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1. 发明申请

WO2003094861A3 BIS-BENZIMIDAZOLES AND RELATED COMPOUNDS AS POTASSIUM CHANNEL MODULATORS 审中-公开
公开(公告)号：WO2003094861A3
公开(公告)日：2003-11-20
申请号：PCT/US2003/015225
申请日：2003-05-13
申请人： ICAGEN, INC. , WANG, Xiaodong , FULP, Alan, Bradley , VAN RHEE, Albert, Michiel , SPEAR, Kerry, Leigh
发明人： WANG, Xiaodong , FULP, Alan, Bradley , VAN RHEE, Albert, Michiel , SPEAR, Kerry, Leigh
IPC分类号： C07D403/10
摘要： The present invention provides a genus of bis-benzimidazole compounds, methods and pharmaceutical compositions that are useful as modulators of potassium ion channels. The compounds of the invention are of use in both therapeutic and diagnostic methods.

2. 发明申请

WO2013021181A1 A DRIVE ARRANGEMENT FOR A WIND TURBINE 审中-公开
标题翻译：风力发电机的驱动装置
公开(公告)号：WO2013021181A1
公开(公告)日：2013-02-14
申请号：PCT/GB2012/051893
申请日：2012-08-03
申请人： DAVID BROWN GEAR SYSTEMS LIMITED , DEWAR, Alan Bradley , EDMONDSON, Scott Douglas , TRAN, Scott
发明人： DEWAR, Alan Bradley , EDMONDSON, Scott Douglas , TRAN, Scott
IPC分类号： F03D11/00 , F16H1/46 , F16H1/28
CPC分类号： H02K7/116 , F03D9/25 , F03D15/00 , F03D15/10 , F03D80/70 , F05B2260/40311 , F16H1/2818 , F16H1/46 , F16H37/041 , F16H57/021 , Y02E10/721 , Y02E10/722 , Y02E10/726
摘要： The invention relates to a drive arrangement for a wind turbine, and to a wind turbine incorporating a drive arrangement. In one embodiment, a drive arrangement (12) for a wind turbine (10) is disclosed which comprises a rotor shaft (20); a gearbox assembly (22) for transferring torque from the rotor shaft to an electrical power generator (18), the gearbox assembly comprising: an input shaft (40); an output shaft (42); a primary gear stage (44); and a secondary gear stage (46), each gear stage having a plurality of planet gears (52; 58) positioned around the output shaft, an annular gear (84; 86) meshed with the planet gears, and a sun gear (82; 88) meshed with the planet gears and arranged to transfer torque to the output shaft. The drive arrangement also comprises a drive transfer mechanism (24) for transferring torque from the rotor shaft into the gearbox assembly via the input shaft; and a primary load carrying member (56) for releasably mounting the gearbox assembly to a housing (34) of the wind turbine. The rotor shaft is at least partly hollow, having an internal cavity (28) in which at least part of the gearbox assembly and at least part of the drive transfer mechanism are located. The gearbox assembly comprising the input shaft, output shaft, primary and secondary gear stages is mountable within the rotor shaft as a single unit by means of the primary load carrying member.
摘要翻译：本发明涉及一种用于风力涡轮机的驱动装置和涉及驱动装置的风力涡轮机。在一个实施例中，公开了一种用于风力涡轮机（10）的驱动装置（12），其包括转子轴（20）; 用于将扭矩从转子轴传递到发电机（18）的变速箱组件（22），所述变速箱组件包括：输入轴（40）; 输出轴（42）; 主齿轮级（44）; 和副齿轮级（46），每个齿轮级具有围绕输出轴定位的多个行星齿轮（52; 58），与行星齿轮啮合的环形齿轮（84; 86）和太阳齿轮（82; 88）与行星齿轮啮合并布置成将扭矩传递到输出轴。驱动装置还包括用于经由输入轴将转矩从转子轴传递到齿轮箱组件中的驱动传递机构（24）以及用于将所述齿轮箱组件可释放地安装到所述风力涡轮机的壳体（34）的主负载承载构件（56）。转子轴至少部分是中空的，具有内腔（28），齿轮箱组件的至少一部分和驱动传递机构的至少一部分位于其中。包括输入轴，输出轴，初级和次级齿轮级的变速箱组件可通过主负载承载构件作为单个单元安装在转子轴内。

