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1. 发明专利

JP4527356B2 Antioxidants consisting of a composition having an antioxidant effect 有权
公开(公告)号：JP4527356B2
公开(公告)日：2010-08-18
申请号：JP2003027902
申请日：2003-02-05
申请人：三和酒類株式会社 , 株式会社大麦発酵研究所
发明人：俊彦内海 , 美保子古寺 , 吉史古田 , 英樹外薗 , 俊郎大森 , 泰史梅本
IPC分类号： C09K15/34 , C12F3/08 , A61K9/19 , A61K36/06 , A61K36/899 , A61P1/04 , A61P3/10 , A61P9/10 , A61P9/12 , A61P17/00 , A61P17/10 , A61P35/00 , A61P39/06 , C09K15/06 , C09K15/08

4. 发明专利

JP2005065647A Method for producing useful substance by utilizing bacterium that can produce useful product that produces bacteriocin 有权
标题翻译：通过利用细菌生产有用的物质的方法，可以生产有用的产品，生产细菌
公开(公告)号：JP2005065647A
公开(公告)日：2005-03-17
申请号：JP2003303560
申请日：2003-08-27
申请人： Omugi Hakko Kenkyusho:Kk , Sanwa Shiyurui Kk , Shinseiki Hakko Kenkyusho:Kk , 三和酒類株式会社 , 有限会社新世紀発酵研究所 , 株式会社大麦発酵研究所
发明人： ISHIZAKI FUMIAKI , KONO AKIHIKO , OMORI TOSHIRO , FURUTA YOSHIFUMI , NAKAMURA TERUHIRO , UMEMOTO YASUSHI
IPC分类号： C12P7/56 , C12P1/04 , C12R1/01
摘要： PROBLEM TO BE SOLVED: To provide a method for producing a useful substance by utilizing a bacterium that produce the useful substance producing bacteriocin in no need of heat sterilization, inhibits metal corrosion to prevent individual parts of the plant installation from deterioration, suppress the decomposition of culture medium compositions and the production hindrance of the useful substance and can carry out the production of the useful substance without production of by-product hazardous to human body. SOLUTION: In the method for producing a useful substance by utilizing a bacterium that produces the useful substance, the useful substance-producing bacterium forms the useful substance and produces the bacteriocin that has anti-bacterial and/or bacteriocidal effect. Thus, the culture medium is prepared by this bacteriocin formed here and simultaneously the culture apparatus can be subjected to pasteurization treatment. COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：待解决的问题：提供一种通过利用不需要加热灭菌来生产产生细菌素的有用物质的细菌来生产有用物质的方法，抑制金属腐蚀以防止植物装置的各个部件劣化，抑制培养基组合物的分解和有用物质的生产阻碍，并且可以在不产生对人体有害的副产物的情况下进行有用物质的生产。解决方案：在通过利用产生有用物质的细菌生产有用物质的方法中，有用的物质产生细菌形成有用物质并产生具有抗细菌和/或杀菌作用的细菌素。因此，通过这里形成的这种细菌素制备培养基，同时可以对培养装置进行巴氏灭菌处理。版权所有（C）2005，JPO＆NCIPI

