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1. 发明授权

US6120776A Diagnostic skin test for tuberculosis 失效
标题翻译：肺结核诊断皮肤试验
公开(公告)号：US6120776A
公开(公告)日：2000-09-19
申请号：US569221
申请日：1996-02-12
申请人： Kaare Hasl.o slashed.v , .ANG.se Bengaard Andersen , Thomas Oettinger
发明人： Kaare Hasl.o slashed.v , .ANG.se Bengaard Andersen , Thomas Oettinger
IPC分类号： A61K39/04 , C07K14/35 , C12N15/31 , C12P21/04 , C12N1/12 , C12P21/06
CPC分类号： A61K39/04 , C07K14/35
摘要： Diagnostic methods capable of discriminating between cell mediated immunologic responses due to on the one hand active tuberculosis caused by bacteria belonging to the tuberculosis complex (Mycobacterium tuberculosis, Mycobacterium africanum and Mycobacterium bovis) and on the other hand vaccination with an immunogenic agent conferring immunity to tuberculosis. A diagnostic kit is also provided, comprising a polypeptide (e.g. MPT64) capable of eliciting a delayed type hypersensitivity reaction (Dth) in animals with active tuberculosis, but not in animals vaccinated against TB with an immunogenic agent (e.g. M. bovis BCG strain: Danish 1331). Also provided are polypeptide fragments comprising a T-cell epitope of MPT64 as well as nucleic acid fragments encoding these polypeptide fragments.
摘要翻译： PCT No.PCT / DK94 / 00270 Sec。 371日期：1996年2月12日 102（e）日期1996年2月12日PCT提交1994年6月30日PCT公布。出版物WO95 / 01440 1995年1月12日的诊断方法能够区分由于结核分枝杆菌（结核分枝杆菌，非洲分枝杆菌和牛分枝杆菌）引起的一方面由活细菌结核引起的细胞介导的免疫反应的诊断方法，另一方面用免疫原性赋予结核病免疫力的代理人。还提供了诊断试剂盒，其包含能够在具有活性结核病的动物中引发延迟型超敏反应（Dth）的多肽（例如MPT64），但不包括用免疫原性试剂（例如牛分枝杆菌BCG株：丹麦语1331）。还提供了包含MPT64的T细胞表位的多肽片段以及编码这些多肽片段的核酸片段。

2. 发明授权

US5955077A Tuberculosis vaccine 失效
标题翻译：结核疫苗
公开(公告)号：US5955077A
公开(公告)日：1999-09-21
申请号：US465640
申请日：1995-06-05
申请人： Peter Andersen , .ANG.se Bengaard Andersen , Kaare Haslov , Anne Lund Sorensen
发明人： Peter Andersen , .ANG.se Bengaard Andersen , Kaare Haslov , Anne Lund Sorensen
IPC分类号： A61K39/04 , A61P31/06 , C07K14/35 , A61K39/00 , C07K1/00 , C12P21/06
CPC分类号： A61K39/04 , C07K14/35 , C12R1/19 , A61K2039/523 , A61K2039/53
摘要： The invention relates to novel secreted antigens from mycobacteria capable of evoking early (within 4 days) immunological responses from T-helper cells in the form of gamma-interferon release in memory immune animals after rechallenge infection with mycobacteria of the tuberculosis complex. The antigens are present in short term filtrates (ST-CF) from cultured mycobacteria belonging to the tuberculosis complex. One of these antigens, a polypeptide with an apparent molecular weight of 6 kDa, has been identified, and the DNA encoding the polypeptide has been cloned and sequenced. The antigens of the invention are believed useful especially in vaccines, but also in diagnostic compositions, especially for diagnosing infection with virulent mycobacteria. Also disclosed are nucleic acid fragments encoding the antigens as well as methods of immunizing animals/humans and methods of diagnosing tuberculosis.
摘要翻译：本发明涉及能够以结核分枝杆菌复合体分枝杆菌感染后的记忆免疫动物中早期（4天内）诱发来自T-辅助细胞的免疫反应以γ-干扰素释放的形式的分枝杆菌的新型分泌型抗原。抗原存在于来自属于结核病复合体的培养的分枝杆菌的短期滤液（ST-CF）中。已经鉴定了这些抗原中的一种，表观分子量为6kDa的多肽，并且已经克隆并测序了编码该多肽的DNA。认为本发明的抗原特别用于疫苗，而且在诊断组合物中尤其是用于诊断有毒分枝杆菌的感染是有用的。还公开了编码抗原的核酸片段以及免疫动物/人的方法和诊断结核病的方法。