3. 发明申请

WO2005121126A1 POLYCYCLIC PYRAZINES AS POTASSIUM ION CHANNEL MODULATORS 审中-公开
标题翻译：聚氯乙烯作为钾离子通道调节剂
公开(公告)号：WO2005121126A1
公开(公告)日：2005-12-22
申请号：PCT/US2005/012525
申请日：2005-04-13
申请人： ICAGEN, INC. , ASTELLAS PHARMA INC. , WANG, Xiaodong , SPEAR, Kerry, Leigh , FULP, Alan, Bradley , SECONI, Darrick , SUZUKI, Takeshi , ISHII, Takahiro , MORITOMO, Ayako
发明人： WANG, Xiaodong , SPEAR, Kerry, Leigh , FULP, Alan, Bradley , SECONI, Darrick , SUZUKI, Takeshi , ISHII, Takahiro , MORITOMO, Ayako
IPC分类号： C07D401/12
CPC分类号： C07D401/14 , C07D213/73 , C07D401/04 , C07D405/04 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/14 , C07D417/14
摘要： The present invention provides a genus of polycyclic pyrazines of formula I (I) that are useful as modulators of potassium ion channels. The modulators of the invention are of use in both therapeutic and diagnostic methods; wherein A and B are independently substituted or unsubstituted 5- or 6-membered heterocycloalkyl, or substituted or unsubstituted 5- or 6- membered heteroaryl, W 1 is formula II (II); W 2 is -CH=, -NH-, -N=, -S-, or -O-; Z 1 is formula III (III) or formula IV (IV); Z 2 is -CH=, -NH-, -N=, -S-, or -O-; Y is a bond, -CH=N-NH-, -NH-CH 2 -, or -NR 5 -; s and t are independently integers from 1 to 4; R 1 , R 2A , R 2B and R 3 are independently or unsubstituted alkyle, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted 3- to 7- membered cycloalkyl,, substituted or unsubstituted 5- to 7-membered heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; and R 5 is H, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted 3- to 7- membered cycloalkyl,, substituted or unsubstituted 5- to 7-membered heterocycloalkyl, substituted or unsubstituted aryl or substituted or unsubstituted heteroaryl; wherein if s is greater than one, then each R 1 is optionally different; wherein if t is greater than on, then each R 3 is optionally different; wherein two R 1 groups are optionally joined together with the atoms to which they are attached to form a substituted or unsubstituted ring; and wherein two R 3 groups are optionally joined together with the atoms to which they are attached to form a susbtituted or unsubstituted ring.
摘要翻译：本发明提供了可用作钾离子通道调节剂的式I（I）的多环吡嗪属。本发明的调节剂可用于治疗和诊断方法; 其中A和B独立地为取代或未取代的5-或6-元杂环烷基，或取代或未取代的5-或6-元杂芳基，W 1为式II（II）; W 2是-CH =，-NH-，-N =，-S-或-O-; Z 1是式III（III）或式IV（IV）; Z 2是-CH =，-NH-，-N =，-S-或-O-; Y是键，-CH = N-NH-，-NH-CH 2 - 或-NR 5 - ; s和t独立地为1至4的整数; R 1，R 2A，R 2B和R 3独立地是未取代的烷基，取代或未取代的烷基，取代或未取代的杂烷基，取代或未取代的3-至7-元环烷基，取代或未取代的 5-至7-元杂环烷基，取代或未取代的芳基或取代或未取代的杂芳基; 并且R 5是H，取代或未取代的烷基，取代或未取代的杂烷基，取代或未取代的3-至7-元环烷基，取代或未取代的5-至7-元杂环烷基，取代或未取代的芳基或取代或未取代的杂芳基 ; 其中如果s大于1，则每个R 1任选地不同; 其中如果t大于on，则每个R 3任选地不同; 其中两个R 1基团任选地与它们所连接的原子连接在一起形成取代或未取代的环; 并且其中两个R 3基团任选地与它们所连接的原子连接在一起以形成未取代或未取代的环。

