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1. 发明授权

US08722076B2 Photochrome- or near IR dye-coupled polymeric matrices for medical articles 失效
标题翻译：用于医疗用品的光致变色或近红外染料偶联聚合物基质
公开(公告)号：US08722076B2
公开(公告)日：2014-05-13
申请号：US13248203
申请日：2011-09-29
申请人： Emily R. Rolfes Meyering , Aron B. Anderson
发明人： Emily R. Rolfes Meyering , Aron B. Anderson
IPC分类号： A61F2/00 , A61K9/00 , A61F13/00 , C08F26/06
CPC分类号： C08F20/36 , A61L29/085 , A61L29/14 , A61L2400/10
摘要： The invention provides polymers comprising pendent photochrome or near IR dye groups, as well as polymeric matrices made from these polymers, which can be used as or in association with a medical article. The polymers can be synthesized using methods that facilitate the preparation of medical articles having good biocompatibility. Exemplary polymeric matrices are in the form of lubricious coatings on medical devices, such as catheters. Visualization by irradiation of the photochrome or near IR dye can improve detection of the polymeric matrix on a device or in the body. This, in turn can improve aspects of a medical procedure, such as device insertion or matrix formation, as well as being useful for assessing the quality of the matrix.
摘要翻译：本发明提供了包含侧基光色素或近红外染料基团的聚合物，以及由这些聚合物制成的聚合物基质，其可以作为或与医疗制品结合使用。可以使用促进制备具有良好生物相容性的医疗制品的方法来合成聚合物。示例性的聚合物基质是医疗装置如导管上的润滑涂层的形式。通过照射光斑或靠近IR染料的可视化可以改善在装置或身体中的聚合物基质的检测。这又可以改善诸如装置插入或矩阵形成之类的医疗过程的方面，并且可用于评估矩阵的质量。

2. 发明授权

US07833548B2 Bioactive agent release coating and controlled humidity method 有权
标题翻译：生物活性剂释放涂层和受控湿度法
公开(公告)号：US07833548B2
公开(公告)日：2010-11-16
申请号：US11207380
申请日：2005-08-19
申请人： Ralph A. Chappa , Robert W. Hergenrother , Aron B. Anderson , Linh V. Tran , Laurie R. Lawin , Ronald F. Ofstead
发明人： Ralph A. Chappa , Robert W. Hergenrother , Aron B. Anderson , Linh V. Tran , Laurie R. Lawin , Ronald F. Ofstead
IPC分类号： A61K9/14
CPC分类号： A61L31/16 , A61L29/085 , A61L29/16 , A61L31/10 , A61L2300/602 , A61L2300/606
摘要： A coating composition in the form of a one or multi-part system, and method of applying such a composition under conditions of controlled humidity, for use in coating device surfaces to control and/or improve their ability to release bioactive agents in aqueous systems. The coating composition is particularly adapted for use with medical devices that undergo significant flexion and/or expansion in the course of their delivery and/or use, such as stents and catheters. The composition includes the bioactive agent in combination with a first polymer component such as polyalkyl(meth)acrylate, polyaryl(meth)acrylate, polyaralkyl(meth)acrylate, or polyaryloxyalkyl(meth)acrylate and a second polymer component such as poly(ethylene-co-vinyl acetate).
摘要翻译：一种或多种制剂形式的涂料组合物，以及在受控湿度条件下施用这种组合物的方法，用于涂覆装置表面以控制和/或提高其在水性体系中释放生物活性剂的能力。涂料组合物特别适用于在其递送和/或使用过程中经历显着弯曲和/或膨胀的医疗装置，例如支架和导管。组合物包括与第一聚合物组分如（甲基）丙烯酸聚烷基酯，（甲基）丙烯酸聚芳酯，（甲基）丙烯酸聚烷基酯或（甲基）丙烯酰基烷基酯）和第二聚合物组分如聚（乙烯 - 共 - 乙酸乙烯酯）。

