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1. 发明专利

GB0418614D0 Fishing float improvement 未知
公开(公告)号：GB0418614D0
公开(公告)日：2004-09-22
申请号：GB0418614
申请日：2004-08-20
申请人： BEER DAVID E J , BEER MARTIN

2. 发明专利

DD211055A1 未知
公开(公告)号：DD211055A1
公开(公告)日：1984-07-04
申请号：DD24434182
申请日：1982-10-28
申请人： SCHNAESKE BERNHARD , BEER MARTIN , STARKE FRANK , WACHS SIGFRIED , SCHIECHE HELGA
发明人： SCHNAESKE BERNHARD , BEER MARTIN , STARKE FRANK , WACHS SIGFRIED , SCHIECHE HELGA
IPC分类号： A01K31/06

3. 发明专利

DE1744658U 未知
公开(公告)号：DE1744658U
公开(公告)日：1957-05-09
申请号：DEB0027009
申请日：1956-09-12
申请人： BEER MARTIN FRIEDRICH
发明人： BEER MARTIN FRIEDRICH

4. 发明申请

WO2006086377A2 METHOD OF DETECTION OF CLASSICAL SWINE FEVER 审中-公开
标题翻译：检测经典开关的方法
公开(公告)号：WO2006086377A2
公开(公告)日：2006-08-17
申请号：PCT/US2006/004271
申请日：2006-02-08
申请人： IDEXX LABORATORIES , HOFFMANN, Bernd , DEPNER, Klaus , BEER, Martin
发明人： HOFFMANN, Bernd , DEPNER, Klaus , BEER, Martin
IPC分类号： C12Q1/70 , C12Q1/68 , C07J17/00 , C07H21/04
CPC分类号： C12Q1/70
摘要： The invention relates to a multiplex real-time RT-PCR assay with a heterologous internal control system (i.e., EGFP-RNA) for the simple and fast diagnosis of classical swine fever virus (CSFV). Primers and FAM-labeled TaqMan probes, specific for CSFV were selected by analyzing the consensus sequence of the 5 '-non translated region of various CSFV strains. For determining the analytical sensitivity an in vitro transcript (T7-PC3Alf) of the 5' NTR was constructed and tested. Furthermore, a primer - probe system for the detection of the internal control sequence was established, and a multiplex assay using CSF-System 1 and the IC real-time PCR could be performed as a one-tube assay without loss of sensitivity or specificity.
摘要翻译：本发明涉及用于简单和快速诊断典型猪瘟病毒（CSFV）的异源内部对照系统（即EGFP-RNA）的多重实时RT-PCR测定。通过分析各种CSFV毒株5'非翻译区的共有序列，选择引物和FAM标记的TaqMan探针，对CSFV特异性。为了确定分析灵敏度，构建并测试了5'NTR的体外转录物（T7-PC3Alf）。此外，建立了用于检测内部控制序列的引物 - 探针系统，使用CSF-System 1和IC实时PCR的多重测定可以作为单管测定进行，而不损失敏感性或特异性。

5. 发明申请

WO2011144360A1 MARKER VACCINE FOR CLASSICAL SWINE FEVER 审中-公开
标题翻译：标志性灭火剂
公开(公告)号：WO2011144360A1
公开(公告)日：2011-11-24
申请号：PCT/EP2011/002624
申请日：2011-05-18
申请人： RIEMSER ARZNEIMITTELAG , BEER, Martin , BLOME , Sandra , LEIFER, Immanuel
发明人： BEER, Martin , BLOME , Sandra , LEIFER, Immanuel
IPC分类号： A61K39/12 , C07K14/18 , C12N15/01
CPC分类号： C12Q1/70 , A61K39/12 , A61K2039/5254 , A61K2039/542 , A61K2039/552 , A61K2039/6081 , C07K14/005 , C12N2770/24322 , C12N2770/24334 , G01N33/56983
摘要： The invention relates to a marker vaccine for prophylactic treatment of classical swine fever comprising modified live attenuated classical swine fever virus. The viral amino acid sequence of the TAV-epitope of the E2 protein comprises a different sequence from that of a wild-type classical swine fever virus. The invention relates to pharmaceutical compositions of the marker vaccine. The invention also relates to a method of manufacturing marker vaccines for prevention of classical swine fever using selective antibody pressure.
摘要翻译：本发明涉及一种用于预防性治疗经典猪瘟的标记疫苗，其包含改良的减毒经典猪瘟病毒。 E2蛋白的TAV-表位的病毒氨基酸序列包含与野生型经典猪瘟病毒不同的序列。本发明涉及标记疫苗的药物组合物。本发明还涉及使用选择性抗体压力制备用于预防传统猪瘟的标记疫苗的方法。

