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1. 发明申请

WO2012135636A1 LANTIBIOTIC NAI-802, PHARMACEUTICALLY ACCEPTABLE SALTS, COMPOSITIONS, AND USES THEREOF 审中-公开
标题翻译： LANTIBIOTIC NAI-802，药物接受口服，组合物及其用途
公开(公告)号：WO2012135636A1
公开(公告)日：2012-10-04
申请号：PCT/US2012/031487
申请日：2012-03-30
申请人： SENTINELLA PHARMACEUTICALS, INC. , MAFFIOLI, Sonia, Ilaria , SIMONE, Matteo , MONCIARDINI, Paolo , GASPARI, Eleonora
发明人： MAFFIOLI, Sonia, Ilaria , SIMONE, Matteo , MONCIARDINI, Paolo , GASPARI, Eleonora
IPC分类号： A61K38/00
CPC分类号： C07K7/56 , A61K38/12 , C07K14/365 , C12R1/045
摘要： The present invention concerns novel lantibiotic compounds, processes for the isolation and preparation thereof, pharmaceutical compositions containing the same, pharmaceutical acceptable salts thereof, and methods of use of the lantibiotics as antibacterial agents.
摘要翻译：本发明涉及新型的抗生素化合物，其分离和制备方法，含有它们的药物组合物，其药学上可接受的盐以及作为抗菌剂使用的羊毛硫抗生素的方法。

2. 发明申请

WO2012012542A1 METHODS OF USE OF CYCLIC AMIDE DERIVATIVES TO TREAT SCHIZOPHRENIA 审中-公开
标题翻译：使用环状酰胺衍生物治疗苯丙酸的方法
公开(公告)号：WO2012012542A1
公开(公告)日：2012-01-26
申请号：PCT/US2011/044697
申请日：2011-07-20
申请人： CYRENAIC PHARMACEUTICALS, INC. , LUTHRINGER, Remy, Henri , PELLEGRINI, Lorenzo , KARABELAS, Argeris, N.
发明人： LUTHRINGER, Remy, Henri , PELLEGRINI, Lorenzo , KARABELAS, Argeris, N.
IPC分类号： A01N43/40 , A61K31/445 , C07D217/00 , C07D217/02 , C07D217/22 , C07D401/00
CPC分类号： C07D401/06 , A61K31/454 , A61K45/06 , H04L5/001 , H04L5/0016 , H04L5/0019 , H04L5/0048 , H04L5/005 , H04L5/0053 , H04W4/00
摘要： Disclosed herein are compositions and methods for treating schizophrenia and symptoms of schizophrenia, including negative symptoms of schizophrenia.
摘要翻译：本文公开了用于治疗精神分裂症和精神分裂症症状的组合物和方法，包括精神分裂症的阴性症状。

3. 发明申请

WO2009151619A1 POVIDONE IODINE, A NOVEL ALTERNATIVE PRESERVATIVE FOR OPHTHALMIC COMPOSITIONS 审中-公开
标题翻译： POVIDONE IODINE，一种用于眼科组合物的新型替代防腐剂
公开(公告)号：WO2009151619A1
公开(公告)日：2009-12-17
申请号：PCT/US2009/003521
申请日：2009-06-10
申请人： FORESIGHT BIOTHERAPEUTICS, INC. , CAPRIOTTI, Joseph, A. , LIANG, Bo , SAMSON, C., Michael , STEIN, Jason , WEISER, Michael
发明人： CAPRIOTTI, Joseph, A. , LIANG, Bo , SAMSON, C., Michael , STEIN, Jason , WEISER, Michael
IPC分类号： A01N45/00 , A61K31/56
CPC分类号： A01N43/36 , A61K9/0048 , A61K31/56 , A61K31/79 , A61K45/06 , A61L12/105 , A61K2300/00
摘要： The invention includes a preserved ophthalmic preparation comprising povidone- iodine (PVP-I) at a concentration sufficient to preserve the ophthalmic preparation, and at least one member selected from the group consisting of a steroidal anti-inflammatory compound, a non-steroidal anti-inflammatory compound, an antibacterial compound, an anti-allergy compound, and an anti-glaucoma compound. The invention also includes adding PVP-I to an ophthalmic composition in order to preserve the composition, wherein the PVP-I is added at a concentration sufficient to preserve the composition.
摘要翻译：本发明包括含有足以保护眼用制剂的浓度的聚维酮碘（PVV-I）的保存眼用制剂，以及选自甾族抗炎化合物，非甾体抗炎药物，炎性化合物，抗菌化合物，抗过敏化合物和抗青光眼化合物。本发明还包括向眼用组合物中加入PVP-1以保留组合物，其中以足以保留组合物的浓度加入PVP-1。

