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    • 1. 发明授权
    • Process for the preparation of substituted thiazolines and their intermediates
    • 制备取代噻唑啉及其中间体的方法
    • US06894170B2
    • 2005-05-17
    • US10270324
    • 2002-10-15
    • Sylvia KrichAlexander RiederFerdinand HeuGerhard Steinbauer
    • Sylvia KrichAlexander RiederFerdinand HeuGerhard Steinbauer
    • C12P41/00C07B55/00C07B57/00C07C319/02C07C319/28C07C323/58C07D277/12C07D417/04C07D277/10
    • C07D417/04C07C319/02C07D277/12C07C323/58
    • Process for the preparation of substituted thiazolines of the formula (I) in which Ar is a phenyl, naphthyl, thienyl, pyridyl or quinolinyl radical which can optionally be substituted by one or more substituents from the group consisting of halogen, OH, benzyloxy, C1-C4-alkyl, C1-C4-alkoxy, COOR1 where R1 is H or C1-C4-alkyl, by coupling of (S)-α-methylcysteine hydrochloride of the formula (II) with a nitrile of the formula (III) Ar—CN in which Ar is as defined above, or a corresponding C1-C4-alkyl imidate, in which (S)-α-methylcysteine hydrochloride of the formula (II) is reacted in a suitable solvent with a nitrile of the formula (III) or a corresponding C1-C4-alkyl imidate in the presence of a tertiary base at a pH of 6.5 to 10 at 50° C. up to the reflux temperature to give the corresponding thiazoline of the formula (I), and processes for the preparation of (S)-α-methylcysteine hydrochloride and its use for the preparation of thiazolines of the formula (I).
    • 制备式(I)的取代噻唑啉的方法,其中Ar是苯基,萘基,噻吩基,吡啶基或喹啉基,其可以任选地被一个或多个选自卤素,OH,苄氧基,C C 1 -C 4 - 亚烷基,C 1 -C 4 - 烷氧基,COOR 1 - 其中R 1是H或C 1 -C 4 - 烷基,通过将(S)-α-甲基半胱氨酸盐酸盐与 式(II)与式(III)的腈<?in-line-formula description =“In-line formula”end =“lead”?> Ar-CN <?in-line-formula description =“In- 其中Ar如上所定义,或其相应的C 1 -C 4 - 亚烷基亚氨酸酯,其中(S) - 式(II)的α-甲基半胱氨酸盐酸盐在合适的溶剂中与式(III)的腈或相应的C 1 -C 4 - 亚烷基亚氨基酯反应 在pH为6.5t的叔碱存在下进行 o 10在50℃直到回流温度,得到相应的式(I)噻唑啉,以及制备(S)-α-甲基半胱氨酸盐酸盐的方法及其用于制备式(I)的噻唑啉的用途 一世)。
    • 2. 发明申请
    • Process for the preparation of substituted thiazolines and their intermediates
    • 制备取代噻唑啉及其中间体的方法
    • US20050101782A1
    • 2005-05-12
    • US11011110
    • 2004-12-15
    • Sylvia KrichAlexander RiederFerdinand HeuGerhard Steinbauer
    • Sylvia KrichAlexander RiederFerdinand HeuGerhard Steinbauer
    • C12P41/00C07B55/00C07B57/00C07C319/02C07C319/28C07C323/58C07D277/12C07D417/04
    • C07D417/04C07C319/02C07D277/12C07C323/58
    • Process for the preparation of substituted thiazolines of the formula (I) in which Ar is a phenyl, naphthyl, thienyl, pyridyl or quinolinyl radical which can optionally be substituted by one or more substituents from the group consisting of halogen, OH, benzyloxy, C1-C4-alkyl, C1-C4-alkoxy, COOR1 where R1 is H or C1-C4-alkyl, by coupling of (S)-α-methylcysteine hydrochloride of the formula (II) with a nitrile of the formula (III) Ar—CN in which Ar is as defined above, or a corresponding C1-C4-alkyl imidate, in which (S)-α-methylcysteine hydrochloride of the formula (II) is reacted in a suitable solvent with a nitrile of the formula (III) or a corresponding C1-C4-alkyl imidate in the presence of a tertiary base at a pH of 6.5 to 10 at 50° C. up to the reflux temperature to give the corresponding thiazoline of the formula (I), and processes for the preparation of (S)-α-methylcysteine hydrochloride and its use for the preparation of thiazolines of the formula (I).
