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1. 发明申请

WO2009061849A1 EXTRACT OF FRAXINUS EXCELSIOR SEEDS AND THERAPEUTIC APPLICATIONS THEREFOR 审中-公开
标题翻译： FRAXINUS EXCELSIOR种子的提取及其治疗应用
公开(公告)号：WO2009061849A1
公开(公告)日：2009-05-14
申请号：PCT/US2008/082524
申请日：2008-11-05
申请人： NATUREX , BAI, Naisheng , DIKANSKY, Jacques , HE, Kan , ROLLER, Marc , BILY, Antoine , IBARRA, Alvin
发明人： HE, Kan , ROLLER, Marc , BILY, Antoine , IBARRA, Alvin
IPC分类号： A61Q9/00
CPC分类号： A61K36/63 , A61K31/7088
摘要： A Fraxinus excelsior seed extract that can be administered for therapeutic treatment of a subject, including a human, by blocking fat synthesis, activating PPAR-alpha, increasing hypoglycemic activity, reducing bodyweight, controlling fasting plasma insulin levels against hyperinsulinemia, and promoting insulin sensitivity and causing a beneficial acute insulinotropic effect. The Fraxinus excelsior seed extract includes, inter alia, an isolated compound (2S, 3E, 4S) 2H-Pyran-4-acetic acid-3-ethylidene-2-[(6-O-β-D-glucopyranosyl-β-D- glucopyranosyl) oxy]-3,4-dihydro-5-(methoxycarbonyl) methyl ester, commonly called excelside A, an isolated compound (2S, 3E, 4S) 2H-Pyran-4-acetic acid-3-ethylidene-2-[(6-O- β-D-glucopyranosyl-β-D-glucopyranosyl) oxy]-3,4-dihydro-5-(methoxycarbonyl) 2-(4- hydroxyphenyl) ethyl ester, commonly called excelside B, and the compounds GI5, GI3, nuzhenide, and oleoside dimethyl ester.
摘要翻译：可以通过阻断脂肪合成，激活PPAR-α，增加降血糖活性，降低体重，控制空腹血浆胰岛素水平对抗高胰岛素血症，以及促进胰岛素敏感性以及促进胰岛素敏感性的方法，将可以用于治疗受试者包括人的Fraxinus excelsior种子提取物引起有益的急性促胰岛素作用。 Fraxinus excelsior种子提取物尤其包括分离的化合物（2S，3E，4S）2H-吡喃-4-乙酸-3-亚乙基-2 - [（6-O-β-D-吡喃葡萄糖基-β-D - 吡喃葡萄糖基）氧基] -3,4-二氢-5-（甲氧基羰基）甲酯，通常称为excelside A，分离的化合物（2S，3E，4S）2H-吡喃-4-乙酸-3-亚乙基-2- 氧基] -3,4-二氢-5-（甲氧基羰基）2-（4-羟基苯基）乙酯（通常称为excelside B）的化合物和化合物（6-O-D-D-吡喃葡萄糖基-β- GI5，GI3，nunzhenide和油脂二甲酯。

2. 发明申请

WO2011047321A1 EXTRACT OF ROSMARINUS OFFICINALIS L. LEAVES FOR PHARMACEUTICAL APPLICATIONS 审中-公开
标题翻译：罗非鱼的提取L.药物应用的叶子
公开(公告)号：WO2011047321A1
公开(公告)日：2011-04-21
申请号：PCT/US2010/052925
申请日：2010-10-15
申请人： NATUREX S.A. , HE, Kan , ROLLER, Marc , IBARRA, Alvin , BAI, Naisheng , DIKANSKY, Jacques
发明人： HE, Kan , ROLLER, Marc , IBARRA, Alvin , BAI, Naisheng
IPC分类号： A61K36/53
CPC分类号： A61K36/53
摘要： Disclosed are methods of alleviating oxidative stress, regulating blood glucose levels, and controlling pancreatic lipase activity by administering a Rosemary extract. Such methods may be useful to help body weight and body fat, prevent obesity, and treat hyperglycemia, hyperinsulinemia, cardiovascular disease and Type-2 diabetes. Preferred extracts contain 20% or 50% carnosic acid.
摘要翻译：公开了通过施用迷迭香提取物来减轻氧化应激，调节血糖水平和控制胰脂肪酶活性的方法。这些方法可用于帮助体重和身体脂肪，预防肥胖，以及治疗高血糖症，高胰岛素血症，心血管疾病和2型糖尿病。优选的提取物含有20％或50％的鼠尾草酸。

