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2. 发明专利

GB2389795A Ankle braces 未知
公开(公告)号：GB2389795A
公开(公告)日：2003-12-24
申请号：GB0214472
申请日：2002-06-22
申请人： ATKINSON JENNIFER ANNE , MOORE TIMOTHY IAN
发明人： MOORE TIMOTHY IAN
IPC分类号： A61F5/01
摘要： A shell 14 for an ankle brace is semi-rigid and has an inner surface shaped to conform to a side surface of a person's leg 18 between an upper extent 62 above the person's ankle bone 30 and a lower extent 50 below the person's ankle bone but above the base of the heel, and between a forward extent 42,46 towards the front of the person's leg and a rearward extent (44,48), Fig 2 towards the rear of the person's leg. The shell has a portion 28 shaped to register the shell with respect to the person's ankle bone 30. The shell is bifurcated by a slot 60 extending from the upper extent towards the registration portion. By registering the shell with respect to the ankle bone, a better fit can be achieved. The bifurcation of the shell facilitates flexing of the shell so that it can adapt to the curvature of the surface of the leg, so as to provide a more comfortable fit of the shell and a more even pressure distribution than if the shell were not bifurcated.

4. 发明申请

WO2008125800A3 MMP ACTIVATED VASCULAR DISRUPTING AGENTS 审中-公开
标题翻译： MMP激活血管破坏剂
公开(公告)号：WO2008125800A3
公开(公告)日：2008-12-04
申请号：PCT/GB2008001043
申请日：2008-03-27
申请人： UNIV BRADFORD , GILL JASON , LOADMAN PAUL , FALCONER ROB , PATTERSON LAURENCE , ATKINSON JENNIFER , BIBBY MIKE
发明人： GILL JASON , LOADMAN PAUL , FALCONER ROB , PATTERSON LAURENCE , ATKINSON JENNIFER , BIBBY MIKE
IPC分类号： A61K47/48 , A61P9/08 , A61P29/02 , A61P35/00 , C07K7/06
CPC分类号： A61K47/48246 , A61K31/165 , A61K31/704 , A61K47/55 , A61K47/60 , A61K47/65 , C07K7/06
摘要： The present invention relates to compounds, and pharmaceutically acceptable salts thereof, comprising a vascular disrupting agent (VDA) associated and a MMP proteolytic cleavage site. The compounds are useful in the treatment of cancer.
摘要翻译：本发明涉及包含相关血管破坏剂（VDA）和MMP蛋白水解切割位点的化合物及其药学上可接受的盐。该化合物可用于治疗癌症。

5. 发明申请

WO2008125800A2 COMPOUNDS 审中-公开
标题翻译：化合物
公开(公告)号：WO2008125800A2
公开(公告)日：2008-10-23
申请号：PCT/GB2008/001043
申请日：2008-03-27
申请人： UNIVERSITY OF BRADFORD , GILL, Jason , LOADMAN, Paul , FALCONER, Rob , PATTERSON, Laurence , ATKINSON, Jennifer , BIBBY, Mike
发明人： GILL, Jason , LOADMAN, Paul , FALCONER, Rob , PATTERSON, Laurence , ATKINSON, Jennifer , BIBBY, Mike
IPC分类号： A61K47/48 , C07K7/06 , A61P35/00 , A61P29/02 , A61P9/08
CPC分类号： A61K47/65 , A61K31/165 , A61K31/704 , A61K47/55 , A61K47/60 , C07K7/06
摘要： The present invention relates to compounds, and pharmaceutically acceptable salts thereof, comprising a vascular disrupting agent (VDA) associated and a MMP proteolytic cleavage site. The compounds are useful in the treatment of cancer.
摘要翻译：本发明涉及包含相关血管破坏剂（VDA）和MMP蛋白水解切割位点的化合物及其药学上可接受的盐。该化合物可用于治疗癌症。

6. 发明申请

WO2010046628A1 COMPOUNDS 审中-公开
标题翻译：化合物
公开(公告)号：WO2010046628A1
公开(公告)日：2010-04-29
申请号：PCT/GB2009/002484
申请日：2009-10-20
申请人： UNIVERSITY OF BRADFORD , FALCONER, Robert, Andrew , GILL, Jason , ATKINSON, Jennifer , LOADMAN, Paul , BIBBY, Michael , PATTERSON, Laurence
发明人： FALCONER, Robert, Andrew , GILL, Jason , ATKINSON, Jennifer , LOADMAN, Paul , BIBBY, Michael , PATTERSON, Laurence
IPC分类号： A61K47/48 , C07K7/06 , A61P35/00
CPC分类号： A61K47/64 , A61K31/135 , A61K31/165 , A61K47/55 , A61K47/556 , A61K47/60 , A61K47/65 , C07K7/06
摘要： The present invention relates to prodrugs of vascular disrupting agents comprising a vascular disrupting agent (VDA) associated with a MMP proteolytic cleavage site and to the use of such prodrugs in the targeted treatment of cancer.
摘要翻译：本发明涉及包含与MMP蛋白水解切割位点相关的血管破坏剂（VDA）的血管破坏剂的前体药物以及在靶向治疗癌症中使用这些前药。

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