3. 发明申请

US20100158799A1 METHOD AND COMPOSITION FOR BIOACTIVE AGENT RELEASE IN VIVO 审中-公开
标题翻译：生物活性物质释放的方法和组合
公开(公告)号：US20100158799A1
公开(公告)日：2010-06-24
申请号：US12716753
申请日：2010-03-03
申请人： Stephen J. Chudzik , Timothy M. Kloke , Laurie R. Lawin , Ronald F. Ofstead , Ralph A. Chappa , Robert W. Hergenrother , Aron B. Anderson , Linh V. Tran
发明人： Stephen J. Chudzik , Timothy M. Kloke , Laurie R. Lawin , Ronald F. Ofstead , Ralph A. Chappa , Robert W. Hergenrother , Aron B. Anderson , Linh V. Tran
IPC分类号： A61K51/00 , A61K47/32 , A61K31/7052 , A61K31/56 , A61K38/02 , A61K38/16 , A61K38/43 , A61P43/00
CPC分类号： A61L31/16 , A61L29/085 , A61L29/16 , A61L31/10 , A61L2300/606 , C08L33/06
摘要： A composition for bioactive agent release in vivo. The composition includes the bioactive agent in combination with a mixture of a first polymer component such as poly(butyl methacrylate) and a second polymer component such as poly(ethylene-co-vinyl acetate).
摘要翻译：生物活性剂在体内释放的组合物。组合物包括与第一聚合物组分如聚（甲基丙烯酸丁酯）和第二聚合物组分如聚（乙烯 - 共 - 乙酸乙烯酯）的混合物的组合的生物活性剂。

4. 发明授权

US06465525B1 Latent reactive blood compatible agents 有权
标题翻译：潜在的反应性血液相容剂
公开(公告)号：US06465525B1
公开(公告)日：2002-10-15
申请号：US09177318
申请日：1998-10-22
申请人： Patrick E. Guire , Aron B. Anderson , Richard A. Amos , Terrence P. Everson
发明人： Patrick E. Guire , Aron B. Anderson , Richard A. Amos , Terrence P. Everson
IPC分类号： A01N3500
CPC分类号： A61K31/12 , A61K31/74 , A61K47/6957 , A61L27/227 , A61L27/34 , A61L27/507 , A61L29/048 , A61L29/085 , A61L31/047 , A61L31/10 , A61L33/0011 , A61L33/0029 , A61L33/0082
摘要： A reagent and related method for use in passivating a biomaterial surface, the reagent including a latent reactive group and a bifunctional aliphatic acid (e.g., fatty acid), in combination with a spacer group linking the latent reactive group to the aliphatic acid in a manner that preserves the desired function of each group. Once bound to the surface, via the latent reactive group, the reagent presents the aliphatic acid to the physiological environment, in vivo, in a manner (e.g., concentration and orientation) sufficient to hold and orient albumin.
摘要翻译：用于钝化生物材料表面的试剂和相关方法，所述试剂包括潜在反应性基团和双官能脂族酸（例如，脂肪酸），与间接基团组合，所述间隔基团以潜在的反应性基团与脂肪酸连接这保留了每个组的所需功能。一旦结合到表面，通过潜在的反应性基团，试剂以足以保持和定向白蛋白的方式（例如，浓度和取向）在体内将脂肪酸呈现给生理环境。

5. 发明申请

US20120082713A1 PHOTOCHROME- OR NEAR IR DYE-COUPLED POLYMERIC MATRICES FOR MEDICAL ARTICLES 失效
标题翻译：医学文章的红外线耦合聚合物基片
公开(公告)号：US20120082713A1
公开(公告)日：2012-04-05
申请号：US13248203
申请日：2011-09-29
申请人： Emily R. Rolfes Meyering , Aron B. Anderson
发明人： Emily R. Rolfes Meyering , Aron B. Anderson
IPC分类号： A61K9/00 , A61P37/02 , A61L31/10 , A61P31/00 , C08F20/36 , A61P29/00 , A61P23/00
CPC分类号： C08F20/36 , A61L29/085 , A61L29/14 , A61L2400/10
摘要： The invention provides polymers comprising pendent photochrome or near IR dye groups, as well as polymeric matrices made from these polymers, which can be used as or in association with a medical article. The polymers can be synthesized using methods that facilitate the preparation of medical articles having good biocompatibility. Exemplary polymeric matrices are in the form of lubricious coatings on medical devices, such as catheters. Visualization by irradiation of the photochrome or near IR dye can improve detection of the polymeric matrix on a device or in the body. This, in turn can improve aspects of a medical procedure, such as device insertion or matrix formation, as well as being useful for assessing the quality of the matrix.
摘要翻译：本发明提供了包含侧基光色素或近红外染料基团的聚合物，以及由这些聚合物制成的聚合物基质，其可以作为或与医疗制品结合使用。可以使用促进制备具有良好生物相容性的医疗制品的方法来合成聚合物。示例性的聚合物基质是医疗装置如导管上的润滑涂层的形式。通过照射光斑或靠近IR染料的可视化可以改善在装置或身体中的聚合物基质的检测。这反过来可以改善诸如装置插入或矩阵形成之类的医疗过程的方面，并且可用于评估矩阵的质量。