5. 发明专利

JP2004217928A Production method for composition having activating action of natural killer cell and production method for activated natural killer cell-containing composition 审中-公开
标题翻译：具有自然杀伤细胞活化作用的组合物的生产方法和用于活化的天然杀伤细胞含有组合物的生产方法
公开(公告)号：JP2004217928A
公开(公告)日：2004-08-05
申请号：JP2003433294
申请日：2003-12-26
申请人： National Institute Of Advanced Industrial & Technology , Omugi Hakko Kenkyusho:Kk , Sanwa Shiyurui Kk , 三和酒類株式会社 , 株式会社大麦発酵研究所 , 独立行政法人産業技術総合研究所
发明人： OMORI TOSHIRO , UMEMOTO YASUSHI , FURUTA YOSHIFUMI , SOTOZONO HIDEKI , KODERA MIHOKO , OBA HIDEKI
IPC分类号： A61K31/715 , A61K35/14 , A61K36/06 , A61K36/899 , A61P35/00 , A61P35/02 , A61P43/00 , C08B37/14 , C12N5/07 , C12N5/071 , C12N5/0783 , A61K35/70 , A61K35/72 , A61K35/78 , C12N5/06
摘要： PROBLEM TO BE SOLVED: To provide a production method for a composition having an activating action of a dispensed NK cell from a barley shochu distillation residual liquid, and to provide a production method for an activated NK cell-containing composition. SOLUTION: The producing method of a composition having an activating action of a NK cell comprises at least the steps of: obtaining a liquid component by solid-liquid separating the barley shochu distillation residual liquid by-produced in a producing method of the shochu using barley as a raw material, and applying a thickening treatment to the liquid component by ultrafiltrating using an ultrafiltration membrane, and in the thickening treatment to the liquid component by ultrafiltrating, containing substantially no uronic acid, but containing a polysaccharide consisting of xylose, arabinose and glucose, obtaining a thickened liquid having the activating action of the NK cell, and obtaining the composition comprising the thickened liquid. The producing method of the activated NK cell-containing composition comprises containing the activated NK cell with the composition having the activating action of the NK cell. COPYRIGHT: (C)2004,JPO&NCIPI
摘要翻译：解决问题的方法：提供从大麦烧酒蒸馏残留液中分配的NK细胞的活化作用的组合物的制造方法，提供含活性NK细胞的组合物的制造方法。解决方案：具有NK细胞活化作用的组合物的制备方法至少包括以下步骤：通过以下方法获得液体成分：将生产的副产的大麦烧酒蒸馏残余液体固液分离，使用大麦作为原料的烧酒，通过使用超滤膜进行超滤处理，对液体成分进行增稠处理，在通过超滤的液体成分的粗化处理中，基本上不含糖醛酸，但含有由木糖，阿拉伯糖和葡萄糖，得到具有NK细胞活化作用的增稠液，得到包含增稠液体的组合物。活化的含有NK细胞的组合物的制备方法包括含有具有NK细胞活化作用的组合物的活化的NK细胞。版权所有（C）2004，JPO＆NCIPI

6. 发明专利

JP3958089B2 Continuous culture method of anaerobic bacteria 有权
公开(公告)号：JP3958089B2
公开(公告)日：2007-08-15
申请号：JP2002087215
申请日：2002-03-26
申请人：三和酒類株式会社 , 有限会社新世紀発酵研究所 , 株式会社大麦発酵研究所
发明人：吉史古田 , 俊郎大森 , 泰史梅本 , 文彬石崎
IPC分类号： C12N1/20 , C12N1/00 , C12P7/02 , C12P7/06 , C12P7/40 , C12P7/56
CPC分类号： C12P7/06 , C12N1/20 , C12P7/02 , C12P7/40 , C12P7/56 , Y02E50/17

