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1. 发明授权

US07529667B1 Automated dialog system and method 有权
标题翻译：自动对话系统和方法
公开(公告)号：US07529667B1
公开(公告)日：2009-05-05
申请号：US11219628
申请日：2005-09-06
申请人： Allen Louis Gorin , Irene Langkilde Geary , Marilyn Ann Walker , Jeremy H. Wright
发明人： Allen Louis Gorin , Irene Langkilde Geary , Marilyn Ann Walker , Jeremy H. Wright
IPC分类号： G10L15/08 , G10L15/22
CPC分类号： H04M3/4936 , G10L15/1815 , G10L15/22
摘要： This invention concerns a method and system for monitoring an automated dialog system for the automatic recognition of language understanding errors based on a user's input communications. The method illustratively determines whether a probability of understanding the user's input communication exceeds a first threshold. If the first threshold is exceeded, further dialog is conducted with the user. Otherwise, the user may be directed to a human for assistance. The method also illustratively determines whether the probability also exceeds a second threshold, the second threshold being higher than the first. If so, then further dialog is conducted with the user using the current dialog strategy. However, if the probability falls between a first threshold and a second threshold, the dialog strategy may be adapted in order to improve the chances of conducting a successful dialog with the user. Conducting further automated dialog with the user in an attempt to identify a particular task that the user wants the system to perform is carried out only upon a determination that there is at least a predetermined probability that further automated dialog will enable the system to identify the particular task.
摘要翻译：本发明涉及用于基于用户的输入通信来监视用于自动识别语言理解错误的自动对话系统的方法和系统。该方法说明性地确定理解用户的输入通信的概率是否超过第一阈值。如果超过了第一个阈值，则与用户进行进一步的对话。否则，用户可能被指示给人以寻求帮助。该方法还说明性地确定概率是否也超过第二阈值，第二阈值高于第一阈值。如果是这样，则使用当前的对话策略与用户进行进一步的对话。然而，如果概率落在第一阈值和第二阈值之间，则可以调整对话策略以便提高与用户进行成功对话的机会。只有在确定进一步自动化对话将使得系统能够识别特定的可能性的至少一个预定概率时，才进行与用户进行进一步自动化对话以试图识别用户希望系统执行的特定任务任务。

2. 发明申请

US20050176964A1 Nicotinamide derivatives useful as p38 inhibitors 有权
标题翻译：可用作p38抑制剂的烟酰胺衍生物
公开(公告)号：US20050176964A1
公开(公告)日：2005-08-11
申请号：US10503968
申请日：2003-02-10
申请人： Nicola Aston , Paul Bamborough , Ann Walker
发明人： Nicola Aston , Paul Bamborough , Ann Walker
IPC分类号： A61K20060101 , A61K31/443 , A61K31/4436 , A61K31/4439 , A61K31/444 , A61K31/496 , A61P20060101 , A61P3/10 , A61P7/02 , A61P9/10 , A61P11/00 , A61P11/02 , A61P11/04 , A61P11/06 , A61P11/08 , A61P13/12 , A61P17/02 , A61P17/04 , A61P17/06 , A61P19/00 , A61P19/02 , A61P19/04 , A61P19/06 , A61P19/08 , A61P19/10 , A61P21/00 , A61P25/00 , A61P25/04 , A61P25/08 , A61P25/14 , A61P25/16 , A61P25/28 , A61P27/14 , A61P29/00 , A61P31/00 , A61P31/04 , A61P31/06 , A61P31/18 , A61P33/02 , A61P33/06 , A61P35/00 , A61P37/06 , A61P37/08 , A61P39/02 , A61P43/00 , C07D20060101 , C07D213/82 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/12 , C07D417/12 , C07D211/82 , C07D213/46 , C07D41/02
CPC分类号： C07D213/82 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/12 , C07D417/12
摘要： Compounds of formula (I): are inhibitors of p38 kinase and are useful in the treatment of conditions or disease states mediated by p38 kinase activity or mediated by cytokines produced by the activity of p38.
摘要翻译：式（I）化合物：p38激酶的抑制剂，可用于治疗由p38激酶活性介导的或由p38活性产生的细胞因子介导的病状或疾病状态。