3. 发明授权

US5985935A Treatment and prophylaxis of diseases caused by parasites, or bacteria 失效
公开(公告)号：US5985935A
公开(公告)日：1999-11-16
申请号：US302726
申请日：1994-11-01
申请人： Arsalan Kharazmi , S.o slashed.ren Br.o slashed.gger Christensen , Chen Ming , Thor Grundtvig Theander
发明人： Arsalan Kharazmi , S.o slashed.ren Br.o slashed.gger Christensen , Chen Ming , Thor Grundtvig Theander
IPC分类号： A61K31/12 , A61K31/135 , A61K31/165 , A61K31/22 , A61K31/27 , A61K31/34 , A61K36/48 , A61P31/04 , A61P33/02 , A61P37/00 , C07C45/00 , C07C45/45 , C07C45/62 , C07C45/67 , C07C45/71 , C07C45/74 , C07C45/78 , C07C47/575 , C07C49/835 , C07C49/84 , C07C67/14 , C07C69/007 , C07C69/24 , C07C225/22 , C07C271/44 , C07C323/22 , C07C323/59 , C07D207/32 , C07D207/333 , C07D301/12 , C07D303/32 , C07D307/46 , C07D311/64 , C07K5/02
CPC分类号： C07D207/333 , A61K31/12 , A61K31/135 , A61K31/165 , A61K31/22 , A61K31/27 , A61K31/34 , C07C271/44 , C07C323/59 , C07C45/00 , C07C45/62 , C07C45/67 , C07C45/673 , C07C45/71 , C07C45/74 , C07C45/78 , C07C47/575 , C07C49/835 , C07C49/84 , C07C69/24 , C07D303/32 , C07D307/46 , C07D311/64 , C07K5/0215 , Y10S977/775 , Y10S977/907
摘要： Aromatic compounds, or prodrugs thereof, which contain an alkylating site and which are capable of alkylating the thiol group in N-acetyl-L-cysteine, in particular bis-aromatic .alpha.,.beta.-unsaturated ketones, are used for the preparation of pharmaceutical compositions or medicated feed, food or drinking water for the treatment or prophylaxis of diseases caused by microorganisms or parasites, in particular protozoa such as Leishmannia, Trypanosoma, Toxoplasma, Plasmodium, Pneumocystis, Babesia and Theileria, intestinal protozoa such as Trichormionas and Ciardia; Coccidia such as Eimeria, Isospora, Cryptosporidium; Cappilaria, Microsporidium, Sarcocystis. Trichlodina, Trichoditella, Dacihylogurus, Pseudodacthylogurus, Acantocephalus, Ichthylophtherius, Botrecephalus; and intracellular bacteria, in particular Mycobacterium, Legionella species, Listeria and Salmonella. Preferred compounds have the formula (II): X.sub.m --Ph--C(O)--CH.dbd.CH--Ph--Y.sub.n, wherein each phenyl group (Ph) may be mono- or polysubstituted; X and Y designate AR.sub.H or AZ, wherein A is O, S, NH or N(C.sub.1-6 alkyl), R.sub.H designates aliphatic hydrocarbyl, and Z is H or a masking group which is decomposed to liberate AH; m is 0, 1 or 2, and n is 0, 1, 2 or 3, whereby, when m is 2, then the two X are the same or different, and when n is 2 or 3, then the two or three Y are the same or different, with the proviso that n and m are not both 0. As examples of such compounds, chalcones, e.g. licochalcone A (obtainable i.a. from batches of Chinese licorice root of Glycyrrhiza species, e.g. G. uralensis or G. inflata) as well as hydroxy, alk(en)yl, and/or alk(en)yloxy analogues thereof are active in vitro and/or in vivo against i.a. L. major and P. falciparum.

