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1. 发明申请

US20090203093A1 Protein Targeting To Lipid Bodies 审中-公开
标题翻译：蛋白质靶向脂质体
公开(公告)号：US20090203093A1
公开(公告)日：2009-08-13
申请号：US12307690
申请日：2007-07-10
申请人： Alexander Steinbüchel , Marc Wältermann , Jan Hänisch
发明人： Alexander Steinbüchel , Marc Wältermann , Jan Hänisch
IPC分类号： C12P7/64 , C12N15/87 , C07K14/00 , C12N15/11 , C12N15/00 , C12N1/21
CPC分类号： C12N15/625 , C07K14/195 , C07K2319/01 , C12N1/20 , C12P7/6463 , C12P21/02
摘要： The present invention relates to a method of targeting a protein of interest to an intracellular hydrophobic inclusion body of a bacterial cell by means of a fusion protein comprising a hydrophobic targeting peptide operatively linked with said protein of interest; methods of microbial production of a lipophilic compound of interest by means of a recombinant bacterial host comprising intracellular inclusion bodies having at least one enzyme which is involved in the biosynthesis of said lipophilic compound targeted to said inclusion bodies; as well as corresponding fusion proteins, coding sequences, expression vectors and recombinant hosts.
摘要翻译：本发明涉及通过融合蛋白将目的蛋白质靶向细菌细胞的细胞内疏水性包涵体的方法，所述融合蛋白包含与所述感兴趣的蛋白质可操作地连接的疏水性靶向肽; 通过包含细胞内包涵体的重组细菌宿主微生物生产感兴趣的亲脂性化合物的方法，所述细胞内包涵体具有至少一种涉及所述包涵体的所述亲脂性化合物的生物合成的酶; 以及相应的融合蛋白，编码序列，表达载体和重组宿主。

2. 再颁专利

USRE37543E1 DNA sequence useful for the production of polyhydroxyalkanoates 有权
标题翻译：可用于生产聚羟基链烷酸酯的DNA序列
公开(公告)号：USRE37543E1
公开(公告)日：2002-02-05
申请号：US09570842
申请日：2000-05-12
申请人： Niels Krüger , Alexander Steinbüchel
发明人： Niels Krüger , Alexander Steinbüchel
IPC分类号： C12N121
CPC分类号： C12P7/625 , C12N9/1029 , C12N15/8243
摘要： A genomic fragment harboring the gene phaG was cloned by phenotype complementation of Pseudomonas putida KT2440 mutants, defective in the polyhydroxyalkanoic acid (PHA) synthesis via de novo fatty acid biosynthesis but not affected in PHA biosynthesis via fatty acid &bgr;-oxidation. The 885-bp phaG gene encodes a protein of 295 amino acids with a molecular weight of 33.876 Da. The transcriptional induction of phaG could be observed under conditions of PHA synthesis via de novo fatty acid biosynthesis whereas no induction was detected under conditions which favor PHA synthesis via fatty acid degradation by &bgr;-oxidation. The phaG gene is useful for the production of PHAs in bacteria and plants.
摘要翻译：携带基因phaG的基因组片段通过假单胞菌属假单胞菌KT2440突变体的表型互补克隆，其通过从头脂肪酸生物合成在聚羟基链烷酸（PHA）合成中缺陷，但通过脂肪酸β-氧化不受PHA生物合成的影响。 885 bp的phaG基因编码295个氨基酸的蛋白质，分子量为33.876Da。 phaG的转录诱导可以通过从头脂肪酸生物合成的PHA合成条件下观察到，而在通过β-氧化的脂肪酸降解有利于PHA合成的条件下，没有检测到诱导。 phaG基因可用于在细菌和植物中生产PHAs。

