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1. 发明专利

ES2439706T3 Aplicaciones terapéuticas de extractos de semillas de Fraxinus excelsior 未知
公开(公告)号：ES2439706T3
公开(公告)日：2014-01-24
申请号：ES08847183
申请日：2008-11-05
申请人： NATUREX INC , BAI NAISHENG , DIKANSKY JACQUES , NATUREX SA
发明人： HE KAN , ROLLER MARC , BILY ANTOINE , IBARRA ALVIN , DIKANSKY JACQUES , BAI NAISHENG
IPC分类号： A61Q9/00
摘要： Extracto de semillas de Fraxinus excelsior que comprende GI5 o nuzhenida para su uso en un método terapéutico de control del peso corporal o reducción de la grasa corporal.

2. 发明公开

EP2214790A1 EXTRACT OF FRAXINUS EXCELSIOR SEEDS AND THERAPEUTIC APPLICATIONS THEREFOR 有权转让
标题翻译：从白蜡，怡东籽提取治疗应用
公开(公告)号：EP2214790A1
公开(公告)日：2010-08-11
申请号：EP08847183.4
申请日：2008-11-05
申请人： Naturex, Inc. , Bai, Naisheng , Dikansky, Jacques
发明人： HE, Kan , ROLLER, Marc , BILY, Antoine , IBARRA, Alvin , DIKANSKY, Jacques , BAI, Naisheng
IPC分类号： A61Q9/00
CPC分类号： A61K36/63 , A61K31/7088
摘要： A Fraxinus excelsior seed extract that can be administered for therapeutic treatment of a subject, including a human, by blocking fat synthesis, activating PPAR-alpha, increasing hypoglycemic activity, reducing bodyweight, controlling fasting plasma insulin levels against hyperinsulinemia, and promoting insulin sensitivity and causing a beneficial acute insulinotropic effect. The Fraxinus excelsior seed extract includes, inter alia, an isolated compound (2S, 3E, 4S) 2H-Pyran-4-acetic acid-3-ethylidene-2-[(6-O-β-D-glucopyranosyl-β-D- glucopyranosyl) oxy]-3,4-dihydro-5-(methoxycarbonyl) methyl ester, commonly called excelside A, an isolated compound (2S, 3E, 4S) 2H-Pyran-4-acetic acid-3-ethylidene-2-[(6-O- β-D-glucopyranosyl-β-D-glucopyranosyl) oxy]-3,4-dihydro-5-(methoxycarbonyl) 2-(4- hydroxyphenyl) ethyl ester, commonly called excelside B, and the compounds GI5, GI3, nuzhenide, and oleoside dimethyl ester.

3. 发明申请

WO2007109119A2 NEOBRITANNILACTONE B AND ACETYL NEOBRITANNILACTONE B 审中-公开
标题翻译： NEOBRITANNILACTONE B和ACETYL NEOBRITANNILACTONE B
公开(公告)号：WO2007109119A2
公开(公告)日：2007-09-27
申请号：PCT/US2007/006612
申请日：2007-03-16
申请人： RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY , HO, Chi-Tang , BAI, Naisheng , PAN, Min-Hsiung
发明人： HO, Chi-Tang , BAI, Naisheng , PAN, Min-Hsiung
IPC分类号： A61K31/365
CPC分类号： A61K31/365
摘要： Provided herein are methods of inducing apoptosis in cancer cells using neobritannilactone B (NAB) or acety neobritannilactone B (ANAB). Also provided are pharmaceutical compositions and methods for using NAB or ANAB to prevent or treat cancer in a mammal. Exemplary cancers include, for example, colon cancer, leukemia, and gastric cancer.
摘要翻译：本文提供了使用新戊酰胆碱B（NAB）或乙酰新几内酯B（ANAB）诱导癌细胞凋亡的方法。还提供了使用NAB或ANAB预防或治疗哺乳动物癌症的药物组合物和方法。示例性的癌症包括例如结肠癌，白血病和胃癌。

4. 发明申请

WO2006073457A3 BIOACTIVE COMPOUNDS AND METHODS OF USES THEREOF 审中-公开
标题翻译：生物活性化合物及其使用方法
公开(公告)号：WO2006073457A3
公开(公告)日：2007-02-01
申请号：PCT/US2005015280
申请日：2005-05-02
申请人： UNIV RUTGERS , UNIV MINNESOTA , WELLGEN INC , DONG ZIGANG , BODE ANNE , HO CHI-TANG , BAI NAISHENG , DUSHENKOV SLAVIK
发明人： DONG ZIGANG , BODE ANNE , HO CHI-TANG , BAI NAISHENG , DUSHENKOV SLAVIK
IPC分类号： C07D303/00 , A01N37/10 , A01N43/16 , A61K31/235 , A61K31/35 , C07D305/14 , C07D311/78 , C07D311/94
CPC分类号： C07D493/20 , A61K36/53
摘要： In one aspect, the present invention provides compounds having formula I or IV as shown below: as further defined herein. In additional aspects, the present invention provides compositions and kits comprising the compounds of the invention and methods for their use, for example, for the prevention or treatment of a cancer.
摘要翻译：在一个方面，本发明提供如下所示的具有式I或IV的化合物：如本文进一步定义。在另外的方面，本发明提供了包含本发明化合物的组合物和试剂盒及其用于例如预防或治疗癌症的方法。

