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1. 发明申请

WO2006055447A2 CATIONIC NANOPARTICLE HAVING AN INORGANIC CORE 审中-公开
标题翻译：具有无机核心的阳离子纳米颗粒
公开(公告)号：WO2006055447A2
公开(公告)日：2006-05-26
申请号：PCT/US2005041027
申请日：2005-11-15
申请人： GEN ELECTRIC , ACAR HAVVA YAGCI , TORRES ANDREW SOLIZ
发明人： ACAR HAVVA YAGCI , TORRES ANDREW SOLIZ
IPC分类号： A61K49/18 , A61K9/14 , A61K9/51 , A61K47/48
CPC分类号： A61K9/5115 , A61K47/6923 , A61K47/6929 , A61K49/1848 , A61K49/1851 , B82Y5/00
摘要： A cationic nanoparticle 100 having an inorganic core 120 and at least one outer cationic coating 140 is described. The at least one outer cationic coating 140 substantially covers the inorganic core 120 and has at least one organo-silane. The organo-silane includes: -Si(R 1 ) 3 wherein R 1 independently at each occurrence is an alkoxy group, a hydroxyl group, a halide, an alkyl group, or hydrogen, and wherein at least one R 1 of the three R 1 s is not an alkyl group. A nanocomplex 500 having a cationic nanoparticle 100 and at least one oligonucleotide 160 attached to the cationic nanoparticle 100 is also described. Methods of making cationic nanoparticles and nanocomplexes are also described. Also described are methods of delivering an oligonucleotide 160 into a cell in-vitro, to a subject in-vivo, and monitoring the delivery of an oligonucleotide.
摘要翻译：描述了具有无机核心120和至少一个外部阳离子涂层140的阳离子纳米粒子100。至少一个外部阳离子涂层140基本上覆盖无机芯120并具有至少一种有机硅烷。有机硅烷包括：-Si（R 1）3，其中R 1在每次出现时独立地是烷氧基，羟基，卤化物，烷基或氢，并且其中三个R 1的至少一个R 1不是烷基。还描述了具有连接到阳离子纳米颗粒100上的阳离子纳米颗粒100和至少一个寡核苷酸160的纳米复合物500。还描述了制备阳离子纳米颗粒和纳米复合物的方法。还描述了在体外将寡核苷酸160递送到体内的受试者并监测寡核苷酸的递送的方法。

2. 发明申请

WO2005021618A2 PHASE TRANSFER CATALYZED METHOD FOR PREPARATION OF POLYETEHRIMIDES 审中-公开
标题翻译：用于制备聚烯烃的相转移催化方法
公开(公告)号：WO2005021618A2
公开(公告)日：2005-03-10
申请号：PCT/US2004/025799
申请日：2004-08-10
申请人： GENERAL ELECTRIC COMPANY , BRUNELLE, Daniel, Joseph , ACAR, Havva, Yagci , KHOURI, Farid, Fouad , GUGGENHEIM, Thomas, Link , WOODRUFF, David, Winfield , JOHNSON, Norman, Enoch
发明人： BRUNELLE, Daniel, Joseph , ACAR, Havva, Yagci , KHOURI, Farid, Fouad , GUGGENHEIM, Thomas, Link , WOODRUFF, David, Winfield , JOHNSON, Norman, Enoch
IPC分类号： C08G73/10
CPC分类号： C08G73/124 , C08G73/121
摘要： Polyether polymers, such as polyetherimides, are prepared by the reaction of a dihydroxy-substituted aromatic hydrocarbon alkali metal salt, such as bisphenol A disodium salt, with a bis(N-(chlorophthalimido))aromatic compound, such as 1,3-and/or 1,4-bis[N-(4-chlorophthalimido)]benzene, in a solvent such as o-dichlorobenzene and in the presence of a phase transfer catalyst such as a hexaalkylguanidinium chloride. Several embodiments may be employed to improve the method. They comprise employing substantially dry reagents, employing a high solids level in solvent, beginning with an excess of bis(N-(chlorophthalimido))-aromatic compound and incrementally adding alkali metal salt, employing alkali metal salt of small particle size, and using reagents of high purity.
摘要翻译：聚醚聚合物如聚醚酰亚胺通过二羟基取代的芳族烃碱金属盐如双酚A二钠盐与双（N-（氯代邻苯二甲酰亚氨基））芳族化合物例如1,3-和 /或1,4-双[N-（4-氯邻苯二甲酰亚氨基）]苯，在溶剂如邻二氯苯中，并在相转移催化剂如六烷基氯化胍的存在下进行。可以采用几个实施例来改进该方法。它们包括使用基本上干燥的试剂，在溶剂中使用高固体含量，从过量的双（N-（氯代邻苯二甲酰亚胺基）） - 芳族化合物开始，并逐渐加入碱金属盐，使用小粒径的碱金属盐，并使用试剂高纯度。

