专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明公开

EP1969373A2 MULTIPLEXED DETECTION OF ANTI-RED CELL ALLOANTIBODIES 审中-公开
标题翻译：复用检测抗红细胞同种抗体
公开(公告)号：EP1969373A2
公开(公告)日：2008-09-17
申请号：EP07716339.2
申请日：2007-01-04
申请人： BioArray Solutions Ltd. , Banerjee, Sukanta
发明人： BANERJEE, Sukanta
IPC分类号： G01N33/53
CPC分类号： G01N33/80 , Y10T436/106664 , Y10T436/13 , Y10T436/2525
摘要： Disclosed are methods for detecting antibody in a sample, where the antibody targets an antigen expressed by red blood cells or red blood cell ghosts. Rather than detecting the binding events between a particular antigen antibody pair (as in traditional agglutination based assays) the methods herein allow for multiplexed detection of clinically important allo-immune antibodies to blood group antigens. Specifically the method involves generating fluorescently encoded red blood cells or red blood cell ghosts with known antigen presentation and using them to detect the presence of antibody in serum/plasma with a fluorescent sandwich type immunoassay. The assay results can be read using flow cytometric or fluorescent microscope based imaging techniques.

2. 发明公开

EP1969373A4 MULTIPLEXED DETECTION OF ANTI-RED CELL ALLOANTIBODIES 审中-公开
标题翻译：复用检测抗红细胞同种抗体
公开(公告)号：EP1969373A4
公开(公告)日：2010-05-26
申请号：EP07716339
申请日：2007-01-04
申请人： BIOARRAY SOLUTIONS LTD , BANERJEE SUKANTA
发明人： BANERJEE SUKANTA
IPC分类号： G01N33/53 , G01N33/80
CPC分类号： G01N33/80 , Y10T436/106664 , Y10T436/13 , Y10T436/2525

3. 发明申请

WO2004064988A2 METHOD FOR CONTROLLING SOLUTE LOADING OF POLYMER MICROPARTICLES 审中-公开
标题翻译：用于控制聚合物微量元素的溶解负载的方法
公开(公告)号：WO2004064988A2
公开(公告)日：2004-08-05
申请号：PCT/US2004001433
申请日：2004-01-21
申请人： BIOARRAY SOLUTIONS LTD , BANERJEE SUKANTA , GEORGESCU CECILIA , SEUL MICHAEL
发明人： BANERJEE SUKANTA , GEORGESCU CECILIA , SEUL MICHAEL
IPC分类号： C08J3/215 , B01F
CPC分类号： C08J3/212 , C08J3/215 , C08J3/22 , C08J2325/08
摘要： Solute-loaded polymer microparticles are obtained by immersing microparticles in a bath comprising a selected solute dissolved in a ternary solvent system. A first solvent of the ternary system is a strong solvent for both the solute and the polymer from which the microparticle was formed. A second solvent is a weak solvent or non- solvent for the solute and the polymer (tuning solvent). A third solvent is a weak solvent or non-solvent for the solute and polymer, but serves as a co-solvent with respect to the first and second solvents in that it is miscible with both the first and second solvents. The amount of solute incorporated into the microparticles is controlled by adjusting the ratio of solute with respect to the microparticle polymer, and by adjusting the composition of the ternary solvent system, principally the amount of tuning solvent. The method is particularly useful for providing libraries of combinatorially encoded microparticles containing distinguishable dye loadings, particularly distinguishable fluorescent dye loadings.
摘要翻译：通过将微粒浸入包含溶解在三元溶剂系统中的选定溶质的浴中来获得溶质负载的聚合物微粒。三元体系的第一溶剂是溶质和形成微粒的聚合物的强溶剂。第二溶剂是用于溶质和聚合物（调谐溶剂）的弱溶剂或非溶剂。第三溶剂是用于溶质和聚合物的弱溶剂或非溶剂，但是作为相对于第一和第二溶剂的共溶剂，因为它可与第一溶剂和第二溶剂混溶。通过调节溶质相对于微粒聚合物的比例，调节三元溶剂体系的组成，主要是调谐溶剂的量来控制掺入微粒的溶质量。该方法对于提供包含可区分的染料负载，特别是可区分的荧光染料负载的组合编码的微粒的文库是特别有用的。

