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1. 发明申请

WO2020181354A1 ENDOGENOUS PLANT EXPRESSION ENHANCER 审中-公开
公开(公告)号：WO2020181354A1
公开(公告)日：2020-09-17
申请号：PCT/CA2019/050319
申请日：2019-03-14
申请人： MITSUBISHI TANABE PHARMA CORPORATION , MEDICAGO INC. , NATIONAL UNIVERSITY CORPORATION NARA INSTITUTE OF SCIENCE AND TECHNOLOGY
发明人： LAVOIE, Pierre-Olivier , D'AOUST, Marc-Andre , KATO, Ko , YAMASAKI, Shotaro
IPC分类号： C12N15/113 , A01H5/00 , C07K14/08 , C07K14/11 , C12N15/13 , C12N15/40 , C12N15/44 , C12N15/82 , C12N5/10 , C12P21/02
摘要： An isolated expression enhancer active in a plant, portion of a plant or plant cell, the expression enhancer is provided. The isolated expression enhancer may be selected from the group consisting of nbEPI42 (SEQ ID NO:1); nbSNS46 (SEQ ID NO:2); nbCSY65 (SEQ ID NO:3); nbHEL40 (SEQ ID NO:4); and nbSEP44 (SEQ ID NO:5). Methods for using the isolated expression enhancer are also provided.

2. 发明申请

WO2016115630A1 ROTAVIRUS-LIKE PARTICLE PRODUCTION IN PLANTS 审中-公开
标题翻译：罗非鱼样植物生产粒子
公开(公告)号：WO2016115630A1
公开(公告)日：2016-07-28
申请号：PCT/CA2016/050043
申请日：2016-01-21
申请人： MEDICAGO INC. , MITSUBISHI TANABE PHARMA CORPORATION
发明人： LAVOIE, Pierre-Olivier , D'AOUST, Marc-Andre
IPC分类号： C12N7/04 , A01H5/00 , C12N15/46 , C12N15/82 , C12N15/86 , C12N7/01 , C12N7/02
CPC分类号： C12N7/04 , A61K39/12 , A61K2039/5258 , C12N7/02 , C12N15/8257 , C12N15/86 , C12N2720/12322 , C12N2720/12323 , C12N2720/12334 , C12N2720/12351
摘要： A method of producing a rotavirus-like particle (RLP) in a plant is provided. The method comprises expressing within a host or host cell for example a plant, portion of a plant or plant cell one or more nucleic acid comprising one or more regulatory region operatively linked to a first, second and third nucleotide sequence, the regulatory region active in the host or host cell. The first nucleotide sequence encoding a first rotavirus protein, the second nucleotide sequence encoding a second rotavirus protein and the third nucleotide sequence encoding a third rotavirus protein. The first, second and third encode rotavirus protein NSP4 and VP2 or VP6 and VP4 or VP7. The host or host cell is incubated under conditions that permit the expression of the nucleic acids, so that NSP4 and either VP2 of VP6 and VP4 or VP7 are expressed, thereby producing the RLP. Hosts comprising the RLP, compositions comprising the RLP and method for using the composition are also provided.
摘要翻译：提供了一种在植物中产生轮状病毒样颗粒（RLP）的方法。该方法包括在宿主或宿主细胞内表达例如植物，植物或植物细胞的一部分，一个或多个核酸，其包含与第一，第二和第三核苷酸序列可操作地连接的一个或多个调节区，宿主或宿主细胞。编码第一轮状病毒蛋白的第一核苷酸序列，编码第二轮状病毒蛋白的第二核苷酸序列和编码第三轮状病毒蛋白的第三核苷酸序列。第一，第二和第三编码轮状病毒蛋白NSP4和VP2或VP6和VP4或VP7。宿主或宿主细胞在允许核酸表达的条件下孵育，使得VP6和VP4或VP7的NSP4和VP2都被表达，从而产生RLP。还提供了包含RLP的宿主，包含RLP的组合物和使用该组合物的方法。