3. 发明申请

US20050090491A1 2'-Methyl-5'-(1,3,4-oxadiazol-2-yl)-1,1'-biphenyl-4-carboxamide derivatives and their use as p38 kinase inhibitors 失效
标题翻译： 2'-甲基-5' - （1,3,4-恶二唑-2-基）-1,1'-联苯-4-甲酰胺衍生物及其作为p38激酶抑制剂的用途
公开(公告)号：US20050090491A1
公开(公告)日：2005-04-28
申请号：US10492497
申请日：2002-10-16
申请人： Richard Angell , Paul Bamborough , George Cockerill , Kathryn Smith , Ann Walker
发明人： Richard Angell , Paul Bamborough , George Cockerill , Kathryn Smith , Ann Walker
IPC分类号： A61K31/4245 , A61P1/04 , A61P3/10 , A61P7/00 , A61P7/02 , A61P9/00 , A61P9/04 , A61P9/10 , A61P9/14 , A61P11/00 , A61P11/02 , A61P11/06 , A61P13/02 , A61P13/08 , A61P13/12 , A61P15/00 , A61P17/02 , A61P17/06 , A61P19/00 , A61P19/02 , A61P19/06 , A61P19/08 , A61P19/10 , A61P21/00 , A61P25/00 , A61P25/04 , A61P25/08 , A61P25/14 , A61P25/16 , A61P25/28 , A61P27/02 , A61P29/00 , A61P29/02 , A61P31/04 , A61P31/06 , A61P31/18 , A61P33/02 , A61P33/06 , A61P35/00 , A61P37/00 , A61P37/06 , A61P37/08 , A61P43/00 , C07D271/10 , C07D417/02 , A61K31/454 , A61K31/496 , A61K31/5377 , A61K31/541 , C07D413/02
CPC分类号： C07D271/10
摘要： Compounds of formula (I) wherein when m is 0 to 4 R1 is selected from C1-6alkyl, C3-7cycloalkyl, C2-6alkenyl, —SO2NR4R5, —CONR4R5 and —COOR4; and when m is 2 to 4 R1 is additionally selected from C1-6alkoxy, hydroxy, NR4R5, —NR4SO2R5, —NR4SOR5, —NR4COR5, and —NR4CONR4R5; R2 is selected from hydrogen, C1-6alkyl and —(CH2)n—C3-7cycloalkyl; R3 is the group R6 is selected from hydrogen and C1-4alkyl; U is selected from methyl and halogen; X and Y are each selected independently from hydrogen, methyl and halogen; m is selected from 0, 1, 2, 3 and 4 wherein each carbon atom of the resulting carbon chain may be optionally substituted with one or two groups selected independently from C1-6alkyl; n is selected from 0, 1, 2 and 3; r is selected from 0, 1 and 2; or pharmaceutically acceptable salts or solvates thereof, and their use as pharmaceuticals, particularly as p38 kinase inhibitors.
摘要翻译：式（I）的化合物，其中当m为0至4时R 1选自C 1-6烷基，C 3-7环烷基，C 2-6烯基，-SO 2 NR 4 R 5，-CONR 4 R 5和-COOR 4; 当m为2至4时，R1另外选自C1-6烷氧基，羟基，NR4R5，-NR4SO2R5，-NR4SOR5，-NR4COR5和-NR4CONR4R5; R2选自氢，C1-6烷基和 - （CH2）n-C3-7环烷基; R3为基团R6选自氢和C1-4烷基; U选自甲基和卤素; X和Y各自独立地选自氢，甲基和卤素; m选自0,1,2,3和4，其中所得碳链的每个碳原子可以任选被一个或两个独立地选自C 1-6烷基的基团取代; n选自0,1,2和3; r选自0,1和2; 或其药学上可接受的盐或溶剂化物，以及它们作为药物的用途，特别是作为p38激酶抑制剂。

4. 发明申请

US20050065195A1 Oxadiazolyl-biphenylcarboxamides and their use as p38 kinase inhibitors 审中-公开
标题翻译：恶二唑基 - 联苯甲酰胺及其作为p38激酶抑制剂的用途
公开(公告)号：US20050065195A1
公开(公告)日：2005-03-24
申请号：US10492711
申请日：2002-10-16
申请人： Richard Angell , Paul Bamborough , George Cockerill , Kathryn Smith , Ann Walker
发明人： Richard Angell , Paul Bamborough , George Cockerill , Kathryn Smith , Ann Walker
IPC分类号： A61K31/4245 , A61K31/427 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/506 , A61K31/5377 , A61P1/04 , A61P3/10 , A61P7/00 , A61P7/02 , A61P9/04 , A61P9/10 , A61P9/14 , A61P11/00 , A61P11/02 , A61P11/06 , A61P13/12 , A61P17/00 , A61P17/06 , A61P19/02 , A61P19/06 , A61P19/08 , A61P19/10 , A61P21/00 , A61P25/00 , A61P25/04 , A61P25/08 , A61P25/14 , A61P25/16 , A61P25/28 , A61P27/14 , A61P29/00 , A61P31/04 , A61P31/06 , A61P31/08 , A61P31/18 , A61P33/06 , A61P35/00 , A61P37/06 , A61P37/08 , A61P39/02 , A61P43/00 , C07D271/10 , C07D413/12 , C07D417/12 , C07D521/00 , A61K31/195 , A61K31/277 , A61K31/4172
CPC分类号： C07D271/10 , C07D231/12 , C07D233/56 , C07D249/08 , C07D413/12 , C07D417/12
摘要： Compounds of formula (I), wherein R3 is the group; or pharmaceutically acceptable salts or solvates thereof, and their use as pharmaceuticals, particularly as p38 kinase inhibitors.
摘要翻译：式（I）的化合物，其中R 3为基团; 或其药学上可接受的盐或溶剂化物，以及它们作为药物的用途，特别是作为p38激酶抑制剂。