4. 发明申请

WO2007064462A1 PHAGE PARTICLE DIAGNOSTIC REAGENTS 审中-公开
标题翻译：噬菌体诊断试剂
公开(公告)号：WO2007064462A1
公开(公告)日：2007-06-07
申请号：PCT/US2006/044134
申请日：2006-11-14
申请人： THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA , THE SCRIPPS RESEARCH INSTITUTE , SIEGEL, Donald , BARBAS, Carlos, F., III
发明人： SIEGEL, Donald , BARBAS, Carlos, F., III
IPC分类号： C12N7/00 , C12P21/06 , G01N33/53
CPC分类号： G01N33/555 , G01N33/6854
摘要： The present invention relates to novel methods for detecting a member of a known binding pair in a sample, including a cell, where one member of the pair (termed the "receptor") is expressed by a bacteriophage, which phage is then used to detect the presence of the other member of the pair (termed the "ligand" or "target"). Rather than detecting the binding of the phage using antibody-based technology, the present invention relates to detecting marker molecule associated with the phage. In one aspect, the invention relates to identifying an antigen-bearing moiety (e.g., a red blood cell antigen) of interest present on a cell, e.g., a. red blood cell, using antibody- displaying bacteriophage, as well as detecting anti-red blood cell auto- or alloantibodies and/or complement in a sample, using antiglobulin reagent-displaying bacteriophage and detecting a marker molecule associated with the phage. In one aspect, the phenotype of the phage is not linked with the genotype of the phage.
摘要翻译：本发明涉及用于检测样品中已知结合对的成员的新方法，包括细胞，其中一对成员（称为“受体”）由噬菌体表达，然后使用该噬菌体检测该对的另一成员的存在（称为“配体”或“靶”）。本发明不是使用基于抗体的技术检测噬菌体的结合，而是检测与噬菌体相关的标记分子。一方面，本发明涉及鉴定细胞上存在的感兴趣部分（例如，红细胞抗原），例如，红细胞，使用抗体展示噬菌体，以及使用抗球蛋白试剂显示噬菌体和检测与噬菌体相关的标记分子来检测样品中的抗红细胞自身或同种异体抗体和/或补体。一方面，噬菌体的表型与噬菌体的基因型不相关。

5. 发明申请

WO2013040347A1 STABLE POVIDONE-IODINE COMPOSITIONS 审中-公开
标题翻译：稳定的POVIDONE-IODINE组合物
公开(公告)号：WO2013040347A1
公开(公告)日：2013-03-21
申请号：PCT/US2012/055402
申请日：2012-09-14
申请人： FORESIGHT BIOTHERAPEUTICS, INC. , CAPRIOTTI, Joseph , LIANG, Bo , SAMSON, C., Michael , STEIN, Jason , WEISER, Michael
发明人： CAPRIOTTI, Joseph , LIANG, Bo , SAMSON, C., Michael , STEIN, Jason , WEISER, Michael
IPC分类号： A01N29/00
CPC分类号： A61K31/79 , A01N59/12 , A61K9/0014 , A61K9/0046 , A61K9/0048 , A61K31/192 , A61K31/196 , A61K31/381 , A61K31/415 , A61K31/4535 , A61K31/573 , A61K33/18 , A61K2300/00
摘要： Disclosed herein are PVP-I-containing compositions, as well as methods of making such compositions, which provide reliable stability for PVP-I preparations, including preparations comprising PVP-I and one or more additional components.
摘要翻译：本文公开了含PVP-1的组合物，以及制备这种组合物的方法，其为PVP-1制剂提供可靠的稳定性，包括包含PVP-1和一种或多种另外的组分的制剂。