3. 发明申请

WO2020168424A9 ROTAVIRUS VP7 FUSION PROTEINS AND ROTAVIRUS-LIKE PARTICLES COMPRISING THEM 审中-公开
公开(公告)号：WO2020168424A9
公开(公告)日：2020-08-27
申请号：PCT/CA2020/050212
申请日：2020-02-19
申请人： MEDICAGO INC. , MITSUBISHI TANABE PHARMA CORPORATION
发明人： D'AOUST, Marc-Andre , LAVOIE, Pierre-Olivier
IPC分类号： C12N15/46 , A01H5/00 , A61K39/15 , A61P31/14 , A61P37/04 , C07K14/14 , C07K16/10 , C07K19/00 , C12N15/62 , C12N15/82 , C12N7/01
摘要： Nucleic acids encoding rotavirus VP7 fusion proteins and rotavirus-like particle (RLPs) comprising the rotavirus VP7 fusion proteins are provided. Methods for rotavirus VP7 fusion protein and RLP production in plants are also described. The VP7 fusion protein comprises a first sequence encoding a 7-1a subdomain, a second sequence encoding a 7-2 domain and a third sequence encoding a 7-1b subdomain; wherein the sequence of the 7-2 domain is derived from a first rotavirus strain and the sequence of the 7-la subdomain, the sequence of the 7-1b subdomain or the sequence of the 7-la subdomain and the sequence of the 7-1b subdomain are derived from a second rotavirus strain.

4. 发明申请

WO2020168424A1 ROTAVIRUS VP7 FUSION PROTEINS AND ROTAVIRUS-LIKE PARTICLES COMPRISING THEM 审中-公开
公开(公告)号：WO2020168424A1
公开(公告)日：2020-08-27
申请号：PCT/CA2020/050212
申请日：2020-02-19
申请人： MEDICAGO INC. , MITSUBISHI TANABE PHARMA CORPORATION
发明人： D'AOUST, Marc-Andre , LAVOIE, Pierre-Olivier
IPC分类号： C12N15/46 , A01H5/00 , A61K39/15 , A61P31/14 , A61P37/04 , C07K14/14 , C07K16/10 , C07K19/00 , C12N15/62 , C12N15/82 , C12N7/01
摘要： Nucleic acids encoding rotavirus VP7 fusion proteins and rotavirus-like particle (RLPs) comprising the rotavirus VP7 fusion proteins are provided. Methods for rotavirus VP7 fusion protein and RLP production in plants are also described. The VP7 fusion protein comprises a first sequence encoding a 7-1a subdomain, a second sequence encoding a 7-2 domain and a third sequence encoding a 7-1b subdomain; wherein the sequence of the 7-2 domain is derived from a first rotavirus strain and the sequence of the 7-la subdomain, the sequence of the 7-1b subdomain or the sequence of the 7-la subdomain and the sequence of the 7-1b subdomain are derived from a second rotavirus strain.

