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1. 发明申请

WO2014153674A1 INFLUENZA VIRUS-LIKE PARTICLE PRODUCTION IN PLANTS 审中-公开
标题翻译：在植物中的流感病毒样颗粒生产
公开(公告)号：WO2014153674A1
公开(公告)日：2014-10-02
申请号：PCT/CA2014/050326
申请日：2014-03-28
申请人： MEDICAGO INC.
发明人： COUTURE, Manon , D'AOUST, Marc-Andre , VEZINA, Louis-Philippe
IPC分类号： C12N15/82 , A01H5/00 , A61K39/145 , A61P31/16 , A61P37/04 , C07K14/11 , C12N15/44 , C12N7/01 , C12N7/04
CPC分类号： C12N15/8258 , A61K39/12 , A61K39/145 , A61K2039/5258 , A61K2039/54 , C07K14/005 , C07K2319/02 , C12N7/00 , C12N15/8257 , C12N2760/16122 , C12N2760/16123 , C12N2760/16134 , C12N2760/16151 , C12N2760/16171 , C12N2760/16222 , C12N2760/16223 , C12N2760/16234 , C12N2760/16251 , C12N2760/16271
摘要： A method of producing a virus like particle (VLP) in a plant comprising modified hemagglutinin is provided. The method comprises introducing a nucleic acid comprising a regulatory region active in the plant and operatively linked to a nucleotide sequence encoding a modified influenza hemagglutinin (HA) protein into the plant, or portion of the plant, the modified HA protein comprises a modified proteolytic loop. Followed by incubating the plant or portion of the plant under conditions that permit the expression of the nucleic acids, thereby producing the VLP. The modified proteolytic loop may comprise one or more protease cleavage sites exhibiting reduced or abolished cleavage by a protease. The nucleotide sequence encoding the HA may be selected from the group consisting of B HA, C, H1, H2, H3, H4, H5, H6, H7, H8, H9, H10, H11, H12, H13, H14, H15, and H16. Also described is a virus like particle (VLP) produced by the method, and plants expressing the VLP. The virus like particle (VLP) may comprise plant-specific N-glycans, or modified N- glycans.
摘要翻译：提供了在包含改良血凝素的植物中生产病毒样颗粒（VLP）的方法。该方法包括将包含在植物中具有活性的调节区的核酸引入植物或植物的一部分中并与编码经修饰的流感血凝素（HA）蛋白的核苷酸序列有效连接），所述修饰的HA蛋白包含修饰的蛋白水解环。随后在允许核酸表达的条件下温育植物或植物的部分，从而产生VLP。修饰的蛋白水解环可以包含一个或多个蛋白酶切割位点，其表现出由蛋白酶减少或消除的切割。编码HA的核苷酸序列可以选自B HA，C，H1，H2，H3，H4，H5，H6，H7，H8，H9，H10，H11，H12，H13，H14，H15和 H16。还描述了通过该方法产生的病毒样颗粒（VLP）和表达VLP的植物。病毒样颗粒（VLP）可以包含植物特异性N-聚糖或修饰的N-聚糖。

2. 发明申请

WO2014066995A1 METHOD AND SYSTEM FOR DETECTING AND DIAGNOSING A GASEOUS FUEL LEAK IN A DUAL FUEL INTERNAL COMBUSTION ENGINE SYSTEM 审中-公开
标题翻译：用于检测和诊断双燃料内燃机系统中的气体燃料泄漏的方法和系统
公开(公告)号：WO2014066995A1
公开(公告)日：2014-05-08
申请号：PCT/CA2013/050756
申请日：2013-10-08
申请人： WESTPORT POWER INC.
发明人： HAAS, Jordan C. , TOUCHETTE, Alain M.J. , WARDLAW, Jamie Y.
IPC分类号： F02M65/00 , F02M43/00 , G01M15/04 , G01M15/09
CPC分类号： F02D19/10 , F02B2201/064 , F02D19/0623 , F02D41/0027 , F02D41/221 , F02D2041/225 , F02D2200/0602 , F02M43/00 , Y02T10/36
摘要： A method for detecting and diagnosing a gaseous fuel leak in a dual fuel internal combustion engine system comprises producing a fault signal indicating that there is a leak of gaseous fuel into liquid fuel when an amount of gaseous fuel is detected in the liquid fuel return line through which liquid fuel is returned from the fuel injector to the fuel supply. The method can further comprise diagnosing a failure of the fuel injector or of at least one of the system components which regulate the gaseous fuel and the liquid fuel supply pressures by evaluating if an amount of gaseous fuel has been detected in the liquid fuel return line and calculating the pressure differential between the liquid fuel rail pressure and the gaseous fuel rail pressure.
摘要翻译：一种用于在双燃料内燃机系统中检测和诊断气体燃料泄漏的方法包括：当在液体燃料返回管线中检测到气体燃料的量时，产生一个故障信号，该故障信号指示气体燃料泄漏为液态燃料哪些液体燃料从燃料喷射器返回到燃料供应。该方法还可以包括通过评估在液体燃料返回管线中是否检测到气体燃料的量来诊断燃料喷射器或调节气体燃料和液体燃料供应压力的至少一个系统部件的故障，以及计算液体燃料轨道压力和气体燃料轨道压力之间的压力差。