6. 发明申请

WO2012012543A1 METHODS OF USE CYCLIC AMIDE DERIVATIVES TO TREAT SIGMA RECEPTOR-MEDIATED DISORDERS 审中-公开
标题翻译：使用环状酰胺衍生物治疗SIGMA受体介导的疾病的方法
公开(公告)号：WO2012012543A1
公开(公告)日：2012-01-26
申请号：PCT/US2011/044698
申请日：2011-07-20
申请人： CYRENAIC PHARMACEUTICALS INC. , LUTHRINGER, Remy, Henri , PELLEGRINI, Lorenzo , KARABELAS, Argeris, N.
发明人： LUTHRINGER, Remy, Henri , PELLEGRINI, Lorenzo , KARABELAS, Argeris, N.
IPC分类号： A01N43/40 , A61K31/445 , C07D217/00 , C07D217/02 , C07D217/22 , C07D401/00
CPC分类号： A61K31/454 , A61K31/445 , A61K45/06
摘要： Disclosed herein are compositions and methods for treating a sigma-2 receptor- mediated condition or disorder, including treating one or more symptoms of a sigma-2 receptor-mediated condition or disorder.
摘要翻译：本文公开了用于治疗σ-2受体介导的病症或病症的组合物和方法，包括治疗σ-2受体介导的病症或病症的一种或多种症状。

7. 发明申请

WO2008027521A1 NOVEL COMPOSITIONS AND METHODS FOR TREATMENT OF DISEASES RELATED TO ACTIVATED LYMPHOCYTES 审中-公开
标题翻译：用于治疗与活化淋巴细胞相关的疾病的新型组合物和方法
公开(公告)号：WO2008027521A1
公开(公告)日：2008-03-06
申请号：PCT/US2007/019150
申请日：2007-08-30
申请人： IMMUNE CONTROL, INC. , ROTH, Stephen , BUCK, Clayton , SELF, Christopher , OLSON, Gary
发明人： ROTH, Stephen , BUCK, Clayton , SELF, Christopher , OLSON, Gary
IPC分类号： C07D417/06 , C07D417/14 , A61K31/5415
CPC分类号： C07D279/26 , C07D279/28 , C07D417/06 , C07D417/12 , C09B21/00
摘要： The present invention relates to inhibiting proliferation and inducing apoptosis in activated lymphocytes, including T cells and B cells. The invention also provides compositions and methods for inhibiting proliferation and inducing apoptosis in activated lymphocytes, as well methods for treating diseases associated with activated lymphocytes by administering 5-HT receptor antagonists.
摘要翻译：本发明涉及抑制增殖并诱导活化的淋巴细胞（包括T细胞和B细胞）的细胞凋亡。本发明还提供了用于抑制增殖和诱导活化淋巴细胞凋亡的组合物和方法，以及通过施用5-HT受体拮抗剂治疗与活化淋巴细胞相关的疾病的方法。

8. 发明申请

WO2007070709A2 SKELETAL SITE -SPECIFIC CHARACTERIZATION OF OROFACIAL AND ILIAC CREST HUMAN BONE MARROW TROMAL CELLS IN SAME INDIVIDUALS 审中-公开
标题翻译：骨骼位置 - 在同一个体中OROFACIAL和ILIAC CROSS人骨髓瘤细胞的特征表征
公开(公告)号：WO2007070709A2
公开(公告)日：2007-06-21
申请号：PCT/US2006/048104
申请日：2006-12-14
申请人： THE TRUSTEES THE UNIVERSITY OF PENNESYLVANIA , AKINTOYE, Sunday, O. , SHI, Songtao , ROBEY, Pamela, G.
发明人： AKINTOYE, Sunday, O. , SHI, Songtao , ROBEY, Pamela, G.
IPC分类号： G01N33/53
CPC分类号： G01N33/5005 , G01N33/566 , G01N33/567 , G01N2800/245
摘要： The present invention relates to methods and compositions useful for the detection, enrichment and use of orofacial-derived bone marrow stromal cells. In one aspect, the invention relates to the use of characteristics specific to orofacial-derived bone marrow stromal cells to distinguish orofacial-derived bone marrow stromal cells from other cells.
摘要翻译：本发明涉及可用于检测，富集和使用口腔衍生的骨髓基质细胞的方法和组合物。一方面，本发明涉及用于口面衍生的骨髓基质细胞特异性的特征来区分来自其他细胞的口腔衍生的骨髓基质细胞。

