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1. 发明专利

GB342883A Improvements in and relating to propellers for flying, swimming and other moving objects 未知
公开(公告)号：GB342883A
公开(公告)日：1931-02-12
申请号：GB240530
申请日：1930-01-23
申请人： JOHN MAIER BEHRING
IPC分类号： F42B10/22
摘要： 342,883. Projectiles; torpedoes. BEHRING, J. MAIER-, 3573, Kensington Avenue, Philadelphia, U.S.A. Jan. 23, 1930, No. 2405. [Class 9 (i) and 9 (ii).] For ships, projectiles, torpedoes, and other bodies adapted to travel through air or water, a nose member is provided of substantially conical form and is adapted to be mounted at the front of the body, and is formed with a helical spiral having one flank parallel with the axis, the other flank extending at right-angles to the first, the helical spiral extending from the base to the apex. The body 1 has an extension 7 in which is supported the driving shaft 3, 16, of , a conical member 17 which has a spiral exterior with flanks 21 parallel to the axis and another flank 22 at right-angles thereto. When the spiral nose is fitted to a torpedo it may be driven off the main engine shaft, or by a separate engine. When fitted to a projectile it is screwed on to the extension and rotates bodily with the projectile.

2. 发明授权

US09464934B2 System and method for correcting spectral response using a radiometric correction filter 有权
标题翻译：使用辐射校正滤波器校正光谱响应的系统和方法
公开(公告)号：US09464934B2
公开(公告)日：2016-10-11
申请号：US13347788
申请日：2012-01-11
申请人： Ryan Priore , John Maier
发明人： Ryan Priore , John Maier
IPC分类号： G01N21/00 , G01J3/02 , G01J3/44 , G01N21/27 , G01N21/65 , G01J3/28 , G01J3/12
CPC分类号： G01J3/02 , G01J3/0297 , G01J3/28 , G01J3/44 , G01J2003/1213 , G01N21/276 , G01N21/65 , G01N2201/1293
摘要： The present disclosure provides for a correction filter that may be configured to comprise a predetermined arrangement of thin film layers. This arrangement of thin film layers may be such that it effectively enables a correction filter to generate a predetermined spectral response, wherein said predetermined spectral response is substantially the same as a determined instrument response correction associated with an instrument. The invention of the present disclosure therefore provides for effectively compensating for transmission inefficiencies associated with an instrument without the need for separate reference measurements to determine and correct for instrument response.
摘要翻译：本公开提供了一种校正滤波器，其可被配置为包括薄膜层的预定排列。薄膜层的这种布置可以使得其有效地使得校正滤波器能够产生预定的光谱响应，其中所述预定光谱响应与与仪器相关联的确定的仪器响应校正基本相同。因此，本公开的发明提供了有效地补偿与仪器相关联的传输效率低下，而不需要单独的参考测量来确定和校正仪器响应。

3. 发明申请

US20110208462A1 System and method for instrument correction using transmission efficiency 审中-公开
标题翻译：使用传输效率进行仪器校正的系统和方法
公开(公告)号：US20110208462A1
公开(公告)日：2011-08-25
申请号：US12931836
申请日：2011-02-11
申请人： John Maier , Michael Fuhrman
发明人： John Maier , Michael Fuhrman
IPC分类号： G06F19/00
CPC分类号： G01J3/02 , G01J3/0297 , G01J3/44 , G01N21/276 , G01N21/65 , G01N2201/1293
摘要： A system and method for providing an instrument response correction based on transmission efficiency. Test data may be acquired at a first operating point. A look-up table may be searched to determine an instrument response correction. This look-up table may comprise a plurality of instrument response corrections, each instrument response correction corresponding to an intensity response of the sample at an operating point. The instrument response correction may then be applied to correct for environmental factors that may affect transmission efficiency. A system may comprise an illumination source, a collection optics, a tunable filter, a detector, a sensor and a control unit. The detector may detect interacted photons generated by illuminating a sample and generate test data. The sensor may be configured to sense an operating condition and transmit this information to the control unit which is configured to search a look-up table to determine the appropriate instrument response correction.
摘要翻译：一种基于传输效率提供仪器响应校正的系统和方法。可以在第一操作点获取测试数据。可以搜索查找表以确定仪器响应校正。该查找表可以包括多个仪器响应校正，每个仪器响应校正对应于在操作点处的样品的强度响应。然后可以应用仪器响应校正来校正可能影响传输效率的环境因素。系统可以包括照明源，收集光学器件，可调谐滤波器，检测器，传感器和控制单元。检测器可以检测通过照射样品产生的相互作用的光子并产生测试数据。传感器可以被配置为感测操作条件并将该信息发送到控制单元，该控制单元被配置为搜索查找表以确定适当的仪器响应校正。

