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1. 发明申请

WO1997025063A1 COMPOSITIONS INCLUDING CALCIUM INFLUX BLOCKERS FOR INHIBITING CELL GROWTH 审中-公开
标题翻译：组合物包括用于抑制细胞生长的钙通道阻断剂
公开(公告)号：WO1997025063A1
公开(公告)日：1997-07-17
申请号：PCT/CA1997000019
申请日：1997-01-13
申请人： THE WELLESLEY CENTRAL HOSPITAL , BERGER, Stuart, Alan , GOMMERMAN, Jennifer, Lynn
发明人： THE WELLESLEY CENTRAL HOSPITAL
IPC分类号： A61K45/06
CPC分类号： A61K45/06
摘要： A general feature of the present invention is the induction of the death of stimulated cells by a Ca influx blocker. The invention, in its various aspects, includes administration of compositions that induce cell death including administration of a composition to a mammal, e.g., a human for therapeutic purposes; compositions, e.g., a composition having a Ca influx blocker and an agent which normally stimulates cells in which cell death is to be induced; kits of compositions, e.g., a kit having a Ca influx blocker and an agent which normally stimulates cells in which cell death is to be induced; use of such compositions or kits of compositions as anti-inflammatory agents and/or anti-proliferative agents; and use of a Ca influx blocker or use of Ca influx blocker and agent in the preparation of a medicament for use in inducing cell death. The invention includes a method for diagnosing the susceptibility of diseased animals to treatment with a Ca influx blocker or the combination of a Ca influx blocker and agent which normally stimulates cells in order that the treatment can induce cell death. The invention includes a method for screening potential compounds as Ca influx blockers.
摘要翻译：本发明的一般特征是通过Ca 2+流入阻断剂诱导刺激细胞的死亡。本发明在其各个方面包括施用诱导细胞死亡的组合物，包括向哺乳动物（例如人）施用组合物用于治疗目的; 组合物，例如具有Ca 2+流入阻断剂的组合物和通常刺激其中诱导细胞死亡的细胞的试剂; 组合物试剂盒，例如具有Ca 2+流入阻断剂的试剂盒和通常刺激其中诱导细胞死亡的细胞的试剂; 使用这样的组合物或成套组合物作为抗炎剂和/或抗增殖剂; 以及使用Ca 2+流入阻断剂或使用Ca 2+流入阻断剂和药剂制备用于诱导细胞死亡的药物。本发明包括用于诊断患病动物用Ca 2+流入阻断剂或Ca 2+流入阻断剂和通常刺激细胞的药剂的组合的敏感性的方法，以便该治疗可诱导细胞死亡。本发明包括用于筛选潜在化合物作为Ca 2+流入阻断剂的方法。

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