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1. 发明申请

WO2006055447A3 NANOPARTICLES HAVING A MAGNETIC CORE AND A CATIONIC ORGANO-SILANE COATING FOR THE DELIVERY OF OLIGONUCLEOTIDES 审中-公开
公开(公告)号：WO2006055447A3
公开(公告)日：2006-05-26
申请号：PCT/US2005/041027
申请日：2005-11-15
申请人： GENERAL ELECTRIC COMPANY , ACAR, Havva Yagci , TORRES, Andrew Soliz
发明人： ACAR, Havva Yagci , TORRES, Andrew Soliz
IPC分类号： A61K49/18 , A61K47/48 , A61K9/51 , A61K9/14
摘要： A cationic nanoparticle 100 having an inorganic core 120 and at least one outer cationic coating 140 is described. The at least one outer cationic coating 140 substantially covers the inorganic core 120 and has at least one organo-silane. The organo-silane includes: -Si(R 1 ) 3 wherein R 1 independently at each occurrence is an alkoxy group, a hydroxyl group, a halide, an alkyl group, or hydrogen, and wherein at least one R 1 of the three R 1 s is not an alkyl group. A nanocomplex 500 having a cationic nanoparticle 100 and at least one oligonucleotide 160 attached to the cationic nanoparticle 100 is also described. Methods of making cationic nanoparticles and nanocomplexes are also described. Also described are methods of delivering an oligonucleotide 160 into a cell in-vitro, to a subject in-vivo, and monitoring the delivery of an oligonucleotide.

2. 发明申请

WO2006055447A2 CATIONIC NANOPARTICLE HAVING AN INORGANIC CORE 审中-公开
标题翻译：具有无机核心的阳离子纳米颗粒
公开(公告)号：WO2006055447A2
公开(公告)日：2006-05-26
申请号：PCT/US2005041027
申请日：2005-11-15
申请人： GEN ELECTRIC , ACAR HAVVA YAGCI , TORRES ANDREW SOLIZ
发明人： ACAR HAVVA YAGCI , TORRES ANDREW SOLIZ
IPC分类号： A61K49/18 , A61K9/14 , A61K9/51 , A61K47/48
CPC分类号： A61K9/5115 , A61K47/6923 , A61K47/6929 , A61K49/1848 , A61K49/1851 , B82Y5/00
摘要： A cationic nanoparticle 100 having an inorganic core 120 and at least one outer cationic coating 140 is described. The at least one outer cationic coating 140 substantially covers the inorganic core 120 and has at least one organo-silane. The organo-silane includes: -Si(R 1 ) 3 wherein R 1 independently at each occurrence is an alkoxy group, a hydroxyl group, a halide, an alkyl group, or hydrogen, and wherein at least one R 1 of the three R 1 s is not an alkyl group. A nanocomplex 500 having a cationic nanoparticle 100 and at least one oligonucleotide 160 attached to the cationic nanoparticle 100 is also described. Methods of making cationic nanoparticles and nanocomplexes are also described. Also described are methods of delivering an oligonucleotide 160 into a cell in-vitro, to a subject in-vivo, and monitoring the delivery of an oligonucleotide.
摘要翻译：描述了具有无机核心120和至少一个外部阳离子涂层140的阳离子纳米粒子100。至少一个外部阳离子涂层140基本上覆盖无机芯120并具有至少一种有机硅烷。有机硅烷包括：-Si（R 1）3，其中R 1在每次出现时独立地是烷氧基，羟基，卤化物，烷基或氢，并且其中三个R 1的至少一个R 1不是烷基。还描述了具有连接到阳离子纳米颗粒100上的阳离子纳米颗粒100和至少一个寡核苷酸160的纳米复合物500。还描述了制备阳离子纳米颗粒和纳米复合物的方法。还描述了在体外将寡核苷酸160递送到体内的受试者并监测寡核苷酸的递送的方法。

3. 发明申请

WO2005122022A2 METHOD FOR IDENTIFYING SUB-SEQUENCES OF INTEREST IN A SEQUENCE 审中-公开
标题翻译：用于识别序列中利益的子序列的方法
公开(公告)号：WO2005122022A2
公开(公告)日：2005-12-22
申请号：PCT/US2005017552
申请日：2005-05-19
申请人： GEN ELECTRIC , EVANS SCOTT CHARLES , BUSH STEPHEN FRANCIS , TORRES ANDREW SOLIZ
发明人： EVANS SCOTT CHARLES , BUSH STEPHEN FRANCIS , TORRES ANDREW SOLIZ
IPC分类号： G01N33/48 , G01N33/50 , G06F17/30
CPC分类号： G06F19/22
摘要： The present technique provides for the analysis of a data series to identify sequences of interest within the series. The analysis may be used to iteratively update a grammar used to analyze the data series or updated versions of the data series. Furthermore, the technique provides for the calculation of a minimum description length heuristic, such as a symbol compression ratio, for each sub-sequence of the analyzed data sequence. The technique may then compare a selected heuristic value against one or more reference conditions to determine if additional iteration is to be performed. The grammar and the data sequence may be updated between iterations to include a symbol representing a string corresponding to the selected heuristic value based upon a non-termination result of the comparison. Alternatively, the string corresponding to the selected heuristic value may be identified as a sequence of interest based upon a termination result of the comparison.
摘要翻译：本技术提供数据序列的分析以识别该系列内的感兴趣序列。该分析可用于迭代地更新用于分析数据系列或数据系列的更新版本的语法。此外，该技术提供了对分析数据序列的每个子序列的最小描述长度启发式（例如符号压缩比）的计算。然后，技术可以将所选择的启发式值与一个或多个参考条件进行比较，以确定是否要执行附加迭代。可以在迭代之间更新语法和数据序列，以基于比较的非终止结果来包括表示对应于所选择的启发式值的字符串的符号。或者，可以基于比较的终止结果将对应于所选择的启发式值的字符串识别为感兴趣的序列。