4. 发明授权

US5231168A Malaria antigen 失效
标题翻译：疟疾抗原
公开(公告)号：US5231168A
公开(公告)日：1993-07-27
申请号：US409658
申请日：1989-09-18
申请人： Morten Dziegiel , Martin Borre , Soren Jepsen , Jens Vuust , Klaus Rieneck , Annette Wind , Palle H. Jakobsen
发明人： Morten Dziegiel , Martin Borre , Soren Jepsen , Jens Vuust , Klaus Rieneck , Annette Wind , Palle H. Jakobsen
IPC分类号： A61K38/00 , A61K39/00 , C07K14/445 , C07K16/20
CPC分类号： C07K14/445 , C07K16/205 , A61K38/00 , A61K39/00
摘要： The present invention relates to a polypeptide comprising a characteristic amino acid sequence derived from the Plasmodium falciparum antigen GLURP, a polypeptide which is recognized by an antibody raised against or reactive with a polypeptide comprising said characteristic amino acid sequence and/or an antibody reactive with native GLURP, a nucleic acid molecule (DNA-fragment) encoding said polypeptide, an expression vector carrying the nucleic acid molecule, an organism expressing said nucleic acid molecule so as to produce said polypeptide, a monoclonal antibody directed against said polypeptide, a diagnostic agent comprising said antibody or said polypeptide for use in assaying Plasmodium falciparum infection and thus diagnosing malaria, and the use of said antibody or said polypeptide for therapeutic purposes, e.g. as a component in a vaccine.
摘要翻译：本发明涉及包含衍生自恶性疟原虫抗原GLURP的特征性氨基酸序列的多肽，多抗体由抗体产生或与包含所述特征性氨基酸序列的多肽产生反应的抗体和/或与天然的抗体反应的抗体 GLURP，编码所述多肽的核酸分子（DNA片段），携带核酸分子的表达载体，表达所述核酸分子以产生所述多肽的生物，针对所述多肽的单克隆抗体，包括所述抗体或所述多肽用于测定恶性疟原虫感染并因此诊断疟疾，以及所述抗体或所述多肽用于治疗目的的用途，例如作为疫苗的一个组成部分。

5. 发明申请

WO2008138341A3 METHODS FOR DETECTION OF "PONTIAC" SUBGROUPS OF LEGIONELLA PNEUMOPHILA SEROGROUP 1 审中-公开
标题翻译：检测PON A A A A 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
公开(公告)号：WO2008138341A3
公开(公告)日：2009-01-08
申请号：PCT/DK2008000177
申请日：2008-05-09
申请人： STATENS SERUMINSTITUT , ULDUM SOREN
发明人： ULDUM SOREN
IPC分类号： C12Q1/68 , G01N33/569
CPC分类号： C12Q1/689 , Y02A50/451
摘要： Methods based on serogroup specific DNA sequences and subgroup- specific gene of Lpn serogroup (sg) 1 strains for detection and discrimination of all monoclonal Lpn sg 1 Pontiac and non-Pontiac subgroups in clinical and environmental samples are described. Primers were designed for the Lipopolysaccharide (LPS) associated (lag-1) gene, which codes for a common LPS epitope specific for the MAb 3/1 of the Dresden monoclonal panel (sg 1 "Pontiac" subgroups), and primers for open reading frame 2 (ORF 2) DNA sequence of the LPS biosynthesis gene cluster of Lpn sg 1. PCR with primers to the lag-l gene and ORF 2 can be used for diagnosis of LD caused by Lpn sg 1 without need for isolation by culture. The PCR method can be used as a rapid method for detection and discrimination between the Pontiac and non-Pontiac subgroups of Lpn sg 1 in clinical and environmental samples before culture and serogroup results can be obtained. The PCR and DNA methods based on lag-1 gene and ORF 2 DNA sequences could be a valuable tool in outbreak investigations and in risk assessment.
摘要翻译：描述了基于血清群特异性DNA序列和Lpn血清群（sg）亚群特异性基因的方法，用于检测和鉴别临床和环境样品中所有单克隆Lpn sg 1庞蒂亚克和非庞蒂亚克亚群的菌株。针对脂多糖（LPS）相关（lag-1）基因设计引物，其编码特异于德累斯顿单克隆抗体片段（sg 1“庞蒂亚克”亚组）的MAb 3/1的常见LPS表位，以及用于开放阅读的引物 Lpn sg 1的LPS生物合成基因簇的框架2（ORF 2）DNA序列1.具有lag-1基因和ORF 2的引物的PCR可用于由Lpn sg1引起的LD的诊断，而不需要通过培养分离。 PCR方法可作为培养前临床和环境样品中庞蒂亚克和非庞蒂亚组Lpn sg 1的检测和鉴别的快速方法，可以获得血清学结果。基于lag-1基因和ORF 2 DNA序列的PCR和DNA方法可能是疫情调查和风险评估中的有价值工具。