6. 发明授权

US08034369B2 Controlled release bioactive agent delivery device 失效
标题翻译：控制释放生物活性剂输送装置
公开(公告)号：US08034369B2
公开(公告)日：2011-10-11
申请号：US11225301
申请日：2005-09-12
申请人： Aron B. Anderson , Laurie R. Lawin , Byron C. Shen , Eugene de Juan , Signe E. Varner , Ralph A. Chappa
发明人： Aron B. Anderson , Laurie R. Lawin , Byron C. Shen , Eugene de Juan , Signe E. Varner , Ralph A. Chappa
IPC分类号： A61F2/00
CPC分类号： A61K31/58 , A61F2310/00353 , A61K9/0051
摘要： The invention provides a controlled release bioactive agent delivery device for treatment of an eye that includes a body member having a direction of extension, a longitudinal axis along the direction of extension, and a proximal end and a distal end, wherein at least a portion of the body member deviates from the direction of extension, and a polymeric coated composition in contact with a surface of the body member, the polymeric coated composition including a first polymer, a second polymer, and a bioactive agent. The first polymer and the second polymer are hydrophobic, and the body member has a length such that, upon placement of the device at an implantation site within a posterior segment of an eye, the device does not enter a central visual field of the eye. The invention also provides methods method of delivering bioactive agent to a posterior region of an eye.
摘要翻译：本发明提供一种用于治疗眼睛的控制释放生物活性剂递送装置，其包括具有延伸方向的本体构件，沿着延伸方向的纵向轴线，以及近端和远端，其中至少一部分身体构件偏离延伸方向，以及与本体构件的表面接触的聚合物涂覆的组合物，聚合物涂覆的组合物包括第一聚合物，第二聚合物和生物活性剂。第一聚合物和第二聚合物是疏水性的，并且本体构件具有这样的长度，使得当将该装置放置在眼睛后部的植入部位时，该装置不进入眼睛的中心视野。本发明还提供了将生物活性剂递送到眼后部区域的方法。

7. 发明授权

US06254634B1 Coating compositions 失效
标题翻译：涂料组合物
公开(公告)号：US06254634B1
公开(公告)日：2001-07-03
申请号：US09095371
申请日：1998-06-10
申请人： Aron B. Anderson , Ralph A. Chappa , Terrence P. Everson
发明人： Aron B. Anderson , Ralph A. Chappa , Terrence P. Everson
IPC分类号： A61F206
CPC分类号： G02B1/043 , A61L27/34 , A61L31/10 , A61L33/0029 , Y10S623/901 , C08L83/04
摘要： An article (e.g., in the form of an implantable medical article) in the form of a support material bearing an intermediate layer consisting of a functional silicone polymer formulation, the intermediate layer having photoimmobilized thereon a target compound. In another aspect, a method of fabricating an article including the steps of providing a support material, applying an intermediate layer and photoimmobilizing a target compound onto the intermediate layer, and optionally, reforming the support material into a final desired article.
摘要翻译：支撑材料形式的制品（例如，可植入医疗制品的形式），该支撑材料具有由功能性硅氧烷聚合物制剂组成的中间层，该中间层在其上具有光固化性的目标化合物。在另一方面，一种制造制品的方法，包括以下步骤：提供支撑材料，施加中间层并将目标化合物光固化到中间层上，以及任选地将载体材料重整成最终期望的制品。

8. 发明授权

US08021680B2 Controlled release bioactive agent delivery device 失效
标题翻译：控制释放生物活性剂输送装置
公开(公告)号：US08021680B2
公开(公告)日：2011-09-20
申请号：US10835530
申请日：2004-04-29
申请人： Aron B. Anderson , Laurie R. Lawin , Byron C. Shen , Eugene de Juan , Signe E. Varner , Ralph A. Chappa
发明人： Aron B. Anderson , Laurie R. Lawin , Byron C. Shen , Eugene de Juan , Signe E. Varner , Ralph A. Chappa
IPC分类号： A61F2/00
CPC分类号： A61K31/58 , A61F2310/00353 , A61K9/0051
摘要： The invention provides a controlled release bioactive agent delivery device that includes a body member having a direction of extension, a longitudinal axis along the direction of extension, and a proximal end and a distal end, wherein at least a portion of the body member deviates from the direction of extension, and a polymeric coated composition in contact with the body member, the polymeric coated composition including a first polymer, a second polymer, and a bioactive agent, wherein the first polymer comprises polyalkyl(meth)acrylate, aromatic poly(meth)acrylate, or a combination of polyalkyl(meth)acrylate and aromatic poly(meth)acrylate, and wherein the second polymer comprises poly(ethylene-co-vinyl acetate). The invention also provides methods of delivering a bioactive agent to a patient in a controlled release manner, as well as methods of making a controlled release bioactive agent delivery device.
摘要翻译：本发明提供一种控制释放的生物活性剂递送装置，其包括具有延伸方向的本体构件，沿着延伸方向的纵向轴线，以及近端和远端，其中，身体构件的至少一部分偏离所述聚合物涂覆组合物包括第一聚合物，第二聚合物和生物活性剂，其中所述第一聚合物包含（甲基）丙烯酸烷基酯，（甲基）丙烯酸烷基酯，芳族聚（甲基）丙烯酸酯，）丙烯酸酯或聚（甲基）丙烯酸烷基酯和芳族聚（甲基）丙烯酸酯的组合，其中第二聚合物包括聚（乙烯 - 共 - 乙酸乙烯酯）。本发明还提供了以受控释放方式将生物活性剂递送到患者的方法，以及制备受控释放的生物活性剂递送装置的方法。

