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1. 发明申请

US20030219421A1 Calbindin-D28k protection against glucocorticoid induced cell death 审中-公开
标题翻译： Calbindin-D28k保护免受糖皮质激素诱导的细胞死亡
公开(公告)号：US20030219421A1
公开(公告)日：2003-11-27
申请号：US10155567
申请日：2002-05-23
申请人： University of Medicine & Dentistry of New Jersey
发明人： Sylvia Christakos
IPC分类号： A61K048/00 , C07H021/04 , C12P021/02 , C12N015/86 , C12N005/08
CPC分类号： C07K14/4747 , A61K48/00
摘要： The present invention provides novel compositions containing a calbindin-D28k therapeutic element, which is involved in the regulation of apoptosis, and may be administered for the prevention of an abnormal apoptosis response in cells. In particular the compositions and methods of the present invention may be used for the prevention or induction of apoptosis in such cells types as osteoblasts and osteocytes. Specifically, the compositions and methods of the present invention are useful for the prevention of diseases associated with glucocorticoid induced cell death. Specifically, the compositions and methods of the present invention may be useful in the prevention of glucocorticoid induced cell death in osteoblasts and the treatment of such conditions as glucocorticoid induced osteoporosis.
摘要翻译：本发明提供含有钙结合素-D28k治疗元件的新型组合物，其涉及凋亡调节，并且可以用于预防细胞中异常凋亡应答。特别地，本发明的组合物和方法可用于预防或诱导类似于成骨细胞和骨细胞的类型的细胞凋亡。具体地，本发明的组合物和方法可用于预防与糖皮质激素诱导的细胞死亡有关的疾病。具体地说，本发明的组合物和方法可用于预防成骨细胞中糖皮质激素诱导的细胞死亡和治疗糖皮质激素诱导的骨质疏松症等病症。

2. 发明授权

US08974800B2 Proteins expressed by mycobacterium tuberculosis and not by BCG and their use as diagnostic reagents and vaccines 有权
标题翻译：由结核分枝杆菌而不是BCG表达的蛋白质及其用作诊断试剂和疫苗
公开(公告)号：US08974800B2
公开(公告)日：2015-03-10
申请号：US13893659
申请日：2013-05-14
申请人： University of Medicine & Dentistry of New Jersey
发明人： Maria Laura Gennaro
IPC分类号： A61K39/04 , A61K39/02 , A61K39/00 , C07K14/35 , G01N33/569 , G01N33/50 , A61K38/00
CPC分类号： A61K49/0006 , A61K38/00 , A61K39/00 , A61K39/04 , A61K2039/53 , C07K14/35 , G01N33/5091 , G01N33/5695 , G01N2333/35 , G01N2333/57 , G01N2800/26 , Y10S435/863
摘要： The present invention is directed to reagents useful for generating immune responses to Mycobacterium tuberculosis and for diagnosing infection and disease in a subject that has been exposed to M. tuberculosis.
摘要翻译：本发明涉及可用于产生对结核分枝杆菌的免疫应答并用于诊断暴露于结核分枝杆菌的受试者中的感染和疾病的试剂。

3. 发明申请

US20130251739A1 PROTEINS EXPRESSED BY MYCOBACTERIUM TUBERCULOSIS AND NOT BY BCG AND THEIR USE AS DIAGNOSTIC REAGENTS AND VACCINES 有权
标题翻译：蛋白质由MYCOBACTERIUM TUBCCOSOSIS表达，而不是BCG及其作为诊断试剂和疫苗使用
公开(公告)号：US20130251739A1
公开(公告)日：2013-09-26
申请号：US13893659
申请日：2013-05-14
申请人： University of Medicine & Dentistry of New Jersey
发明人： Maria Laura Gennaro
IPC分类号： A61K39/04 , C07K14/35
CPC分类号： A61K49/0006 , A61K38/00 , A61K39/00 , A61K39/04 , A61K2039/53 , C07K14/35 , G01N33/5091 , G01N33/5695 , G01N2333/35 , G01N2333/57 , G01N2800/26 , Y10S435/863
摘要： The present invention is directed to reagents useful for generating immune responses to Mycobacterium tuberculosis and for diagnosing infection and disease in a subject that has been exposed to M. tuberculosis.
摘要翻译：本发明涉及可用于产生对结核分枝杆菌的免疫应答并用于诊断暴露于结核分枝杆菌的受试者中的感染和疾病的试剂。

