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1. 发明申请

WO2004064838A1 PHARMACEUTICAL COMPOSITIONS AND METHODS FOR TREATING MULTIDRUG RESISTANT CANCER 审中-公开
标题翻译：药物组合物和治疗多发性硬化性癌症的方法
公开(公告)号：WO2004064838A1
公开(公告)日：2004-08-05
申请号：PCT/CA2004/000033
申请日：2004-01-19
申请人： UNIVERSITY HEALTH NETWORK , BERGER, Stuart, A. , ZHANG, Yicheng
发明人： BERGER, Stuart, A. , ZHANG, Yicheng
IPC分类号： A61K31/4535
CPC分类号： A61K45/06 , A61K31/4436 , A61K31/4535 , A61K31/704 , A61K2300/00
摘要： The invention relates to a pharmaceutical composition comprising i) ketotifen or an analog thereof and ii) a chemotherapeutic drug subject to multi-drug resistance by P-gp, such as doxorubicin or an analog thereof. The pharmaceutical composition is useful for treating cancer. The pharmaceutical composition is also useful for i) preventing or treating multi-drug resistance in a subject or ii) preventing a chemotherapeutic drug subject to multi-drug resistance by P-gp induced cardiac tissue damage in a subject, such as doxorubicin or an analog thereof. The invention relates to a pharmaceutical composition comprising i) ketotifen or an analog thereof and ii) a chemotherapeutic drug subject to multi-drug resistance by P-gp, such as doxorubicin or an analog thereof. The pharmaceutical composition is useful for treating cancer. The pharmaceutical composition is also useful for i) preventing or treating multi-drug resistance in a subject or ii) preventing a chemotherapeutic drug subject to multi-drug resistance by P-gp induced cardiac tissue damage in a subject, such as doxorubicin or an analog thereof.
摘要翻译：本发明涉及药物组合物，其包含i）酮替芬或其类似物，和ii）受P-gp多药耐药的化疗药物，例如多柔比星或其类似物。该药物组合物可用于治疗癌症。药物组合物还可用于i）预防或治疗受试者的多重耐药性，或ii）通过P-gp诱导的受试者的心脏组织损伤（例如多柔比星或类似物）预防受多药耐药性的化疗药物它们。本发明涉及药物组合物，其包含i）酮替芬或其类似物，和ii）受P-gp多药耐药的化疗药物，例如多柔比星或其类似物。该药物组合物可用于治疗癌症。药物组合物还可用于i）预防或治疗受试者的多重耐药性，或ii）通过P-gp诱导的受试者的心脏组织损伤（例如多柔比星或类似物）预防受多药耐药性的化疗药物它们。

2. 发明申请

WO2010127444A1 INCREASING PROTEIN PRODUCTION B\ INCREASING ABC50 EXPRESSION OR ACTIVITY 审中-公开
$INCREASING PROTEIN PRODUCTION B\ INCREASING ABC50 EXPRESSION OR ACTIVITY$
标题翻译：增加蛋白质生产B \增加ABC50表达或活性
公开(公告)号：WO2010127444A1
公开(公告)日：2010-11-11
申请号：PCT/CA2010/000681
申请日：2010-05-05
申请人： UNIVERSITY HEALTH NETWORK , BERGER, Stuart, A.
发明人： BERGER, Stuart, A.
IPC分类号： C12N15/63 , C12N15/113 , C12N15/12 , C12N15/67 , C12N15/867 , C12P21/02 , C12P21/08
CPC分类号： C07K16/00 , C07K16/2812 , C07K2317/14 , C12N15/113 , C12N2310/11 , C12N2310/14 , C12N2310/531 , C12N2799/027 , C12P21/02
摘要： The disclosure provides methods and materials for increasing the expression of a protein of interest such as an antibody by a cell. ABC50 expression or activity is increased which increases expression of the protein or antibody of interest. The disclosure also provides methods and materials for increasing the sensitivity of a cell to an endoplasmic reticulum stress agent such as Econozole by decreasing the level of ABC50.
摘要翻译：本公开提供了用于增加感兴趣的蛋白质的表达的方法和材料，例如细胞的抗体。增加ABC50表达或活性，这增加了感兴趣的蛋白质或抗体的表达。本公开还提供了通过降低ABC50的水平来增加细胞对内质网应激剂（例如依曲唑）的敏感性的方法和材料。