7. 发明专利

JP2007084503A Composition containing ingredient originated from grain as active ingredient and having neovascularization inhibitory action 有权
标题翻译：含有成分作为活性成分并具有新生血管抑制作用的成分组成
公开(公告)号：JP2007084503A
公开(公告)日：2007-04-05
申请号：JP2005277652
申请日：2005-09-26
申请人： National Institute Of Advanced Industrial & Technology , Omugi Hakko Kenkyusho:Kk , Sanwa Shiyurui Kk , 三和酒類株式会社 , 株式会社大麦発酵研究所 , 独立行政法人産業技術総合研究所
发明人： OMORI TOSHIRO , SOTOZONO HIDEKI , KODERA MIHOKO , UMEMOTO YASUSHI , HAYASHI KEI , OBA HIDEKI , TAKESHIMA NAOKI
IPC分类号： A61K36/899 , A23K1/16 , A23K1/18 , A23L1/30 , A61P27/02 , A61P29/00 , A61P35/00 , A61P43/00
摘要： PROBLEM TO BE SOLVED: To provide a composition having an excellent neovascularization inhibitory action from an inexpensive and relatively easily available material not having a problem on safety, preferably barley, by a simple treatment method suitable for practical production in a factory scale without passing through a troublesome purification process. SOLUTION: This composition for inhibiting neovascularization contains an ingredient originated from a gramineae plant, preferably an ingredient originated from barley, as active ingredient having a neovascularization inhibitory action. The ingredient originated from barley is selected from the group consisting of an unmilled barley ethyl alcohol extraction fraction and an unmilled barley alkali extraction fraction. The composition for inhibiting the neovascularization is a composition for treating or preventing diseases having neovascularization to be inhibited, concretely diseases caused by abnormal neovascularization in tumors or cancers, chronic inflammations or retinopathy. The composition is in a form selected from the group consisting of food additives, food materials, foods, drinks, medicines/quasi-drugs, and feeds for inhibiting neovascularization. COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：待解决的问题：通过适用于工厂规模的实际生产的简单的处理方法，从不具有安全性问题的廉价且相对容易获得的材料，优选大麦提供具有优异的新血管形成抑制作用的组合物，没有通过一个麻烦的净化过程。解决方案：用于抑制新生血管形成的组合物含有起源于禾本科植物，优选来自大麦的成分的成分，作为具有新血管形成抑制作用的活性成分。起源于大麦的成分选自未熟化的大麦乙醇提取级分和未熟化的大麦碱提取级分。用于抑制新血管形成的组合物是用于治疗或预防具有新血管形成被抑制的疾病的组合物，具体是由肿瘤或癌症中的异常新血管形成引起的疾病，慢性炎症或视网膜病变。组合物为选自食品添加剂，食品材料，食品，饮料，药物/准药物和用于抑制新血管形成的饲料的形式。版权所有（C）2007，JPO＆INPIT

8. 发明专利

JP2005130736A Composition obtained from barley shochu distillation residual liquid, having vasodepressor activity and excellent gustatory 有权
标题翻译：从BARLEY SHOCHU蒸馏残留液中获得的组合物，具有VASODEPRESSOR活性和优异的监测
公开(公告)号：JP2005130736A
公开(公告)日：2005-05-26
申请号：JP2003368502
申请日：2003-10-29
申请人： Omugi Hakko Kenkyusho:Kk , Sanwa Shiyurui Kk , 三和酒類株式会社 , 株式会社大麦発酵研究所
发明人： OMORI TOSHIRO , MOCHIZUKI SATOSHI
IPC分类号： A23L1/305 , A23L1/221 , A61K36/899 , A61P9/12 , C12F3/10 , A61K35/78
摘要： PROBLEM TO BE SOLVED: To obtain a composition having remarkable vasodepressor activity and excellent gustatory using barley Shochu distillation residual liquid which is a by-product in a manufacturing process of Shochu (distilled alcoholic drink in Japan) made from barley. SOLUTION: This composition comprises a non-adsorptive fraction which is collected via an adsorption/separation treatment using a synthetic adsorbent, of a liquid fraction obtained by subjecting the distillation residual liquid of barley Shochu which is a by-product in a manufacturing process of Shochu made from barley to solid-liquid separation. The non-adsorptive fraction contains several kinds of peptides having an average chain length of 3.0 to 5.0, and the amino acids of these peptides are composed of 24 to 38% of glutamic acid, 4 to 20% of glycine, 5 to 10% of aspartic acid, 4 to 9% of proline and 4 to 8% of serine in 100% of the total content of the amino acids derived from the peptides. COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：待解决的问题：为了获得具有显着的血管抑制剂活性的组合物，并且使用大麦Shochu蒸馏残留液体，并且是由大麦制造的Shochu（日本的蒸馏酒精饮料）的制造过程中的副产物，具有优异的味觉。解决方案：该组合物包括通过使用合成吸附剂的吸附/分离处理而收集的非吸附级分，其通过在制造中将作为副产物的大麦Shochu的蒸馏残余液体从大麦制成的烧酒到固液分离。非吸附级分含有平均链长为3.0〜5.0的多种肽，这些肽的氨基酸为24〜38％的谷氨酸，4〜20％的甘氨酸，5〜10％的甘氨酸天冬氨酸，4至9％的脯氨酸和4至8％的丝氨酸，占衍生自肽的氨基酸总量的100％。版权所有（C）2005，JPO＆NCIPI