4. 发明申请

WO2009158425A1 RESPIRATORY AIR TEMPERATURE AND PRESSURE SENSOR 审中-公开
标题翻译：呼吸空气温度和压力传感器
公开(公告)号：WO2009158425A1
公开(公告)日：2009-12-30
申请号：PCT/US2009/048496
申请日：2009-06-24
申请人： DYMEDIX CORPORATION , HENKE, Reinhold , JOHNSTON, Evan, Stuart , JONES, Alan, Bradley
发明人： HENKE, Reinhold , JOHNSTON, Evan, Stuart , JONES, Alan, Bradley
IPC分类号： A61B5/087 , H01L41/113
CPC分类号： H01L41/1132 , A61B5/0878 , A61B5/4818 , A61B5/6819 , A61B5/6833 , A61B2562/0271
摘要： An apparatus and method can be configured to detect respiratory air temperature information and respiratory air pressure information from a patient using a first piezoelectric film (10) and a second piezoelectric film (110), wherein at least a portion of the second piezoelectric film overlaps at least a portion of the first piezoelectric film. In an example, the first and second piezoelectric films can be sized and shaped to be disposed on an upper lip of a subject. In certain examples, the first piezoelectric film can include a non-overlap portion (400) exposed to nasal respiration, and the second piezoelectric film can include a non-overlap portion (300) exposed to oral respiration.
摘要翻译：一种装置和方法可以被配置为使用第一压电膜（10）和第二压电膜（110）来检测来自患者的呼吸空气温度信息和呼吸气压信息，其中第二压电膜的至少一部分重叠在第一压电膜的至少一部分。在一个示例中，第一和第二压电膜的尺寸和形状可被设置在被检体的上唇上。在某些实施例中，第一压电膜可以包括暴露于鼻呼吸的非重叠部分（400），并且第二压电膜可以包括暴露于口腔呼吸的非重叠部分（300）。

5. 发明申请

WO2005113490A1 SULFONE-CONTAINING PRODRUGS 审中-公开
标题翻译：含SULFONE的PRODRUGS
公开(公告)号：WO2005113490A1
公开(公告)日：2005-12-01
申请号：PCT/US2005/018134
申请日：2005-05-23
申请人： ICAGEN, INC. , FULP, Alan, Bradley , MCNAUGHTON-SMITH, Grant, Andrew , REED, Aimee, D. , WANG, Xiaodong
发明人： FULP, Alan, Bradley , MCNAUGHTON-SMITH, Grant, Andrew , REED, Aimee, D. , WANG, Xiaodong
IPC分类号： C07C311/21
CPC分类号： C07D271/06 , C07C311/21 , C07D263/32 , C07D277/28 , C07F9/653
摘要： Compounds, compositions and methods are provided which are useful in the treatment of diseases through the modulation of potassium ion flux through voltage-dependent potassium channels. More particularly, the invention provides sulfone-containing prodrugs, and compositions and methods utilizing sulfone-containing prodrugs that are useful in the treatment of diseases by blocking potassium channels associated with the onset or recurrence of the indicated conditions. Exemplary diseases treatable with the compounds, compositions and methods of the invention include sickle cell disease and glaucoma.
摘要翻译：提供了通过电压依赖钾通道调节钾离子通量可用于治疗疾病的化合物，组合物和方法。更具体地，本发明提供含砜的前药，以及利用含砜前药的组合物和方法，其可用于通过阻断与指定条件的发作或复发相关的钾通道来治疗疾病。用本发明化合物，组合物和方法治疗的示例性疾病包括镰状细胞病和青光眼。