4. 发明申请

WO2010076237A2 NANOPARTICLE CONTRAST AGENTS FOR DIAGNOSTIC IMAGING 审中-公开
标题翻译：用于诊断成像的纳米对比剂
公开(公告)号：WO2010076237A2
公开(公告)日：2010-07-08
申请号：PCT/EP2009/067468
申请日：2009-12-18
申请人： GENERAL ELECTRIC COMPANY , GE HEALTHCARE AS , COLBORN, Robert Edgar , BONITATIBUS JR., Peter John , TORRES, Andrew Soliz , MARINO, Michael Ernest , BUTTS, Matthew David , KULKARNI, Amit , BALES, Brian C. , HAY, Bruce Allan
发明人： COLBORN, Robert Edgar , BONITATIBUS JR., Peter John , TORRES, Andrew Soliz , MARINO, Michael Ernest , BUTTS, Matthew David , KULKARNI, Amit , BALES, Brian C. , HAY, Bruce Allan
IPC分类号： A61K49/04 , A61K49/18
CPC分类号： A61K49/0428 , A61K49/1848 , B82Y5/00
摘要： Nanoparticles (10) functionalized with at least one zwitterionic moiety, and compositions comprising said nanoparticles are provided. The nanoparticles (10) have characteristics that result in minimal retention of the particles in the body compared to other nanoparticles. The nanoparticle (10) comprises a core (20), having a core surface (30) essentially free of silica, and a shell (40) attached to the core surface (30). The shell (40) comprises at least one silane- functionalized zwitterionic moiety. Further, methods of making said nanoparticles and methods of their use as diagnostic agents are provided.
摘要翻译：提供用至少一个两性离子部分官能化的纳米颗粒（10）和包含所述纳米颗粒的组合物。与其他纳米颗粒相比，纳米颗粒（10）具有导致颗粒在体内的最小保留的特征。纳米颗粒（10）包括具有基本上不含二氧化硅的芯表面（30）和连接到芯表面（30）的壳体（40）的芯体（20）。壳（40）包含至少一个硅烷官能化的两性离子部分。此外，提供制备所述纳米颗粒的方法及其用作诊断剂的方法。

5. 发明申请

WO2010076237A3 NANOPARTICLE CONTRAST AGENTS FOR DIAGNOSTIC IMAGING 审中-公开
标题翻译：用于诊断成像的纳米对比剂
公开(公告)号：WO2010076237A3
公开(公告)日：2011-02-03
申请号：PCT/EP2009067468
申请日：2009-12-18
申请人： GEN ELECTRIC , GE HEALTHCARE AS , COLBORN ROBERT EDGAR , BONITATIBUS JR PETER JOHN , TORRES ANDREW SOLIZ , MARINO MICHAEL ERNEST , BUTTS MATTHEW DAVID , KULKARNI AMIT , BALES BRIAN C , HAY BRUCE ALLAN
发明人： COLBORN ROBERT EDGAR , BONITATIBUS JR PETER JOHN , TORRES ANDREW SOLIZ , MARINO MICHAEL ERNEST , BUTTS MATTHEW DAVID , KULKARNI AMIT , BALES BRIAN C , HAY BRUCE ALLAN
IPC分类号： A61K49/04 , A61K49/18
CPC分类号： A61K49/0428 , A61K49/1848 , B82Y5/00
摘要： Nanoparticles (10) functionalized with at least one zwitterionic moiety, and compositions comprising said nanoparticles are provided. The nanoparticles (10) have characteristics that result in minimal retention of the particles in the body compared to other nanoparticles. The nanoparticle (10) comprises a core (20), having a core surface (30) essentially free of silica, and a shell (40) attached to the core surface (30). The shell (40) comprises at least one silane- functionalized zwitterionic moiety. Further, methods of making said nanoparticles and methods of their use as diagnostic agents are provided.
摘要翻译：提供用至少一个两性离子部分官能化的纳米颗粒（10）和包含所述纳米颗粒的组合物。与其他纳米颗粒相比，纳米颗粒（10）具有导致颗粒在体内的最小保留的特征。纳米颗粒（10）包括具有基本上不含二氧化硅的芯表面（30）和连接到芯表面（30）的壳体（40）的芯体（20）。壳（40）包含至少一个硅烷官能化的两性离子部分。此外，提供制备所述纳米颗粒的方法及其用作诊断剂的方法。

