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1. 发明申请

WO2009097165A3 ORDERED COATINGS FOR DRUG ELUTING STENTS AND MEDICAL DEVICES 审中-公开
公开(公告)号：WO2009097165A3
公开(公告)日：2009-08-06
申请号：PCT/US2009/030077
申请日：2009-01-05
申请人： MEDTRONIC VASCULAR INC. , TEDESCHI, Eugene , FRANCIS, Richard , BIRDSALL, Matthew
发明人： TEDESCHI, Eugene , FRANCIS, Richard , BIRDSALL, Matthew
IPC分类号： A61L31/10 , A61L31/16
摘要： A system for treating a vascular condition comprises a therapeutic agent eluting stent having a layered coating on the stent framework. The coating releases therapeutically effective amounts of one or more therapeutic agents in and ordered sequence and over a selected time period. Another embodiment of the invention includes a method of treating a vascular condition by placing a stent having a layered coating at a treatment site and delivering a therapeutically effective amount of one or more therapeutic agents at the treatment site in an ordered sequence and over a selected time period.

2. 发明申请

WO2009048813A1 MEDICAL IMPLANT WITH INTERNAL DRUG DELIVERY SYSTEM 审中-公开
标题翻译：具有内部药物输送系统的医疗植入物
公开(公告)号：WO2009048813A1
公开(公告)日：2009-04-16
申请号：PCT/US2008/078791
申请日：2008-10-03
申请人： MEDTRONIC VASCULAR INC. , OZDIL, Feridun , RAJALINGAM, Robert , MOLONEY, Noreen, F. , ALLEN, Jeffrey , BIRDSALL, Matthew , UNTEREKER, Darrel , GROSS, Jeffrey , DOLAN, Mark
发明人： OZDIL, Feridun , RAJALINGAM, Robert , MOLONEY, Noreen, F. , ALLEN, Jeffrey , BIRDSALL, Matthew , UNTEREKER, Darrel , GROSS, Jeffrey , DOLAN, Mark
IPC分类号： A61F2/82 , A61F2/90
CPC分类号： A61F2/90 , A61F2250/0068
摘要： A system for treating a vascular condition includes a catheter and a stent disposed on the catheter. The stent includes tubing having a wall defining a central lumen and a plurality of holes. The system further includes a therapeutic agent disposed within the central lumen of the tubing. A method of manufacturing a therapeutic agent carrying stent includes inserting a therapeutic agent within a therapeutic agent delivery system into the central lumen of a hollow metal tube and forming a stent framework from the hollow tube.
摘要翻译：用于治疗血管病症的系统包括导管和设置在导管上的支架。支架包括具有限定中心腔和多个孔的壁的管。该系统还包括设置在管的中心腔内的治疗剂。制造治疗剂携带支架的方法包括将治疗剂递送系统内的治疗剂插入中空金属管的中心腔并从中空管形成支架框架。

3. 发明申请

WO2008154138A2 DRUG LOADED IMPLANTABLE MEDICAL DEVICE 审中-公开
标题翻译：药物装载可植入装置
公开(公告)号：WO2008154138A2
公开(公告)日：2008-12-18
申请号：PCT/US2008/064469
申请日：2008-05-22
申请人： MEDTRONIC VASCULAR INC. , DOLAN, Mark , REA, Susan , KANTOR, John
发明人： DOLAN, Mark , REA, Susan , KANTOR, John
IPC分类号： A61F2/90
CPC分类号： A61F2/91 , A61F2230/0054 , A61F2250/0068
摘要： A drug eluting implantable device includes an exterior surface on the device and at least one recess formed in the exterior surface. The device further include at least one sidewall protruding from the exterior surface adjacent the at least one recess defining a channel with the recess into which the drug may be loaded, the sidewall including a perpendicular portion substantially perpendicular to the exterior surface and the sidewall further including a parallel portion extending from the perpendicular portion, the parallel portion extending from the perpendicular portion at an angle greater than about 90 degrees as measured with reference to the exterior surface.
摘要翻译：药物洗脱可植入装置包括装置上的外表面和形成在外表面中的至少一个凹陷。所述装置还包括至少一个侧壁，所述至少一个侧壁从邻近所述至少一个凹部的所述外表面突出，所述至少一个凹部限定具有所述凹部的通道，所述凹部可被装载到所述凹部中，所述侧壁包括基本上垂直于所述外表面的垂直部分，从垂直部分延伸的平行部分，平行部分以相对于外表面测量的大于约90度的角度从垂直部分延伸。