9. 发明申请

WO2006098758A2 COMPOSITIONS, METHODS AND KITS RELATING TO CTHRC1, A NOVEL MODULATOR OF COLLAGEN MATRIX 审中-公开
标题翻译：关于CTHRC1的组合物，方法和工具，胶原蛋白的新型调节剂
公开(公告)号：WO2006098758A2
公开(公告)日：2006-09-21
申请号：PCT/US2005/030005
申请日：2005-08-24
申请人： MAINE MEDICAL CENTER RESEARCH INSTITUTE , LINDNER, Volkhard
发明人： LINDNER, Volkhard
IPC分类号： A01K67/00 , C07H21/04 , A61K39/395 , A61K39/00 , C07K14/785
CPC分类号： C07K14/78 , A01K67/0275 , A01K2217/05 , A01K2227/105 , A01K2267/035 , A61K38/00 , A61K2039/505 , C07K14/4702 , C07K14/51 , C07K16/18 , C07K2319/00 , C07K2319/41 , C07K2319/60 , C12N15/8509
摘要： The invention relates to a novel CTHRC1 nucleic acid and protein encoded thereby. Expression of CTHRC1 is induced by injury in, among others, arteries and skin, and CTHRC1 is expressed in bone, cartilage, kidney, lung and brain. CTHRC1 expression is associated with collagen matrix production, arterial remodeling, arterial restenosis, constrictive remodeling, vessel injury, ectopic ossification, fibrosis, and the like. CTHRC1 also plays a role in cell-cell and cell-matrix adhesion, cell-migration, and bone, cartilage, skin and brain development. CTHRC1 also regulates the level of BMPs, including BMP1 and BMP4, and the invention encompasses methods relating to affecting the level of BMPs by affecting the level of CTHRC1. In addition, the invention relates to modulation of the level of CTHRC1 to affect processes associated with fibrosis mediated by formation of collagen matrix. The invention further relates to methods of treating, preventing, and/or detecting these diseases, disorders or conditions, where the methods comprise modulating or detecting CTHRC1 expression and/or production of CTHRC1 polypeptide. The invention also relates to affecting CTHRC1 expression using cytokines.
摘要翻译：本发明涉及由此编码的新型CTHRC1核酸和蛋白质。 CTHRC1的表达是由动脉和皮肤等损伤引起的，CTHRC1在骨，软骨，肾，肺和脑中表达。 CTHRC1表达与胶原基质产生，动脉重塑，动脉再狭窄，缩窄重塑，血管损伤，异位骨化，纤维化等有关。 CTHRC1也在细胞和细胞 - 基质粘附，细胞迁移和骨，软骨，皮肤和脑发育中发挥作用。 CTHRC1还规定BMPs，包括BMP1和BMP4的水平，本发明包括通过影响CTHRC1水平影响BMP水平的方法。此外，本发明涉及调节CTHRC1的水平以影响与形成胶原基质介导的纤维化相关的过程。本发明还涉及治疗，预防和/或检测这些疾病，病症或病症的方法，其中所述方法包括调节或检测CTHRC1表达和/或产生CTHRC1多肽。本发明还涉及使用细胞因子影响CTHRC1表达。

10. 发明申请

WO2013033369A2 ENGINEERED PLANT BIOMASS FOR BIODIESEL AND BIOETHANOL PRODUCTION 审中-公开
标题翻译：用于生物柴油和生物柴油生产的工程植物生物量
公开(公告)号：WO2013033369A2
公开(公告)日：2013-03-07
申请号：PCT/US2012/053099
申请日：2012-08-30
申请人： TYTON BIOSCIENCES , BORYSYUK, Mykola , POGREBNYAK, Natalia , ANDRIANOV, Vyacheslav , KOSTENYUK, Igor
发明人： BORYSYUK, Mykola , POGREBNYAK, Natalia , ANDRIANOV, Vyacheslav , KOSTENYUK, Igor
IPC分类号： C12N15/82
CPC分类号： C12N15/8245 , C10L1/026 , C10L2200/0476 , C10L2270/026 , C12N5/04 , C12N9/2417 , C12N9/242 , C12N9/90 , C12N15/62 , C12N15/8201 , C12N15/8247 , C12Y504/00
摘要： The disclosure encompassed herein relates, in part, to a method for increasing energy density of plant biomass that can be used for production of renewable fuel, such as biodiesel oil and/or ethanol. In an aspect, genetic engineering for enhanced sugar accumulation can be achieved by overexpressing a bacterial enzyme sucrose isomerase. Sugars or oils extracted from the plants of the disclosure encompassed herein may be used for industrial purposes such as heating, producing bio-fuels such as biodiesel fuel, or lubricating applications.
摘要翻译：本文包括的公开内容部分地涉及用于提高可用于生产可再生燃料（例如生物柴油和/或乙醇）的植物生物量的能量密度的方法。在一方面，用于增强糖积累的基因工程可以通过过表达细菌酶蔗糖异构酶来实现。从本文公开的公开的植物提取的糖或油可以用于工业目的，例如加热，生产生物燃料，例如生物柴油燃料或润滑应用。

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