6. 发明申请

WO2005063335B1 MONOCLONAL DES-LYS<58>-beta2-MICROGLOBULIN ANTIBODIES FOR MEASUREMENT AND MANAGEMENT OF HEMODIALYSIS COMPLICATIONS 审中-公开
公开(公告)号：WO2005063335B1
公开(公告)日：2005-10-27
申请号：PCT/DK2004000895
申请日：2004-12-22
申请人： STATENS SERUMINSTITUT , HEEGAARD NIELS HENRIK HELWEG , CORLIN DORTHE BIANCA
发明人： HEEGAARD NIELS HENRIK HELWEG , CORLIN DORTHE BIANCA
IPC分类号： C07K16/28 , G01N33/53 , G01N33/68 , A61P13/12 , A61K39/395 , A61P29/00 , A61P35/00 , A61P37/00 , G01N33/50
CPC分类号： C07K16/2833 , C07K2317/34 , G01N33/6896 , G01N2333/70539
摘要： beta2-microglobulin (beta2m) is susceptible to specific cleavage after and subsequent removal of its Lysine-58 amino acid residue in various chronic disease conditions. This has been shown by incubating patient sera with normal beta2m and following structural alterations by electrophoretic techniques. At present, only very elaborate analytical methods can be used to analyze the state of beta2m in a complex sample matrix such as a serum sample because no specific reagent, e.g. an antibody, is available. The present invention provides antibodies that are specific for the cleaved variant of beta2m, des Lys -beta2-microglobulin, in free solution in biological fluids. These antibodies may be used in methods for detecting des-Lys beta2-microglobulin and in particular in in vitro diagnostic procedures. In addition to such methods, the invention provides antibodies for use as medicaments and for the preparation of medicaments as well as a method for generating the antibodies, devices for reducing the content of des-Lys -beta2-microglobulin in a given material such as a hemodialysis fluid and, finally, in vitro diagnostic kits.