6. 发明申请

WO2008034857A1 PESTIVIRUS MUTANT FOR USE IN A VACCINE 审中-公开
标题翻译：生物活性物质用于疫苗
公开(公告)号：WO2008034857A1
公开(公告)日：2008-03-27
申请号：PCT/EP2007/059923
申请日：2007-09-20
申请人： INTERVET INTERNATIONAL B.V. , BEER, Martin , REIMANN, Ilona , KOENIG, Patricia
发明人： BEER, Martin , REIMANN, Ilona , KOENIG, Patricia
IPC分类号： A61K39/12 , C12N7/04
CPC分类号： C12N7/00 , A61K39/12 , A61K2039/5254 , A61K2039/552 , C12N2770/24334 , C12N2770/24362
摘要： The present invention aims at providing new pestivirus mutants for use in vaccines. The present inventors worked with pestivirus mutants containing mutations in the coding region for the Npro protein of the virus. The mutants according to the present invention are characterized in that the mutant is based on a cp strain of the virus wherein part of the gene sequence encoding the Npro region is deleted, wherein said deleted part does not encompass the coding sequence for the N-terminal twelve amino acids of the Npro protein. Preferably the pestivirus is the Bovine Viral Diarrhea Virus (BVDV). Especially for BVDV it was found that a mutant according to the invention is a safe and efficient vaccine candidate.
摘要翻译：本发明旨在提供用于疫苗的新的瘟病毒突变体。本发明人使用了在病毒的Npro蛋白的编码区中含有突变的瘟病毒突变体。根据本发明的突变体的特征在于，所述突变体是基于病毒的cp株，其中编码Npro区的基因序列的部分被缺失，其中所述缺失部分不包含N末端的编码序列 Npro蛋白的十二个氨基酸。优选地，瘟病毒是牛病毒性腹泻病毒（BVDV）。特别是对于BVDV，发现根据本发明的突变体是安全有效的疫苗候选物。

7. 发明申请

WO2004016794A1 REPLICONS OF PESTIVIRUSES THAT DO NOT EXPRESS C AND OR E1 PROTEIN AND INFECTIOUS VIRAL PARTICLES CONTAINING SAME, THAT CAN BE USED IN VACCINES 审中-公开
标题翻译：不能表达C和/或蛋白质的蛋白质和含有可能在疫苗中使用的感染性病毒颗粒的替代物
公开(公告)号：WO2004016794A1
公开(公告)日：2004-02-26
申请号：PCT/EP2003/009031
申请日：2003-08-12
申请人： AKZO NOBEL N.V. , BEER, Martin , REIMANN, Ilona
发明人： BEER, Martin , REIMANN, Ilona
IPC分类号： C12N15/86
CPC分类号： C12N7/00 , A61K39/12 , A61K2039/5254 , A61K2039/543 , A61K2039/552 , C07K14/005 , C12N15/86 , C12N2770/24322 , C12N2770/24343 , C12N2770/24362
摘要： The present invention provides new Pestiviral RNA genomes (replicons) that are able to replicate, and can be packaged into infectious viral particles in cells that complement the missing protein(s), but do not produce infectious progeny virus. Such replicons can be useful for vaccine purposes. The replicons encode most, preferably all, envelop proteins of the virus, while, on the other hand, it would not be capable of producing infectious progeny virus. The present invention provides a Pestiviral replicon, preferably from the Bovine Viral Diarrhea Virus (BVDV), which expresses all structural proteins except for a functional C or E1 protein. Preferably at least part of the coding sequence of the E1 or C protein has been deleted from said replicon. The present inventors proved for the first time, that both C and E1 structural proteins are essential for the formation of infectious pestiviruses. Furthermore it was shown that deletion of C and E1 does not impact the ability of RNA self-replication. By using cell lines constitutively expressing pestiviral structural proteins, Capsid- or E1-proteins can be efficiently trans -complemented. The resulting virions are able to infect bovine target cells and to transfer the replicons without generating replication-competent virus progeny. In other words, no infectious progeny virus is produced. The complemented virions are indistinguishable from wild-type Pestivirus.in virus neutralization experiments. Recombinations yielding infectious wild-type virus were not detected in any of the complementation experiments. The complemented viruses may be used for the safe and efficacious immunization against BVDV.
摘要翻译：本发明提供能够复制并且可以包装在补充缺失的蛋白质但不产生感染性后代病毒的细胞中的感染性病毒颗粒中的新的瘟病毒RNA基因组（复制子）。这样的复制子可以用于疫苗目的。复制子编码病毒的大多数，优选全部包膜蛋白，而另一方面，它将不能产生感染性后代病毒。本发明提供了一种优选来自牛病毒性腹泻病毒（BVDV）的Pestiviral复制子，其表达除功能性C或E1蛋白以外的所有结构蛋白。优选地，E1或C蛋白的编码序列的至少一部分已经从所述复制子中删除。本发明人首次证明了C和E1结构蛋白对于形成感染性瘟病毒是必不可少的。此外，显示C和E1的缺失不影响RNA自我复制的能力。通过使用组成型表达瘟病毒结构蛋白的细胞系，衣壳蛋白或E1蛋白可以有效地反式互补。所得到的病毒粒子能够感染牛靶细胞并转移复制子，而不产生具有复制能力的病毒后代。换句话说，没有产生感染性后代病毒。补充的病毒粒子与野生型瘟病毒在病毒中和实验中无法区分。在任何互补实验中未检测到产生感染性野生型病毒的重组。补充的病毒可用于对BVDV的安全有效的免疫。

