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1. 发明申请

WO2002090389A1 MONOCLONAL ANTIBODY FOR NKX3.1 AND METHOD FOR DETECTING SAME 审中-公开
标题翻译： NKX3.1的单克隆抗体及其检测方法
公开(公告)号：WO2002090389A1
公开(公告)日：2002-11-14
申请号：PCT/US2002/014938
申请日：2002-05-10
申请人： UNIVERSITY OF MEDICINE & DENTISTRY OF NEW JERSEY
发明人： ABATE-SHEN, Cory , SHEN, Michael, M. , KIM, Minjung
IPC分类号： C07K16/00
CPC分类号： C07K16/22 , C07K16/3069 , G01N33/57434
摘要： The present invention pertains to a monoclonal antibody, or fragment thereof, having an antigen-binding specific region for NKX3.1 and to a hybridoma cell line for producing the monoclonal antibody. The present invention also pertains to a method for detecting the presence of NKX3.1 in a sample. The method comprises (a) contacting a biopsy tissue sample with a monoclonal antibody, or a fragment thereof, having an antigen-binding specific region for NKX3.1, under conditions permitting immunospecific binding between the monoclonal antibody, or a fragment thereof, and NKX3.1 in the sample; and (b) detecting whether immunospecific binding has occurred to detect the presence of NKX3.l in the sample.
摘要翻译：本发明涉及具有NKX3.1的抗原结合特异性区域和用于制备单克隆抗体的杂交瘤细胞系的单克隆抗体或其片段。本发明还涉及用于检测样品中NKX3.1的存在的方法。该方法包括（a）在允许单克隆抗体或其片段与NKX3之间的免疫特异性结合的条件下，将活检组织样品与具有NKX3.1的抗原结合特异性区域的单克隆抗体或其片段接触 .1样品中和（b）检测是否发生了免疫特异性结合以检测样品中NKX3l的存在。

2. 发明申请

WO1997043642A1 ASSAY FOR GLYCOPROTEINS CONTAINING MANNOSE 6-PHOSPHATE 审中-公开
标题翻译：含有6-PHOSPHONE的甘氨酸的测定
公开(公告)号：WO1997043642A1
公开(公告)日：1997-11-20
申请号：PCT/US1997008382
申请日：1997-05-13
申请人： UNIVERSITY OF MEDICINE & DENTISTRY OF NEW JERSEY
发明人： UNIVERSITY OF MEDICINE & DENTISTRY OF NEW JERSEY , LOBEL, Peter , RASKA, Karel
IPC分类号： G01N33/53
CPC分类号： G01N33/57415 , G01N33/57434 , G01N33/57449
摘要： This invention relates to methods for detecting mannose 6-phosphorylated glycoproteins which are useful as prognostic markers for many types of cancer including breast cancer, ovarian cancer, and prostate cancer. The methods of detection include histological and biochemical (protein blotting) assays using any probe that recognizes mannose 6-phosphorylated glycoproteins. Such probes include derivatives of purified mannose 6-phosphate receptors, fragments of mannose 6-phosphate receptors, genetically engineered mannose 6-phosphate receptors, and antibodies that recognize mannose 6-phosphorylated oligosaccharides and glycoproteins. The results of a study employing the inventive prognostic marker show that patients testing positive for mannose 6-phosphorylated glycoproteins are significantly more likely to die of breast cancer within five years than are patients testing negative for mannose 6-phosphorylated glycoproteins.
摘要翻译：本发明涉及用于检测甘露糖6-磷酸化糖蛋白的方法，其可用作许多类型的癌症包括乳腺癌，卵巢癌和前列腺癌的预后标志物。检测方法包括使用识别甘露糖6-磷酸化糖蛋白的任何探针的组织学和生化（蛋白质印迹）测定。这样的探针包括纯化的甘露糖-6-磷酸受体的衍生物，甘露糖-6-磷酸受体的片段，遗传工程化的甘露糖-6-磷酸受体，以及识别甘露糖6-磷酸化寡糖和糖蛋白的抗体。使用本发明的预后标志物的研究结果表明，甘露糖6-磷酸化糖蛋白阳性的患者比在甘露糖6-磷酸化糖蛋白阴性的患者五年内显着更可能死于乳腺癌。

