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1. 发明授权

US6120776A Diagnostic skin test for tuberculosis 失效
标题翻译：肺结核诊断皮肤试验
公开(公告)号：US6120776A
公开(公告)日：2000-09-19
申请号：US569221
申请日：1996-02-12
申请人： Kaare Hasl.o slashed.v , .ANG.se Bengaard Andersen , Thomas Oettinger
发明人： Kaare Hasl.o slashed.v , .ANG.se Bengaard Andersen , Thomas Oettinger
IPC分类号： A61K39/04 , C07K14/35 , C12N15/31 , C12P21/04 , C12N1/12 , C12P21/06
CPC分类号： A61K39/04 , C07K14/35
摘要： Diagnostic methods capable of discriminating between cell mediated immunologic responses due to on the one hand active tuberculosis caused by bacteria belonging to the tuberculosis complex (Mycobacterium tuberculosis, Mycobacterium africanum and Mycobacterium bovis) and on the other hand vaccination with an immunogenic agent conferring immunity to tuberculosis. A diagnostic kit is also provided, comprising a polypeptide (e.g. MPT64) capable of eliciting a delayed type hypersensitivity reaction (Dth) in animals with active tuberculosis, but not in animals vaccinated against TB with an immunogenic agent (e.g. M. bovis BCG strain: Danish 1331). Also provided are polypeptide fragments comprising a T-cell epitope of MPT64 as well as nucleic acid fragments encoding these polypeptide fragments.
摘要翻译： PCT No.PCT / DK94 / 00270 Sec。 371日期：1996年2月12日 102（e）日期1996年2月12日PCT提交1994年6月30日PCT公布。出版物WO95 / 01440 1995年1月12日的诊断方法能够区分由于结核分枝杆菌（结核分枝杆菌，非洲分枝杆菌和牛分枝杆菌）引起的一方面由活细菌结核引起的细胞介导的免疫反应的诊断方法，另一方面用免疫原性赋予结核病免疫力的代理人。还提供了诊断试剂盒，其包含能够在具有活性结核病的动物中引发延迟型超敏反应（Dth）的多肽（例如MPT64），但不包括用免疫原性试剂（例如牛分枝杆菌BCG株：丹麦语1331）。还提供了包含MPT64的T细胞表位的多肽片段以及编码这些多肽片段的核酸片段。

2. 发明授权

US5955077A Tuberculosis vaccine 失效
标题翻译：结核疫苗
公开(公告)号：US5955077A
公开(公告)日：1999-09-21
申请号：US465640
申请日：1995-06-05
申请人： Peter Andersen , .ANG.se Bengaard Andersen , Kaare Haslov , Anne Lund Sorensen
发明人： Peter Andersen , .ANG.se Bengaard Andersen , Kaare Haslov , Anne Lund Sorensen
IPC分类号： A61K39/04 , A61P31/06 , C07K14/35 , A61K39/00 , C07K1/00 , C12P21/06
CPC分类号： A61K39/04 , C07K14/35 , C12R1/19 , A61K2039/523 , A61K2039/53
摘要： The invention relates to novel secreted antigens from mycobacteria capable of evoking early (within 4 days) immunological responses from T-helper cells in the form of gamma-interferon release in memory immune animals after rechallenge infection with mycobacteria of the tuberculosis complex. The antigens are present in short term filtrates (ST-CF) from cultured mycobacteria belonging to the tuberculosis complex. One of these antigens, a polypeptide with an apparent molecular weight of 6 kDa, has been identified, and the DNA encoding the polypeptide has been cloned and sequenced. The antigens of the invention are believed useful especially in vaccines, but also in diagnostic compositions, especially for diagnosing infection with virulent mycobacteria. Also disclosed are nucleic acid fragments encoding the antigens as well as methods of immunizing animals/humans and methods of diagnosing tuberculosis.
摘要翻译：本发明涉及能够以结核分枝杆菌复合体分枝杆菌感染后的记忆免疫动物中早期（4天内）诱发来自T-辅助细胞的免疫反应以γ-干扰素释放的形式的分枝杆菌的新型分泌型抗原。抗原存在于来自属于结核病复合体的培养的分枝杆菌的短期滤液（ST-CF）中。已经鉴定了这些抗原中的一种，表观分子量为6kDa的多肽，并且已经克隆并测序了编码该多肽的DNA。认为本发明的抗原特别用于疫苗，而且在诊断组合物中尤其是用于诊断有毒分枝杆菌的感染是有用的。还公开了编码抗原的核酸片段以及免疫动物/人的方法和诊断结核病的方法。

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