专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20120078524A1 System and method for diagnosis tissue samples using fluorescence and raman techniques 审中-公开
标题翻译：使用荧光和拉曼技术诊断组织样本的系统和方法
公开(公告)号：US20120078524A1
公开(公告)日：2012-03-29
申请号：US13136366
申请日：2011-07-29
申请人： Shona Stewart , Jeffrey Cohen , Amy Drauch , John Maier
发明人： Shona Stewart , Jeffrey Cohen , Amy Drauch , John Maier
IPC分类号： G01N33/48 , G01N21/64 , G01J3/44
CPC分类号： A61B5/0059 , A61B5/417 , G01J3/02 , G01J3/0291 , G01J3/0294 , G01J3/10 , G01J3/2823 , G01J3/32 , G01J3/44 , G01J2003/2826 , G01N21/6458 , G01N21/65 , G01N21/658 , G01N2021/656 , G01N2201/1293 , G01N2201/1296 , G02B21/16 , G02B21/365 , G06F19/325 , G16H50/70
摘要： A system and method for determining a diagnosis of a test biological sample. A system comprising a first illumination source to illuminate a sample, a first detector for generating a fluorescence data set of said sample, a means for determining a region of interest, a second illumination source to illuminate said region of interest, a second detector to generate a Raman data set of said region of interest, and a means for determining a diagnosis of said sample. A method comprising illuminating a sample, generating a fluorescence data set of said sample, and assessing the fluorescence data set to identify a region of interest, illuminating a region of interest, and generating Raman data set. This Raman data set may be assessed to determine a diagnosis of the sample. A diagnosis may include a metabolic state, a clinical outcome, a disease progression, a disease state, and combinations thereof.
摘要翻译：用于确定测试生物样品的诊断的系统和方法。一种系统，包括用于照亮样品的第一照明源，用于产生所述样品的荧光数据集的第一检测器，用于确定感兴趣区域的装置，用于照亮所述感兴趣区域的第二照明源，产生所述感兴趣区域的拉曼数据集，以及用于确定所述样本的诊断的装置。一种方法，包括照亮样品，产生所述样品的荧光数据集，以及评估所述荧光数据集以识别感兴趣区域，照亮感兴趣区域，以及产生拉曼数据集。可以评估该拉曼数据集以确定样品的诊断。诊断可以包括代谢状态，临床结果，疾病进展，疾病状态及其组合。

2. 发明申请

US20120083678A1 System and method for raman chemical analysis of lung cancer with digital staining 审中-公开
标题翻译：数字染色法肺癌化学分析系统与方法
公开(公告)号：US20120083678A1
公开(公告)日：2012-04-05
申请号：US13200779
申请日：2011-09-30
申请人： Amy Drauch , John Maier
发明人： Amy Drauch , John Maier
IPC分类号： A61B5/1455 , G06F19/00 , G01J3/44
CPC分类号： G01J3/44 , A61B5/0075 , G01J3/26
摘要： The present disclosure provides for a system and method for diagnosing biological samples that combines the visual staining features familiar to pathologists with the accurate, reliable, and nondestructive capabilities of Raman chemical imaging. The invention disclosed herein may be applied to diagnose lung cancer samples. A method may comprise illuminating a biological sample to generate interacted photons, filtering said interacted photons using a tunable filter, and detecting interacted photons to generate a test Raman data set representative of said sample. The method may further comprise applying at least one chemometric technique and/or a digital stain to said test Raman data set. This test Raman data set may be analyzed to diagnose said sample as comprising at least one of: adenocarcinoma, mesothelioma, and combinations thereof. A system may comprise an illumination source, a tunable filter, and a detector configured to generate a test Raman data set representative of a biological sample.
摘要翻译：本公开提供了用于诊断生物样品的系统和方法，其将病理学家熟悉的视觉染色特征与拉曼化学成像的准确，可靠和非破坏性能力相结合。本文公开的本发明可以应用于诊断肺癌样品。一种方法可以包括照射生物样品以产生相互作用的光子，使用可调谐滤波器过滤所述相互作用的光子，以及检测相互作用的光子以产生代表所述样品的测试拉曼数据集。该方法还可以包括向所述测试拉曼数据集施加至少一种化学计量技术和/或数字染色。可以分析该测试拉曼数据集以诊断所述样品包括以下至少一种：腺癌，间皮瘤及其组合。系统可以包括照明源，可调谐滤波器和被配置为生成表示生物样品的测试拉曼数据集的检测器。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式