3. 发明申请

WO1991016922A1 ANALOGS OF GLYCOPROTEIN HORMONES HAVING ALTERED IMMUNOLOGICAL CHARACTERISTICS, EFFICACY AND/OR RECEPTOR SPECIFICITY 审中-公开
标题翻译：具有改变的免疫学特征，有效和/或受体特异性的糖蛋白HORMONES的模拟
公开(公告)号：WO1991016922A1
公开(公告)日：1991-11-14
申请号：PCT/US1991003162
申请日：1991-05-07
申请人： UNIVERSITY OF MEDICINE & DENTISTRY OF NEW JERSEY , CAMPBELL, Robert, K. , MOYLE, William, R.
发明人： UNIVERSITY OF MEDICINE & DENTISTRY OF NEW JERSEY
IPC分类号： A61K37/38
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , C07K14/575 , C07K14/59 , C07K16/26 , C07K2319/00 , C07K2319/02 , C07K2319/75 , C12N15/85 , C12N15/89 , C12N2760/20222 , C12N2800/108
摘要： The invention relates to modified chorionic gonadotropin (CG) alpha, beta-heterodimeric polypeptides comprising a glycoprotein hormone alpha-subunit polypeptide and a non-naturally occurring beta-subunit polypeptide. The modifications in the beta-subunit polypeptide involve the deletion, addition, or substitution of one or more amino acid residues. The modified heterodimeric polypeptides of the invention have different properties compared to native hCG. Certain alpha, beta-heterodimeric polypeptides bind to LH and FSH receptors and stimulate steroidogenesis in testicular and ovarian cells. Other alpha, beta-heterodimeric polypeptides bind to LH receptors but have lower efficacy than hCG to stimulate steroidogenesis in testicular and ovarian cells.
摘要翻译：本发明涉及包含糖蛋白激素α-亚基多肽和非天然存在的β-亚基多肽的修饰的绒毛膜促性腺激素（CG）α，β-异二聚体多肽。 β亚基多肽中的修饰涉及一个或多个氨基酸残基的缺失，添加或取代。与天然hCG相比，本发明的修饰的异二聚体多肽具有不同的特性。某些α，β-异二聚体多肽结合LH和FSH受体并刺激睾丸和卵巢细胞中的类固醇发生。其他α，β-异二聚体多肽与LH受体结合，但具有比hCG更低的功效，以刺激睾丸和卵巢细胞中的类固醇生成。

4. 发明申请

WO2014004609A2 RAPID ASSAYS FOR T-CELL ACTIVATION BY RNA MEASUREMENTS USING FLOW CYTOMETRY 审中-公开
标题翻译：通过使用流式细胞术检测RNA测定的T细胞活化快速测定
公开(公告)号：WO2014004609A2
公开(公告)日：2014-01-03
申请号：PCT/US2013/047774
申请日：2013-06-26
申请人： UNIVERSITY OF MEDICINE & DENTISTRY OF NEW JERSEY
发明人： BUSHKIN, Yuri , GENNARO, Maria Laura , TYAGI, Sanjay , PINE, Richard
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6841 , C12Q2565/626
摘要： The present invention relates to a method for rapidly detecting copies of at least one RNA molecule expressed in individual cells and uses thereof.
摘要翻译：本发明涉及快速检测在各个细胞中表达的至少一种RNA分子的拷贝及其用途的方法。