3. 发明申请

WO2014036645A1 PICORNAVIRUS-LIKE PARTICLE PRODUCTION IN PLANTS 审中-公开
标题翻译： PICORNAVIRUS-like颗粒生产在植物
公开(公告)号：WO2014036645A1
公开(公告)日：2014-03-13
申请号：PCT/CA2013/050666
申请日：2013-08-29
申请人： MEDICAGO INC.
发明人： D'AOUST, Marc-Andre , LAVOIE, Pierre-Olivier , COUTURE, Manon , POULIN, Lucie , VEZINA, Louis-Philippe
IPC分类号： C12N7/04 , A01H5/00 , C07K14/085 , C07K16/10 , C12N15/41 , C12N15/82 , C12N7/01
CPC分类号： C07K14/005 , A61K39/125 , A61K39/13 , C07K16/1009 , C07K2317/10 , C12N7/00 , C12N15/8258 , C12N2770/32322 , C12N2770/32323 , C12N2770/32351 , C12N2770/32623 , C12N2770/32634 , C12N2800/22
摘要： A method of producing a picornavirus-like particle (PVLP) in a plant is provided. The method comprises introducing a first nucleic acid and a second nucleic acid into the plant, portion of the plant, or a plant cell. The first nucleic acid comprising a first regulaton region active in the plant operatively linked to a nucleotide sequence encoding a picornavims polypeptide. The second nucleic acid comprising a second regulaton region active in the plant and operationally linked to a nucleotide sequence encoding one or more picornavims protease. The plant, portion of the plant, or plant cell is incubated under conditions that permit the expression of the nucleic acids, thereby producing the PVLP. A PVLP comprising the polypeptide is also provided.
摘要翻译：提供了一种在植物中生产小核糖核酸病毒样颗粒（PVLP）的方法。该方法包括将第一核酸和第二核酸引入植物，植物部分或植物细胞中。第一核酸包含在植物中有活性的第一调节区，其与编码小RNA聚糖多肽的核苷酸序列有效连接。所述第二核酸包含在植物中有活性的第二调节区，并且与编码一种或多种微晶蛋白酶蛋白酶的核苷酸序列有效连接。植物，植物部分或植物细胞在允许核酸表达的条件下温育，从而产生PVLP。还提供了包含该多肽的PVLP。