8. 发明申请

WO2011151404A1 METHOD FOR SPECIFIC DETECTION OF CLASSICAL SWINE FEVER VIRUS 审中-公开
标题翻译：特殊检测经典开关病毒的方法
公开(公告)号：WO2011151404A1
公开(公告)日：2011-12-08
申请号：PCT/EP2011/059122
申请日：2011-06-01
申请人： Labor Diagnostik GmbH Leipzig , HOFFMANN, Bernd , LEIFER, Immanuel , BEER, Martin , GAUNITZ, Christine
发明人： HOFFMANN, Bernd , LEIFER, Immanuel , BEER, Martin , GAUNITZ, Christine
IPC分类号： C12Q1/70
CPC分类号： C12Q1/70
摘要： The present invention relates to a method for determining the presence of a classical swine fewer virus (CSFV) in a subject comprising the detection of the NS5A region of at least one classical swine fewer virus (CSFV) genome in a sample derived from said subject. The invention further relates to a kit for determining the presence of a classical swine fewer virus (CSFV) and to nucleic acids as well as to the use of the kit and/or nucleic acids in said method.
摘要翻译：本发明涉及一种用于确定受试者中存在经典猪较少病毒（CSFV）的方法，所述方法包括检测来源于所述受试者的样品中至少一种经典猪少病毒（CSFV）基因组的NS5A区域。本发明进一步涉及用于确定经典的猪更少病毒（CSFV）和核酸的存在以及所述方法中所述试剂盒和/或核酸的使用的试剂盒。

9. 发明申请

WO2004020644A1 NON-HUMAN HERPESVIRUSES AS VECTORS 审中-公开
标题翻译：非人类草药作为向量
公开(公告)号：WO2004020644A1
公开(公告)日：2004-03-11
申请号：PCT/EP2003/009689
申请日：2003-09-01
申请人： GENEART GMBH , BEER, Martin , OSTERRIEDER, Nikolaus , RUDOLPH, Jens , TRAPP, Sascha , WAGNER, Ralf
发明人： BEER, Martin , OSTERRIEDER, Nikolaus , RUDOLPH, Jens , TRAPP, Sascha , WAGNER, Ralf
IPC分类号： C12N15/86
CPC分类号： C12N15/86 , A61K48/00 , A61K2039/523 , C12N2710/16743
摘要： The present invention relates to animal viruses such as animal herpesviruses as a vector for diagnostic, therapeutic and prophylactic delivery of foreign genes and nucleic acids to animals, human or primary cells derived thereof, respectively. By using said viruses, the prevention and treatment of infectious, autoimmune and tumor diseases as well as allergies and genetic disorders can be treated. The present invention relates further to procedures to efficiently transduce primary human cells with recombinant animal viruses in vitro and in vivo. The invention further relates to a kit useful (i) for diagnosis and monitoring of innate and adoptive immune responses as well as (ii) for gene therapy and (iii) immunization purposes.
摘要翻译：本发明涉及动物病毒如动物疱疹病毒作为用于向动物，衍生自其衍生的人或原代细胞的外源基因和核酸的诊断，治疗和预防性递送的载体。通过使用所述病毒，可以治疗感染性，自身免疫性和肿瘤疾病以及过敏和遗传疾病的预防和治疗。本发明还涉及在体外和体内有重组动物病毒有效转导原代人细胞的方法。本发明还涉及用于（i）用于诊断和监测先天性和过继性免疫应答的试剂盒，以及（ii）用于基因治疗和（iii）免疫目的。

10. 发明申请

WO2012038454A1 BVDV VACCINE 审中-公开
公开(公告)号：WO2012038454A1
公开(公告)日：2012-03-29
申请号：PCT/EP2011/066377
申请日：2011-09-21
申请人： INTERVET INTERNATIONAL B.V. , BEER, Martin , REIMANN, Ilona , KOENIG, Patricia
发明人： BEER, Martin , REIMANN, Ilona , KOENIG, Patricia
IPC分类号： A61K39/295 , C07K14/18 , A61K39/12 , C12N7/00 , C12N7/04
CPC分类号： A61K39/12 , A61K39/295 , A61K39/40 , A61K39/42 , A61K2039/5254 , A61K2039/552 , A61K2039/70 , C07K14/005 , C12N2770/24322 , C12N2770/24334 , C12N2770/24362
摘要： The present invention relates to BVD virus and to its uses, to vaccines and combination vaccines comprising such a virus, their use as a medicament, their use in the treatment of Bovine Viral Diarrhoea and to methods for the preparation of such vaccines.
摘要翻译：本发明涉及BVD病毒及其用途，包含这种病毒的疫苗和组合疫苗，它们作为药物的用途，其用于治疗牛病毒性腹泻的用途以及用于制备这种疫苗的方法。

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