4. 发明申请

US20110007309A1 Method for Analysis of Pathogenic Microorganisms Using Raman Spectroscopic Techniques 有权
标题翻译：使用拉曼光谱技术分析病原微生物的方法
公开(公告)号：US20110007309A1
公开(公告)日：2011-01-13
申请号：US12834462
申请日：2010-07-12
申请人： Shona Stewart , John Maier , Patrick Treado
发明人： Shona Stewart , John Maier , Patrick Treado
IPC分类号： G01J3/44
CPC分类号： G01N21/65 , G01J3/2823 , G01J3/44 , G01N21/658 , G01N33/1826
摘要： A method for assessing the presence of a pathogenic microorganism in a sample. A sample is illuminated to thereby produce a first plurality of interacted photons which may be scattered, emitted, reflected and/or absorbed by the sample. The first plurality of interacted photons are assessed to thereby generate a Raman data set representative of the sample. This Raman data set is analyzed to thereby determine at least one of: the presence of a pathogenic microorganism in said sample and the absence of a pathogenic microorganism in said sample. The Raman data set may comprise at least one of a Raman spectrum and/or a Raman chemical image representative of the sample. The analysis may comprise comparing said Raman data set to at least one reference Raman data set representative of a known sample. This may be achieved using a chemometric technique.
摘要翻译：用于评估样品中病原微生物的存在的方法。照射样品从而产生可被样品散射，发射，反射和/或吸收的第一多个相互作用的光子。评估第一组多个相互作用的光子，从而产生代表样品的拉曼数据集。分析该拉曼数据集，从而确定所述样品中病原微生物的存在和所述样品中不存在致病微生物中的至少一种。拉曼数据集可以包括代表样品的拉曼光谱和/或拉曼化学图像中的至少一个。分析可以包括将所述拉曼数据集与代表已知样本的至少一个参考拉曼数据集进行比较。这可以使用化学计量技术来实现。

5. 发明申请

US20100309464A1 Raman Chemical Imaging of Threat Agents Using Pulsed Laser Excitation and Time-Gated Detection 审中-公开
标题翻译：使用脉冲激光激发和时间门控检测的威胁剂的拉曼化学成像
公开(公告)号：US20100309464A1
公开(公告)日：2010-12-09
申请号：US12619336
申请日：2009-11-16
申请人： Patrick J. Treado , Matthew Nelson , Jeffrey Cohen , John Maier
发明人： Patrick J. Treado , Matthew Nelson , Jeffrey Cohen , John Maier
IPC分类号： G01J3/44
CPC分类号： G01J3/2803 , G01J3/0218 , G01J3/027 , G01J3/0291 , G01J3/2889 , G01J3/44 , G01N21/274 , G01N21/65 , G01N2201/0216 , G01N2201/0697
摘要： The disclosure provides for a system and method for detecting a threat agent. A sample is illuminated to produce photons Raman scattered and emitted by the sample. The Raman scattered photons are collected using time-gated detection without collecting the emitted photons. A Raman spectroscopic data set is generated from said Raman scattered photons wherein said Raman spectroscopic data comprises at least one of a Raman spectrum and a Raman chemical image. The Raman spectroscopic data is assessed to thereby determine the presence or absence of a threat agent in the sample. The sample may be in a target area. The sample may be illuminated using a pulsed laser or an intensity modulated laser. The illumination source may be synchronized with a gating element that enables time-gated detection.
摘要翻译：本公开提供了用于检测威胁代理的系统和方法。样品被照亮以产生被样品分散和发射的光子拉曼。使用时间门控检测收集拉曼散射的光子，而不收集发射的光子。从所述拉曼散射光子产生拉曼光谱数据集，其中所述拉曼光谱数据包括拉曼光谱和拉曼化学图像中的至少一个。评估拉曼光谱数据，从而确定样品中威胁剂的存在或不存在。样本可能在目标区域。可以使用脉冲激光或强度调制激光来照亮样品。照明源可以与启用时间门控检测的门控元件同步。