6. 发明申请

WO2010125088A3 NANOPARTICLE CONTRAST AGENTS FOR DIAGNOSTIC IMAGING 审中-公开
公开(公告)号：WO2010125088A3
公开(公告)日：2010-11-04
申请号：PCT/EP2010/055685
申请日：2010-04-28
申请人： GENERAL ELECTRIC COMPANY , GE HEALTHCARE AS , COLBORN, Robert Edgar , BONITATIBUS JR., Peter John , TORRES, Andrew Soliz , MARINO, Michael Ernest , BUTTS, Matthew David , KULKARNI, Amit , BALES, Brian, C. , HAY, Bruce Allan
发明人： COLBORN, Robert Edgar , BONITATIBUS JR., Peter John , TORRES, Andrew Soliz , MARINO, Michael Ernest , BUTTS, Matthew David , KULKARNI, Amit , BALES, Brian, C. , HAY, Bruce Allan
IPC分类号： A61K49/04 , A61K49/18
摘要： Compositions of nanoparticles functionalized with at least one net positively charged group and at least one net negatively charged group, methods for making a plurality of nanoparticles, and methods of their use as diagnostic agents are provided. The nanoparticles have characteristics that result in minimal retention of the particles in the body compared to other nanoparticles. The nanoparticle comprises a coreand a shell. The shell comprises a plurality of silane moieties; at least one silane moiety of the plurality is functionalized with a net positively charged group and at least one silane moiety of the plurality is functionalized with a net negatively charged group.

7. 发明申请

WO2010125088A2 NANOPARTICLE CONTRAST AGENTS FOR DIAGNOSTIC IMAGING 审中-公开
标题翻译：用于诊断成像的纳米对比剂
公开(公告)号：WO2010125088A2
公开(公告)日：2010-11-04
申请号：PCT/EP2010055685
申请日：2010-04-28
申请人： GEN ELECTRIC , GE HEALTHCARE AS , COLBORN ROBERT EDGAR , BONITATIBUS JR PETER JOHN , TORRES ANDREW SOLIZ , MARINO MICHAEL ERNEST , BUTTS MATTHEW DAVID , KULKARNI AMIT , BALES BRIAN C , HAY BRUCE ALLAN
发明人： COLBORN ROBERT EDGAR , BONITATIBUS JR PETER JOHN , TORRES ANDREW SOLIZ , MARINO MICHAEL ERNEST , BUTTS MATTHEW DAVID , KULKARNI AMIT , BALES BRIAN C , HAY BRUCE ALLAN
IPC分类号： A61K49/04
CPC分类号： A61K49/0428 , A61K49/1848 , B82Y5/00
摘要： Compositions of nanoparticles functionalized with at least one net positively charged group and at least one net negatively charged group, methods for making a plurality of nanoparticles, and methods of their use as diagnostic agents are provided. The nanoparticles have characteristics that result in minimal retention of the particles in the body compared to other nanoparticles. The nanoparticle comprises a coreand a shell. The shell comprises a plurality of silane moieties; at least one silane moiety of the plurality is functionalized with a net positively charged group and at least one silane moiety of the plurality is functionalized with a net negatively charged group.
摘要翻译：提供了用至少一个净正电荷基团和至少一个净负电荷基团官能化的纳米颗粒的组合物，制备多个纳米颗粒的方法及其用作诊断剂的方法。与其他纳米颗粒相比，纳米颗粒具有导致颗粒在体内的最小保留的特征。纳米颗粒包括芯和壳。壳包含多个硅烷部分; 多个的至少一个硅烷部分用净正电荷基团官能化，并且多个的至少一个硅烷部分用净带负电基团官能化。

8. 发明申请

WO2005122022A3 METHOD FOR IDENTIFYING SUB-SEQUENCES OF INTEREST IN A SEQUENCE 审中-公开
公开(公告)号：WO2005122022A3
公开(公告)日：2005-12-22
申请号：PCT/US2005/017552
申请日：2005-05-19
申请人： GENERAL ELECTRIC COMPANY , EVANS, Scott, Charles , BUSH, Stephen, Francis , TORRES, Andrew, Soliz
发明人： EVANS, Scott, Charles , BUSH, Stephen, Francis , TORRES, Andrew, Soliz
IPC分类号： G06F19/00
摘要： The present technique provides for the analysis of a data series to identify sequences of interest within the series. The analysis may be used to iteratively update a grammar used to analyze the data series or updated versions of the data series. Furthermore, the technique provides for the calculation of a minimum description length heuristic, such as a symbol compression ratio, for each sub-sequence of the analyzed data sequence. The technique may then compare a selected heuristic value against one or more reference conditions to determine if additional iteration is to be performed. The grammar and the data sequence may be updated between iterations to include a symbol representing a string corresponding to the selected heuristic value based upon a non-termination result of the comparison. Alternatively, the string corresponding to the selected heuristic value may be identified as a sequence of interest based upon a termination result of the comparison.

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