9. 发明授权

US07976862B2 Controlled release bioactive agent delivery device 失效
标题翻译：控制释放生物活性剂输送装置
公开(公告)号：US07976862B2
公开(公告)日：2011-07-12
申请号：US11203879
申请日：2005-08-15
申请人： Aron B. Anderson , Laurie R. Lawin , Byron C. Shen , Eugene de Juan , Signe E. Varner , Ralph A. Chappa
发明人： Aron B. Anderson , Laurie R. Lawin , Byron C. Shen , Eugene de Juan , Signe E. Varner , Ralph A. Chappa
IPC分类号： A61F2/00
CPC分类号： A61K31/58 , A61F2310/00353 , A61K9/0051
摘要： The invention provides implantable sustained release bioactive agent delivery devices that include a body member having a direction of extension, a longitudinal axis along the direction of extension, and a proximal end and a distal end, wherein at least a portion of the body member deviates from the direction of extension; and a polymeric coated composition in contact with a surface of the body member, the polymeric coated composition including a first polymer, a second polymer, and a bioactive agent. The polymeric coated composition is formulated to provide controlled release of bioactive agent over time when introduced into physiological conditions. Methods of preparing implantable devices configured and formulated to provide controlled release of bioactive agent are also provided.
摘要翻译：本发明提供了可植入的缓释生物活性剂递送装置，其包括具有延伸方向的本体构件，沿着延伸方向的纵向轴线，以及近端和远端，其中，身体构件的至少一部分偏离延伸方向; 以及与本体构件的表面接触的聚合物涂覆的组合物，所述聚合物涂覆的组合物包含第一聚合物，第二聚合物和生物活性剂。配制聚合物涂覆的组合物以在引入生理条件时随时间提供生物活性剂的受控释放。还提供了配制和配制以提供生物活性剂的受控释放的可植入装置的制备方法。

10. 发明授权

US07824704B2 Controlled release bioactive agent delivery device 失效
标题翻译：控制释放生物活性剂输送装置
公开(公告)号：US07824704B2
公开(公告)日：2010-11-02
申请号：US11203981
申请日：2005-08-15
申请人： Aron B. Anderson , Laurie R. Lawin , Byron C. Shen , Eugene de Juan , Signe E. Varner , Ralph A. Chappa
发明人： Aron B. Anderson , Laurie R. Lawin , Byron C. Shen , Eugene de Juan , Signe E. Varner , Ralph A. Chappa
IPC分类号： A61F2/00
CPC分类号： A61K31/58 , A61F2310/00353 , A61K9/0051
摘要： The invention provides retrievable devices for sustained delivery of bioactive agent to a site within a patient, the devices including a body member having a direction of extension, a longitudinal axis along the direction of extension, and a proximal end and a distal end, wherein at least a portion of the body member deviates from the direction of extension; a cap at the proximal end of the body member; and a polymeric coated composition in contact with a surface of the body member, the polymeric coated composition including a first polymer, a second polymer, and a bioactive agent.
摘要翻译：本发明提供了用于将生物活性剂持续递送到患者内的部位的可回收装置，所述装置包括具有延伸方向的本体构件，沿着延伸方向的纵向轴线，以及近端和远端，其中，身体构件的至少一部分偏离延伸方向; 在主体构件的近端处的帽; 以及与本体构件的表面接触的聚合物涂覆的组合物，所述聚合物涂覆的组合物包含第一聚合物，第二聚合物和生物活性剂。

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