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1. 发明申请

US20150018411A1 COMPOUNDS AS PPAR BETA/DELTA INHIBITORS FOR TREATING PPAR BETA/DELTA-MEDIATED DISEASES 审中-公开
标题翻译：作为PPAR BET / DELTA抑制剂的化合物用于治疗PPARβ/ DELTA介导的疾病
公开(公告)号：US20150018411A1
公开(公告)日：2015-01-15
申请号：US14123815
申请日：2012-06-06
申请人： Wibke Diederich , Stefanie Dorr , Kerstin Kaddatz , Gerhard Klebe , Rolf Muller , Simone Naruhn , Veronika Pape , Josefine Stockert , Philipp Manuel Toth
发明人： Wibke Diederich , Stefanie Dorr , Kerstin Kaddatz , Gerhard Klebe , Rolf Muller , Simone Naruhn , Veronika Pape , Josefine Stockert , Philipp Manuel Toth
IPC分类号： C07D333/40 , C07C213/08
CPC分类号： C07D333/40 , C07C213/08 , C07D333/34 , C07D333/38 , C07D409/12
摘要： The present invention concerns substances which act as selective ligands of nuclear receptors of the PPAR beta/delta subtype and which can be used for the treatment of PPAR beta/delta-mediated diseases. The substances of this invention act as inhibitors of PPAR beta/delta receptors.
摘要翻译：本发明涉及作为PPARβ/δ亚型的核受体的选择性配体并可用于治疗PPARβ/δ介导的疾病的物质。本发明的物质作为PPARβ/δ受体的抑制剂。

2. 发明申请

WO2021173592A1 SYNTHETIC ROCAGLATES WITH BROAD-SPECTRUM ANTIVIRAL ACTIVITIES AND USES THEREOF 审中-公开
公开(公告)号：WO2021173592A1
公开(公告)日：2021-09-02
申请号：PCT/US2021/019295
申请日：2021-02-23
申请人： MEMORIAL SLOAN-KETTERING CANCER CENTER , PHILIPPS-UNIVERSITAT MARBURG
发明人： WENDEL, Hans-Guido , GRUNWELLER, Arnold
IPC分类号： A61K31/34 , A61K31/343 , A61K45/06 , A61P31/12 , A61P31/14
摘要： Described herein are compositions, uses thereof, and methods for treating a viral infection in a host cell or organism infected by the virus, such as coronaviruses (e.g., severe acute respiratory syndrome coronavirus [SARS-CoV], severe acute respiratory syndrome coronavirus 2 [SARS-CoV-2, the virus and its mutant forms that cause COVID-19], Middle East respiratory syndrome coronavirus [MERS-CoV]), Zika virus, Lassa virus, Crimean Congo hemorrhagic fever virus, hepatitis E virus, and other RNA viruses. Also described herein are synthetic rocaglate compositions, uses thereof, and methods for reducing or inhibiting translation initiation of a messenger ribonucleic acid (mRNA) of a virus in a host cell or organism infected by the virus.

3. 发明申请

US20130095037A1 PEPTIDE DERIVATIVES OF EXENDIN-4 审中-公开
标题翻译：维生素-4的肽衍生物
公开(公告)号：US20130095037A1
公开(公告)日：2013-04-18
申请号：US13593866
申请日：2012-08-24
申请人： Martin GOTTHARDT , Martin Béhé , Thomas Behr , Burkhard J. Göke
发明人： Martin GOTTHARDT , Martin Béhé , Thomas Behr , Burkhard J. Göke
IPC分类号： C07K14/605 , G01N33/74 , A61K51/08
CPC分类号： C07K14/605 , A61K51/08 , C07K14/57563 , G01N33/74
摘要： In the current invention peptides, which are derived from GLP-1 (glucagon-like peptide-1) and exendin-3 and/or exendin-4, are provided which bond to the GLP-1 receptor and can be used, labeled or unlabeled, for the production of an agent for diagnostic and therapy of benign and malignant diseases, in which GLP-1 receptor expression plays a role.
摘要翻译：在本发明中，提供了衍生自GLP-1（胰高血糖素样肽-1）和毒蜥外泌肽-3和/或毒蜥外泌肽-4的肽，其与GLP-1受体结合并可以使用，标记或未标记用于生产GLP-1受体表达起作用的良性和恶性疾病的诊断和治疗药物。