5. 发明授权

US07472060B1 Automated dialog system and method 有权
标题翻译：自动对话系统和方法
公开(公告)号：US07472060B1
公开(公告)日：2008-12-30
申请号：US11219629
申请日：2005-09-06
申请人： Allen Louis Gorin , Irene Langkilde Geary , Marilyn Ann Walker , Jeremy H. Wright
发明人： Allen Louis Gorin , Irene Langkilde Geary , Marilyn Ann Walker , Jeremy H. Wright
IPC分类号： G10L15/14 , G10L15/22
CPC分类号： H04M3/4936 , G10L15/1815 , G10L15/22
摘要： This invention concerns a method and system for monitoring an automated dialog system for the automatic recognition of language understanding errors based on a user's input communications in a dialog with the user. The probability of conducting a successful dialog with the user is determined based, at least in part, on understanding data from at least one prior dialog exchange of the dialog.
摘要翻译：本发明涉及一种用于基于用户在与用户的对话中的输入通信来自动识别语言理解错误来监视自动对话系统的方法和系统。至少部分地基于理解来自对话的至少一个先前对话交换的数据来确定与用户进行成功对话的概率。

6. 发明申请

US20070142372A1 Fused heteroaryl derivatives for use as p38 kinase inhibitors in the treatment of i.a. rheumatoid arthritis 失效
标题翻译：用作p38激酶抑制剂的稠合杂芳族衍生物用于治疗i.a. 类风湿关节炎
公开(公告)号：US20070142372A1
公开(公告)日：2007-06-21
申请号：US10587614
申请日：2005-01-27
申请人： Sebastien Campos , Stephen Swanson , Ann Walker
发明人： Sebastien Campos , Stephen Swanson , Ann Walker
IPC分类号： A61K31/5377 , A61K31/416 , C07D413/02 , C07D405/02
CPC分类号： C07D403/04 , C07D405/06 , C07D413/06
摘要： Compounds of formula (I): are inhibitors of p38 kinase and are useful in the treatment of conditions or disease states mediated by p38 kinase activity or mediated by cytokines produced by the activity of p38.
摘要翻译：式（I）化合物：p38激酶的抑制剂，可用于治疗由p38激酶活性介导的或由p38活性产生的细胞因子介导的病状或疾病状态。

7. 发明申请

US20070129354A1 Biphenyl carboxylic amide p38 kinase inhibitors 失效
标题翻译：联苯羧酰胺p38激酶抑制剂
公开(公告)号：US20070129354A1
公开(公告)日：2007-06-07
申请号：US10551502
申请日：2004-04-07
申请人： Nicola Aston , Paul Bamborough , Katherine Jones , Vipulkumar Patel , Stephen Swanson , Ann Walker
发明人： Nicola Aston , Paul Bamborough , Katherine Jones , Vipulkumar Patel , Stephen Swanson , Ann Walker
IPC分类号： A61K31/54 , A61K31/5377 , A61K31/495 , A61K31/445 , A61K31/426 , A61K31/421 , A61K31/4164 , A61K31/40 , A61K31/165
CPC分类号： C07D271/06 , C07C235/42 , C07C235/46 , C07C237/30 , C07C237/42 , C07C275/42 , C07C311/04 , C07C311/15 , C07C2601/02 , C07D295/088 , C07D295/185
摘要： Compound of formula (I): or pharmaceutically acceptable derivatives thereof, and their use as pharmaceuticals, particularly as p38 kinase inhibitors.
摘要翻译：式（I）化合物或其药学上可接受的衍生物及其作为药物的用途，特别是作为p38激酶抑制剂。