5. 发明申请

WO2013166609A1 ROTAVIRUS-LIKE PARTICLE PRODUCTION IN PLANTS 审中-公开
标题翻译：在植物中的旋风样颗粒生产
公开(公告)号：WO2013166609A1
公开(公告)日：2013-11-14
申请号：PCT/CA2013/050364
申请日：2013-05-10
申请人： MEDICAGO INC. , MITSUBISHI TANABE PHARMA CORPORATION
发明人： D'AOUST, Marc-Andre , LANDRY, Nathalie , LAVOIE, Pierre-Olivier , ARAI, Masaaki , ASAHARA, Naomi , MUTEPFA, David Levi Rutendo , HITZEROTH, Inga Isabel , RYBICKI, Edward Peter
IPC分类号： C12N7/04 , A61K39/15 , A61P31/14 , A61P37/04 , C07K14/14 , C12N15/46 , C12N15/82 , C12N7/01
CPC分类号： A61K39/15 , A61K39/12 , A61K2039/5258 , C07K14/005 , C12N7/00 , C12N7/02 , C12N15/8203 , C12N15/8214 , C12N15/8216 , C12N15/8218 , C12N15/8221 , C12N15/8258 , C12N2720/12334 , C12N2720/12351
摘要： A method of producing a virus-like particle (VLP) in a plant is provided. The method comprises introducing a first nucleic acid into the plant, or portion of the plant. The first nucleic acid comprising a first regulatory region active in the plant operatively linked to a nucleotide sequence encoding one or more rotavirus structural protein for example but not limited to rotavirus protein VP2. The nucleotide sequence may further comprise one or more than one amplification element and/or a compartment targeting sequence. A second nucleic acid might be introduced into the plant, or portion of the plant. The second nucleic acid comprises a second regulatory region active in the plant and operatively linked to a nucleotide sequence encoding one or more rotavirus structural protein, for example but not limited to rotavirus protein VP6. Optionally, a third nucleic acid and/ or fourth nucleic acid might be introduced into the plant, or portion of the plant. The third nucleic acid comprises a third regulatory region active in the plant and operatively linked to a nucleotide sequence encoding one or more rotavirus structural protein, for example but not limited to rotavirus protein VP4. The fourth nucleic acid comprises a fourth regulatory region active in the plant and operatively linked to a nucleotide sequence encoding one or more rotavirus structural protein, for example but not limited to rotavirus protein VP7. The plant or portion of the plant is incubated under conditions that permit the expression of the nucleic acids, thereby producing the VLP.
摘要翻译：提供了一种在植物中生产病毒样颗粒（VLP）的方法。该方法包括将第一核酸引入植物或植物的一部分。所述第一核酸包含在植物中活性的第一调节区，其可操作地连接于编码一种或多种轮状病毒结构蛋白（例如但不限于轮状病毒蛋白VP2）的核苷酸序列。核苷酸序列还可以包含一个或多于一个扩增元件和/或隔室靶向序列。可以将第二种核酸引入植物或植物的一部分。第二核酸包含在植物中有活性的第二调控区，并可操作地连接于编码一种或多种轮状病毒结构蛋白（例如但不限于轮状病毒蛋白VP6）的核苷酸序列。任选地，第三核酸和/或第四核酸可以被引入植物或植物的一部分。第三核酸包含在植物中活性的第三调节区，并且与编码一种或多种轮状病毒结构蛋白（例如但不限于轮状病毒蛋白VP4）的核苷酸序列可操作地连接。第四核酸包含在植物中活性的第四调节区，并且可操作地连接于编码一种或多种轮状病毒结构蛋白（例如但不限于轮状病毒蛋白VP7）的核苷酸序列。将植物或植物的一部分在允许核酸表达的条件下温育，从而产生VLP。

6. 发明公开

EP3765618A1 PLANT EXPRESSION ENHANCER 审中-实审转让
公开(公告)号：EP3765618A1
公开(公告)日：2021-01-20
申请号：EP19767538.2
申请日：2019-03-14
申请人： Medicago Inc. , National University corporation Nara Institute of Science and Technology , Mitsubishi Tanabe Pharma Corporation
发明人： LAVOIE, Pierre-Olivier , D'AOUST, Marc-Andre , KATO, Ko , YAMASAKI, Shotaro
IPC分类号： C12N15/113 , A01H5/00 , C07K14/11 , C12N15/13 , C12N15/33 , C12N15/40 , C12N15/44 , C12N15/82 , C12N5/10 , C12P21/02

7. 发明授权

EP3256575B1 ROTAVIRUS-LIKE PARTICLE PRODUCTION IN PLANTS 无效转让
公开(公告)号：EP3256575B1
公开(公告)日：2020-07-29
申请号：EP16739705.8
申请日：2016-01-21
申请人： Medicago Inc. , Mitsubishi Tanabe Pharma Corporation
发明人： LAVOIE, Pierre-Olivier , D'AOUST, Marc-Andre
IPC分类号： C12N7/04 , A01H5/00 , C12N15/46 , C12N15/82 , C12N15/86 , C12N7/01 , C12N7/02