3. 发明申请

WO1997025063A1 COMPOSITIONS INCLUDING CALCIUM INFLUX BLOCKERS FOR INHIBITING CELL GROWTH 审中-公开
标题翻译：组合物包括用于抑制细胞生长的钙通道阻断剂
公开(公告)号：WO1997025063A1
公开(公告)日：1997-07-17
申请号：PCT/CA1997000019
申请日：1997-01-13
申请人： THE WELLESLEY CENTRAL HOSPITAL , BERGER, Stuart, Alan , GOMMERMAN, Jennifer, Lynn
发明人： THE WELLESLEY CENTRAL HOSPITAL
IPC分类号： A61K45/06
CPC分类号： A61K45/06
摘要： A general feature of the present invention is the induction of the death of stimulated cells by a Ca influx blocker. The invention, in its various aspects, includes administration of compositions that induce cell death including administration of a composition to a mammal, e.g., a human for therapeutic purposes; compositions, e.g., a composition having a Ca influx blocker and an agent which normally stimulates cells in which cell death is to be induced; kits of compositions, e.g., a kit having a Ca influx blocker and an agent which normally stimulates cells in which cell death is to be induced; use of such compositions or kits of compositions as anti-inflammatory agents and/or anti-proliferative agents; and use of a Ca influx blocker or use of Ca influx blocker and agent in the preparation of a medicament for use in inducing cell death. The invention includes a method for diagnosing the susceptibility of diseased animals to treatment with a Ca influx blocker or the combination of a Ca influx blocker and agent which normally stimulates cells in order that the treatment can induce cell death. The invention includes a method for screening potential compounds as Ca influx blockers.
摘要翻译：本发明的一般特征是通过Ca 2+流入阻断剂诱导刺激细胞的死亡。本发明在其各个方面包括施用诱导细胞死亡的组合物，包括向哺乳动物（例如人）施用组合物用于治疗目的; 组合物，例如具有Ca 2+流入阻断剂的组合物和通常刺激其中诱导细胞死亡的细胞的试剂; 组合物试剂盒，例如具有Ca 2+流入阻断剂的试剂盒和通常刺激其中诱导细胞死亡的细胞的试剂; 使用这样的组合物或成套组合物作为抗炎剂和/或抗增殖剂; 以及使用Ca 2+流入阻断剂或使用Ca 2+流入阻断剂和药剂制备用于诱导细胞死亡的药物。本发明包括用于诊断患病动物用Ca 2+流入阻断剂或Ca 2+流入阻断剂和通常刺激细胞的药剂的组合的敏感性的方法，以便该治疗可诱导细胞死亡。本发明包括用于筛选潜在化合物作为Ca 2+流入阻断剂的方法。

4. 发明申请

WO2006079216A1 LIPOSOMAL COMPOSITIONS FOR PARENTERAL DELIVERY OF AGENTS 审中-公开
标题翻译：用于家族代理的药物组合物
公开(公告)号：WO2006079216A1
公开(公告)日：2006-08-03
申请号：PCT/CA2006/000114
申请日：2006-01-30
申请人： BC CANCER AGENCY , UNIVERSITY HEALTH NETWORK , WASAN, Ellen , BALLY, Marcel , COGSWELL, Sebastian , BERGER, Stuart
发明人： WASAN, Ellen , BALLY, Marcel , COGSWELL, Sebastian , BERGER, Stuart
IPC分类号： A61K31/4174 , A61P35/00 , A61P31/10 , A61K9/127 , A61K47/48
CPC分类号： A61K9/1271 , A61K9/1278 , A61K31/4174
摘要： The invention provides methods and compositions for loading an agent, such as econazole, onto a liposome for parental delivery. The loading of the agent into a liposome comprises combining the agent with a micelle-forming compound to form a micelle including the agent, where the agent is releasable from the micelle-forming compound, and adding the micelle to the liposome, where the micelle combines with the liposome such that the agent is loaded into the liposome to form a loaded liposome. The methods are suitable for the loading of poorly soluble agents onto liposome.
摘要翻译：本发明提供了用于将药剂（例如益康唑）加载到用于亲代递送的脂质体上的方法和组合物。将试剂加载到脂质体中包括将试剂与胶束形成化合物组合以形成包含试剂的胶束，其中试剂可从胶束形成化合物释放，并将胶束加入脂质体中，其中胶束结合与脂质体一起使得试剂加载到脂质体中以形成负载的脂质体。该方法适用于将难溶性物质加载到脂质体上。

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