8. 发明授权

US07228252B2 Increased precision position sensors 有权
标题翻译：增加精密位置传感器
公开(公告)号：US07228252B2
公开(公告)日：2007-06-05
申请号：US10523396
申请日：2004-11-04
申请人： Richard J. R. Alexander , Richard W Manley , Carol Ann Walker
发明人： Richard J. R. Alexander , Richard W Manley , Carol Ann Walker
IPC分类号： G01C9/00 , G01C17/00
CPC分类号： G01D5/145
摘要： An increased precision position sensor includes a first magnetic field sensing device; a second magnetic field sensing device; and a processor, the processor further includes a calibrator; a mathematical model to predict the magnetic field at a given position relative to the object; and an estimator algorithm to compare the measured magnetic field within the predicted magnetic field, thereby calculating the most likely position of the position sensor relative to the magnetic object. A position sensor in accordance with the invention is capable of locating the axis of a cylindrical magnetic object to within ±0.5 mm through 70 mm thick aluminium, and is expected to find application, in the aerospace industry, or other industries where high precision during manufacture is required. The invention may be conveniently embodied in a portable, handheld device.
摘要翻译：增加的精密位置传感器包括第一磁场感测装置; 第二磁场感测装置; 和处理器，所述处理器还包括校准器; 用于预测相对于物体的给定位置处的磁场的数学模型; 以及用于比较预测磁场内的测量磁场的估计器算法，由此计算位置传感器相对于磁性物体的最可能的位置。根据本发明的位置传感器能够将圆柱形磁性物体的轴线定位在±0.5mm至70mm厚的铝之间，并且预期在航空航天工业或其他制造中具有高精度的其它工业中应用是必须的。本发明可以方便地实现在便携式手持设备中。

9. 发明申请

US20060276516A1 Nicotinamide Derivatives Useful as p38 Inhibitors 有权
标题翻译：适用于p38抑制剂的烟酰胺衍生物
公开(公告)号：US20060276516A1
公开(公告)日：2006-12-07
申请号：US11462858
申请日：2006-08-07
申请人： Nicola Aston , Paul Bamborough , Ann Walker
发明人： Nicola Aston , Paul Bamborough , Ann Walker
IPC分类号： A61K31/455 , C07D213/46
CPC分类号： C07D213/82 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/12 , C07D417/12
摘要： Compounds of formula (I): are inhibitors of p38 kinase and are useful in the treatment of conditions or disease states mediated by p38 kinase activity or mediated by cytokines produced by the activity of p38.
摘要翻译：式（I）化合物：p38激酶的抑制剂，可用于治疗由p38激酶活性介导的或由p38活性产生的细胞因子介导的病状或疾病状态。

10. 发明授权

US06751591B1 Method and system for predicting understanding errors in a task classification system 有权
标题翻译：用于预测任务分类系统中的理解错误的方法和系统
公开(公告)号：US06751591B1
公开(公告)日：2004-06-15
申请号：US09765393
申请日：2001-01-22
申请人： Allen Louis Gorin , Irene Langkilde Geary , Marilyn Ann Walker , Jeremy H. Wright
发明人： Allen Louis Gorin , Irene Langkilde Geary , Marilyn Ann Walker , Jeremy H. Wright
IPC分类号： G10L1518
CPC分类号： G10L15/22
摘要： This invention concerns a method and system for monitoring an automated dialog system for the automatic recognition of language understanding errors based on a user's input communications in a task classification system. The method may include determining whether the user's input communication can be understood in order to make a task classification decision. If the user's input communication cannot be understood and a task classification decision cannot be made, a probability of understanding the user's input communication may be determined. If the probability exceeds a first threshold, further dialog may be conducted with the user. Otherwise, the user may be directed to a human for assistance. In another possible embodiment, the method operates as above except that if the probability exceeds a second threshold, the second threshold being higher than the first, then further dialog may be conducted with the user using the current dialog strategy. However, if the probability falls between a first threshold and a second threshold, the dialog strategy may be adapted in order to improve the chances of conducting a successful dialog with the user. This process may be cumulative. In particular, the first dialog exchange may be stored in a database. Then, a second dialog exchange is conducted with the user. As a result, a second determination is made as to whether the user's input communication can be understood can be conducted based on the stored first exchange and the current second exchanges. This cumulative process may continue using a third and fourth exchange, if necessary.
摘要翻译：本发明涉及一种用于监视基于用户在任务分类系统中的输入通信的语言理解错误的自动识别的自动对话系统的方法和系统。该方法可以包括确定是否可以理解用户的输入通信以便进行任务分类决定。如果不能理解用户的输入通信，并且不能进行任务分类决定，则可以确定理解用户的输入通信的概率。如果概率超过第一阈值，则可以与用户进行进一步的对话。否则，用户可能被指示给人以寻求帮助。在另一个可能的实施例中，除了如果概率超过第二阈值，则该方法高于第一阈值，则可以使用当前对话策略与用户进行进一步的对话。然而，如果概率落在第一阈值和第二阈值之间，则可以调整对话策略以便提高与用户进行成功对话的机会。这个过程可能是累积的。特别地，第一对话交换可以存储在数据库中。然后，与用户进行第二次对话交换。结果，可以基于所存储的第一交换和当前的第二交换进行关于用户的输入通信是否可以被理解的第二确定。如有必要，此累积过程可能会继续使用第三次和第四次交换。

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