4. 发明申请

WO2013166609A1 ROTAVIRUS-LIKE PARTICLE PRODUCTION IN PLANTS 审中-公开
标题翻译：在植物中的旋风样颗粒生产
公开(公告)号：WO2013166609A1
公开(公告)日：2013-11-14
申请号：PCT/CA2013/050364
申请日：2013-05-10
申请人： MEDICAGO INC. , MITSUBISHI TANABE PHARMA CORPORATION
发明人： D'AOUST, Marc-Andre , LANDRY, Nathalie , LAVOIE, Pierre-Olivier , ARAI, Masaaki , ASAHARA, Naomi , MUTEPFA, David Levi Rutendo , HITZEROTH, Inga Isabel , RYBICKI, Edward Peter
IPC分类号： C12N7/04 , A61K39/15 , A61P31/14 , A61P37/04 , C07K14/14 , C12N15/46 , C12N15/82 , C12N7/01
CPC分类号： A61K39/15 , A61K39/12 , A61K2039/5258 , C07K14/005 , C12N7/00 , C12N7/02 , C12N15/8203 , C12N15/8214 , C12N15/8216 , C12N15/8218 , C12N15/8221 , C12N15/8258 , C12N2720/12334 , C12N2720/12351
摘要： A method of producing a virus-like particle (VLP) in a plant is provided. The method comprises introducing a first nucleic acid into the plant, or portion of the plant. The first nucleic acid comprising a first regulatory region active in the plant operatively linked to a nucleotide sequence encoding one or more rotavirus structural protein for example but not limited to rotavirus protein VP2. The nucleotide sequence may further comprise one or more than one amplification element and/or a compartment targeting sequence. A second nucleic acid might be introduced into the plant, or portion of the plant. The second nucleic acid comprises a second regulatory region active in the plant and operatively linked to a nucleotide sequence encoding one or more rotavirus structural protein, for example but not limited to rotavirus protein VP6. Optionally, a third nucleic acid and/ or fourth nucleic acid might be introduced into the plant, or portion of the plant. The third nucleic acid comprises a third regulatory region active in the plant and operatively linked to a nucleotide sequence encoding one or more rotavirus structural protein, for example but not limited to rotavirus protein VP4. The fourth nucleic acid comprises a fourth regulatory region active in the plant and operatively linked to a nucleotide sequence encoding one or more rotavirus structural protein, for example but not limited to rotavirus protein VP7. The plant or portion of the plant is incubated under conditions that permit the expression of the nucleic acids, thereby producing the VLP.
摘要翻译：提供了一种在植物中生产病毒样颗粒（VLP）的方法。该方法包括将第一核酸引入植物或植物的一部分。所述第一核酸包含在植物中活性的第一调节区，其可操作地连接于编码一种或多种轮状病毒结构蛋白（例如但不限于轮状病毒蛋白VP2）的核苷酸序列。核苷酸序列还可以包含一个或多于一个扩增元件和/或隔室靶向序列。可以将第二种核酸引入植物或植物的一部分。第二核酸包含在植物中有活性的第二调控区，并可操作地连接于编码一种或多种轮状病毒结构蛋白（例如但不限于轮状病毒蛋白VP6）的核苷酸序列。任选地，第三核酸和/或第四核酸可以被引入植物或植物的一部分。第三核酸包含在植物中活性的第三调节区，并且与编码一种或多种轮状病毒结构蛋白（例如但不限于轮状病毒蛋白VP4）的核苷酸序列可操作地连接。第四核酸包含在植物中活性的第四调节区，并且可操作地连接于编码一种或多种轮状病毒结构蛋白（例如但不限于轮状病毒蛋白VP7）的核苷酸序列。将植物或植物的一部分在允许核酸表达的条件下温育，从而产生VLP。

5. 发明申请

WO2013044390A1 INCREASING VIRUS-LIKE PARTICLE YIELD IN PLANTS 审中-公开
标题翻译：在植物中增加病毒样颗粒物
公开(公告)号：WO2013044390A1
公开(公告)日：2013-04-04
申请号：PCT/CA2012/050681
申请日：2012-09-28
申请人： MEDICAGO INC.
发明人： D'AOUST, Marc-Andre , COUTURE, Manon , VEZINA, Louis-Philippe
IPC分类号： C07K14/11 , A01H5/00 , A23K1/14 , A23L1/30 , A61K39/145 , A61P31/16 , A61P37/04 , C07K16/08 , C12N15/00 , C12N15/44 , C12N15/82 , C12N7/00
CPC分类号： C07K14/005 , A61K39/145 , C07K16/1018 , C12N7/00 , C12N15/8257 , C12N15/8258 , C12N2760/16223 , C12N2760/16234 , C12N2760/16251
摘要： A method of producing a virus like particle (VLP) in a plant is provided. The method comprises introducing a first nucleic acid and a second nucleic acid into the plant, or portion of the plant. The first nucleic acid comprises a first regulatory region active in the plant and operatively linked to a nucleotide sequence encoding a structural virus protein. The second nucleic acid comprises a second regulatory region active in the plant and operatively linked to a nucleotide sequence encoding a channel protein, for example but not limited to a proton channel protein. The plant or portion of the plant is incubated under conditions that permit the expression of the nucleic acids, thereby producing the VLP.
摘要翻译：提供了一种在植物中生产病毒样颗粒（VLP）的方法。该方法包括将第一核酸和第二核酸引入植物或植物的一部分。第一核酸包含在植物中有活性的第一调节区，并与编码结构病毒蛋白的核苷酸序列有效连接。第二核酸包含在植物中有活性的第二调节区，并可操作地连接于编码通道蛋白的核苷酸序列，例如但不限于质子通道蛋白。将植物或植物的一部分在允许核酸表达的条件下温育，从而产生VLP。