4. 发明申请

WO2005031305A3 SURFACE IMMOBILIZED POLYELECTROLYTE WITH MULTIPLE FUNCTIONAL GROUPS CAPABLE OF COVALENTLY BONDING TO BIOMOLECULES 审中-公开
标题翻译：具有多个功能组合的表面固定聚电解质，可共同连接生物分子
公开(公告)号：WO2005031305A3
公开(公告)日：2006-03-30
申请号：PCT/US2004031058
申请日：2004-09-22
申请人： BIOARRAY SOLUTIONS LTD , WANG XINWEN , BANERJEE SUKANTA
发明人： WANG XINWEN , BANERJEE SUKANTA
IPC分类号： C12M1/34 , C12Q1/68 , G01N20060101 , G01N33/53 , G01N33/543 , B05D3/00 , B32B9/04 , C07H21/04
CPC分类号： C12Q1/6834 , C07H21/04 , G01N33/54353 , C12Q2563/119
摘要： A polyelectrolyte having multiple exposed functional groups, each such group being capable of covalently bonding to a molecule, is immobilized on a surface for the purpose of bonding to a biomolecule. The biomolecule can be, for example, a nucleic acid, e.g., an amine functionalized oligonucleotide. The polyelectrolyte can include, e.g., BSA (Bovine Serum Albumin) which is bound to a functionalized surface using a covalent immobilization strategy, e.g., reaction with the surface of a tosyl-activated microparticle. Following such reaction, exposed reactive functional groups on the protein, such as amine, carboxyl, thiol, hydroxyl groups can further be utilized to covalently couple the oligonucleotide of interest using suitable chemistry.
摘要翻译：具有多个暴露的官能团的聚电解质，每个这样的基团能够共价键合到分子，固定在表面上用于与生物分子结合的目的。生物分子可以是例如核酸，例如胺官能化的寡核苷酸。聚电解质可以包括例如BSA（牛血清白蛋白），其使用共价固定策略结合到官能化表面，例如与甲苯磺酰基活化的微粒的表面反应。在这样的反应之后，蛋白质上暴露的反应性官能团如胺，羧基，硫醇，羟基可进一步用于使用合适的化学物质共价连接感兴趣的寡核苷酸。

5. 发明申请

WO2005042763A2 OPTIMIZATION OF GENE EXPRESSION ANALYSIS USING IMMOBILIZED CAPTURE PROBES 审中-公开
标题翻译：使用固定捕获探针优化基因表达分析
公开(公告)号：WO2005042763A2
公开(公告)日：2005-05-12
申请号：PCT/US2004035426
申请日：2004-10-26
申请人： BIOARRAY SOLUTIONS LTD , SEUL MICHAEL , BANERJEE SUKANTA , YANG JIACHENG , VENER TATIANA
发明人： SEUL MICHAEL , BANERJEE SUKANTA , YANG JIACHENG , VENER TATIANA
IPC分类号： C12Q20060101 , C12Q1/68 , C12Q
CPC分类号： C12Q1/6832 , B01J2219/00459 , B01J2219/00576 , B01J2219/00608 , B01J2219/00648 , B01J2219/00722 , C12Q1/6809 , C12Q1/6834 , C12Q1/6837 , C12Q2537/143 , C12Q2565/501 , C12Q2565/507 , C12Q2533/101 , C12Q2565/514 , C12Q2565/519
摘要： Disclosed are methods of multiplexed analysis of oligonucleotides in a sample, including: methods of probe and target "engineering", as well as methods of assay signal analysis relating to the modulation of the probe-target affinity constant, K by a variety of factors including the elastic properties of target strands and layers of immobilized ("grafted") probes; and assay methodologies relating to: the tuning of assay signal intensities including dynamic range compression and on-chip signal amplification; the combination of hybridization-mediated and elongation-mediated detection for the quantitative determination of abundance of messages displaying a high degree of sequence similarity, including, for example, the simultaneous determination of the relative expression levels, and identification of the specific class of, untranslated AU-rich subsequences located near the 3' terminus of mRNA; and a new method of subtractive differential gene expression analysis which requires only a single color label.
摘要翻译：公开了样品中寡核苷酸多重分析的方法，包括：探针和靶标“工程”的方法，以及通过多种因素与探针 - 靶亲和常数K的调节相关的信号分析方法，包括目标链和固定（“接枝”）探针层的弹性性质; 以及与以下方法相关的测定方法：调整测定信号强度，包括动态范围压缩和片上信号放大; 杂交介导和延长介导检测的组合用于定量测定显示高度序列相似性的消息丰度，包括例如同时确定相对表达水平，以及鉴定特异性类别，未翻译位于mRNA的3'末端附近的富含子序列; 以及仅需要单一颜色标签的减法差分基因表达分析的新方法。

