酒的方法
公开(公告)号：WO2009049385A1
公开(公告)日：2009-04-23
申请号：PCT/BE2008/000081
申请日：2008-10-20
申请人： FUGEIA NV , AERTS, Guido , AMAN, Per , ANDERSSON, Annica , BROEKAERT, Willem , DELCOUR, Jan , LANDBERG, Rikard
发明人： AERTS, Guido , AMAN, Per , ANDERSSON, Annica , BROEKAERT, Willem , DELCOUR, Jan , LANDBERG, Rikard
IPC分类号： C12C5/00 , C12H1/22
CPC分类号： C12C5/00 , C12H1/22
摘要： The present invention relates to a method for brewing bottom fermented beer, such method comprising the use of cereal bran, preferably wheat or rye bran, at a ratio of 15% to 50% of the grist. The method of the present invention allows the brewing of beers having an excellent taste and taste stability during ageing at a comparatively low raw material cost.
摘要翻译：本发明涉及一种酿造底部发酵啤酒的方法，所述方法包括使用谷物麸，优选小麦或黑麦麸，其比例为粗粉的15％至50％。本发明的方法允许在相对低的原料成本下，在老化期间具有优异的味道和味道稳定性的啤酒的酿造。

7. 发明申请

WO2008074891A2 PLANTS HAVING ENHANCED YIELD-RELATED TRAITS AND A METHOD FOR METHOD FOR MAKING THE SAME 审中-公开
标题翻译：具有增强的相关旅行者的植物及其制造方法
公开(公告)号：WO2008074891A2
公开(公告)日：2008-06-26
申请号：PCT/EP2007/064510
申请日：2007-12-21
申请人： BASF PLANT SCIENCE GMBH , REZEAU, Christophe , FRANKARD, Valerie , SANZ MOLINERO, Ana Isabel , BROEKAERT, Willem
发明人： REZEAU, Christophe , FRANKARD, Valerie , SANZ MOLINERO, Ana Isabel , BROEKAERT, Willem
IPC分类号： C12N15/82 , C12N15/55 , C12N9/50 , C12N9/64 , A01H5/00 , A01H5/10
CPC分类号： C12N15/8261 , C07K14/415 , Y02A40/146
摘要： The present invention relates generally to the field of molecular biology and concerns a method for enhancing various economically important yield-related traits in plants. More specifically, the present invention concerns a method for enhancing yield-related traits in plants by modulating expression in a plant of a nucleic acid encoding a Yield Enhancing Protein (YEP). The YEP is selected from a V acuolar P rocessing E nzyme (VPE) or a CCA1-like polypeptide ora SAP-like polypeptide or a S eed Y ield P romoting F actor 1 (SYPF1) polypeptide ora Ribulose-1,5-bisphosphate carboxylase/oxygenase ( R uBis C O) a ctivase (RCA) polypeptide. The present invention also concerns plants having modulated expression of a nucleic acid encoding such a YEP, which plants have enhanced yield-related traits relative to control plants. The invention also provides hitherto unknown YEP-encoding nucleic acids, and constructs comprising the same, useful in performing the methods of the invention.
摘要翻译：本发明一般涉及分子生物学领域，涉及增强植物中各种经济上重要的产量相关性状的方法。更具体地，本发明涉及一种通过调节植物中编码产量增强蛋白（YEP）的核酸的表达来增强植物中产量相关性状的方法。 YEP选自真空加工酶（VPE）或CCA1样多肽或SAP样多肽或种子产量促进因子1（SYPF1）多肽或核酮糖-1,5-二磷酸羧化酶/加氧酶（RuBisCO）活化酶（ RCA）多肽。本发明还涉及具有调节编码这种YEP的核酸表达的植物，该植物相对于对照植物具有增强的产量相关性状。本发明还提供了迄今为止未知的YEP编码核酸和包含其的构建体，其可用于实施本发明的方法。

8. 发明申请

WO2006029987A1 ROOT EVALUATION 审中-公开
标题翻译： ROOT评估
公开(公告)号：WO2006029987A1
公开(公告)日：2006-03-23
申请号：PCT/EP2005/054466
申请日：2005-09-08
申请人： CROPDESIGN N.V. , LEJEUNE, Pierre , BROEKAERT, Willem , LEYNS, Frederik , DHONT, Frederik
发明人： LEJEUNE, Pierre , BROEKAERT, Willem , LEYNS, Frederik , DHONT, Frederik
IPC分类号： A01G9/00 , A01G31/00 , A01G1/00
CPC分类号： H04N7/002 , A01C1/00 , A01G2/00 , A01G9/00 , A01G31/00 , Y02P60/216
摘要： A method is provided comprising (i) growing a plant in a substantially transparent container charged with a particulate, non-transparent growing medium; and (ii) evaluating plant roots through said transparent container by digital imaging. An apparatus for evaluating plant roots in a high throughput manner is also provided.
摘要翻译：提供了一种方法，其包括（i）在装有微粒非透明生长介质的基本上透明的容器中生长植物; 和（ii）通过数字成像通过所述透明容器评估植物根。还提供了一种用于以高通量方式评估植物根的装置。