    • 制备式(I)的取代噻唑啉的方法,其中Ar是苯基,萘基,噻吩基,吡啶基或喹啉基,其可以任选地被一个或多个选自卤素,OH,苄氧基,C C 1 -C 4 - 亚烷基,C 1 -C 4 - 烷氧基,COOR 1 - 其中R 1是H或C 1 -C 4 - 烷基,通过将(S)-α-甲基半胱氨酸盐酸盐与 式(II)与式(III)的腈<?in-line-formula description =“In-line formula”end =“lead”?> Ar-CN <?in-line-formula description =“In- 其中Ar如上所定义,或其相应的C 1 -C 4 - 亚烷基亚氨酸酯,其中(S) - 式(II)的α-甲基半胱氨酸盐酸盐在合适的溶剂中与式(III)的腈或相应的C 1 -C 4 - 亚烷基亚氨基酯反应 在pH为6.5的叔碱存在下进行 至10℃,直到回流温度,得到相应的式(I)噻唑啉,以及制备(S)-α-甲基半胱氨酸盐酸盐的方法及其用于制备式(I)的噻唑啉的用途 一世)。
    • 5. 发明授权
    • Fibers for reinforcing matrix materials
    • 用于增强基体材料的纤维
    • US06773646B2
    • 2004-08-10
    • US10624072
    • 2003-07-21
    • Klaus-Alexander RiederNeal S. BerkeStephen J. FylerMichael Macklin
    • Klaus-Alexander RiederNeal S. BerkeStephen J. FylerMichael Macklin
    • D01D1000
    • B29C70/10C04B14/48C04B16/06C08J5/04D01D5/253D01D10/00E04C5/073Y10T428/249932Y10T428/24994Y10T428/2929Y10T428/2933
    • Exemplary mechanically-flattened fibers of the invention comprise generally elongate bodies having varied width or thickness dimensions and micro-diastrophic surface deformities. Preferred fibers are elongate synthetic polymer or multipolymer blend fibers for reinforcing matrix materials such as concrete, shotcrete, gypsum-containing materials, asphalt, plastic, rubber, and other matrix materials. Preferred methods for manufacturing such fibers comprise subjecting synthetic polymer fibers to compressive forces sufficient to achieve flattening and surface micro-diastrophism without substantially shredding and abrading the fibers. Further exemplary fibers and methods involve mechanically-flattening intertwined or braided fibers or fiber bundles, thereby providing fibers having physical impressions thereon of the intertwinement or braidingand, optionally though preferably of micro-diastrophic surface deformities.
    • 本发明的示例性的机械平坦纤维包括具有变化的宽度或厚度尺寸和微尺度表面变形的大体细长体。 优选的纤维是用于增强基体材料的细长的合成聚合物或多聚体共混纤维,例如混凝土,喷浆混凝土,含石膏的材料,沥青,塑料,橡胶和其它基质材料。 用于制造这种纤维的优选方法包括使合成聚合物纤维具有足够的压缩力,以实现扁平化和表面微地壳性,而不会基本上切碎和研磨纤维。 进一步的示例性纤维和方法涉及机械地平坦缠绕或编织的纤维或纤维束,从而提供在其上具有交织或编织的物理印象的纤维,并且任选地优选地具有微小的表面畸形。
    • 7. 发明授权
    • Three-dimensional twisted fibers and processes for making same
    • 三维扭曲纤维及其制造方法
    • US06340522B1
    • 2002-01-22
    • US09615595
    • 2000-07-13
    • Sean BurkeMichael B. MacklinKlaus-Alexander RiederJean-François Trottier
    • Sean BurkeMichael B. MacklinKlaus-Alexander RiederJean-François Trottier
    • D01F600
    • E04C5/073E04C5/012Y10T428/2904Y10T428/2922Y10T428/2976
    • Exemplary fibers of the invention, useful for reinforcing hydratable cementitious materials such as concrete and mortar, have three-dimensional twist curvatures. Preferably, the fibers are flat or flattened and have first and second opposed flat or flattened ends that are twisted out of phase, and which preferably define therebetween an intermediate elongate fiber body having a curvature in more than one direction. Processes of the invention comprise forming a fiber with a three-dimensional twisted shape by twisting at least two fibers together to form a twisted fiber bundle to impart a twist curvature into the fiber material. The twisted fiber bundle can then be cut into separate fibers or stored on bobbins for shipment to another location for cutting. Advantages of the invention include enhanced dispersibility of the fibers in hydratable cementitious compositions.
    • 用于增强可水合胶结材料如混凝土和砂浆的本发明的示例性纤维具有三维扭曲曲率。 优选地,纤维是平的或扁平的并且具有相位扭曲的第一和第二相对的平坦或平坦的端部,并且优选地在其间限定具有多于一个方向上的曲率的中间细长纤维体。 本发明的方法包括通过将至少两根纤维扭曲在一起形成具有三维扭曲形状的纤维,以形成扭曲的纤维束,以向纤维材料赋予扭曲曲率。 然后将扭绞的纤维束切割成单独的纤维或存储在线轴上以便运送到另一个位置进行切割。 本发明的优点包括增加纤维在可水合胶结组合物中的分散性。