5. 发明申请

WO2003104789A1 MULTIFUNCTIONAL BIOSENSOR BASED ON ZnO NANOSTRUCTURES 审中-公开
标题翻译：基于ZnO纳米结构的多功能生物传感器
公开(公告)号：WO2003104789A1
公开(公告)日：2003-12-18
申请号：PCT/US2003/017822
申请日：2003-06-06
申请人： RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY , UNIVERSITY OF MEDICINE & DENTISTRY OF NEW JERSEY
发明人： LU, Yicheng , ZHANG, Zheng , EMANETOGLU, Nuri, William , INOUYE, Masayori , MIROCHNITCHENKO, Oleg
IPC分类号： G01N27/327
CPC分类号： G01N21/6428 , C12Q1/6825 , C12Q1/6837 , G01N27/4145 , G01N27/4146 , G01N29/022 , G01N33/54373 , G01N33/5438 , G01N2021/6432 , G01N2291/011 , G01N2291/014 , G01N2291/0255 , G01N2291/0256 , G01N2291/0423 , G01N2291/0426 , C12Q2565/501 , C12Q2565/607
摘要： The present invention provides the multifunctional biological and biochemical sensor technology based on ZnO nanostructures. The ZnO nanotips (12) serve as strong DNA or protein molecule binding sites to enhance the immobilization. Patterned ZnO nanotips are used to provide conductivity-based biosensors (10). Patterned ZnO nanotips are also used as the gate (26) for field-effect transistor (FET) type sensors (20). Patterned ZnO nanotips are integrated with SAW (30) or BAW (56) based biosensors. These ZnO nanotip based devices operate in multimodal operation combining electrical, acoustic and optical sensing mechanisms. The multifunctional biosensors can be arrayed and combined into one biochip, which will enhance the sensitivity and accuracy of biological and biochemical detection due to strong immobilization and multimodal operation capability. Such biological and biochemical sensor technology are useful in detection of RNA-DNA, DNA-DNA, protein-protein, protein-DNA and protein-small molecules interaction. It can be further applied for drug discovery, and for environmental monitoring and protection.
摘要翻译：本发明提供了基于ZnO纳米结构的多功能生物和生物化学传感器技术。 ZnO纳米尖端（12）用作强的DNA或蛋白质分子结合位点以增强固定。图案化的ZnO纳米技术用于提供基于导电率的生物传感器（10）。图案化的ZnO纳米技术也用作场效应晶体管（FET）型传感器（20）的栅极（26）。图案化的ZnO纳米片与SAW（30）或基于BAW（56）的生物传感器集成。这些基于ZnO纳米管的器件在电气，声学和光学感测机构的多模式操作中工作。多功能生物传感器可以排列并组合成一个生物芯片，由于强固定和多模态操作能力，提高了生物和生化检测的灵敏度和准确性。这种生物和生物化学传感器技术可用于RNA-DNA，DNA-DNA，蛋白质 - 蛋白质，蛋白质 - DNA和蛋白质 - 小分子相互作用的检测。可进一步应用于药物发现，环境监测和保护。