9. 发明申请

WO2003025185A1 A METHOD TO MODIFY CELL NUMBER, ARCHITECTURE AND YIELD OF PLANTS BY OVEREXPRESSING THE E2F TRANSCRIPTION FACTOR 审中-公开
标题翻译：通过过度表达E2F转录因子修饰植物细胞数，构建和产量的方法
公开(公告)号：WO2003025185A1
公开(公告)日：2003-03-27
申请号：PCT/EP2002/010236
申请日：2002-09-12
申请人： CROPDESIGN N.V. , BEECKMAN, Tom , DE VEYLDER, Lieven , INZE, Dirk , MIRONOV, Vladimir , BROEKAERT, Willem , DILLEN, Willy , FRANKARD, Valerie
发明人： BEECKMAN, Tom , DE VEYLDER, Lieven , INZE, Dirk , MIRONOV, Vladimir , BROEKAERT, Willem , DILLEN, Willy , FRANKARD, Valerie
IPC分类号： C12N15/82
CPC分类号： C12N15/8216 , C12N15/8261 , Y02A40/146
摘要： The present invention relates to a method for modifying plant growth and development processes by affecting cell cycle regulation comprising modulating expression of members of the plant E2F transcription factor family. More specific the invention relates to methods for stimulating cell division in a plant. The invention further relates to transgenic plants produced by the methods of the invention having altered plant growth and development characteristics compared to their isogenic counterparts. Preferably, the plant characteristics modified by the present invention include enlarged cotyledons, enhanced growth rate, stress resistance and seedling survival, more cells, more tillers, more panicles.
摘要翻译：本发明涉及通过影响细胞周期调节来修饰植物生长和发育过程的方法，其包括调节植物E2F转录因子家族成员的表达。更具体地，本发明涉及刺激植物细胞分裂的方法。本发明还涉及通过与其同基因对应物相比具有改变的植物生长和发育特征的本发明方法生产的转基因植物。优选地，通过本发明修饰的植物特征包括扩大的子叶，增强的生长速率，抗胁迫性和幼苗存活，更多的细胞，更多的分蘖，更多的穗。

10. 发明申请

WO2002083901A2 PLANT GROWTH REGULATING GENES, PROTEINS AND USES THEREOF 审中-公开
标题翻译：植物生长调节基因，蛋白质及其用途
公开(公告)号：WO2002083901A2
公开(公告)日：2002-10-24
申请号：PCT/EP2002/004035
申请日：2002-04-11
申请人： CROPDESIGN N.V. , SAUTER, Margret , LORBIECKE, René , MIRONOV, Vladimir , FRANKARD, Valérie , DILLEN, Willy , LEJEUNE, Pierre , BROEKAERT, Willem
发明人： SAUTER, Margret , LORBIECKE, René , MIRONOV, Vladimir , FRANKARD, Valérie , DILLEN, Willy , LEJEUNE, Pierre , BROEKAERT, Willem
IPC分类号： C12N15/29
CPC分类号： C12N15/8262 , C07K14/415 , C12N15/8237 , C12N15/8261 , Y02A40/146
摘要： Provided are methods for controlling or altering the growth characteristics of a plant or of an organ or tissue or cell of this plant. This method comprises introduction and/or expression of one or more Growth Regulating Proteins functional in a plant or parts thereof and/or one or more DNA sequences encoding such proteins. Another method comprises contacting a plant or plant tissue with the purified Growth Regulated Protein or the active product derived from it. Provided are also DNA sequences encoding plant Growth Regulating Protein(s) as well as methods for obtaining the same. Furthermore, vectors comprising said DNA sequences are described, wherein the DNA sequences are operatively linked to regulatory elements allowing expression in prokaryotic and/or eukaryotic host cells. In addition, proteins encoded by said DNA sequences, antibodies to said proteins and methods for their production are provided. Furthermore, regulatory sequences, which naturally regulate the expression of the above-described DNA sequences, are described. Methods for the identification of compounds being capable of interacting with said Growth Regulating Proteins are described as well. Furthermore, transgenic plant cells, plant tissues and plants containing the above-described DNA sequences and vectors are described, as well as the use of the aforementioned DNA sequences, vectors, proteins, antibodies, regulatory sequences and/or compounds identified by the method of the invention in plant cell and tissue culture, plant breeding and/or agriculture.
摘要翻译：提供了用于控制或改变植物或该植物的器官或组织或细胞的生长特性的方法。该方法包括在植物或其部分和/或编码这种蛋白质的一个或多个DNA序列中引入和/或表达一种或多种功能的生长调节蛋白。另一种方法包括使植物或植物组织与纯化的生长调节蛋白或其衍生的活性产物接触。还提供编码植物生长调节蛋白的DNA序列以及获得其的方法。此外，描述了包含所述DNA序列的载体，其中所述DNA序列可操作地连接到允许在原核和/或真核宿主细胞中表达的调节元件。此外，提供了由所述DNA序列编码的蛋白质，对所述蛋白质的抗体及其生产方法。此外，描述了调节序列，其自然调节上述DNA序列的表达。还描述了用于鉴定能够与所述生长调节蛋白相互作用的化合物的方法。此外，描述了含有上述DNA序列和载体的转基因植物细胞，植物组织和植物，以及使用上述DNA序列，载体，蛋白质，抗体，调节序列和/或化合物本发明在植物细胞和组织培养，植物育种和/或农业中。

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