3. 发明申请

US20140087428A1 Microorganisms And Methods For Producing Substituted Phenols 有权
标题翻译：微生物和生产取代苯酚的方法
公开(公告)号：US20140087428A1
公开(公告)日：2014-03-27
申请号：US13985261
申请日：2012-06-18
申请人： Stefan Lambrecht , Jens-Michael Hilmer , Manuel Pesaro , Jens Kroll , Gunda Hansen , Alexander Steinbüchel , Christian Fleige
发明人： Stefan Lambrecht , Jens-Michael Hilmer , Manuel Pesaro , Jens Kroll , Gunda Hansen , Alexander Steinbüchel , Christian Fleige
IPC分类号： C12P19/32 , C12P7/42 , C12P7/22 , C12P7/24
CPC分类号： C12P19/32 , C12N9/0008 , C12P7/22 , C12P7/24 , C12P7/42 , C12Y102/01067 , Y02P20/52
摘要： The present invention is concerned with methods for producing vanillin, feroyl-CoA, ferulic acid, coniferyl aldehyde and/or coniferyl alcohol. Also, the invention relates to microorganisms useful in such production method, and to the construction of such microorganisms.
摘要翻译：本发明涉及生产香草醛，芳酰基-CoA，阿魏酸，松柏醛和/或松柏醇的方法。此外，本发明涉及可用于这种生产方法的微生物和这种微生物的构建。

4. 发明授权

US06759219B2 Methods for the biosynthesis of polyesters 有权
标题翻译：聚酯的生物合成方法
公开(公告)号：US06759219B2
公开(公告)日：2004-07-06
申请号：US09380773
申请日：1999-09-03
申请人： Silke Hein , Brigitte Söhling , Gerhard Gottschalk , Alexander Steinbüchel
发明人： Silke Hein , Brigitte Söhling , Gerhard Gottschalk , Alexander Steinbüchel
IPC分类号： C12P762
CPC分类号： C12N9/93 , C07H21/04 , C12N9/1029 , C12N9/13 , C12N15/8243 , C12P7/625
摘要： Coexpression of a polyhydroxyalkanoic acid synthase and either a fatty acid: acyl-CoA transferase or an acyl-CoA synthetase in cells enables the biosynthesis of polyester materials. Plasmids, bacteria, materials, and methods for the preparation of polyesters are disclosed.
摘要翻译：聚羟基链烷酸合酶和脂肪酸：酰基-CoA转移酶或酰基-CoA合成酶在细胞中的共表达使得能够生物合成聚酯材料。公开了用于制备聚酯的质粒，细菌，材料和方法。

5. 发明申请

US20120015413A1 Microorganisms with Extended Substrate Utilization Range 有权
标题翻译：具有扩展底物利用范围的微生物
公开(公告)号：US20120015413A1
公开(公告)日：2012-01-19
申请号：US13183638
申请日：2011-07-15
申请人： Shanna Sichwart , Birgit Haschenhermes , Daniel Bröker , Alexander Steinbüchel , Stephan Hetzler , Perttu Koskinen
发明人： Shanna Sichwart , Birgit Haschenhermes , Daniel Bröker , Alexander Steinbüchel , Stephan Hetzler , Perttu Koskinen
IPC分类号： C12P7/64 , C12P7/62 , C12P1/04 , C12N1/21 , C12N15/74
CPC分类号： C12N9/90 , C07K14/245 , C12N1/20 , C12N1/22 , C12N9/001 , C12N9/1205 , C12P7/625
摘要： The present invention relates to a microorganism of the genus Cupriavidus or Ralstonia, which is genetically modified to express phosphomannose isomerase (EC5.3.1.8) and facilitated diffusion protein for mannose uptake (EC1.3.1.74), and optionally mannofructokinase (EC2.7.1.4) and/or xylose isomerase (EC 5.3.1.5), xylulokinase (E 2.7.1.17) and xylose proton symporter E or a high affinity ABC-transporter. A modified Cupriavidus or Ralstonia host is capable of growing on mannose, xylose, arabinose, glucose, or galactose, or a combination thereof as the carbon source.
摘要翻译：本发明涉及一种经遗传修饰以表达磷酸甘露糖异构酶（EC5.3.1.8）并促进甘露糖摄取的扩散蛋白（EC1.3.1.74）和任选的甘露糖肌苷酸酶（EC2）的微生物。 7.1.4）和/或木糖异构酶（EC 5.3.1.5），木酮糖激酶（E 2.7.1.17）和木糖质子转运蛋白E或高亲和力ABC转运蛋白。修饰的Cupriavidus或Ralstonia宿主能够在甘露糖，木糖，阿拉伯糖，葡萄糖或半乳糖或其组合作为碳源生长。