7. 发明申请

WO2005060330A3 FREEZE-DRIED VACCINE ADJUVANT 审中-公开
标题翻译：冷冻干燥的疫苗补充剂
公开(公告)号：WO2005060330A3
公开(公告)日：2005-08-04
申请号：PCT/DK2004000893
申请日：2004-12-21
申请人： STATENS SERUMINSTITUT , AGGER ELSE MARIE , ANDERSEN PETER
发明人： AGGER ELSE MARIE , ANDERSEN PETER
IPC分类号： A61K31/14 , A61K39/04 , A61K39/39 , A61K9/127
CPC分类号： A61K39/39 , A61K31/14 , A61K39/04 , A61K2039/55511 , A61K2039/55544 , A61K2039/55555 , A61K2039/55572
摘要： The present invention discloses a new adjuvant component that possesses the capacity to elicit a strong and long-persisting immune response, when administered in combination with an antigenic substance even though this antigenic substance may have only poor immunogenicity per se, and which can be freeze-dried and subsequently dissolved without heating. The adjuvant of the invention comprises a quaternary amine with a halogen counter ion of the formula NR R R R -hal, wherein R and R independently each is a short chain alkyl group containing to 1 to 3 carbon atoms, preferably methyl groups, R and R independently each is an alken containing from 12 to 20 carbon atoms, preferable from 14 to 18 carbon atoms, and hal is a halogen atom.
摘要翻译：本发明公开了一种当与抗原物质组合使用时具有引发强而持久的免疫应答能力的新辅助成分，尽管该抗原物质本身可能仅具有差的免疫原性，干燥并随后溶解而不加热。本发明的佐剂包括具有式NR 1 R 2 R 3 R 4卤素的卤素抗衡离子的季胺，其中R 1和R 2各自独立地为含有1至3个碳原子的短链烷基，优选甲基，R 3和R 4各自独立地为含有12至20个碳原子的烯烃，优选14至18个碳原子，hal为卤素原子。

8. 发明申请

WO2005004911A3 ADJUVANT COMBINATIONS OF LIPOSOMES AND MYCOBACTERIAL LIPIDS FOR IMMUNIZATION COMPOSITIONS AND VACCINES 审中-公开
标题翻译：用于免疫组合物和疫苗的脂质体和肌醇脂的补充剂组合
公开(公告)号：WO2005004911A3
公开(公告)日：2005-02-17
申请号：PCT/DK2004000488
申请日：2004-07-07
申请人： STATENS SERUMINSTITUT , AGGER ELSE MARIE , ANDERSEN PETER , OLSEN ANJA , ROSENKRANDS IDA
发明人： AGGER ELSE MARIE , ANDERSEN PETER , OLSEN ANJA , ROSENKRANDS IDA
IPC分类号： A61K39/04 , A61P31/06 , A61K39/39
CPC分类号： A61K39/04 , A61K2039/55555 , A61K2039/55594
摘要： The present invention provides a vaccine adjuvant consisting of a combination of a surfactant i.e. dimethyldioctadecylammonium-bromide/chloride (DDA) and a lipid extract from The present invention provides a vaccine adjuvant consisting of a combination of a surfactant i.e. dimethyldeoctadecylammonium-bromide/chloride (DDA) and a lipid extract from .The total lipid extract contains both apolar 1ipids, polar lipids, and lipids of intermediate polarity of which the apolar lipids were found to induce the most powerful immune responses. The total lipids may be extracted with chloroform/methanol and re-dissolved in water before the addition of surfactant. This preparation may be used to induce prominent cell-mediated immune responses in a mammal in order to combat pathogens, or as a treatment for cancer.
摘要翻译：本发明提供了由表面活性剂，即二甲基十二烷基溴化铵/氯化物（DDA）和脂质提取物的组合组成的疫苗佐剂。本发明提供了由表面活性剂即二甲基十八烷基溴化铵/氯化物（DDA）组合的疫苗佐剂）和来自<本发明的脂质提取物提供由表面活性剂组合的疫苗佐剂，即二甲基十八烷基溴化铵/氯化物（DDA）和牛分枝杆菌的脂质提取物。本发明提供由表面活性剂，即二甲基十八烷基溴化铵/氯化物（DDA）和来自牛分枝杆菌的脂质提取物的组合组成的疫苗佐剂。本发明提供由表面活性剂组合的疫苗佐剂，即二甲基十八烷基溴化铵/ 氯化物（DDA）和牛分枝杆菌BCG的脂质提取物本发明提供了由表面活性剂即二甲基十八烷基溴化铵/氯化物（DDA）和牛分枝杆菌BCG的脂质提取物的组合组成的疫苗佐剂。本发明提供了一种疫苗由表面活性剂即二甲基十八烷基溴化铵/氯化物（DDA）和牛分枝杆菌BCG的脂质提取物的组合组成的佐剂。本发明提供了由表面活性剂，即二甲基十八烷基溴化铵/氯化物（DDA）和牛分枝杆菌BCG的脂质提取物的组合组成的疫苗佐剂。本发明提供一种由表面活性剂即二甲基十八烷基溴化铵/氯化物（DDA）和牛分枝杆菌BCGI的脂质提取物的组合组成的疫苗佐剂。总脂质提取物含有非极性脂质，极性脂质和脂质发现非极性脂质诱导最强大的免疫应答的中间极性。总脂质可以用氯仿/甲醇萃取，并在加入表面活性剂之前再溶解在水中。这种制剂可用于在哺乳动物中诱导突出的细胞介导的免疫应答，以抵抗病原体，或作为癌症的治疗。