4. 发明申请

WO2008127889A2 DEGRADABLE POLYMERS INCORPORATING GAMMA- BUTYROLACTONE 审中-公开
标题翻译：加入甘油 - 丁基酮的可降解聚合物
公开(公告)号：WO2008127889A2
公开(公告)日：2008-10-23
申请号：PCT/US2008/059361
申请日：2008-04-04
申请人： MEDTRONIC VASCULAR INC. , CHEN, Mingfei , CHENG, Peiwen , GUO, Ya , UDIPI, Kishore
发明人： CHEN, Mingfei , CHENG, Peiwen , GUO, Ya , UDIPI, Kishore
CPC分类号： A61L31/148 , A61F2210/0004 , A61L27/18 , A61L27/34 , A61L27/54 , A61L27/58 , A61L31/06 , A61L31/10 , A61L31/16 , A61L2300/252 , A61L2300/258 , A61L2300/402 , A61L2300/414 , A61L2300/432 , C08G63/08 , C08G63/823 , C09D167/04 , C08L67/04
摘要： Disclosed herein are implantable medical devices having controlled release biodegradable polymer coatings thereon wherein the polymer comprises a monomer formed from ring opening of γ-butyrolactone and at least one additional monomer selected from the group consisting of trimethylene carbonate, lactide, polyethylene glycol, glycolide, the monomers formed from ring opening of ε-caprolactone, 4-tert- butyl caprolactone, and N-acetyl caprolactone, and combinations thereof, and at least one drug releasable from the biodegradable polymer. Also disclosed are implantable medical devices form of the biodegradable polymers and processes for forming the polymers.
摘要翻译：本文公开了具有其上具有控制释放的可生物降解的聚合物涂层的可植入医疗装置，其中所述聚合物包含由γ-丁内酯的开环形成的单体和至少一种选自三亚甲基碳酸酯，丙交酯，聚乙二醇，乙交酯，由ε-己内酯，4-叔丁基己内酯和N-乙酰己内酯的开环形成的单体及其组合，以及可从可生物降解的聚合物中释放的至少一种药物。还公开了可生物降解聚合物的可植入医疗装置形式和形成聚合物的方法。

5. 发明申请

WO2008094760A3 TEXTURED MEDICAL DEVICES 审中-公开
公开(公告)号：WO2008094760A3
公开(公告)日：2008-08-07
申请号：PCT/US2008/051128
申请日：2008-01-16
申请人： MEDTRONIC VASCULAR INC , MELDER, Robert
发明人： MELDER, Robert
IPC分类号： A61L31/14 , A61L27/50 , A61L29/14
摘要： Disclosed are medical devices having textured surfaces and biocompatible coatings disposed thereon. The textured surfaces allow for durable coatings to be applied to the medical device without a previous pre-coating having been applied. The biocompatible coating can further comprise a bioactive agent.

6. 发明申请

WO2008070356A3 BLOCK BIODEGRADABLE COPOLYMERS FOR MEDICAL DEVICES 审中-公开
公开(公告)号：WO2008070356A3
公开(公告)日：2008-06-12
申请号：PCT/US2007/082954
申请日：2007-10-30
申请人： MEDTRONIC VASCULAR, INC. , GUO, Ya , CHENG, Peiwen
发明人： GUO, Ya , CHENG, Peiwen
IPC分类号： A61L31/06 , A61L31/10 , A61L31/16
摘要： Disclosed herein are implantable medical devices comprising controlled release biodegradable block copolymers or coated with controlled release block copolymers and at least one drug releasable from the block copolymer. The controlled release block copolymers comprise least two blocks selected from the group consisting of polyesters, polyethers, and polyurethanes.

7. 发明申请

WO2007121055A1 BIODEGRADABLE BIOCOMPATIBLE AMPHIPHILIC COPOLYMERS FOR COATING AND MANUFACTURING MEDICAL DEVICES 审中-公开
标题翻译：用于涂料和制造医疗设备的生物可降解的生物降解性共聚物
公开(公告)号：WO2007121055A1
公开(公告)日：2007-10-25
申请号：PCT/US2007/065281
申请日：2007-03-27
申请人： MEDTRONIC VASCULAR, INC. , CHENG, Peiwen , GUO, Ya , CHEN, Mingfei , UDIPI, Kishore
发明人： CHENG, Peiwen , GUO, Ya , CHEN, Mingfei , UDIPI, Kishore
IPC分类号： A61L31/10 , C08G63/64 , C08G63/66
CPC分类号： C08G63/66 , A61L27/18 , A61L27/34 , A61L27/58 , A61L31/06 , A61L31/10 , A61L31/148 , C08G65/331 , C09D167/00 , C08L71/02
摘要： Disclosed in the present invention are biodegradable biocompatible amphiphilic copolymers for coating and manufacturing medical devices. The properties of the polymers in the present invention are fine tuned for optimal performance depending on the medical purpose. Moreover, the polymers of the present invention retain and release bioactive drugs in a controlled manner.
摘要翻译：在本发明中公开了用于涂覆和制造医疗装置的可生物降解的生物相容性两亲性共聚物。根据医疗目的，本发明中的聚合物的性质被微调以获得最佳性能。此外，本发明的聚合物以受控的方式保留和释放生物活性药物。