6. 发明申请

WO2003041568A2 A THREE-DIMENSIONAL MATRIX FOR PRODUCING LIVING TISSUE EQUIVALENTS 审中-公开
标题翻译：用于生产生活组织等效物的三维矩阵
公开(公告)号：WO2003041568A2
公开(公告)日：2003-05-22
申请号：PCT/US2002/036837
申请日：2002-11-15
申请人： UNIVERSITY OF MEDICINE & DENTISTRY OF NEW JERSEY , HEWITT, Charles, W. , STRANDE, Louise , SCHUSTER, Kevin
发明人： HEWITT, Charles, W. , STRANDE, Louise , SCHUSTER, Kevin
IPC分类号： A61B
CPC分类号： C12N5/0068 , A61K35/12 , C12N5/0698 , C12N2500/38 , C12N2500/40 , C12N2501/135 , C12N2501/15 , C12N2501/39 , C12N2501/395 , C12N2502/094 , C12N2502/1323 , C12N2533/56
摘要： The primary aspect of the present invention it directed to a three-dimensional matrix, a living tissue equivalent, a tissue microarray, methods of making thereof, and methods of using thereof. In one embodiment of the invention, the three-dimensional matrix comprises fibroblasts and a fibrin matrix. In a preferred embodiment, the three-dimensional matrix comprises blood plasma, thrombin and fibroblasts. The three-dimensional matrix in accordance with this invention may be used to construct living tissue equivalents, including but not limited to skin, blood vessel, bone, tendon, ligaments, and organ equivalents, among many others. Furthermore, the living tissue equivalents may be used to test the effect of various agents and to study the mechanism of disease and the efficacy of various treatment protocols.
摘要翻译：本发明的主要方面涉及三维基质，活组织当量，组织微阵列，其制备方法及其使用方法。在本发明的一个实施方案中，三维基质包含成纤维细胞和纤维蛋白基质。在优选的实施方案中，三维基质包括血浆，凝血酶和成纤维细胞。根据本发明的三维基质可以用于构建活组织等同物，包括但不限于皮肤，血管，骨，腱，韧带和器官等同物等等。此外，可以使用活组织等同物来测试各种药剂的作用并研究疾病的机制和各种治疗方案的功效。

7. 发明申请

WO2003011395A2 METHOD OF UTILIZING NEUROTROPHINS TO MANIPULATE REPRODUCTIVE CAPACITY 审中-公开
标题翻译：使用神经营养素来调节生殖能力的方法
公开(公告)号：WO2003011395A2
公开(公告)日：2003-02-13
申请号：PCT/US2002/024345
申请日：2002-07-31
申请人： UNIVERSITY OF MEDICINE & DENTISTRY OF NEW JERSEY , SEIFER, David , SHELDEN, Robert , FENG, Bo , DREYFUS, Cheryl
发明人： SEIFER, David , SHELDEN, Robert , FENG, Bo , DREYFUS, Cheryl
IPC分类号： A61P
CPC分类号： A61K31/352 , A61K38/185 , G01N33/74 , G01N2500/10
摘要： Methods and kits are provided for manipulating and predicting the reproductive capacity of a female subject. The presence of endogenous neurotrophins and addition of exogenous neurotrophins, particularly BDNF, NT-4/5, and NGF, increase the reproductive capacity of a female patient by binding to receptors on the oocytes and stimulating maturation of the oocytes. Administration of antagonists act as a contraceptive because the antagonists prevent the neurotrophins from binding to oocyte receptors. Neurotrophins may also be used to stimulate the maturation of oocyte in vitro .
摘要翻译：提供了方法和试剂盒，用于操纵和预测女性受试者的生殖能力。内源性神经营养因子的存在和外源性神经营养因子，特别是BDNF，NT-4/5和NGF的添加通过结合卵母细胞上的受体并刺激卵母细胞的成熟来增加女性患者的生殖能力。拮抗剂的施用作为避孕药，因为拮抗剂可防止神经营养蛋白结合卵母细胞受体。也可以使用神经营养蛋白刺激体外卵母细胞的成熟。