8. 发明授权

EP2847324B1 ROTAVIRUS-LIKE PARTICLE PRODUCTION IN PLANTS 有权转让
公开(公告)号：EP2847324B1
公开(公告)日：2018-01-03
申请号：EP13787880.7
申请日：2013-05-10
申请人： Medicago Inc. , Mitsubishi Tanabe Pharma Corporation
发明人： D'AOUST, Marc-Andre , LANDRY, Nathalie , LAVOIE, Pierre-Olivier , ARAI, Masaaki , ASAHARA, Naomi , MUTEPFA, David Levi Rutendo , HITZEROTH, Inga Isabel , RYBICKI, Edward Peter
IPC分类号： C12N7/04 , A61K39/15 , A61P31/14 , A61P37/04 , C07K14/14 , C12N15/46 , C12N15/82 , C12N7/01
CPC分类号： A61K39/15 , A61K39/12 , A61K2039/5258 , C07K14/005 , C12N7/00 , C12N7/02 , C12N15/8203 , C12N15/8214 , C12N15/8216 , C12N15/8218 , C12N15/8221 , C12N15/8258 , C12N2720/12334 , C12N2720/12351
摘要： A method of producing a virus-like particle (VLP) in a plant is provided. The method comprises introducing a first nucleic acid into the plant, or portion of the plant. The first nucleic acid comprising a first regulatory region active in the plant operatively linked to a nucleotide sequence encoding one or more rotavirus structural protein for example but not limited to rotavirus protein VP2. The nucleotide sequence may further comprise one or more than one amplification element and/or a compartment targeting sequence. A second nucleic acid might be introduced into the plant, or portion of the plant. The second nucleic acid comprises a second regulatory region active in the plant and operatively linked to a nucleotide sequence encoding one or more rotavirus structural protein, for example but not limited to rotavirus protein VP6. Optionally, a third nucleic acid and/ or fourth nucleic acid might be introduced into the plant, or portion of the plant. The third nucleic acid comprises a third regulatory region active in the plant and operatively linked to a nucleotide sequence encoding one or more rotavirus structural protein, for example but not limited to rotavirus protein VP4. The fourth nucleic acid comprises a fourth regulatory region active in the plant and operatively linked to a nucleotide sequence encoding one or more rotavirus structural protein, for example but not limited to rotavirus protein VP7. The plant or portion of the plant is incubated under conditions that permit the expression of the nucleic acids, thereby producing the VLP.

9. 发明公开

EP3927829A1 ROTAVIRUS VP7 FUSION PROTEINS AND ROTAVIRUS-LIKE PARTICLES COMPRISING THEM 审中-公开
公开(公告)号：EP3927829A1
公开(公告)日：2021-12-29
申请号：EP20759791.5
申请日：2020-02-19
申请人： Medicago Inc. , Mitsubishi Tanabe Pharma Corporation
发明人： D'AOUST, Marc-Andre , LAVOIE, Pierre-Olivier
IPC分类号： C12N15/46 , A01H5/00 , A61K39/15 , A61P31/14 , A61P37/04 , C07K14/14 , C07K16/10 , C07K19/00 , C12N15/62 , C12N15/82 , C12N7/01

10. 发明公开

EP3597757A1 ROTAVIRUS-LIKE PARTICLE PRODUCTION IN PLANTS 有权
公开(公告)号：EP3597757A1
公开(公告)日：2020-01-22
申请号：EP19186469.3
申请日：2013-05-10
申请人： Medicago Inc. , Mitsubishi Tanabe Pharma Corporation
发明人： D'AOUST, Marc-Andre , LANDRY, Nathalie , LAVOIE, Pierre-Olivier , ARAI, Masaaki , ASAHARA, Naomi , MUTEPFA, David Levi Rutendo , HITZEROTH, Inga Isabel , RYBICKI, Edward Peter
IPC分类号： C12N15/82 , C12N15/46 , C12N7/04 , C07K14/14 , A61K39/15 , A61P31/14 , A61P37/04
摘要： A method of producing a virus-like particle (VLP) in a plant is provided. The method comprises introducing a first nucleic acid into the plant, or portion of the plant. The first nucleic acid comprising a first regulatory region active in the plant operatively linked to a nucleotide sequence encoding one or more rotavirus structural protein for example but not limited to rotavirus protein VP2. The nucleotide sequence may further comprise one or more than one amplification element and/or a compartment targeting sequence. A second nucleic acid might be introduced into the plant, or portion of the plant. The second nucleic acid comprises a second regulatory region active in the plant and operatively linked to a nucleotide sequence encoding one or more rotavirus structural protein, for example but not limited to rotavirus protein VP6. Optionally, a third nucleic acid and/ or fourth nucleic acid might be introduced into the plant, or portion of the plant. The third nucleic acid comprises a third regulatory region active in the plant and operatively linked to a nucleotide sequence encoding one or more rotavirus structural protein, for example but not limited to rotavirus protein VP4. The fourth nucleic acid comprises a fourth regulatory region active in the plant and operatively linked to a nucleotide sequence encoding one or more rotavirus structural protein, for example but not limited to rotavirus protein VP7. The plant or portion of the plant is incubated under conditions that permit the expression of the nucleic acids, thereby producing the VLP.

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