3. 发明申请

WO2010129307A1 APPLICATION OF AMERICAN GINSENG TO ENHANCE NEUROCOGNITIVE FUNCTION 审中-公开
标题翻译：美国金森应用于增强神经元功能
公开(公告)号：WO2010129307A1
公开(公告)日：2010-11-11
申请号：PCT/US2010/032629
申请日：2010-04-27
申请人： NATUREX S.A. , SCHOLEY, Andrew , IBARRA, Alvin , HE, Kan , ROLLER, Marc , DIKANSKY, Jacques
发明人： SCHOLEY, Andrew , IBARRA, Alvin , HE, Kan , ROLLER, Marc
IPC分类号： A61K36/254 , A61K36/258
CPC分类号： A61K36/258
摘要： Disclosed are methods of enhancing neurocognitive function by administering of American Ginseng. Preferred dosages in the range of 5 to 50 mg total genosides enhance cognitive function-including, improvement of working memory (WM) performance, attentional performance (e.g., Choice Reaction Time accuracy), and calmness.
摘要翻译：公开的是通过施用美国人参来增强神经认知功能的方法。优选的剂量范围为5至50mg的总苷类增强了认知功能，包括改善工作记忆（WM）性能，注意性能（例如，选择反应时间精度）和平静度。

4. 发明申请

WO2010021935A1 ANTIOXIDANT AND PHYSICAL PERFORMANCE EFFECTS OF A GRAPE EXTRACT 审中-公开
标题翻译：提取物的抗氧化剂和物理性能的影响
公开(公告)号：WO2010021935A1
公开(公告)日：2010-02-25
申请号：PCT/US2009/053905
申请日：2009-08-14
申请人： NATUREX S.A. , LEMAIRE, Benoit , LAFAY, Sophie , IBARRA, Alvin , ROLLER, Marc , DIKANSKY, Jacques
发明人： LEMAIRE, Benoit , LAFAY, Sophie , IBARRA, Alvin , ROLLER, Marc
IPC分类号： A61K36/87
CPC分类号： A61K36/87
摘要： A method of enhancing physical performance during exercise by administering an amount of a grape extract effective to treat a subject. A preferred grape extract comprises a concentration of flavanol monomers of greater than about 5 % by weight, and more preferably within a range from about 12 % by weight to about 50 % by weight, and a concentration of flavanol dimers preferably greater than about 2 % by weight, and more preferably within a range from about 6 % by weight to about 20 % by weight. The flavanol monomers preferably include catechin, epicatechin, epicatechin gallate, and gallic acid. The flavanol dimers preferably include procyanidin B1, procyanidin B2, procyanidin B3, procyanidin B4, and procyanidin B2-O-gallate.
摘要翻译：一种通过施用一定量的有效治疗受试者的葡萄提取物来增强运动期间的身体表现的方法。优选的葡萄提取物包含大于约5重量％，更优选在约12重量％至约50重量％范围内的黄烷醇单体的浓度，并且黄烷醇二聚体的浓度优选大于约2重量％，更优选在约6重量％至约20重量％的范围内。黄烷醇单体优选包括儿茶素，表儿茶素，表儿茶素没食子酸酯和没食子酸。黄烷醇二聚体优选包括原花青素B1，原花青素B2，原花青素B3，原花青素B4和原花青素B2-O-没食子酸酯。

5. 发明公开

EP2214790A1 EXTRACT OF FRAXINUS EXCELSIOR SEEDS AND THERAPEUTIC APPLICATIONS THEREFOR 有权转让
标题翻译：从白蜡，怡东籽提取治疗应用
公开(公告)号：EP2214790A1
公开(公告)日：2010-08-11
申请号：EP08847183.4
申请日：2008-11-05
申请人： Naturex, Inc. , Bai, Naisheng , Dikansky, Jacques
发明人： HE, Kan , ROLLER, Marc , BILY, Antoine , IBARRA, Alvin , DIKANSKY, Jacques , BAI, Naisheng
IPC分类号： A61Q9/00
CPC分类号： A61K36/63 , A61K31/7088
摘要： A Fraxinus excelsior seed extract that can be administered for therapeutic treatment of a subject, including a human, by blocking fat synthesis, activating PPAR-alpha, increasing hypoglycemic activity, reducing bodyweight, controlling fasting plasma insulin levels against hyperinsulinemia, and promoting insulin sensitivity and causing a beneficial acute insulinotropic effect. The Fraxinus excelsior seed extract includes, inter alia, an isolated compound (2S, 3E, 4S) 2H-Pyran-4-acetic acid-3-ethylidene-2-[(6-O-β-D-glucopyranosyl-β-D- glucopyranosyl) oxy]-3,4-dihydro-5-(methoxycarbonyl) methyl ester, commonly called excelside A, an isolated compound (2S, 3E, 4S) 2H-Pyran-4-acetic acid-3-ethylidene-2-[(6-O- β-D-glucopyranosyl-β-D-glucopyranosyl) oxy]-3,4-dihydro-5-(methoxycarbonyl) 2-(4- hydroxyphenyl) ethyl ester, commonly called excelside B, and the compounds GI5, GI3, nuzhenide, and oleoside dimethyl ester.

