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1. 发明申请

US20060247251A1 2-Cyanopyrrolopyrimidines and pharmaceutical uses thereof 审中-公开
标题翻译： 2-吡喃并吡咯并嘧啶及其药物用途
公开(公告)号：US20060247251A1
公开(公告)日：2006-11-02
申请号：US10544694
申请日：2004-02-05
申请人： Francis Buxton , Takeru Ehara , Pamposh Ganju , Allan Hallett , Osamu Irie , Atsuko Iwasaki , Takanori Kanazawa , Keiichi Masuya , Kazuhiko Nonomura , Junichi Sakaki , Christopher Snell , Chuanzheng Song , Keiko Tanabe , Naoki Teno , Ichiro Umemura , Fumiaki Yokokawa
发明人： Francis Buxton , Takeru Ehara , Pamposh Ganju , Allan Hallett , Osamu Irie , Atsuko Iwasaki , Takanori Kanazawa , Keiichi Masuya , Kazuhiko Nonomura , Junichi Sakaki , Christopher Snell , Chuanzheng Song , Keiko Tanabe , Naoki Teno , Ichiro Umemura , Fumiaki Yokokawa
IPC分类号： A61K31/519 , C07D487/02
CPC分类号： C07D487/04
摘要： The invention relates to pyrrolo pyrimidines of formula (I), wherein Y represents —(CH2)t—O— or —(CH2)r—S—, p is 1 or 2, r is 1, 2 or 3, t is 1, 2 or 3, or Y is —(CH2)j— or —CH═CH—, j is 1 or 2; p is 1 or 2, or Y is —(CH2)f—, f is 1 or 2, p is 1, and the further radicals and symbols have the meaning as defined herein; their preparation, their use as pharmaceuticals, pharmaceutical compositions containing them, the use of such a compound for the manufacture of a pharmaceutical preparation for the treatment of neuropathic pain and to a method for the treatment of such a disease in animals, especially in humans.
摘要翻译：本发明涉及式（I）的吡咯并嘧啶，其中Y代表 - （CH 2）2 - 或 - （CH 2））-S-，p为1或2，r为1,2或3，t为1,2或3，或Y为 - （CH 2 2） - 或-CH-CH-，j为1或2; p为1或2，或Y为 - （CH 2 CH 2）f - ，f为1或2，p为1，其余基团和符号为含义如本文所定义; 它们的制备，它们作为药物的用途，含有它们的药物组合物，这种化合物在制备用于治疗神经性疼痛的药物制剂中的用途以及用于治疗动物，特别是人类中的这种疾病的方法。

2. 发明授权

US07704996B2 Compounds and compositions useful as cathepsin S inhibitors 失效
标题翻译：可用作组织蛋白酶S抑制剂的化合物和组合物
公开(公告)号：US07704996B2
公开(公告)日：2010-04-27
申请号：US11573451
申请日：2005-08-16
申请人： Terance William Hart , Allan Hallett , Fumiaki Yokokawa , Hajime Hirao , Takeru Ehara , Atsuko Iwasaki , Junichi Sakaki , Keiichi Masuya , Masashi Kishida , Osamu Irie
发明人： Terance William Hart , Allan Hallett , Fumiaki Yokokawa , Hajime Hirao , Takeru Ehara , Atsuko Iwasaki , Junichi Sakaki , Keiichi Masuya , Masashi Kishida , Osamu Irie
IPC分类号： C07D239/42 , A61K31/506
CPC分类号： C07D239/36 , C07D239/42 , C07D239/47 , C07D239/48 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D409/12 , C07D409/14 , C07D471/04 , C07D491/10
摘要： The present invention relates to the use of a 2-cyanopyrimidine compound of the formula wherein R1, R2, R3 and X are as defined in the specification and in the claims, in free form or in salt form, and, where possible, in tautomeric form, as an inhibitor of the activity of cathepsin S.
摘要翻译：本发明涉及下式的2-氰基嘧啶化合物的用途：其中R 1，R 2，R 3和X如说明书和权利要求书中所定义，为游离形式或盐形式，并且在可能情况下为互变异构体形式，作为组织蛋白酶S活性的抑制剂。

3. 发明申请

US20140364547A1 POLYESTER RESIN COMPOSITION AND METHOD FOR PRODUCING THE SAME 审中-公开
标题翻译：聚酯树脂组合物及其制造方法
公开(公告)号：US20140364547A1
公开(公告)日：2014-12-11
申请号：US14241575
申请日：2012-08-27
申请人： Atsuko Iwasaki , Kazunobu Sato
发明人： Atsuko Iwasaki , Kazunobu Sato
IPC分类号： C08K5/523 , C08K5/098
CPC分类号： C08K5/523 , C08G63/672 , C08K5/098 , C08L67/02
摘要： The present invention provides a polyester resin composition including, a polyester resin (A) including a dicarboxylic acid unit and a diol unit, 1 to 60 mol % of the diol unit being a diol unit having a cyclic acetal skeleton; a phosphorus compound (B) represented by the following general formula (1); and a basic compound (C), wherein, based on 100 parts by weight of the polyester resin (A), the phosphorus compound (B) is in an amount of 0.005 to 2 parts by weight and the basic compound (C) is in an amount of 0 to 2 parts by weight,and a method for producing the polyester resin composition: (wherein R1, R2, R3 and R4 each independently represent an aryl group, X represents a divalent group derived from an aromatic dihydroxy compound having 6 to 15 carbon atoms, and n is an integer of 1 to 5.)
摘要翻译：本发明提供一种聚酯树脂组合物，其包含具有二羧酸单元和二醇单元的聚酯树脂（A），1〜60摩尔％的二醇单元为具有环状缩醛骨架的二醇单元; 由以下通式（1）表示的磷化合物（B）; 和碱性化合物（C），其中，基于100重量份的聚酯树脂（A），磷化合物（B）的量为0.005〜2重量份，碱性化合物（C）为 0〜2重量份的制造方法和聚酯树脂组合物的制造方法（其中，R1，R2，R3和R4各自独立地表示芳基，X表示由芳香族二羟基化合物衍生的二价基团， 15个碳原子，n为1〜5的整数。）