6. 发明申请

WO2003079401A2 DIRECTED ASSEMBLIY OF FUNCTIONAL HETEROSTRUCTURES 审中-公开
标题翻译：功能性结构的指导性组合
公开(公告)号：WO2003079401A2
公开(公告)日：2003-09-25
申请号：PCT/US2002/020023
申请日：2002-06-21
申请人： BIOARRAY SOLUTIONS, LTD. , BANERJEE, Sukanta , SEUL, Michael , PODUAL, Kairali , HONG, Ye
发明人： BANERJEE, Sukanta , SEUL, Michael , PODUAL, Kairali , HONG, Ye
IPC分类号： H01L
CPC分类号： C08J3/075 , C08J3/28 , C08J2333/26 , C08J2425/06 , C12Q1/6837 , G01N33/5005 , G01N33/545 , G03F7/0047 , G03F7/164 , Y10T428/249952 , Y10T428/25
摘要： The present invention relates to a systematic process for the creation of functionally organized, spatially patterned assemblies polymer-microparticle composites including the AC electric field-mediated assembly of patterned, self-supporting organic (polymeric) films and organic-polymer-microparticle composites of tailored composition and morphology. The present invention further relates to the incorporation of said assemblies into other structures. The present invention also relates to the application of such functional assemblies in materials science and biology. Additional areas of application include sensors, catalysts, membranes, and micro-reactors, and miniaturized format for generation of multifunctional thin films. This invention also provides simple methods and apparatus for synthesizing thin films of tailored composition and morphology.
摘要翻译：本发明涉及一种用于创建功能组织的空间图案化聚合物 - 微粒复合材料的系统方法，其包括图案化的自支撑有机（聚合物）膜和定影的有机 - 聚合物 - 微粒复合材料的AC电场介导组装组成和形态。本发明还涉及将所述组件结合到其它结构中。本发明还涉及这种功能组件在材料科学和生物学中的应用。其他应用领域包括传感器，催化剂，膜和微反应器以及用于产生多功能薄膜的小型化形式。本发明还提供用于合成定制组合物和形态的薄膜的简单方法和装置。

7. 发明申请

WO2007081778A2 MULTIPLEXED DETECTION OF ANTI-RED CELL ALLOANTIBODIES 审中-公开
标题翻译：多重检测抗红细胞细胞
公开(公告)号：WO2007081778A2
公开(公告)日：2007-07-19
申请号：PCT/US2007/000234
申请日：2007-01-04
申请人： BIOARRAY SOLUTIONS LTD. , BANERJEE, Sukanta
发明人： BANERJEE, Sukanta
IPC分类号： G01N33/567
CPC分类号： G01N33/80 , Y10T436/106664 , Y10T436/13 , Y10T436/2525
摘要： Disclosed are methods for detecting antibody in a sample, where the antibody targets an antigen expressed by red blood cells or red blood cell ghosts. Rather than detecting the binding events between a particular antigen antibody pair (as in traditional agglutination based assays) the methods herein allow for multiplexed detection of clinically important allo-immune antibodies to blood group antigens. Specifically the method involves generating fluorescently encoded red blood cells or red blood cell ghosts with known antigen presentation and using them to detect the presence of antibody in serum/plasma with a fluorescent sandwich type immunoassay. The assay results can be read using flow cytometric or fluorescent microscope based imaging techniques.
摘要翻译：公开了用于检测样品中抗体的方法，其中抗体靶向由红细胞或红细胞重影表达的抗原。不是检测特定抗原抗体对之间的结合事件（如在传统的基于凝集的测定法中），本文的方法允许对血型抗原的临床重要的同种异体免疫抗体的多重检测。具体地说，该方法涉及产生具有已知抗原呈递的荧光编码的红细胞或红血细胞鬼，并使用它们以荧光夹心型免疫测定法检测血清/血浆中抗体的存在。可以使用流式细胞仪或基于荧光显微镜的成像技术读取测定结果。

8. 发明申请

WO2004064988A3 METHOD FOR CONTROLLING SOLUTE LOADING OF POLYMER MICROPARTICLES 审中-公开
公开(公告)号：WO2004064988A3
公开(公告)日：2004-08-05
申请号：PCT/US2004/001433
申请日：2004-01-21
申请人： BIOARRAY SOLUTIONS, LTD. , BANERJEE, Sukanta , GEORGESCU, Cecilia , SEUL, Michael
发明人： BANERJEE, Sukanta , GEORGESCU, Cecilia , SEUL, Michael
IPC分类号： B05D7/00
摘要： Solute-loaded polymer microparticles are obtained by immersing microparticles in a bath comprising a selected solute dissolved in a ternary solvent system. A first solvent of the ternary system is a strong solvent for both the solute and the polymer from which the microparticle was formed. A second solvent is a weak solvent or non- solvent for the solute and the polymer (tuning solvent). A third solvent is a weak solvent or non-solvent for the solute and polymer, but serves as a co-solvent with respect to the first and second solvents in that it is miscible with both the first and second solvents. The amount of solute incorporated into the microparticles is controlled by adjusting the ratio of solute with respect to the microparticle polymer, and by adjusting the composition of the ternary solvent system, principally the amount of tuning solvent. The method is particularly useful for providing libraries of combinatorially encoded microparticles containing distinguishable dye loadings, particularly distinguishable fluorescent dye loadings.