6. 发明申请

WO2005100349A2 POLYCYCLIC PYRIDINES AS POTASSIUM ION CHANNEL MODULATORS 审中-公开
标题翻译：作为钾离子通道调节剂的多环吡啶
公开(公告)号：WO2005100349A2
公开(公告)日：2005-10-27
申请号：PCT/US2005/012837
申请日：2005-04-13
申请人： ICAGEN, INC. , ASTELLAS PHARMA INC. , WANG, Xiaodong , SPEAR, Kerry, Leigh , FULP, Alan, Bradley , SECONI, Darrick , SUZUKI, Takeshi , ISHII, Takahiro , MORITOMO, Ayako , KUBOTA, Hideki , KAZAMI, Jun-ichi
发明人： WANG, Xiaodong , SPEAR, Kerry, Leigh , FULP, Alan, Bradley , SECONI, Darrick , SUZUKI, Takeshi , ISHII, Takahiro , MORITOMO, Ayako , KUBOTA, Hideki , KAZAMI, Jun-ichi
IPC分类号： C07D417/14
CPC分类号： C07D401/04 , C07D213/61 , C07D213/65 , C07D213/73 , C07D213/74 , C07D213/75 , C07D213/80 , C07D213/82 , C07D401/14 , C07D405/04 , C07D409/04 , C07D417/04 , C07D417/14 , C07D453/02 , C07D471/04 , C09B57/10
摘要： The present invention provides a genus of polycyclic pyridines that are useful as modulators of potassium ion channels. The modulators of the invention are of use in both therapeutic and diagnostic methods.
摘要翻译：本发明提供了可用作钾离子通道调节剂的多环吡啶类。本发明的调节剂可用于治疗和诊断方法。

7. 发明申请

WO2005099673A1 POLYCYLIC THIAZOLES AS POTASSIUM ION CHANNEL MODULATORS 审中-公开
标题翻译：多氯联苯作为离子通道调节剂
公开(公告)号：WO2005099673A1
公开(公告)日：2005-10-27
申请号：PCT/US2005/012911
申请日：2005-04-13
申请人： ICAGEN, INC. , ASTELLAS PHARMA INC. , WANG, Xiaodong , SPEAR, Kerry, Leigh , PULP, Alan, Bradley , SECONI, Darrick , SUZUKI, Takeshi , ISHII, Takahiro , MORITOMO, Ayako , KUBOTA, Hideki
发明人： WANG, Xiaodong , SPEAR, Kerry, Leigh , PULP, Alan, Bradley , SECONI, Darrick , SUZUKI, Takeshi , ISHII, Takahiro , MORITOMO, Ayako , KUBOTA, Hideki
IPC分类号： A61K9/20
CPC分类号： C07D417/14
摘要： The present invention provides a genus of polycyclic thiazoles that are useful as modulators of potassium ion channels. The modulators of the invention are of use in both therapeutic and diagnostic methods.
摘要翻译：本发明提供了可用作钾离子通道调节剂的多环噻唑属。本发明的调节剂在治疗和诊断方法中都有用。

8. 发明申请

WO2003094861A2 BIS-BENZIMIDAZOLES AND RELATED COMPOUNDS AS POTASSIUM CHANNEL MODULATORS 审中-公开
标题翻译： BIS-苯并咪唑和相关化合物作为钾通道调节剂
公开(公告)号：WO2003094861A2
公开(公告)日：2003-11-20
申请号：PCT/US2003/015225
申请日：2003-05-13
申请人： ICAGEN, INC. , WANG, Xiaodong , FULP, Alan, Bradley , VAN RHEE, Albert, Michiel , SPEAR, Kerry, Leigh
发明人： WANG, Xiaodong , FULP, Alan, Bradley , VAN RHEE, Albert, Michiel , SPEAR, Kerry, Leigh
IPC分类号： A61K
CPC分类号： C07D235/20 , C07D401/14 , C07D413/10 , C07D417/10 , C07D471/04
摘要： The present invention provides a genus of bis-benzimidazole compounds, methods and pharmaceutical compositions that are useful as modulators of potassium ion channels. The compounds of the invention are of use in both therapeutic and diagnostic methods.
摘要翻译：本发明提供了双苯并咪唑化合物，可用作钾离子通道调节剂的方法和药物组合物。本发明的化合物可用于治疗和诊断方法。

