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1. 发明申请

WO2008154138A2 DRUG LOADED IMPLANTABLE MEDICAL DEVICE 审中-公开
标题翻译：药物装载可植入装置
公开(公告)号：WO2008154138A2
公开(公告)日：2008-12-18
申请号：PCT/US2008/064469
申请日：2008-05-22
申请人： MEDTRONIC VASCULAR INC. , DOLAN, Mark , REA, Susan , KANTOR, John
发明人： DOLAN, Mark , REA, Susan , KANTOR, John
IPC分类号： A61F2/90
CPC分类号： A61F2/91 , A61F2230/0054 , A61F2250/0068
摘要： A drug eluting implantable device includes an exterior surface on the device and at least one recess formed in the exterior surface. The device further include at least one sidewall protruding from the exterior surface adjacent the at least one recess defining a channel with the recess into which the drug may be loaded, the sidewall including a perpendicular portion substantially perpendicular to the exterior surface and the sidewall further including a parallel portion extending from the perpendicular portion, the parallel portion extending from the perpendicular portion at an angle greater than about 90 degrees as measured with reference to the exterior surface.
摘要翻译：药物洗脱可植入装置包括装置上的外表面和形成在外表面中的至少一个凹陷。所述装置还包括至少一个侧壁，所述至少一个侧壁从邻近所述至少一个凹部的所述外表面突出，所述至少一个凹部限定具有所述凹部的通道，所述凹部可被装载到所述凹部中，所述侧壁包括基本上垂直于所述外表面的垂直部分，从垂直部分延伸的平行部分，平行部分以相对于外表面测量的大于约90度的角度从垂直部分延伸。

2. 发明申请

WO2007047027A1 INTRALUMINAL STENT, DELIVERY SYSTEM, AND METHOD OF TREATING A VASCULAR CONDITION 审中-公开
标题翻译：血管内支架，输送系统和治疗血管病变的方法
公开(公告)号：WO2007047027A1
公开(公告)日：2007-04-26
申请号：PCT/US2006/037178
申请日：2006-09-22
申请人： MEDTRONIC VASCULAR, INC. , OZDIL, Feridun , JUNGHWA, Jenn , BERGLUND, Joseph , REA, Susan
发明人： OZDIL, Feridun , JUNGHWA, Jenn , BERGLUND, Joseph , REA, Susan
IPC分类号： A61F2/06
CPC分类号： A61F2/92 , A61F2/91 , A61F2/958 , A61F2220/0008 , A61F2230/0054
摘要： An intraluminal stent, an intraluminal stent delivery system, and a method of treating a vascular condition. The stent includes a framework with a plurality of flap portions projecting substantially beyond a central core region. The flap portions are movable from a compressed position and an extended position when the stent is deployed. The system includes a catheter and the intraluminal stent. The method includes positioning an intraluminal stent within a vessel. A plurality of flap portions of the stent is extended from a compressed position into contact with the vessel.
摘要翻译：管腔内支架，腔内支架输送系统和治疗血管病变的方法。支架包括具有大致突出超过中心芯区域的多个翼片部分的框架。当支架展开时，翼片部分可从压缩位置和伸出位置移动。该系统包括导管和管腔内支架。该方法包括将管腔内支架定位在血管内。支架的多个翼片部分从压缩位置延伸以与血管接触。

3. 发明申请

WO2008150719A1 STREAMLINED STENTS 审中-公开
标题翻译：流水线
公开(公告)号：WO2008150719A1
公开(公告)日：2008-12-11
申请号：PCT/US2008/064467
申请日：2008-05-22
申请人： MEDTRONIC VASCULAR INC. , BERGLUND, Joseph , REA, Susan
发明人： BERGLUND, Joseph , REA, Susan
IPC分类号： A61F2/90
CPC分类号： A61F2/90 , A61F2/88 , A61F2002/068 , A61F2250/0013
摘要： A stent for implantation within the body of a patient is disclosed. The stent can be formed from one or more stent modules comprising a plurality of stent struts, one or more of which have an inner contour designed for streamlined fluid flow when the stent is implanted within an anatomical passageway of the patient.
摘要翻译：公开了一种用于植入患者体内的支架。支架可以由包括多个支架支架的一个或多个支架模块形成，其中一个或多个支架支架具有设计用于当支架植入患者的解剖通道内时流线型流体流动的内部轮廓。