5. 发明申请

WO2006017157A1 WEIGHT LOSS COMPOSITION 审中-公开
标题翻译：重量损失组成
公开(公告)号：WO2006017157A1
公开(公告)日：2006-02-16
申请号：PCT/US2005/024218
申请日：2005-07-08
申请人： PURE WORLD BOTANICALS, INC. , ZHENG, Qun Yi , ZHENG, Bo Lin , HE, Kan , CUI, Bao Liang , BAI, Naisheng
发明人： ZHENG, Qun Yi , ZHENG, Bo Lin , HE, Kan , CUI, Bao Liang , BAI, Naisheng
IPC分类号： A61K35/78
CPC分类号： A61K31/375 , A23L33/105 , A23L33/30 , A61K31/198 , A61K36/185 , A61K36/48 , A61K36/484 , A61K36/704 , A61K36/75 , A61K36/82 , A61K2300/00
摘要： The present invention provides a dietary supplement and methods of using the same to promote body weight reduction and/or loss of body fat in a subject, and for the management of obesity. The supplement can further be used to reduce one or more metabolic parameters in a subject, such as blood glucose levels, blood triglyceride levels, and blood cholesterol levels.
摘要翻译：本发明提供了一种膳食补充剂及其使用方法，以促进受试者体重减轻和/或体内脂肪的丧失，以及肥胖的管理。该补充剂可进一步用于减少受试者中的一种或多种代谢参数，例如血糖水平，血液甘油三酯水平和血液胆固醇水平。

6. 发明申请

WO2007109119A3 NEOBRITANNILACTONE B AND ACETYL NEOBRITANNILACTONE B 审中-公开
标题翻译： NEOBRITANNILACTONE B和ACETYL NEOBRITANNILACTONE B
公开(公告)号：WO2007109119A3
公开(公告)日：2007-11-15
申请号：PCT/US2007006612
申请日：2007-03-16
申请人： UNIV RUTGERS , HO CHI-TANG , BAI NAISHENG , PAN MIN-HSIUNG
发明人： HO CHI-TANG , BAI NAISHENG , PAN MIN-HSIUNG
IPC分类号： A01N65/00 , C12N5/00
CPC分类号： A61K31/365
摘要： Provided herein are methods of inducing apoptosis in cancer cells using neobritannilactone B (NAB) or acetyl neobritannilactone B (ANAB). Also provided are pharmaceutical compositions and methods for using NAB or ANAB to prevent or treat cancer in a mammal. Exemplary cancers include, for example, colon cancer, leukemia, and gastric cancer.
摘要翻译：本文提供使用新几内酯B（NAB）或乙酰基新几内酯B（ANAB）诱导癌细胞凋亡的方法。还提供了使用NAB或ANAB预防或治疗哺乳动物癌症的药物组合物和方法。示例性的癌症包括例如结肠癌，白血病和胃癌。

7. 发明申请

WO2006073457A2 BIOACTIVE COMPOUNDS AND METHODS OF USES THEREOF 审中-公开
标题翻译：生物化合物及其使用方法
公开(公告)号：WO2006073457A2
公开(公告)日：2006-07-13
申请号：PCT/US2005/015280
申请日：2005-05-02
申请人： RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY , REGENTS OF THE UNIVERSITY OF MINNESOTA , WELLGEN, INC. , DONG, Zigang , BODE, Anne , HO, Chi-tang , BAI, Naisheng , DUSHENKOV, Slavik
发明人： DONG, Zigang , BODE, Anne , HO, Chi-tang , BAI, Naisheng , DUSHENKOV, Slavik
IPC分类号： A61K31/353 , C07D305/14
CPC分类号： C07D493/20 , A61K36/53
摘要： In one aspect, the present invention provides compounds having formula I or IV as shown below: as further defined herein. In additional aspects, the present invention provides compositions and kits comprising the compounds of the invention and methods for their use, for example, for the prevention or treatment of a cancer.
摘要翻译：在一个方面，本发明提供具有如下所示的式I或IV的化合物：如本文进一步定义。在另外的方面，本发明提供了包含本发明化合物的组合物和试剂盒及其用于例如预防或治疗癌症的方法。

8. 发明申请

WO2011047321A1 EXTRACT OF ROSMARINUS OFFICINALIS L. LEAVES FOR PHARMACEUTICAL APPLICATIONS 审中-公开
标题翻译：罗非鱼的提取L.药物应用的叶子
公开(公告)号：WO2011047321A1
公开(公告)日：2011-04-21
申请号：PCT/US2010/052925
申请日：2010-10-15
申请人： NATUREX S.A. , HE, Kan , ROLLER, Marc , IBARRA, Alvin , BAI, Naisheng , DIKANSKY, Jacques
发明人： HE, Kan , ROLLER, Marc , IBARRA, Alvin , BAI, Naisheng
IPC分类号： A61K36/53
CPC分类号： A61K36/53
摘要： Disclosed are methods of alleviating oxidative stress, regulating blood glucose levels, and controlling pancreatic lipase activity by administering a Rosemary extract. Such methods may be useful to help body weight and body fat, prevent obesity, and treat hyperglycemia, hyperinsulinemia, cardiovascular disease and Type-2 diabetes. Preferred extracts contain 20% or 50% carnosic acid.
摘要翻译：公开了通过施用迷迭香提取物来减轻氧化应激，调节血糖水平和控制胰脂肪酶活性的方法。这些方法可用于帮助体重和身体脂肪，预防肥胖，以及治疗高血糖症，高胰岛素血症，心血管疾病和2型糖尿病。优选的提取物含有20％或50％的鼠尾草酸。