6. 发明申请

WO2013000096A1 ENHANCING CELL WALL PROPERTIES IN PLANTS OR TREES 审中-公开
标题翻译：增加植物或细胞中的细胞壁特性
公开(公告)号：WO2013000096A1
公开(公告)日：2013-01-03
申请号：PCT/CA2012/050450
申请日：2012-06-29
申请人： THE UNIVERSITY OF BRITISH COLUMBIA , MANSFIELD, Shawn D. , UNDA, Faride G.
发明人： MANSFIELD, Shawn D. , UNDA, Faride G.
IPC分类号： C12N15/54 , A01H5/00 , C10G3/00 , C12N15/82 , C12N9/10 , D21H11/00
CPC分类号： C12N15/8261 , A23K10/30 , A23L19/03 , C07K14/472 , C10L5/44 , C12N9/1051 , C12N9/93 , C12N15/8246 , C12Y204/01123 , D21C5/005 , D21H11/00 , Y02E50/10 , Y02E50/30 , Y02P30/20
摘要： The present invention relates to a method for enhancing cell wall properties in plants. The method comprises introducing into the plant, at least one nucleotide construct comprising a nucleic acid molecule operatively linked to a regulatory region active in the plant, wherein said nucleic acid molecule encodes a polypeptide with galactinol synthase (GolS)-like activity and growing the plant under conditions that permit the expression of the nucleic acid, thereby enhancing the cell wall property of the plant.
摘要翻译：本发明涉及增强植物细胞壁性质的方法。该方法包括向植物中引入至少一个核苷酸构建体，其包含与植物中活性的调控区可操作地连接的核酸分子，其中所述核酸分子编码具有肌醇半胱氨酸合成酶（GolS）样活性的多肽，并使植物生长在允许核酸表达的条件下，从而增强植物的细胞壁性质。

7. 发明申请

WO2012171119A1 DUAL FUEL INJECTION VALVE 审中-公开
标题翻译：双燃料注射阀
公开(公告)号：WO2012171119A1
公开(公告)日：2012-12-20
申请号：PCT/CA2012/050348
申请日：2012-05-28
申请人： WESTPORT POWER INC. ET AL. , WICKSTONE, Michael C. , HILL, Philip G. , HUANG, Jian , MUNSHI, Samdeep
发明人： WICKSTONE, Michael C. , HILL, Philip G. , HUANG, Jian , MUNSHI, Samdeep
IPC分类号： F02M43/04 , F02M21/02
CPC分类号： F02M21/0275 , F02D19/0644 , F02D19/0652 , F02D19/0694 , F02D19/10 , F02M43/04 , F02M45/086 , F02M47/027 , F02M61/14 , F02M61/182 , F02M63/007 , F02M2200/46 , F02M2200/8015 , F02M2200/852 , Y02T10/36
摘要： A dual fuel injection valve with concentric needles comprises an inner needle and an outer needle surrounding the inner needle, both needles being located inside the injection valve body. The valve is provided with a first set and a second set of orifices for separately injecting two different fuels directly into the combustion chamber of an internal combustion engine. The outer needle is fixed against rotation with respect to the injection valve body such that an interlace angle between the centerlines of the first series of orifices and second series of orifices is set at different predetermined angles to reduce methane emissions.
摘要翻译：具有同心针的双燃料喷射阀包括内针和围绕内针的外针，两针位于喷射阀体内。阀设置有第一组和第二组孔，用于将两种不同的燃料直接分别注入到内燃机的燃烧室中。外针被固定成相对于喷射阀体的旋转，使得第一系列孔口的中心线和第二连接孔之间的交错角度被设定在不同的预定角度以减少甲烷排放。