4. 发明申请

US20090048230A1 COMPOUNDS AND COMPOSITIONS USEFUL AS CATHEPSIN S INHIBITORS 失效
标题翻译：化合物和组合物有效用作吸收抑制剂
公开(公告)号：US20090048230A1
公开(公告)日：2009-02-19
申请号：US11573451
申请日：2005-08-16
申请人： Terance William Hart , Allan Hallett , Fumiaki Yokokawa , Hajime Hirao , Takeru Ehara , Atsuko Iwasaki , Junichi Sakaki , Keiichi Masuya , Masashi Kishida , Osamu Irie
发明人： Terance William Hart , Allan Hallett , Fumiaki Yokokawa , Hajime Hirao , Takeru Ehara , Atsuko Iwasaki , Junichi Sakaki , Keiichi Masuya , Masashi Kishida , Osamu Irie
IPC分类号： A61K31/506 , C07D413/12 , C07D403/12 , A61P9/00 , A61K31/55 , A61K31/5377
CPC分类号： C07D239/36 , C07D239/42 , C07D239/47 , C07D239/48 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D409/12 , C07D409/14 , C07D471/04 , C07D491/10
摘要： The present invention relates to the use of a 2-cyanopyrimidine compound of the formula wherein R1, R2, R3 and X are as defined in the specification and in the claims, in free form or in salt form, and, where possible, in tautomeric form, as an inhibitor of the activity of cathepsin S.
摘要翻译：本发明涉及下式的2-氰基嘧啶化合物的用途：其中R 1，R 2，R 3和X如说明书和权利要求书中所定义，为游离形式或盐形式，并且在可能情况下为互变异构体形式，作为组织蛋白酶S活性的抑制剂。

5. 发明授权

US08178559B2 Organic compounds 失效
标题翻译：有机化合物
公开(公告)号：US08178559B2
公开(公告)日：2012-05-15
申请号：US13176930
申请日：2011-07-06
申请人： Werner Breitenstein , Takeru Ehara , Claus Ehrhardt , Philipp Grosche , Yuko Hitomi , Yuki Iwaki , Takanori Kanazawa , Kazuhide Konishi , Juergen Klaus Maibaum , Keiichi Masuya , Atsuko Iwasaki , Nils Ostermann , Masaki Suzuki , Atsushi Toyao , Fumiaki Yokokawa
发明人： Werner Breitenstein , Takeru Ehara , Claus Ehrhardt , Philipp Grosche , Yuko Hitomi , Yuki Iwaki , Takanori Kanazawa , Kazuhide Konishi , Juergen Klaus Maibaum , Keiichi Masuya , Atsuko Iwasaki , Nils Ostermann , Masaki Suzuki , Atsushi Toyao , Fumiaki Yokokawa
IPC分类号： A61K31/451 , C07D211/60
CPC分类号： C07D471/04 , C07D211/60 , C07D401/10 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/10 , C07D409/12 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/12
摘要： 3,4-substituted piperidine compounds, these compounds for use in the diagnostic and therapeutic treatment of a warm-blooded animal, especially for the treatment of a disease (=disorder) that depends on activity of renin; the use of a compound of that class for the preparation of a pharmaceutical formulation for the treatment of a disease that depends on activity of renin; the use of a compound of that class in the treatment of a disease that depends on activity of renin; pharmaceutical formulations comprising a 3,4-substituted piperidine compound, and/or a method of treatment comprising administering a 3,4substituted piperidine compound, a method for the manufacture of a 3,4-substituted piperidine compound, and novel intermediates and partial steps for their synthesis are disclosed. The 3,4-disubstituted piperidine compounds have the formula (I), wherein the symbols have the meanings defined in the specification.
摘要翻译： 3,4-取代的哌啶化合物，这些化合物用于诊断和治疗温血动物，特别是用于治疗依赖于肾素活性的疾病（=病症）; 使用该类化合物制备用于治疗依赖于肾素活性的疾病的药物制剂; 使用该类化合物治疗依赖于肾素活性的疾病; 包含3,4-取代的哌啶化合物的药物制剂和/或包括给药3,4代哌啶化合物的方法，制备3,4-取代的哌啶化合物的方法和新的中间体和部分步骤他们的合成被公开。 3,4-二取代的哌啶化合物具有式（I），其中符号具有说明书中定义的含义。

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