6. 发明申请

US20100033717A1 Raman Chemical Imaging of Implantable Drug Delivery Devices 有权
标题翻译：可植入药物递送装置的拉曼化学成像
公开(公告)号：US20100033717A1
公开(公告)日：2010-02-11
申请号：US12537671
申请日：2009-08-07
申请人： Janice Panza , John Maier
发明人： Janice Panza , John Maier
IPC分类号： G01J3/44
CPC分类号： G01J3/44 , G01N21/65 , G01N2201/129
摘要： A system and method of determining an attribute of a biological tissue sample or a drug delivery device. A sample is illuminated with substantially monochromatic light to thereby generate Raman scattered photons. The Raman scattered photons are assessed to thereby generate a spectroscopic data set wherein said spectroscopic data set comprises at least one of: a Raman spectra and a spatially accurate wavelength resolved image. Tile spectroscopic data set is evaluated to determine at least one of: an attribute of a biological tissue sample and a drug delivery device. In one embodiment, the biological tissue comprises arterial tissue. In another embodiment, the drug delivery device is a drug-eluting stent. In another embodiment, Raman chemical imaging can be used to evaluate a sample and identify at least one of: the tissue, a drug, a drug delivery device, and a matrix associated with a drug delivery device.
摘要翻译：一种确定生物组织样品或药物递送装置的属性的系统和方法。用基本单色光照射样品，从而产生拉曼散射光子。评估拉曼散射光子，从而产生光谱数据集，其中所述光谱数据集包括拉曼光谱和空间上准确的波长分辨图像中的至少一个。评估平铺光谱数据集以确定生物组织样品和药物递送装置的属性中的至少一个。在一个实施方案中，生物组织包含动脉组织。在另一个实施方案中，药物递送装置是药物洗脱支架。在另一个实施方案中，拉曼化学成像可用于评估样品并鉴定组织，药物，药物递送装置和与药物递送装置相关联的基质中的至少一种。