9. 发明专利

JP2004238453A Anti-oxidizing action-having composition and method for producing the same composition 有权
公开(公告)号：JP2004238453A
公开(公告)日：2004-08-26
申请号：JP2003027902
申请日：2003-02-05
申请人： Omugi Hakko Kenkyusho:Kk , Sanwa Shiyurui Kk , 三和酒類株式会社 , 株式会社大麦発酵研究所
发明人： UCHIUMI TOSHIHIKO , OMORI TOSHIRO , UMEMOTO YASUSHI , FURUTA YOSHIFUMI , SOTOZONO HIDEKI , KODERA MIHOKO
IPC分类号： C12F3/08 , A61K9/19 , A61K36/06 , A61K36/899 , A61P1/04 , A61P3/10 , A61P9/10 , A61P9/12 , A61P17/00 , A61P17/10 , A61P35/00 , A61P39/06 , C09K15/06 , C09K15/08 , C09K15/34 , A61K35/72 , A61K35/78
摘要： PROBLEM TO BE SOLVED: To obtain an anti-oxidizing action-having composition fractionated from a barley Shochu (Japanese white distilled liquor) distillation residual liquid. SOLUTION: The method for producing the excellent anti-oxidizing action-having composition comprises subjecting the barley shochu distillation residual liquid by-produced on the production of the Shochu using barley as a raw material to a solid-liquid separation to obtain a liquid fraction, subjecting the liquid fraction to an adsorption treatment using a synthetic adsorbent to obtain a synthetic adsorbent non-adsorbable fraction, and then eluting the synthetic adsorbent non-adsorbable fraction with an alkali or ethanol to fractionate the anti-oxidizing action-having composition. COPYRIGHT: (C)2004,JPO&NCIPI

10. 发明专利

JP2004000168A Process for preparing fermentation product containing significant amount of nisin by using barley- and rice shochu distillation residual liquids as medium 有权
公开(公告)号：JP2004000168A
公开(公告)日：2004-01-08
申请号：JP2003078907
申请日：2003-03-20
申请人： Fumiaki Ishizaki , Omugi Hakko Kenkyusho:Kk , Sanwa Shiyurui Kk , 三和酒類株式会社 , 株式会社大麦発酵研究所 , 石崎文彬
发明人： OMORI TOSHIRO , FURUTA YOSHIFUMI , UMEMOTO YASUSHI , DOBASHI ERIKO , KODERA MIHOKO , NAKAMURA TERUHIRO , ISHIZAKI FUMIAKI
IPC分类号： A23L1/00 , A23J3/20 , C12P21/02 , C12R1/01
摘要： PROBLEM TO BE SOLVED: To provide a process for preparing a fermentation product having an excellent taste which is highly suitable for food applications. SOLUTION: A medium used here is obtained by adding sugar to a liquid which comprises liquid components (A) and (B) obtained through solid-liquid separation of a barley Shochu (distilled liquor) distillation residual liquid and a rice Shochu distillation residual liquid, respectively, and whose Brix concentration is adjusted to 0.5-6.0. Nisin-producing lactic bacteria are added to the medium and incubated while controlling the sugar concentration of the culture broth to ≥0.1 g/l and its pH to 4.0-7.0. COPYRIGHT: (C)2004,JPO

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