3. 发明申请

WO2007100473A2 PHASE TRANSFER CATALYZED METHOD FOR PREPARATION OF POLYETHERIMIDES 审中-公开
标题翻译：用于制备聚乙二醇的相转移催化方法
公开(公告)号：WO2007100473A2
公开(公告)日：2007-09-07
申请号：PCT/US2007/003560
申请日：2007-02-09
申请人： GENERAL ELECTRIC COMPANY , BRUNELLE, Daniel, Joseph , ACAR, Havva, Yagci , KHOURI, Farid, Fouad , GUGGENHEIM, Thomas, Link , WOODRUFF, David, Winfield , JOHNSON, Norman, Enoch
发明人： BRUNELLE, Daniel, Joseph , ACAR, Havva, Yagci , KHOURI, Farid, Fouad , GUGGENHEIM, Thomas, Link , WOODRUFF, David, Winfield , JOHNSON, Norman, Enoch
IPC分类号： C08G73/12
CPC分类号： C08G73/12 , C08G73/121 , C08G73/124
摘要： Polyether polymers, such as polyetherimides, are prepared by the reaction of a dihydroxy-substituted aromatic hydrocarbon alkali metal salt, such as bisphenol A disodium salt, with a bis(N-(chlorophthalimido))aromatic compound, such as 1,3- and/or l,4-bis(N-(4-chlorophthalimido))benzene, in a solvent such as o-dichlorobenzene and in the presence of a phase transfer catalyst such as a hexaalkylguanidinium chloride. Several embodiments may be employed to improve the method. They comprise employing substantially dry reagents, employing a high solids level in solvent, beginning with an excess of bis(N-(chlorophthalimido))- aromatic compound and incrementally adding alkali metal salt, employing alkali metal salt of small particle size, and using reagents of high purity.
摘要翻译：聚醚聚合物如聚醚酰亚胺通过二羟基取代的芳族烃碱金属盐如双酚A二钠盐与双（N-（氯代邻苯二甲酰亚胺基））芳族化合物如1,3-和 /或1,4-双（N-（4-氯邻苯二甲酰亚氨基））苯，在溶剂如邻二氯苯中，并在相转移催化剂如六烷基氯化胍的存在下进行。可以采用几个实施例来改进该方法。它们包括使用基本上干的试剂，在溶剂中使用高固体含量，从过量的双（N-（氯代邻苯二甲酰亚胺基）） - 芳族化合物开始，并逐渐加入碱金属盐，使用小粒径的碱金属盐，并使用试剂的高纯度。

4. 发明申请

WO2006055447A3 NANOPARTICLES HAVING A MAGNETIC CORE AND A CATIONIC ORGANO-SILANE COATING FOR THE DELIVERY OF OLIGONUCLEOTIDES 审中-公开
公开(公告)号：WO2006055447A3
公开(公告)日：2006-05-26
申请号：PCT/US2005/041027
申请日：2005-11-15
申请人： GENERAL ELECTRIC COMPANY , ACAR, Havva Yagci , TORRES, Andrew Soliz
发明人： ACAR, Havva Yagci , TORRES, Andrew Soliz
IPC分类号： A61K49/18 , A61K47/48 , A61K9/51 , A61K9/14
摘要： A cationic nanoparticle 100 having an inorganic core 120 and at least one outer cationic coating 140 is described. The at least one outer cationic coating 140 substantially covers the inorganic core 120 and has at least one organo-silane. The organo-silane includes: -Si(R 1 ) 3 wherein R 1 independently at each occurrence is an alkoxy group, a hydroxyl group, a halide, an alkyl group, or hydrogen, and wherein at least one R 1 of the three R 1 s is not an alkyl group. A nanocomplex 500 having a cationic nanoparticle 100 and at least one oligonucleotide 160 attached to the cationic nanoparticle 100 is also described. Methods of making cationic nanoparticles and nanocomplexes are also described. Also described are methods of delivering an oligonucleotide 160 into a cell in-vitro, to a subject in-vivo, and monitoring the delivery of an oligonucleotide.

5. 发明申请

WO2007100473A3 PHASE TRANSFER CATALYZED METHOD FOR PREPARATION OF POLYETHERIMIDES 审中-公开
标题翻译：相转移催化法制备聚醚醚酮
公开(公告)号：WO2007100473A3
公开(公告)日：2007-11-29
申请号：PCT/US2007003560
申请日：2007-02-09
申请人： GEN ELECTRIC , BRUNELLE DANIEL JOSEPH , ACAR HAVVA YAGCI , KHOURI FARID FOUAD , GUGGENHEIM THOMAS LINK , WOODRUFF DAVID WINFIELD , JOHNSON NORMAN ENOCH
发明人： BRUNELLE DANIEL JOSEPH , ACAR HAVVA YAGCI , KHOURI FARID FOUAD , GUGGENHEIM THOMAS LINK , WOODRUFF DAVID WINFIELD , JOHNSON NORMAN ENOCH
IPC分类号： C08G65/00 , C08G73/10 , C08G73/12
CPC分类号： C08G73/12 , C08G73/121 , C08G73/124
摘要： Polyether polymers, such as polyetherimides, are prepared by the reaction of a dihydroxy-substituted aromatic hydrocarbon alkali metal salt, such as bisphenol A disodium salt, with a bis(N-(chlorophthalimido))aromatic compound, such as 1,3- and/or l,4-bis(N-(4-chlorophthalimido))benzene, in a solvent such as o-dichlorobenzene and in the presence of a phase transfer catalyst such as a hexaalkylguanidinium chloride. Several embodiments may be employed to improve the method. They comprise employing substantially dry reagents, employing a high solids level in solvent, beginning with an excess of bis(N-(chlorophthalimido))- aromatic compound and incrementally adding alkali metal salt, employing alkali metal salt of small particle size, and using reagents of high purity.
摘要翻译：通过二羟基取代的芳香烃碱金属盐如双酚A二钠盐与双（N-（氯代邻苯二甲酰亚胺基））芳族化合物如1,3-和和/或1,4-双（N-（4-氯邻苯二甲酰亚胺基））苯在溶剂例如邻二氯苯中并且在相转移催化剂例如六烷基胍氯化物的存在下进行。可以采用几个实施例来改进该方法。它们包括采用基本上干的试剂，在溶剂中使用高固体含量，以过量的双（N-（氯代苯二甲酰亚胺基））芳族化合物开始，并逐渐加入碱金属盐，使用小粒径的碱金属盐，并使用试剂高纯度。