4. 发明申请

US20040214257A1 Method for the treatment of vitamin D related disease 失效
标题翻译：维生素D相关疾病的治疗方法
公开(公告)号：US20040214257A1
公开(公告)日：2004-10-28
申请号：US10232342
申请日：2002-08-30
申请人： University of Medicine & Dentistry of New Jersey
发明人： Sylvia Christakos
IPC分类号： C12Q001/26 , A61K031/59
CPC分类号： A61K31/593 , A61K31/00 , A61K38/02 , A61K38/1709 , A61K2300/00
摘要： The present invention provides a method for treating diseases caused by either an excess or diminution of Vitamin D3. It provides pharmaceutical compositions for the treatment of such diseases and the methods by which these compositions are to be used. Also provided are methods for testing the activity of both 24(OH)ase and CCAATT/Enhancer Binding Protein null (C/EBPnull), as well as, for testing the effect of a compound on said activity. In particular embodiments, a method is provided for reducing the risk of hypercalcimia when administering 1,25(OH)2D3 or its analogs for the treatment of vitamin D diseases. Methods for both enhancing and diminishing 24(OH)ase activity are also provided.
摘要翻译：本发明提供了治疗由维生素D3过量或减少引起的疾病的方法。它提供用于治疗这些疾病的药物组合物和使用这些组合物的方法。还提供了用于测试24（OH）A和CCAATT / Enhancer结合蛋白β（C / EBPbeta）的活性的方法，以及用于测试化合物对所述活性的影响的方法。在具体实施方案中，提供了一种用于在施用1,25（OH）2D3或其类似物以治疗维生素D疾病时降低高钙血症风险的方法。还提供了增强和减少24（OH）活性的方法。

5. 发明申请

US20030108915A1 Glioblastoma multiforme associated protein GliTEN 审中-公开
标题翻译：胶质母细胞瘤多形性相关蛋白GliTEN
公开(公告)号：US20030108915A1
公开(公告)日：2003-06-12
申请号：US10224624
申请日：2002-08-20
申请人： University of Medicine & Dentistry of New Jersey
发明人： Randall D. McKinnon
IPC分类号： C12Q001/68 , G01N033/574 , C07H021/04 , C12N009/00 , C12P021/02 , C12N005/06
CPC分类号： C12Q1/6886 , C12Q2600/158
摘要： Nucleic acid sequences that identify a gene product associated with Glioblastoma Multiforme are disclosed. Nucleic acid probes for mRNA transcripts whose expression is associated with glioblast transformation and methods for using these probes in identifying and treating patients at risk for progression into a malignant phenotype are also disclosed.
摘要翻译：公开了鉴定与多形性成胶质细胞瘤相关的基因产物的核酸序列。还公开了其表达与成胶质细胞转化相关的mRNA转录物的核酸探针和使用这些探针鉴定和治疗患有进展为恶性表型风险的患者的方法。

6. 发明申请

US20040002086A1 Monoclonal antibody for Nkx3.1 and method for detecting the same 审中-公开
标题翻译： Nkx3.1单克隆抗体及其检测方法
公开(公告)号：US20040002086A1
公开(公告)日：2004-01-01
申请号：US10366990
申请日：2003-02-13
申请人： University of Medicine & Dentistry of New Jersey
发明人： Cory Abate-Shen , Michael M. Shen , Minjung Kim
IPC分类号： C12Q001/68 , G01N033/574
CPC分类号： C07K16/22 , C07K16/3069 , G01N33/57434
摘要： The present invention pertains to a monoclonal antibody, or fragment thereof, having an antigen-binding specific region for NKX3.1 and to a hybridoma cell line for producing the monoclonal antibody. The present invention also pertains to a method for detecting the presence of NKX3.1 in a sample. The method comprises (a) contacting a biopsy tissue sample with a monoclonal antibody, or a fragment thereof, having an antigen-binding specific region for NKX3.1, under conditions permitting immunospecific binding between the monoclonal antibody, or a fragment thereof, and NKX3.1 in the sample; and (b) detecting whether immunospecific binding has occurred to detect the presence of NKX3.1 in the sample.
摘要翻译：本发明涉及具有NKX3.1的抗原结合特异性区域和用于制备单克隆抗体的杂交瘤细胞系的单克隆抗体或其片段。本发明还涉及用于检测样品中NKX3.1的存在的方法。该方法包括（a）在允许单克隆抗体或其片段与NKX3之间的免疫特异性结合的条件下，将活检组织样品与具有NKX3.1的抗原结合特异性区域的单克隆抗体或其片段接触 .1样品中和（b）检测是否发生了免疫特异性结合以检测样品中NKX3.1的存在。

7. 发明申请

US20030206886A1 Neutralization of immune suppressive factors for the immunotherapy of cancer 审中-公开
标题翻译：中和免疫抑制因子免疫治疗癌症
公开(公告)号：US20030206886A1
公开(公告)日：2003-11-06
申请号：US10138783
申请日：2002-05-03
申请人： University of Medicine & Dentistry of New Jersey
发明人： Edmund C. Lattime , Claude E. Monken
IPC分类号： A61K048/00 , C12N015/869 , C12N007/00
CPC分类号： C12N15/86 , A61K39/00 , A61K48/00 , A61K2039/505 , C07K16/244 , C12N2710/24143
摘要： The invention provides vectors comprising nucleic acid molecules that encode polypeptides capable of binding immune suppressive factors for the immunotherapy of cancer.
摘要翻译：本发明提供了包含编码能够结合癌症免疫治疗的免疫抑制因子的多肽的核酸分子的载体。