4. 发明申请

WO2008094936A2 STEM CELL COATED STENT 审中-公开
标题翻译：干细胞涂层
公开(公告)号：WO2008094936A2
公开(公告)日：2008-08-07
申请号：PCT/US2008/052349
申请日：2008-01-29
申请人： MEDTRONIC VASCULAR INC. , REA, Susan
发明人： REA, Susan
IPC分类号： A61L31/10 , A61L31/16 , A61L29/08 , A61L29/12 , A61L29/16 , A61F2/06
CPC分类号： A61F2/91 , A61F2/958 , A61F2250/0067 , A61L27/3834 , A61L31/005 , A61L31/10 , A61L31/16 , A61L2300/416 , A61L2300/64
摘要： A method of treating a vascular condition includes applying a plurality of stem cells to an exterior surface of a stent, and enveloping the applied stem cells with a topcoat layer. In addition, the method includes delivering the stent with applied stem cells and topcoat to a treatment region of a vessel within a body; and applying an electrical field to the stent for a predetermined time. A system for treating a vascular condition includes a catheter, a stent disposed on the catheter, at least one layer of stem cells disposed on an exterior surface of the stent, and a topcoat layer surrounding the layer of stem cells. In addition, the system includes at least one electrical lead attached to the stent, the electrical lead operable to induce an electrical field around the stent.
摘要翻译：治疗血管病症的方法包括将多个干细胞施用于支架的外表面，并用外涂层包封所施用的干细胞。此外，该方法包括将施用的干细胞和面漆的支架递送到体内的血管的治疗区域; 以及将电场施加到支架预定时间。用于治疗血管病症的系统包括导管，设置在导管上的支架，设置在支架外表面上的至少一层干细胞和围绕干细胞层的顶涂层。此外，该系统包括附接到支架的至少一个电引线，电引线可操作以诱导支架周围的电场。

5. 发明申请

WO2008094916A1 STENT WITH LONGITUDINAL GROOVE 审中-公开
标题翻译：具有长期的遗传
公开(公告)号：WO2008094916A1
公开(公告)日：2008-08-07
申请号：PCT/US2008/052323
申请日：2008-01-29
申请人： MEDTRONIC VASCULAR INC. , REA, Susan
发明人： REA, Susan
IPC分类号： A61F2/82
CPC分类号： A61F2/91 , A61F2/958 , A61F2250/0068 , Y10S623/903
摘要： A method of treating a vascular condition includes delivering a stent including at least one elongated axial slot to a target region of a vessel and receiving endothelial cell growth in the slots. A system for treating a vascular condition includes a catheter and a stent disposed on the catheter. The stent includes a stent framework including elongated axial slot (290) formed therein and at least one therapeutic agent carried within the elongated axial slots. An outermost surface of the therapeutic agent is recessed within the elongated axial slots from the outer surface of the stent framework to allow endothelial cell growth within the elongated axial slots upon delivery of the stent to a target region of a vessel.
摘要翻译：治疗血管病症的方法包括将包括至少一个细长轴向狭缝的支架递送到血管的靶区域并在狭槽中接收内皮细胞生长。用于治疗血管病症的系统包括导管和设置在导管上的支架。支架包括支架框架，其包括在其中形成的细长轴向槽（290）和在细长的轴向狭槽内承载的至少一个治疗剂。治疗剂的最外表面从支架框架的外表面凹入细长的轴向狭槽内，以便在将支架输送到血管的靶区域时允许内细胞在细长的轴向狭槽内生长。

6. 发明申请

WO2008094915A2 IMPLANTABLE DEVICE WITH RESERVOIRS FOR INCREASED DRUG LOADING 审中-公开
标题翻译：具有用于增加药物装载的储存器的可植入装置
公开(公告)号：WO2008094915A2
公开(公告)日：2008-08-07
申请号：PCT/US2008/052322
申请日：2008-01-29
申请人： MEDTRONIC VASCULAR INC. , REA, Susan , ALLEN, Jeff
发明人： REA, Susan , ALLEN, Jeff
IPC分类号： A61L31/10 , A61L31/16 , A61F2/06
CPC分类号： A61L31/146 , A61F2/91 , A61F2250/0068 , A61L31/16 , A61L2300/61 , A61L2400/18 , Y10S623/901
摘要： A method of manufacturing a drug loaded stent includes applying a photo resistant coating to at least a portion of a stent framework and removing at least a portion of the photo resistant coating from the stent framework. The method further includes applying an etchant to at least a portion of the stent framework and forming a plurality undercut drug reservoirs in the stent framework based on applying the etchant. A stent for treating a vascular condition includes a stent framework, a plurality of undercut reservoirs formed within the stent framework and a therapeutic agent disposed within at least a portion of the plurality of undercut reservoirs.
摘要翻译：制造载药支架的方法包括将抗光涂层施加到支架框架的至少一部分并从支架框架移除至少一部分耐光涂层。该方法还包括将蚀刻剂应用于支架框架的至少一部分并且基于施加蚀刻剂在支架框架中形成多个底切药物储存器。用于治疗血管状态的支架包括支架框架，在支架框架内形成的多个底切储液器和设置在所述多个底切储库的至少一部分内的治疗剂。