9. 发明申请

WO0198765A9 MULTIANALYTE MOLECULAR ANALYSIS 审中-公开
标题翻译：多元分子分析
公开(公告)号：WO0198765A9
公开(公告)日：2003-09-04
申请号：PCT/US0120179
申请日：2001-06-21
申请人： BIOARRAY SOLUTIONS LTD , XIANG LI ALICE , BANERJEE SUKANTA , CHAU WO CHIU , PODUAL KAIRALI
发明人： XIANG LI ALICE , BANERJEE SUKANTA , CHAU WO CHIU , PODUAL KAIRALI
IPC分类号： G01N21/64 , B01J19/00 , C12M1/34 , C12Q1/68 , G01N33/53 , G01N33/543 , G01N33/553 , G01N33/58 , G01N35/00 , G01N27/26 , C12P19/34 , G01N21/00
CPC分类号： C12Q1/6813 , B01J19/0046 , B01J2219/00286 , B01J2219/00315 , B01J2219/00497 , B01J2219/005 , B01J2219/00527 , B01J2219/00545 , B01J2219/00576 , B01J2219/00585 , B01J2219/00596 , B01J2219/00644 , B01J2219/00648 , B01J2219/00653 , B01J2219/00722 , B01J2219/00725 , C12Q1/6837 , C12Q1/6876 , G01N27/745 , G01N33/5434 , G01N33/54346 , G01N33/587 , G01N2035/00564 , G01N2035/00762 , G01N2446/20 , G01N2446/64 , Y10T436/11 , C12Q2565/513 , C12Q2563/143 , C12Q2563/107 , C12Q2563/155
摘要： The present invention provides methods and apparatus for the application of a particle array in bioassay format to perform qualitative and/or quantitative molecular interaction analysis between two classes of molecules (an analyte and a binding agent). The methods and apparatus disclosed herein permit the determination of the presence or absence of association, the strength of association, and/or the rate of association and dissociation governing the binding interactions between the binding agents and the analyte molecules. The present invention is especially useful for performing multiplexed (parallel) assays for qualitative and/or quantitative analysis of binding interactions of a number of analyte molecules in a sample.
摘要翻译：本发明提供了用于以生物测定形式应用颗粒阵列以在两类分子（分析物和结合剂）之间进行定性和/或定量分子相互作用分析的方法和装置。本文公开的方法和装置允许确定结合剂和分析物分子之间的结合相互作用的存在或不存在，缔合的强度，和/或缔合速率和解离速率。本发明特别可用于进行多个（并行）测定以定性和/或定量分析样品中许多分析物分子的结合相互作用。

10. 发明申请

WO2006130347A3 CREATION OF FUNCTIONALIZED MICROPARTICLE LIBRARIES BY OLIGONUCLEOTIDE LIGATION OR ELONGATION 审中-公开
标题翻译：通过寡核苷酸结合或延伸产生功能化的微生物图谱
公开(公告)号：WO2006130347A3
公开(公告)日：2007-11-22
申请号：PCT/US2006019203
申请日：2006-05-17
申请人： BIOARRAY SOLUTIONS LTD , SEUL MICHAEL , YANG JIACHENG , BANERJEE SUKANTA
发明人： SEUL MICHAEL , YANG JIACHENG , BANERJEE SUKANTA
IPC分类号： C12Q1/68
CPC分类号： B01J19/0046 , B01J2219/005 , B01J2219/00545 , B01J2219/00576 , B01J2219/00648 , B01J2219/00722 , B01J2219/00725 , C12N15/1093 , C40B20/04 , C40B50/14
摘要： Disclosed are methods of for constructing a bead-displayed library of oligonucleotide probes (or sequence-modified capture moieties such as protein-nucleic acid conjugates) by ligation of a capture probe, having an analyte-specific sequence, to an anchor probe that is attached, at its 5 '-end, (or possibly at the 3' end) to an encoded carrier such as a color-coded microparticle ("bead"). Such a library can also be constructed by elongation of an anchor probe, using a second probe as the elongation template, wherein the second probe has an anchor-specific subsequence and an analyte-specific subsequence.
摘要翻译：公开了通过将具有分析物特异性序列的捕获探针连接到所连接的锚定探针上来构建寡核苷酸探针（或序列修饰的捕获部分，例如蛋白质 - 核酸缀合物）的珠显示文库的方法在5'端，（或可能在3'端）与经编码的载体（如着色微粒（“珠”））相连。也可以使用第二探针作为延伸模板，通过锚定探针的伸长来构建这种文库，其中第二探针具有锚特异性亚序列和分析物特异性亚序列。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式