8. 发明申请

US20030003157A1 Collagen compositions and methods for making and using the same 审中-公开
标题翻译：胶原组合物及其制备和使用方法
公开(公告)号：US20030003157A1
公开(公告)日：2003-01-02
申请号：US10056998
申请日：2002-01-25
申请人： University of Medicine & Dentistry of New Jersey
发明人： Mark P. Ohan , Michael G. Dunn
IPC分类号： A61K038/39 , A61K009/70
CPC分类号： A61L15/325 , A61L24/102 , A61L27/24 , A61L31/044
摘要： Compositions comprising glucose-incorporated, UV exposed and/or gamma irradiated collagen and methods for making the same are disclosed. The compositions comprise a mixture of collagen and a sugar material which has been exposed to UV radiation, gamma radiation or both.
摘要翻译：公开了包含掺入葡萄糖，UV暴露和/或γ辐射胶原的组合物及其制备方法。组合物包含已经暴露于UV辐射，γ辐射或两者的胶原和糖物质的混合物。

9. 发明申请

US20020046409A1 Roles for Nkx3.1 in prostate development and cancer 审中-公开
标题翻译：前列腺发育和癌症中Nkx3.1的作用
公开(公告)号：US20020046409A1
公开(公告)日：2002-04-18
申请号：US09756151
申请日：2001-01-06
申请人： University of Medicine & Dentistry of New Jersey
发明人： Cory Abate-Shen , Michael M. Shen , Thomas Gridley
IPC分类号： A01K067/027
CPC分类号： C07K14/4702 , A01K67/0271 , A01K67/0276 , A01K2217/075 , A01K2227/105 , A01K2267/0331 , C12N15/8509
摘要： The present invention pertains to a mutant mouse comprising a Nkx3.1 gene having a disruption in at least one exon. The disruption has been introduced into the genome of the mouse by homologous recombination in an embryonic stem cell. The disruption provides a null mutation which results in no expression of Nkx3.1 by the mouse and in defects in prostate ductal morphogenesis and secretory protein production in the mouse. The mouse displays prostatic epithelial hyperplasia and dysplasia. The present invention pertains to a method for screening for a drug, or other therapeutic intervention, useful for preventing or treating prostate cancer. The method comprises administering a drug, or other therapeutic intervention, to a mutant mouse predisposed towards prostate cancer; diagnosing the mutant mouse for prostate a cancer precursor; and comparing the mutant mouse with a control mutant mouse not treated with the drug, or other therapeutic intervention. The presence of a prostate cancer precursor in the mutant mouse in an amount lower than the amount in the control mouse is indicative of a drug, or other therapeutic intervention, useful for preventing or treating prostate cancer.
摘要翻译：本发明涉及包含至少一个外显子中断的Nkx3.1基因的突变小鼠。通过胚胎干细胞中的同源重组将破坏物引入小鼠的基因组中。破坏提供无效突变，其导致小鼠没有表达Nkx3.1，并且导致小鼠中前列腺导管形态发生和分泌蛋白产生的缺陷。小鼠显示前列腺上皮增生和发育不良。本发明涉及用于预防或治疗前列腺癌的药物或其它治疗性干预的方法。该方法包括向倾向于前列腺癌的突变小鼠施用药物或其它治疗干预; 诊断前列腺癌突变小鼠癌症前体; 并将突变小鼠与未用药物治疗的对照突变小鼠或其他治疗干预进行比较。突变小鼠中前列腺癌前体的存在量低于对照小鼠中的量，这表明可用于预防或治疗前列腺癌的药物或其它治疗性干预。

10. 发明申请

US20030236182A1 Therapeutic and diagnostic methods for ulcerative colitis and associated disorders 失效
标题翻译：溃疡性结肠炎及相关疾病的治疗和诊断方法
公开(公告)号：US20030236182A1
公开(公告)日：2003-12-25
申请号：US10359401
申请日：2003-02-05
申请人： University of Medicine & Dentistry of New Jersey
发明人： Kiron M. Das
IPC分类号： A61K031/00
CPC分类号： A61K31/00 , A01K2227/40 , A61K31/131 , A61K31/23 , A61K31/351 , A61K38/1709 , A61K49/0004 , C07K16/18
摘要： This invention relates to the field of therapy and diagnostic methods for ulcerative colitis. Specifically, the method comprises administering a compound or recombinant protein that inhibits interaction between CEP and human tropomyosin. Also included in the invention are methods to screen for drugs useful in treating ulcerative colitis and diagnostic methods for detecting diseases associated with an autoanticen response to hTM in affected tissue.
摘要翻译：本发明涉及溃疡性结肠炎的治疗领域和诊断方法。具体地，该方法包括施用抑制CEP与人原肌球蛋白相互作用的化合物或重组蛋白。本发明还包括筛选可用于治疗溃疡性结肠炎的药物的方法以及用于检测与受影响组织中对hTM的自动反应相关的疾病的诊断方法。

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