7. 发明申请

US20080151225A1 SYSTEM AND METHOD FOR THE DEPOSITION, DETECTION AND IDENTIFICATION OF THREAT AGENTS USING A PHASE MASK 有权
标题翻译：使用相位掩模进行沉积，检测和识别故障代理的系统和方法
公开(公告)号：US20080151225A1
公开(公告)日：2008-06-26
申请号：US11351333
申请日：2006-02-09
申请人： Patrick Treado , Charles Gardner , John Maier
发明人： Patrick Treado , Charles Gardner , John Maier
IPC分类号： G01N21/00 , G01J3/44 , G01N21/65
CPC分类号： G01J3/44 , G01N21/65
摘要： A system method for depositing a sample of a threat agent is deposited onto a substrate. The threat agent is illuminated via an illumination source along an optical path with a plurality of photons to thereby produce photons transmitted, reflected, emitted or Raman scattered by the threat agent. An optical system collects elastic scatter photons produced by the threat agent and at least one of photons transmitted, reflected, emitted or Raman scattered by the threat agent, wherein said illumination source is located along an optical path, and said substrate is located along a plane wherein the optical path is at an angle other than 90° with respect to the substrate plane. The depth of field of the optical system is extended by passing at least one of the following through a phase mask: elastic scattered photons, and photons transmitted, reflected, emitted or Raman scattered by the threat agent.
摘要翻译：将用于沉积威胁剂的样品的系统方法沉积在基底上。通过沿着具有多个光子的光路的照明源照射威胁剂，从而产生被威胁剂散射的透射，反射，发射或拉曼的光子。光学系统收集由威胁剂产生的弹性散射光子和由威胁剂散射的发射，反射，发射或拉曼的光子中的至少一种，其中所述照明源沿着光路定位，并且所述衬底沿着平面其中所述光路相对于所述基板平面成90°以外的角度。通过使以下各项中的至少一个通过相位掩模：弹性散射光子和由威胁剂散发的透射，反射，发射或拉曼的光子来延长光学系统的景深。

8. 发明申请

US20070182959A1 Dynamic imaging of biological cells and other subjects 有权
标题翻译：生物细胞和其他科目的动态成像
公开(公告)号：US20070182959A1
公开(公告)日：2007-08-09
申请号：US10556038
申请日：2005-06-30
申请人： John Maier , Patrick Treado , David Tuschel , Thomas Voigt
发明人： John Maier , Patrick Treado , David Tuschel , Thomas Voigt
IPC分类号： G01J3/44 , G01N21/65
CPC分类号： G01N21/6456 , G01J3/2803 , G01J3/32 , G01J3/36 , G01J3/44 , G01N21/359 , G01N21/6486 , G01N21/65 , G01N21/658 , G01N2021/656
摘要： The invention relates to methods of dynamic chemical imaging, including methods of cellular imaging. The method comprises illuminating at least a portion of a cell with substantially monochromatic light and assessing Raman-shifted light scattered from the illuminated portion at a plurality of discrete times. The Raman-shifted light can be assessed at a plurality of Raman shift (RS) values at each of the discrete times, and the RS values can be selected to be characteristic of a pre-selected component at each of the discrete times. Multivariate analysis of Raman spectral features of the images thus obtained can yield the location and chemical identity of components in the field of view. This information can be combined or overlaid with other spectral data (e.g., a visible microscopic image) obtained from the field of view.
摘要翻译：本发明涉及动态化学成像方法，包括细胞成像方法。该方法包括以基本上单色的光照亮电池的至少一部分，并且在多个离散时间评估从照射部分散射的拉曼偏移光。可以在每个离散时间处以多个拉曼位移（RS）值评估拉曼移位的光，并且可以将每个离散时间的RS值选择为预选择的分量的特征。如此获得的图像的拉曼光谱特征的多变量分析可以产生视场中部件的位置和化学特性。该信息可以与从视野获得的其他光谱数据（例如，可见显微镜图像）组合或覆盖。