8. 发明申请

WO2012171104A1 RABIES VIRUS LIKE PARTICLE PRODUCTION IN PLANTS 审中-公开
标题翻译： RABIES病毒样植物生产
公开(公告)号：WO2012171104A1
公开(公告)日：2012-12-20
申请号：PCT/CA2012/000581
申请日：2012-06-13
申请人： MEDICAGO INC. , D'AOUST, Marc-Andre , LAVOIE, Pierre-Olivier , VEZINA, Louis-Philippe , COUTURE, Manon
发明人： D'AOUST, Marc-Andre , LAVOIE, Pierre-Olivier , VEZINA, Louis-Philippe , COUTURE, Manon
IPC分类号： C12N7/01 , A01H5/00 , A61K39/205 , A61P31/14 , C07K14/145 , C07K16/10 , C12N15/00 , C12N15/47 , C12N15/82 , C12N7/00
CPC分类号： C07K14/005 , A61K39/12 , A61K39/205 , A61K2039/517 , A61K2039/5258 , A61K2039/55505 , C12N15/8258 , C12N2750/12043 , C12N2760/20123 , C12N2760/20134
摘要： A method of producing a virus like particle (VLP) in a plant is provided. The method comprises introducing a first nucleic acid into the plant, or portion of the plant. The first nucleic acid comprising a first regulatory region active in the plant operatively linked to a nucleotide sequence encoding a native rabies virus structural protein. The nucleotide sequence may further comprise one or more than one amplification element. Optionally, a second nucleic acid might be introduced into the plant, or portion of the plant. The second nucleic acid comprising a second regulatory region active in the plant and operatively linked to a nucleotide sequence encoding a matrix protein, for example but not limited to a rabies matrix protein. The plant or portion of the plant is incubated under conditions that permit the expression of the nucleic acids, thereby producing the VLP.
摘要翻译：提供了一种在植物中生产病毒样颗粒（VLP）的方法。该方法包括将第一核酸引入植物或植物的一部分。所述第一核酸包含在植物中活性的第一调节区，其与编码天然狂犬病毒结构蛋白的核苷酸序列有效连接。核苷酸序列还可以包含一个或多于一个的扩增元件。任选地，第二核酸可以被引入植物或植物的一部分。所述第二核酸包含在植物中活性的第二调节区，并与编码基质蛋白（例如但不限于狂犬病基质蛋白）的核苷酸序列有效连接。将植物或植物的一部分在允许核酸表达的条件下温育，从而产生VLP。

9. 发明申请

WO2012058762A1 PLANT EXPRESSION SYSTEM 审中-公开
标题翻译：植物表达系统
公开(公告)号：WO2012058762A1
公开(公告)日：2012-05-10
申请号：PCT/CA2011/001228
申请日：2011-11-03
申请人： MEDICAGO INC. , D'AOUST, Marc-Andre , LAVOIE, Pierre-Olivier , VEZINA, Louis-Philippe
发明人： D'AOUST, Marc-Andre , LAVOIE, Pierre-Olivier , VEZINA, Louis-Philippe
IPC分类号： C12N15/82 , C12N15/00 , C12N15/44 , C12N7/01 , C07K14/11
CPC分类号： C07K14/005 , C12N15/8203 , C12N15/8216 , C12N15/8221 , C12N15/8257 , C12N15/8258 , C12N2750/12022 , C12N2760/16051 , C12N2770/18022 , C12N2820/60 , C12N2830/60
摘要： A plant expression system and methods for expressing a protein of interest in a plant are provided. The plant expression system comprises a first nucleic acid sequence regulatory region sequence, operatively linked with a one or more than one comovirus enhancer, a nucleotide sequence of interest, one or more than one geminivirus amplification elements, and a second nucleic acid encoding a geminivirus replicase. The method of producing a protein of interest in a plant, involves introducing the plant expression system into a plant, or portion of the plant, and incubating the plant or the portion of the plant under conditions that permit the expression of the nucleotide sequence and producing the protein of interest.
摘要翻译：提供植物表达系统和在植物中表达目的蛋白质的方法。植物表达系统包含第一核酸序列调控区序列，其与一个或多于一个的病毒增强子，目的核苷酸序列，一个或多于一个的双核病毒扩增元件可操作地连接，以及编码双重病毒复制子的第二个核酸。在植物中生产感兴趣的蛋白质的方法包括将植物表达系统引入植物或植物的一部分，并且在允许表达核苷酸序列并产生感兴趣的蛋白质

10. 发明申请

WO2011069236A1 METHOD FOR PREPARING HYPOCRELLIN 审中-公开
标题翻译：制备高磷脂酰胆碱的方法
公开(公告)号：WO2011069236A1
公开(公告)日：2011-06-16
申请号：PCT/CA2010/001595
申请日：2010-10-05
申请人： ALBERTA INNOVATES - TECHNOLOGY FUTURES , DU, Minghui , MAUNDER, Darol
发明人： DU, Minghui , MAUNDER, Darol
IPC分类号： C07C45/66 , C07C45/29 , C07C49/755
CPC分类号： C07C45/29 , C07C45/66 , C07C2603/52 , C07C2603/54 , C07C49/755
摘要： A method of synthesizing hypocrellin B from 4,9-dihydroxy-3, 10-perylenequinones is provided. Said method consists in first oxidizing 4,9-dihydroxy-3, 10-perylenequinone, then cyclizing the oxidation product under basic conditions to provide hypocrellin B.
摘要翻译：提供了一种从4,9-二羟基-3,10-苝醌合成hypocrellin B的方法。所述方法包括首先氧化4,9-二羟基-3,10-苝醌，然后在碱性条件下使氧化产物环化以提供低聚物B.

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