6. 发明授权

US06770464B2 Methods for producing poly(hydroxy) fatty acids in bacteria 有权
标题翻译：在细菌中生产聚（羟基）脂肪酸的方法
公开(公告)号：US06770464B2
公开(公告)日：2004-08-03
申请号：US09779427
申请日：2001-02-08
申请人： Alexander Steinbüchel , Mathias Liebergesell , Henry Valentin , Andreas Pries
发明人： Alexander Steinbüchel , Mathias Liebergesell , Henry Valentin , Andreas Pries
IPC分类号： C12P764
CPC分类号： C12N9/00 , C07C59/10 , C12P7/625
摘要： The present invention relates to a process for the production of poly (hydroxy fatty acids) as well as recombinant bacterial strains for carrying out the process. In addition, new poly(hydroxy fatty acids) and new substrates for the production of conventional and new poly(hydroxy fatty acids) are described. Moreover, the invention also relates to a DNA fragment, which codes for a PhaE and a PhaC component of the poly(hydroxy fatty acid) synthase from Thiocapsa pfennigii, as well as the corresponding poly (hydroxy fatty acid) synthase protein.
摘要翻译：本发明涉及一种生产聚（羟基脂肪酸）的方法以及用于进行该方法的重组细菌菌株。此外，还描述了用于生产常规和新的聚（羟基脂肪酸）的新的聚（羟基脂肪酸）和新的底物。此外，本发明还涉及一种DNA片段，其编码来自Thiocapsa pfennigii的聚（羟基脂肪酸）合酶的PhaE和PhaC组分以及相应的聚（羟基脂肪酸）合酶蛋白。

7. 发明授权

US06524831B2 Synthetic enzymes for the production of coniferyl alcohol, coniferylaldehyde, ferulic acid, vanillin and vanillic acid and their use 失效
标题翻译：用于生产针叶树醇，松柏醛，阿魏酸，香草醛和香草酸的合成酶及其用途
公开(公告)号：US06524831B2
公开(公告)日：2003-02-25
申请号：US08976063
申请日：1997-11-21
申请人： Alexander Steinbüchel , Horst Priefert , Jürgen Rabenhorst
发明人： Alexander Steinbüchel , Horst Priefert , Jürgen Rabenhorst
IPC分类号： C12N902
CPC分类号： C12N9/0083 , C12N9/0004 , C12N9/80 , C12P7/22
摘要： The present invention relates to synthetic enzymes for the production of coniferyl alcohol, coniferylaldehyde, ferulic acid, vanillin and vanillic acid, the use thereof for the production of coniferyl alcohol, coniferylaldehyde, ferulic acid, vanillin and vanillic acid, DNA coding for these enzymes and microorganisms transformed with this DNA.
摘要翻译：本发明涉及用于生产针叶树醇，松柏醛，阿魏酸，香草醛和香草酸的合成酶，其用于生产针叶树醇，松柏醛，阿魏酸，香草醛和香草酸的用途，编码这些酶的DNA和用该DNA转化的微生物。

8. 发明授权

US09567618B2 Microorganisms and methods for producing substituted phenols 有权
标题翻译：微生物和生产取代酚的方法
公开(公告)号：US09567618B2
公开(公告)日：2017-02-14
申请号：US13985261
申请日：2012-06-18
申请人： Stefan Lambrecht , Jens-Michael Hilmer , Manuel Pesaro , Jens Kroll , Gunda Hansen , Alexander Steinbüchel , Christian Fleige
发明人： Stefan Lambrecht , Jens-Michael Hilmer , Manuel Pesaro , Jens Kroll , Gunda Hansen , Alexander Steinbüchel , Christian Fleige
IPC分类号： C12N1/12 , C12Q1/68 , C12N9/04 , C12N1/20 , C12N15/00 , C07H21/04 , C12P7/42 , C12P1/06 , C12P7/00 , C12P19/32 , C12N9/02 , C12P7/22 , C12P7/24
CPC分类号： C12P19/32 , C12N9/0008 , C12P7/22 , C12P7/24 , C12P7/42 , C12Y102/01067 , Y02P20/52
摘要： The present invention is concerned with methods for producing vanillin, feroyl-CoA, ferulic acid, coniferyl aldehyde and/or coniferyl alcohol. Also, the invention relates to microorganisms useful in such production method, and to the construction of such microorganisms.
摘要翻译：本发明涉及生产香草醛，芳酰基-CoA，阿魏酸，松柏醛和/或松柏醇的方法。此外，本发明涉及可用于这种生产方法的微生物和这种微生物的构建。