9. 发明申请

WO2005100349A3 POLYCYCLIC PYRIDINES AS POTASSIUM ION CHANNEL MODULATORS 审中-公开
标题翻译：多环吡啶作为钾离子通道调节剂
公开(公告)号：WO2005100349A3
公开(公告)日：2006-03-16
申请号：PCT/US2005012837
申请日：2005-04-13
申请人： ICAGEN INC , ASTELLAS PHARMA INC , WANG XIAODONG , SPEAR KERRY LEIGH , FULP ALAN BRADLEY , SECONI DARRICK , SUZUKI TAKESHI , ISHII TAKAHIRO , MORITOMO AYAKO , KUBOTA HIDEKI , KAZAMI JUN-ICHI
发明人： WANG XIAODONG , SPEAR KERRY LEIGH , FULP ALAN BRADLEY , SECONI DARRICK , SUZUKI TAKESHI , ISHII TAKAHIRO , MORITOMO AYAKO , KUBOTA HIDEKI , KAZAMI JUN-ICHI
IPC分类号： A61K31/4427 , A61P9/10 , C07D213/61 , C07D213/65 , C07D213/73 , C07D213/74 , C07D213/75 , C07D213/80 , C07D213/82 , C07D401/04 , C07D401/14 , C07D405/04 , C07D409/04 , C07D417/04 , C07D417/14 , C07D453/02 , C07D471/04 , C07D419/14 , A61K31/4439 , A61P25/00
CPC分类号： C07D401/04 , C07D213/61 , C07D213/65 , C07D213/73 , C07D213/74 , C07D213/75 , C07D213/80 , C07D213/82 , C07D401/14 , C07D405/04 , C07D409/04 , C07D417/04 , C07D417/14 , C07D453/02 , C07D471/04 , C09B57/10
摘要： The present invention provides a genus of polycyclic pyridines that are useful as modulators of potassium ion channels. The modulators of the invention are of use in both therapeutic and diagnostic methods.
摘要翻译：本发明提供了可用作钾离子通道调节剂的多环吡啶属。本发明的调节剂在治疗和诊断方法中都有用。

10. 发明申请

WO2005002503A2 ASYMMETRIC BENZIMIDAZOLES AND RELATED COMPOUNDS AS POTASSIUM CHANNEL MODULATORS 审中-公开
标题翻译：不对称苯并咪唑及其相关化合物作为钾通道调节剂
公开(公告)号：WO2005002503A2
公开(公告)日：2005-01-13
申请号：PCT/US2004/015155
申请日：2004-05-13
申请人： ICAGEN, INC. , WANG, Xiaodong , FULP, Alan, Bradley
发明人： WANG, Xiaodong , FULP, Alan, Bradley
IPC分类号： A61K
CPC分类号： C07D403/10 , C07D235/08 , C07D401/10 , C07D403/14 , C07D413/10 , C07D413/14 , C07D471/04 , C07D491/04
摘要： The present invention provides a genus of asymmetric benzimidazole compounds, methods and pharmaceutical compositions that are useful as modulators of potassium ion channels. The compounds of the invention are of use in both therapeutic and diagnostic methods.
摘要翻译：本发明提供了一类非对称苯并咪唑化合物，用作钾离子通道调节剂的方法和药物组合物。本发明的化合物可用于治疗和诊断方法。

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