6. 发明申请

WO2005021618A3 PHASE TRANSFER CATALYZED METHOD FOR PREPARATION OF POLYETEHRIMIDES 审中-公开
标题翻译：相转移催化法制备聚醚酰亚胺
公开(公告)号：WO2005021618A3
公开(公告)日：2005-04-21
申请号：PCT/US2004025799
申请日：2004-08-10
申请人： GEN ELECTRIC , BRUNELLE DANIEL JOSEPH , ACAR HAVVA YAGCI , KHOURI FARID FOUAD , GUGGENHEIM THOMAS LINK , WOODRUFF DAVID WINFIELD , JOHNSON NORMAN ENOCH
发明人： BRUNELLE DANIEL JOSEPH , ACAR HAVVA YAGCI , KHOURI FARID FOUAD , GUGGENHEIM THOMAS LINK , WOODRUFF DAVID WINFIELD , JOHNSON NORMAN ENOCH
IPC分类号： C08G73/12 , C08G73/10 , C08G65/40
CPC分类号： C08G73/124 , C08G73/121
摘要： Polyether polymers, such as polyetherimides, are prepared by the reaction of a dihydroxy-substituted aromatic hydrocarbon alkali metal salt, such as bisphenol A disodium salt, with a bis(N-(chlorophthalimido))aromatic compound, such as 1,3-and/or 1,4-bis[N-(4-chlorophthalimido)]benzene, in a solvent such as o-dichlorobenzene and in the presence of a phase transfer catalyst such as a hexaalkylguanidinium chloride. Several embodiments may be employed to improve the method. They comprise employing substantially dry reagents, employing a high solids level in solvent, beginning with an excess of bis(N-(chlorophthalimido))-aromatic compound and incrementally adding alkali metal salt, employing alkali metal salt of small particle size, and using reagents of high purity.
摘要翻译：通过二羟基取代的芳烃烃碱金属盐如双酚A二钠盐与双（N-（氯邻苯二甲酰亚胺基））芳族化合物如1,3-和和/或1,4-双[N-（4-氯邻苯二甲酰亚胺基）]苯在溶剂例如邻二氯苯中并且在相转移催化剂例如六烷基胍氯化物的存在下进行。可以采用几个实施例来改进该方法。它们包括采用基本上干的试剂，在溶剂中使用高固体含量，以过量的双（N-（氯代苯二甲酰亚胺基））芳族化合物开始，并逐渐加入碱金属盐，使用小粒径的碱金属盐，并使用试剂高纯度。

7. 发明申请

WO2005023901A1 COPOLYETHERIMIDES 审中-公开
公开(公告)号：WO2005023901A1
公开(公告)日：2005-03-17
申请号：PCT/US2004/021183
申请日：2004-07-01
申请人： GENERAL ELECTRIC COMPANY , BRUNELLE, Daniel, Joseph , ACAR, Havva, Yagci , KHOURI, Farid, Fouad , RICHARDS, William, David
发明人： BRUNELLE, Daniel, Joseph , ACAR, Havva, Yagci , KHOURI, Farid, Fouad , RICHARDS, William, David
IPC分类号： C08G65/00
CPC分类号： C08G73/123 , C08G73/124 , C08G73/125
摘要： Copolyetherimides comprise phthalimide structural units comprising both 3- and 4- linkages, wherein the designations 3-linkage and 4-linkage refer to the isomeric positions on the phthalimide ring in the totality of phthalimide-comprising structural units in the copolymer. The products have excellent properties, including high glass transition and heat distortion temperatures, high ductility and good melt flow properties, and low polydispersity.
摘要翻译：共聚酰亚胺包括包含3-和4-键的邻苯二甲酰亚胺结构单元，其中3-键和4-键的名称指的是共聚物中邻苯二甲酰亚胺环结构单元总数中邻苯二甲酰亚胺环上的异构体位置。该产品具有优异的性能，包括高玻璃化转变和热变形温度，高延展性和良好的熔体流动性能，以及低多分散性。

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