9. 发明申请

WO0069458A3 ADJUVANT COMBINATIONS FOR IMMUNIZATION COMPOSITION AND VACCINES 审中-公开
标题翻译：用于免疫组合物和疫苗的补充剂组合
公开(公告)号：WO0069458A3
公开(公告)日：2001-03-08
申请号：PCT/DK0000251
申请日：2000-05-12
申请人： STATENS SERUMINSTITUT
发明人： LINDBLAD ERIK B , ELHAY MARTIN J , ANDERSEN PETER , BRANDT LISE OESTERGAARD
IPC分类号： A61K39/39 , A61P37/04
CPC分类号： A61K39/39 , A61K2039/55511 , A61K2039/55544 , A61K2039/5555 , A61K2039/55555 , A61K2039/55566 , A61K2039/55572 , A61K2039/55577
摘要： The present invention relates to adjuvant combinations comprising two or more different adjuvants. In particular the invention relates to adjuvant compositions comprising a quaternary hydrocarbon ammonium halogenide and a hydrophobic second adjuvant component. The invention also relates to vaccines and immunization combination kits comprising two or more adjuvants and an antigenic substance.
摘要翻译：本发明涉及包含两种或更多种不同佐剂的佐剂组合。特别地，本发明涉及包含季铵卤化铵和疏水性第二辅助剂组分的佐剂组合物。本发明还涉及包含两种或更多种佐剂和抗原物质的疫苗和免疫组合试剂盒。

10. 发明申请

WO0029561A8 NUCLEOTIDE CONSTRUCT WITH OPTIMISED CODONS FOR AN HIV GENETIC VACCINE BASED ON A PRIMARY, EARLY HIV ISOLATE AND SYNTHETIC ENVELOPE 审中-公开
标题翻译：基于初级，早期HIV分离和合成包装的HIV遗传疫苗优化构建核苷酸构建体
公开(公告)号：WO0029561A8
公开(公告)日：2001-01-11
申请号：PCT/DK0000144
申请日：2000-03-27
申请人： STATENS SERUMINSTITUT , FOMSGAARD ANDERS
发明人： FOMSGAARD ANDERS
IPC分类号： A61K39/21 , C07H21/04 , C07K14/16 , C12N5/00 , C12N5/06 , C12N7/00 , C12N15/49 , C12P21/06 , A61K31/70
CPC分类号： C07K14/005 , A61K39/12 , A61K39/21 , A61K2039/525 , A61K2039/53 , A61K2039/545 , C12N7/00 , C12N2740/15011 , C12N2740/16122 , C12N2740/16134 , C12N2800/22
摘要： The present invention relates to a method for producing a nucleotide sequence construct with optimized codons for an HIV genetic vaccine based on a primary, early HIV isolate. Specific such nucleotide sequence construct are the synthetic envelope BX08 constructs. The invention further relates to the medical use of such constructs for the treatment and prophylaxis of HIV through DNA vaccine and for diagnostics.
摘要翻译：本发明涉及一种基于初级的早期HIV分离株产生具有针对HIV基因疫苗的优化密码子的核苷酸序列构建体的方法。具体的这种核苷酸序列构建体是合成包膜BX08构建体。本发明还涉及用于通过DNA疫苗治疗和预防HIV并用于诊断的这种构建体的医学用途。

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