7. 发明公开

EP2121069A2 STEM CELL COATED STENT 审中-公开
标题翻译：干细胞涂层支架
公开(公告)号：EP2121069A2
公开(公告)日：2009-11-25
申请号：EP08714101.6
申请日：2008-01-29
申请人： Medtronic Vascular, Inc.
发明人： REA, Susan
IPC分类号： A61L31/10 , A61L31/16 , A61L29/08 , A61L29/12 , A61L29/16 , A61L31/00 , A61L31/14
CPC分类号： A61F2/91 , A61F2/958 , A61F2250/0067 , A61L27/3834 , A61L31/005 , A61L31/10 , A61L31/16 , A61L2300/416 , A61L2300/64
摘要： A method of treating a vascular condition includes applying a plurality of stem cells to an exterior surface of a stent, and enveloping the applied stem cells with a topcoat layer. In addition, the method includes delivering the stent with applied stem cells and topcoat to a treatment region of a vessel within a body; and applying an electrical field to the stent for a predetermined time. A system for treating a vascular condition includes a catheter, a stent disposed on the catheter, at least one layer of stem cells disposed on an exterior surface of the stent, and a topcoat layer surrounding the layer of stem cells. In addition, the system includes at least one electrical lead attached to the stent, the electrical lead operable to induce an electrical field around the stent.

8. 发明公开

EP2121070A2 IMPLANTABLE DEVICE WITH RESERVOIRS FOR INCREASED DRUG LOADING 审中-公开
标题翻译：用于接收较高的药物QUANTITIES集装箱植入装置
公开(公告)号：EP2121070A2
公开(公告)日：2009-11-25
申请号：EP08728474.1
申请日：2008-01-29
申请人： Medtronic Vascular, Inc.
发明人： REA, Susan , ALLEN, Jeff
IPC分类号： A61L31/10 , A61L31/16 , A61F2/06
CPC分类号： A61L31/146 , A61F2/91 , A61F2250/0068 , A61L31/16 , A61L2300/61 , A61L2400/18 , Y10S623/901
摘要： A method of manufacturing a drug loaded stent includes applying a photo resistant coating to at least a portion of a stent framework and removing at least a portion of the photo resistant coating from the stent framework. The method further includes applying an etchant to at least a portion of the stent framework and forming a plurality undercut drug reservoirs in the stent framework based on applying the etchant. A stent for treating a vascular condition includes a stent framework, a plurality of undercut reservoirs formed within the stent framework and a therapeutic agent disposed within at least a portion of the plurality of undercut reservoirs.

9. 发明公开

EP1948081A1 INTRALUMINAL STENT, DELIVERY SYSTEM, AND METHOD OF TREATING A VASCULAR CONDITION 有权
标题翻译：该腔内支架，EINFÜRSYSTEM和法治疗血管病杂志
公开(公告)号：EP1948081A1
公开(公告)日：2008-07-30
申请号：EP06815289.1
申请日：2006-09-22
申请人： Medtronic Vascular, Inc.
发明人： OZDIL, Feridun , JUNGHWA, Jenn , BERGLUND, Joseph , REA, Susan
IPC分类号： A61F2/06
CPC分类号： A61F2/92 , A61F2/91 , A61F2/958 , A61F2220/0008 , A61F2230/0054
摘要： An intraluminal stent, an intraluminal stent delivery system, and a method of treating a vascular condition. The stent includes a framework with a plurality of flap portions projecting substantially beyond a central core region. The flap portions are movable from a compressed position and an extended position when the stent is deployed. The system includes a catheter and the intraluminal stent. The method includes positioning an intraluminal stent within a vessel. A plurality of flap portions of the stent is extended from a compressed position into contact with the vessel.

10. 发明授权

EP2160159B1 DRUG LOADED IMPLANTABLE MEDICAL DEVICE 有权
标题翻译：药物加载植入医疗装置，
公开(公告)号：EP2160159B1
公开(公告)日：2012-01-04
申请号：EP08756107.2
申请日：2008-05-22
申请人： Medtronic Vascular Inc.
发明人： DOLAN, Mark , REA, Susan , KANTOR, John
IPC分类号： A61F2/90
CPC分类号： A61F2/91 , A61F2230/0054 , A61F2250/0068
摘要： A drug eluting implantable device includes an exterior surface on the device and at least one recess formed in the exterior surface. The device further include at least one sidewall protruding from the exterior surface adjacent the at least one recess defining a channel with the recess into which the drug may be loaded, the sidewall including a perpendicular portion substantially perpendicular to the exterior surface and the sidewall further including a parallel portion extending from the perpendicular portion, the parallel portion extending from the perpendicular portion at an angle greater than about 90 degrees as measured with reference to the exterior surface.

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