9. 发明申请

WO2009061849A1 EXTRACT OF FRAXINUS EXCELSIOR SEEDS AND THERAPEUTIC APPLICATIONS THEREFOR 审中-公开
标题翻译： FRAXINUS EXCELSIOR种子的提取及其治疗应用
公开(公告)号：WO2009061849A1
公开(公告)日：2009-05-14
申请号：PCT/US2008/082524
申请日：2008-11-05
申请人： NATUREX , BAI, Naisheng , DIKANSKY, Jacques , HE, Kan , ROLLER, Marc , BILY, Antoine , IBARRA, Alvin
发明人： HE, Kan , ROLLER, Marc , BILY, Antoine , IBARRA, Alvin
IPC分类号： A61Q9/00
CPC分类号： A61K36/63 , A61K31/7088
摘要： A Fraxinus excelsior seed extract that can be administered for therapeutic treatment of a subject, including a human, by blocking fat synthesis, activating PPAR-alpha, increasing hypoglycemic activity, reducing bodyweight, controlling fasting plasma insulin levels against hyperinsulinemia, and promoting insulin sensitivity and causing a beneficial acute insulinotropic effect. The Fraxinus excelsior seed extract includes, inter alia, an isolated compound (2S, 3E, 4S) 2H-Pyran-4-acetic acid-3-ethylidene-2-[(6-O-β-D-glucopyranosyl-β-D- glucopyranosyl) oxy]-3,4-dihydro-5-(methoxycarbonyl) methyl ester, commonly called excelside A, an isolated compound (2S, 3E, 4S) 2H-Pyran-4-acetic acid-3-ethylidene-2-[(6-O- β-D-glucopyranosyl-β-D-glucopyranosyl) oxy]-3,4-dihydro-5-(methoxycarbonyl) 2-(4- hydroxyphenyl) ethyl ester, commonly called excelside B, and the compounds GI5, GI3, nuzhenide, and oleoside dimethyl ester.
摘要翻译：可以通过阻断脂肪合成，激活PPAR-α，增加降血糖活性，降低体重，控制空腹血浆胰岛素水平对抗高胰岛素血症，以及促进胰岛素敏感性以及促进胰岛素敏感性的方法，将可以用于治疗受试者包括人的Fraxinus excelsior种子提取物引起有益的急性促胰岛素作用。 Fraxinus excelsior种子提取物尤其包括分离的化合物（2S，3E，4S）2H-吡喃-4-乙酸-3-亚乙基-2 - [（6-O-β-D-吡喃葡萄糖基-β-D - 吡喃葡萄糖基）氧基] -3,4-二氢-5-（甲氧基羰基）甲酯，通常称为excelside A，分离的化合物（2S，3E，4S）2H-吡喃-4-乙酸-3-亚乙基-2- 氧基] -3,4-二氢-5-（甲氧基羰基）2-（4-羟基苯基）乙酯（通常称为excelside B）的化合物和化合物（6-O-D-D-吡喃葡萄糖基-β- GI5，GI3，nunzhenide和油脂二甲酯。

10. 发明申请

WO2006073457A8 BIOACTIVE COMPOUNDS AND METHODS OF USES THEREOF 审中-公开
标题翻译：生物化合物及其使用方法
公开(公告)号：WO2006073457A8
公开(公告)日：2007-06-21
申请号：PCT/US2005015280
申请日：2005-05-02
申请人： UNIV RUTGERS , UNIV MINNESOTA , WELLGEN INC , DONG ZIGANG , BODE ANNE , HO CHI-TANG , BAI NAISHENG , DUSHENKOV SLAVIK
发明人： DONG ZIGANG , BODE ANNE , HO CHI-TANG , BAI NAISHENG , DUSHENKOV SLAVIK
IPC分类号： C07D303/00 , A01N37/10 , A01N43/16 , A61K31/235 , A61K31/35 , C07D305/14 , C07D311/78 , C07D311/94
CPC分类号： C07D493/20 , A61K36/53
摘要： In one aspect, the present invention provides compounds having formula I or IV as shown below: as further defined herein. In additional aspects, the present invention provides compositions and kits comprising the compounds of the invention and methods for their use, for example, for the prevention or treatment of a cancer.
摘要翻译：一方面，本发明提供具有如下所示的式I或IV的化合物：如本文进一步定义。在另外的方面，本发明提供了包含本发明化合物的组合物和试剂盒及其用于预防或治疗癌症的方法。

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