9. 发明申请

US20070178067A1 System and method for cytological analysis by raman spectroscopic imaging 审中-公开
标题翻译：通过拉曼光谱成像进行细胞学分析的系统和方法
公开(公告)号：US20070178067A1
公开(公告)日：2007-08-02
申请号：US11598248
申请日：2006-11-09
申请人： John Maier , Joseph Demuth , Jeffrey Cohen , Lindy McClelland , Shona Stewart
发明人： John Maier , Joseph Demuth , Jeffrey Cohen , Lindy McClelland , Shona Stewart
IPC分类号： A61K48/00 , C12Q1/00 , G06F19/00
CPC分类号： G01N33/5005 , G01N15/1459 , G01N21/65 , G01N33/574 , G01N33/57407 , G01N2021/656
摘要： A method and system of differentially manipulating cells where the cells, suspended in a fluid, are irradiated with substantially monochromatic light. A Raman data set is obtained from the irradiated cells and where the data set is characteristic of a disease status. The data set is assessed to identify diseased cells. A Raman chemical image of the irradiated cells is also obtained. Based on the assessment and the Raman chemical image, the fluid in which the cells are suspended is differentially manipulated. The diseased cells are directed to a first location and other non-diseased cells are directed to a second location as part of the differential manipulation. The diseased cells may be treated with a physical stress, a chemical stress, and a biological stress and then returned to a patient from whom the diseased cells were obtained prior to the irradiation.
摘要翻译：一种差异操纵细胞的方法和系统，其中悬浮在流体中的细胞用基本上单色的光照射。从照射的细胞获得拉曼数据集，其中数据集是疾病状态的特征。评估数据集以鉴定患病细胞。还获得了照射的细胞的拉曼化学图像。基于评估和拉曼化学图像，细胞悬浮的流体被差异地操纵。病变细胞被引导到第一位置，并且其他非病变细胞被引导到第二位置作为差异操纵的一部分。患病细胞可以用物理应力，化学应力和生物应激治疗，然后返回到在照射之前从其获得患病细胞的患者。

10. 发明申请

US20070070343A1 Method for correlating spectroscopic measurements with digital images of contrast enhanced tissue 有权
标题翻译：将光谱测量与对比增强组织的数字图像相关联的方法
公开(公告)号：US20070070343A1
公开(公告)日：2007-03-29
申请号：US11527839
申请日：2006-09-27
申请人： Jeffrey Cohen , John Maier
发明人： Jeffrey Cohen , John Maier
IPC分类号： G01J3/44 , G01N21/65
CPC分类号： G01J3/02 , G01J3/0264 , G01J3/0289 , G01J3/0291 , G01N21/6458 , G01N21/6486 , G01N21/65 , G01N21/658 , G01N2021/6417 , G01N2021/6423 , G01N2021/656
摘要： A system and method of correlating Raman measurements with digital images of a treated sample and using this correlation to classify the disease state of the sample. A spectroscopic data set is obtained for the sample positioned in the field of view of a spectroscopic device. The positional information about the field of view is stored. With the sample removed from the field of view, the sample is treated with a contrast enhancing agent. Using the stored positional information for the field of view, the treated sample is repositioned in the spectroscopic device's field of view. A digital image of the treated sample positioned in the field of view is obtained. The first spectroscopic data set is linked with the digital image by defining a transformation to map the image spatial coordinates of the digital image to the spectral spatial coordinates of the spectroscopic data. A database having a plurality of spectroscopic data sets, for samples having well characterized pathology, is provided. Each spectroscopic data set is linked to a corresponding digital image, and each spectroscopic data set is associated with the known sample. Each corresponding digital image is associated with the known sample treated with a contrast enhancing agent. For the spectroscopic data set of the sample, the database is searched to identify a spectroscopic data set, of a known sample, matching the sample's spectroscopic data set.
摘要翻译：将拉曼测量与处理的样品的数字图像相关联并使用该相关性来分类样品的疾病状态的系统和方法。对于位于分光装置的视野中的样品获得光谱数据集。存储关于视场的位置信息。从样品中取出样品后，用对比度增强剂处理样品。使用所存储的视场的位置信息，处理的样品在分光装置的视场中重新定位。获得定位在视场中的被处理样品的数字图像。通过定义将数字图像的图像空间坐标映射到光谱数据的谱空间坐标的变换，第一光谱数据集与数字图像相关联。提供了具有多个光谱数据集的数据库，用于具有良好表征的病理学的样本。每个光谱数据集与相应的数字图像相关联，并且每个光谱数据集与已知样本相关联。每个相应的数字图像与用对比度增强剂处理的已知样品相关联。对于样本的光谱数据集，搜索数据库以识别与样本的光谱数据集匹配的已知样本的光谱数据集。

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