8. 发明申请

WO1996001276A1 EXPRESSION OF A FUNCTIONAL HUMAN TYPE I INTERFERON RECEPTOR 审中-公开
标题翻译：功能性人类干扰素受体的表达
公开(公告)号：WO1996001276A1
公开(公告)日：1996-01-18
申请号：PCT/US1995008456
申请日：1995-07-06
申请人： UNIVERSITY OF MEDICINE & DENTISTRY OF NEW JERSEY
发明人： UNIVERSITY OF MEDICINE & DENTISTRY OF NEW JERSEY , PESTKA, Sidney , MARIANO, Thomas, M. , SOH, Jaemog
IPC分类号： C07K14/705
CPC分类号： C12N15/81 , A61K38/00 , C07K14/715
摘要： This invention relates to a yeast artificial chromosome, YAC F136C5, containing a segment of human Chromosome 21 which when introduced into Chinese hamster ovary (CHO) cells confers upon these cells a greatly enhanced response to Hu-IFN- alpha A and Hu-IFN- alpha B2 as well as increased response to Hu-IFN-omega, Hu-IFN- alpha A/D (Bgl), and Hu-IFN- beta . This invention also relates to a functional human type I interferon receptor expressed from the yeast artificial chromosome, YAC F136C5.
摘要翻译：本发明涉及酵母人造染色体YAC F136C5，其含有人染色体21的片段，当引入中国仓鼠卵巢（CHO）细胞赋予这些细胞时，对Hu-IFN-αA和Hu-IFN- α-B2，以及Hu-IFN-ω，Hu-IFN-αA/ D（Bgl）和Hu-IFN-β的增加的反应。本发明还涉及从酵母人造染色体YAC F136C5表达的功能性人I型干扰素受体。

9. 发明申请

WO2013016452A2 CANCER TREATMENT USING BMP INHIBITOR 审中-公开
标题翻译：使用BMP抑制剂的癌症治疗
公开(公告)号：WO2013016452A2
公开(公告)日：2013-01-31
申请号：PCT/US2012/048189
申请日：2012-07-25
申请人： VANDERBILT UNIVERSITY , UNIVERSITY OF MEDICINE & DENTISTRY OF NEW JERSEY , HONG, Charles, C. , LANGENFELD, John
发明人： HONG, Charles, C. , LANGENFELD, John
IPC分类号： A61K31/519 , A61K31/47 , A61K31/5375 , A61P35/00
CPC分类号： C07D487/04 , A61K31/519 , A61K31/5377 , A61N5/10
摘要： Methods for regulating cancer cell growth and survival, inhibiting cancer cell growth, promoting cancer cell death, and/or treating a cancer make use of antagonists of a type I BMP receptor. In some embodiments the cancer is a lung cancer and the cancer cell is a lung cancer cell.
摘要翻译：用于调节癌细胞生长和存活，抑制癌细胞生长，促进癌细胞死亡和/或治疗癌症的方法利用I型BMP受体的拮抗剂。在一些实施方案中，癌症是肺癌，癌细胞是肺癌细胞。

10. 发明申请

WO2006099451A2 NOVEL HUMAN, FELINE, CHICKEN AND OTHER ANIMAL INTERFERONS AND USES THEREOF 审中-公开
标题翻译：新人，鱼，鸡和其他动物干扰物及其用途
公开(公告)号：WO2006099451A2
公开(公告)日：2006-09-21
申请号：PCT/US2006/009229
申请日：2006-03-14
申请人： UNIVERSITY OF MEDICINE & DENTISTRY OF NEW JERSEY , PESTKA, Sidney , KRAUSE, Christopher, D.
发明人： PESTKA, Sidney , KRAUSE, Christopher, D.
CPC分类号： C07K14/555 , C07K14/54
摘要： The invention relates to novel interferon polypeptides and nucleic from humans, felines, chicken and other species and to related compositions and uses. The invention also provides novel interleukin polypeptides and nucleic acids, as well as nucleic acids and polypeptides for interferons and interleukin receptors. The invention also provides antibodies specific for the novel polypeptides, assays for identifying modulators of interferon activity, and methods of treating animals, including humans, afflicted with various disorders and conditions by administering interferon polypeptides, including IFN-P polypeptides and fragments.
摘要翻译：本发明涉及新型干扰素多肽和来自人，猫科动物，鸡和其他物种以及相关组合物和用途的核酸。本发明还提供了新型白介素多肽和核酸，以及用于干扰素和白细胞介素受体的核酸和多肽。本发明还提供了针对新型多肽的特异性抗体，用于鉴定干扰素活性调节剂的测定法，以及通过施用包括IFN-P多肽和片段的干扰素多肽来治疗各种疾病和病症的动物（包括人）的方法。

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