6. 发明公开

EP2331111A1 ANTIOXIDANT AND PHYSICAL PERFORMANCE EFFECTS OF A GRAPE EXTRACT 审中-公开
标题翻译：葡萄提取物对抗氧化状况和体力性能的影响
公开(公告)号：EP2331111A1
公开(公告)日：2011-06-15
申请号：EP09808641.6
申请日：2009-08-14
申请人： Naturex S.A. , Dikansky, Jacques
发明人： LEMAIRE, Benoit , LAFAY, Sophie , IBARRA, Alvin , ROLLER, Marc
IPC分类号： A61K36/87
CPC分类号： A61K36/87
摘要： A method of enhancing physical performance during exercise by administering an amount of a grape extract effective to treat a subject. A preferred grape extract comprises a concentration of flavanol monomers of greater than about 5% by weight, and more preferably within a range from about 12% by weight to about 50% by weight, and a concentration of flavanol dimers preferably greater than about 2% by weight, and more preferably within a range from about 6% by weight to about 20% by weight. The flavanol monomers preferably include catechin, epicatechin, epicatechin gallate, and gallic acid. The flavanol dimers preferably include procyanidin B1, procyanidin B2, procyanidin B3, procyanidin B4, and procyanidin B2-O-gallate.

7. 发明申请

WO2007110452A1 PROCESO PARA LA MODIFICACIÓN DEL COLOR Y PH EN LA PRODUCCIÓN DE UN EXTRACTO DE CACAO RICO EN FIBRA Y ALTAMENTE SOLUBLE Y USO DE ESE EXTRACTO. 审中-公开
标题翻译：用于改变高可溶性纤维素COCOA提取物生产中的颜色和PH的方法以及使用提取物
公开(公告)号：WO2007110452A1
公开(公告)日：2007-10-04
申请号：PCT/ES2006/000144
申请日：2006-03-27
申请人： NATRACEUTICAL, S. A. , MOULAY, Leila , IBARRA, Alvin , VILANOVA, Olga
发明人： MOULAY, Leila , IBARRA, Alvin , VILANOVA, Olga
IPC分类号： A23G1/02
CPC分类号： A23G1/02 , A23G1/0006 , A23G1/56 , A23G2200/06 , A23L33/22
摘要： Proceso para la modificación del color y el pH en la producción de un extracto de cacao rico en fibra y altamente soluble, del tipo empleado como complemento de fibra en alimentación, caracterizado esencialmente porque comprende seis fases o etapas obligadas y tres opcionales, a saber: Obligadas: - Esterilización o tostado de la materia prima, siendo ambas excluyentes entre sí - Tratamiento enzimático para favorecer la extracción de los componentes solubles - Separación de la fase sólida - Concentración de la fase líquida - Secado del concentrado anterior Opcionales: - Molienda de la cascarilla - Adición de barquillo - Alcalinización
摘要翻译：用于在食品中用作纤维补充剂类型的高度可溶的，富含纤维的可可提取物的生产中改变颜色和pH的方法，其基本特征在于其包括六个强制性和三个任选相或步骤，即：强制相或步骤 - 原料的灭菌或焙烧，这两个过程是相互排斥的; 酶处理以促进可溶性成分的提取; 分离固相; 液相浓度; 干燥上述浓缩物; 可选阶段或步骤 - 研磨外壳; 添加滤饼; 碱化。