8. 发明申请

WO2007112159A2 STENT, INTRALUMINAL STENT DELIVERY SYSTEM, AND METHOD OF TREATING A VASCULAR CONDITION 审中-公开
标题翻译： STENT，INTRALUMINAL STENT DELIVERY SYSTEM，AND METHOD OF TRANTING A VASCULAR CONDITION
公开(公告)号：WO2007112159A2
公开(公告)日：2007-10-04
申请号：PCT/US2007/062226
申请日：2007-02-15
申请人： MEDTRONIC VASCULAR, INC. , DOTY, David
发明人： DOTY, David
IPC分类号： A61L31/14 , A61L31/16
CPC分类号： A61L31/148 , A61L31/16 , A61L2300/00
摘要： A stent, a stent delivery system, and a method of treating a vascular condition. The system includes a catheter, an inflatable member operably attached to the catheter, and a biodegradable stent disposed on the inflatable member. The stent includes a biodegradable flexible elongate member including an elongate member wall surrounding a cavity. A biodegradable reinforcing member is positioned within or adjacent the elongate member wall to support the biodegradable sleeve. A biodegradable photo-curable polymer positioned within the cavity. The method includes delivering a biodegradable stent having a cavity filled with a pre-polymer to a treatment site. A balloon is expanded to position the stent at the treatment site. The pre-polymer positioned within the stent cavity is photopolymerized. The deployed stent is supported in a radial direction with a biodegradable reinforcing member.
摘要翻译：支架，支架输送系统和治疗血管病症的方法。该系统包括导管，可操作地附接到导管的可充气构件和设置在可膨胀构件上的可生物降解的支架。支架包括可生物降解的柔性细长构件，其包括围绕空腔的细长构件壁。可生物降解的加强构件定位在细长构件壁内或邻近细长构件壁以支撑可生物降解的套筒。位于腔内的可生物降解的可光固化聚合物。该方法包括将具有填充有预聚物的腔的可生物降解的支架递送至治疗部位。扩张气囊以将支架定位在治疗部位。位于支架腔内的预聚物被光聚合。部署的支架在径向方向上具有可生物降解的加强构件。

9. 发明申请

WO2006107608A1 INTRALUMINAL STENT, DELIVERY SYSTEM, AND METHOD OF TREATING A VASCULAR CONDITION 审中-公开
标题翻译：血管内支架，输送系统和治疗血管病变的方法
公开(公告)号：WO2006107608A1
公开(公告)日：2006-10-12
申请号：PCT/US2006/010587
申请日：2006-03-23
申请人： MEDTRONIC VASCULAR, INC. , CHO, Junghwa
发明人： CHO, Junghwa
IPC分类号： A61F2/06
CPC分类号： A61F2/92 , A61F2/958 , A61F2230/0054
摘要： An intraluminal stent, an intraluminal stent delivery system, and a method of treating a vascular condition. The stent includes a stent body with a plurality of struts. The stent body is expandable from a compressed configuration to a deployed configuration. The struts include at least one sliding assembly for locking the stent body in the deployed configuration. The at least one sliding assembly allows sliding of adjacent struts one to another while the stent body is expanding. The system further includes a catheter and the stent disposed on a portion of the catheter. The method includes positioning an intraluminal stent with a catheter within a vessel. The stent includes minimized overlap of adjacent struts while in a compressed configuration. The stent is expanded from the compressed configuration to an deployed configuration where it is locked. Adjacent struts slide relative one to another while the stent is expanding.
摘要翻译：管腔内支架，腔内支架输送系统和治疗血管病变的方法。支架包括具有多个支柱的支架主体。支架主体可从压缩配置扩展到展开配置。支柱包括至少一个用于将支架主体锁定在展开构型中的滑动组件。至少一个滑动组件允许相邻的支柱在支架主体膨胀时彼此滑动。该系统还包括导管和设置在导管的一部分上的支架。该方法包括将具有导管的管腔内支架定位在血管内。在压缩构型中，支架包括相邻支柱的最小化重叠。支架从压缩配置扩展到被锁定的展开配置。支架扩张时相邻的支柱相对滑动。

10. 发明申请

WO2010011464A1 LOW TEMPERATURE DEPOSITION OF A VAPORIZED DRUG 审中-公开
标题翻译：一种挥发性药物的低温沉积
公开(公告)号：WO2010011464A1
公开(公告)日：2010-01-28
申请号：PCT/US2009/048913
申请日：2009-06-26
申请人： MEDTRONIC VASCULAR INC. , COATES, Paul , COOK, Brian
发明人： COATES, Paul , COOK, Brian
IPC分类号： C23C14/02 , C23C14/12 , A61L29/16 , A61F2/20
CPC分类号： C23C14/12 , A61F2/82 , A61F2250/0067 , A61L31/16 , A61L2300/606 , A61L2300/608 , A61L2420/02 , C23C14/024
摘要： A drug coating is formed by vaporizing a drug in a deposition chamber having an implantable medical device such as a stent loaded therein. A vacuum is utilized to lower the pressure within the deposition chamber, thereby reducing the temperature necessary to vaporize the drug. The drug is then deposited onto the implantable medical device while in a vapor phase to form the drug coating.
摘要翻译：通过在具有植入式医疗装置（诸如其中装载的支架）的沉积室中蒸发药物来形成药物涂层。利用真空来降低沉积室内的压力，从而降低蒸发药物所需的温度。然后将药物在气相中沉积到可植入医疗装置上以形成药物涂层。

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