9. 发明授权

US08986960B2 Microorganisms with extended substrate utilization range 有权
标题翻译：具有延长底物利用范围的微生物
公开(公告)号：US08986960B2
公开(公告)日：2015-03-24
申请号：US13183638
申请日：2011-07-15
申请人： Shanna Sichwart , Birgit Haschenhermes , Daniel Bröker , Alexander Steinbüchel , Stephan Hetzler , Perttu Koskinen
发明人： Shanna Sichwart , Birgit Haschenhermes , Daniel Bröker , Alexander Steinbüchel , Stephan Hetzler , Perttu Koskinen
IPC分类号： C12N9/90 , C12N1/20 , C12N1/22 , C12N9/02 , C12N9/12 , C12P7/62
CPC分类号： C12N9/90 , C07K14/245 , C12N1/20 , C12N1/22 , C12N9/001 , C12N9/1205 , C12P7/625
摘要： Disclosed are microorganisms of the genus Cupriavidus or Ralstonia, which are genetically modified to express phosphomannose isomerase (EC5.3.1.8) and facilitated diffusion protein (EC1.3.1.74) for mannose uptake, and optionally mannofructokinase (EC2.7.1.4). The microorganisms also may be genetically modified to express xylose isomerase (EC 5.3.1.5), xylulokinase (E 2.7.1.17) and xylose proton symporter E or a high affinity ABC-transporter. The genetically modified microorganisms are capable of growing on mannose, xylose, arabinose, glucose, or galactose, or a combination thereof as the carbon source.
摘要翻译：披露了Cupriavidus或Ralstonia属的微生物，其被遗传修饰以表达磷酸甘露糖异构酶（EC5.3.1.8）并促进扩增蛋白（EC1.3.1.74）用于甘露糖摄取，并且可选地甘露糖肌苷酸酶（EC2.7.1.4）。微生物也可以被遗传修饰以表达木糖异构酶（EC 5.3.1.5），木酮糖激酶（E 2.7.1.17）和木糖质子转运蛋白E或高亲和力ABC转运蛋白。遗传修饰的微生物能够在甘露糖，木糖，阿拉伯糖，葡萄糖或半乳糖或其组合作为碳源生长。

10. 发明授权

US08980845B2 Biotechnological production of cyanophycin dipeptides 有权
标题翻译：生物技术生产的蓝藻素二肽
公开(公告)号：US08980845B2
公开(公告)日：2015-03-17
申请号：US12995762
申请日：2009-06-15
申请人： Ahmed Sallam , Alexander Steinbüchel
发明人： Ahmed Sallam , Alexander Steinbüchel
IPC分类号： C07K5/06 , C07K4/04 , C12P13/04 , A61K38/05 , C12P21/06 , A23K1/16 , A23L1/305 , A61K38/16 , C12N9/52
CPC分类号： A61K38/05 , A23K20/147 , A23L33/18 , A23L33/30 , A23V2002/00 , A61K38/164 , C12N9/485 , C12N9/52 , C12P21/06 , C12Y304/15006 , Y02A50/473 , Y02A50/481
摘要： The present invention relates to a process for the enzymatic production of a dipeptide composition from a cyanophycin (CGP) or CGP-like polymer preparation by degrading the polymer preparation with an CGPase, a CGPase particularly adapted for said process, and the use of cyanophycin (CGP) or CGP-like polymers or fragments thereof, notably a dipeptide composition obtained by the process as defined above, as pharmaceutical composition, medicament, or as food or feed substitute.
摘要翻译：本发明涉及一种通过使用CGPase降解聚合物制剂，特别适用于所述方法的CGP酶，将来自氰磷霉素（CGP）或CGP样聚合物制剂的二肽组合物酶促生产的方法和使用氰霉素 CGP）或CGP样聚合物或其片段，特别是通过上述方法获得的二肽组合物作为药物组合物，药物或作为食品或饲料替代物。

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