8. 发明申请

WO2005115160A1 PROCESS FOR PRODUCING COCOA POLYPHENOL CONCENTRATE 审中-公开
标题翻译：生产椰油聚氧乙烯浓缩物的方法
公开(公告)号：WO2005115160A1
公开(公告)日：2005-12-08
申请号：PCT/IB2005/001075
申请日：2005-04-20
申请人： NATRACEUTICAL, S.A. , PONS-ANDREU, José-Vicente , CIENFUEGOS-JOVELLANOS, Elena , IBARRA, Alvin
发明人： PONS-ANDREU, José-Vicente , CIENFUEGOS-JOVELLANOS, Elena , IBARRA, Alvin
IPC分类号： A23G1/00
CPC分类号： A23G1/002 , A23G1/0006
摘要： A process in which cocoa polyphenol concentrate is obtained comprising the steps of: a) subjecting unfermented cocoa beans to a blanching step in water at a temperature in the range from 85-100°C for a time period in the range from 3 to 15 minutes to give unfermented cocoa beans with reduced polyphenol oxidase activity; b) drying the unfermented cocoa beans with reduced polyphenol oxidase activity at a temperature of less than 85°C to obtain dried unfermented cocoa beans with a moisture content of no more than 15%; c) subjecting the dried unfermented cocoa beans to a particle size reduction step to obtain dry unfermented cocoa bean intermediate whereby at least 99 wt% of the product has a particle size less than or equal to 300µm; e) extracting polyphenols from the dry unfermented cocoa bean intermediate to give a cocoa polyphenol extract and extracted solids; d) concentrating the cocoa polyphenol extract to yield a cocoa polyphenol concentrate; and wherein the process further includes a defatting step which is carried out prior to step d).
摘要翻译：获得可可多元酚浓缩物的方法包括以下步骤：a）将未发酵的可可豆在85-100℃范围内的温度下在水中进行漂烫步骤，时间范围为3至15分钟给予具有降低的多酚氧化酶活性的未发酵可可豆; b）在低于85℃的温度下干燥未发酵的可可豆，其具有降低的多酚氧化酶活性，得到水分含量不超过15％的干燥的未发酵可可豆; c）使经干燥的未发酵可可豆进行粒度降低步骤以获得干燥的未发酵可可豆中间体，其中至少99重量％的产物具有小于或等于300μm的粒度; e）从干燥的未发酵可可豆中间体中提取多酚，得到可可多酚提取物和提取的固体; d）浓缩可可多酚提取物以产生可可多元酚浓缩物; 并且其中所述方法还包括在步骤d）之前进行的脱脂步骤。

9. 发明申请

WO2006117416A1 PROCESO PARA PREPARAR UN EXTRACTO DE CACAO ALTAMENTE SOLUBLE 审中-公开
标题翻译：制备高可溶性COCOA萃取物的方法
公开(公告)号：WO2006117416A1
公开(公告)日：2006-11-09
申请号：PCT/ES2005/000377
申请日：2005-07-01
申请人： NATRACEUTICAL, S.A. , MOULAY, Leila , SNIDERMAN, Zachary , IBARRA, Alvin , MARTI BARTUAL, Vicente
发明人： MOULAY, Leila , SNIDERMAN, Zachary , IBARRA, Alvin , MARTI BARTUAL, Vicente
IPC分类号： A23G1/02 , A23G1/00
CPC分类号： A23G1/32 , A23G1/0006 , A23G1/0009 , A23G1/02 , A23G1/56 , A23V2002/00 , A23V2250/5116
摘要： El objectiva de esta invenciòn es obtener un extracto altamente soluble a partir de cascarilla y/ barquillo de cacao. El producto final, rico en fibra dietètica, es ideal para su aplicaciòn en chocolate, panificatiòn, bebidas snacks, làcteos, y productos de reposterìa.
摘要翻译：本发明涉及从可可皮和/或树皮获得高可溶性提取物的方法。富含膳食纤维的最终产品是巧克力，面包制作，饮料，小吃，乳制品和糖果商品的理想选择。

10. 发明申请

WO2006070026A1 MICROEMULSIÓN DE ANTIOXIDANTES POLARES EN ACEITES COMESTIBLES 审中-公开
标题翻译：可食用油中极性抗氧化剂的微乳液
公开(公告)号：WO2006070026A1
公开(公告)日：2006-07-06
申请号：PCT/ES2005/000191
申请日：2005-04-13
申请人： NATRACEUTICAL, S.A. , GALDON MIQUEL, Fernando , PUENTE TOMAS, Muguel Angel , IBARRA, Alvin
发明人： GALDON MIQUEL, Fernando , PUENTE TOMAS, Muguel Angel , IBARRA, Alvin
IPC分类号： A23D7/02
CPC分类号： A23D7/0053 , A23D7/0056 , A23D7/02 , A23D9/06
摘要： La base de esta invención consiste en la formación de microemulsiones a partir de una fracción rica en antioxidantes polares en un medio oleoso, concretamente en aceites comestibles. Estas microemulsiones se caracterizan por su estabilidad y homogeneidad lo que las hace idóneas para incorporarlas en distintos alimentos o productos farmacéuticos. Lo más novedoso de esta invención es que la concentración micelar crítica (CMC) se alcanza mediante eliminación por vacío del exceso de disolvente polar, que es la matriz de los antioxidantes, quedando en la microemulsión parte de este disolvente actuando como co-surfactante.
摘要翻译：本发明涉及食用油中极性抗氧化剂的微乳液。本发明包括在油性介质中，特别是食用油中富含极性抗氧化剂的级分形成微乳液。上述微乳液的特征在于稳定性和均匀性，从而使其适用于不同的食品或药品。本发明最具创新性的方面在于，临界胶束浓度（CMC）通过真空消除过量的极性溶剂即抗氧化剂基质获得，例如将部分所述溶剂留在微乳液中以作为辅助表面活性剂。

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