4. 发明申请

US20120270942A1 Spreading Active Agricultural Agents 审中-公开
标题翻译：传播积极农业代理
公开(公告)号：US20120270942A1
公开(公告)日：2012-10-25
申请号：US13503277
申请日：2010-10-21
申请人： Andreas Greiner , Joachim H. Wendorff , Seema Agarwall , Christoph Hellmann , Michael Breuer , Günter Leithold , Hans E. Hummel , Detlef Hein
发明人： Andreas Greiner , Joachim H. Wendorff , Seema Agarwall , Christoph Hellmann , Michael Breuer , Günter Leithold , Hans E. Hummel , Detlef Hein
IPC分类号： A01N37/02 , B29C47/10 , A01P17/00
CPC分类号： D01D5/0084 , A01N25/34 , A01N37/06 , D01F1/10 , D01F6/84 , A01N25/10 , A01N25/18
摘要： Disclosed herein is a device for the application of agricultural active agents, wherein the device is suitable to be brought to the site of action in a manner temporally and spatially separated from the production process, and comprises a dispenser and non-water-soluble nanofibers and/or mesofibers charged with agricultural active agents. The polymers from which the nanofibers and/or mesofibers are made are preferably biodegradable. The agricultural active agents are selected from fungicides, herbicides, batericides, plant growth regulators and plant nutrients. These are preferably pheromones, kairomones and signaling substances. Furthermore, a method for the production of this device is disclosed, wherein the nanofibers and/or mesofibers charged with active agents are produced via electrospinning. The device is suitable to be used to bring agricultural active agents to the site of action in a manner temporally and spatially separated from the production of this device. The application is suitable to be carried out mechanically or automatically. This is preferably agricultural land used for fruit growing, viticulture, gardening or a commercial row crop. The device according to the present invention is particularly suitable to be used for the regulation of arthropods.
摘要翻译：本文公开了一种用于农业活性剂的应用的装置，其中所述装置适于以与生产过程暂时和空间分离的方式带到作用部位，并且包括分配器和非水溶性纳米纤维， /或带有农药活性剂的介体纤维。制备纳米纤维和/或中间纤维的聚合物优选是可生物降解的。农业活性剂选自杀真菌剂，除草剂，杀螨剂，植物生长调节剂和植物营养素。这些优选是信息素，光酮和信号物质。此外，公开了一种制造该装置的方法，其中通过静电纺丝制备装有活性剂的纳米纤维和/或中间纤维。该装置适合用于将农业活性剂以与该装置的生产在时间和空间上分离的方式带到作用部位。该应用适合机械或自动进行。这最好是用于果实生长，葡萄栽培，园艺或商业排列作物的农业用地。根据本发明的装置特别适用于调节节肢动物。

5. 发明申请

US20110293846A1 METHOD FOR COATING TARGET SURFACES IN THE FORM OF DIELECTRIC SUBSTANCES OR FERROELECTRIC CRYSTALS 审中-公开
标题翻译：用于在电介质物质或微电子晶体形式中涂覆目标表面的方法
公开(公告)号：US20110293846A1
公开(公告)日：2011-12-01
申请号：US13204806
申请日：2011-08-08
申请人： Andreas GREINER , Hans E. Hummel , Joachim H. Wendorff , Mathias Becker , Roland Dersch
发明人： Andreas GREINER , Hans E. Hummel , Joachim H. Wendorff , Mathias Becker , Roland Dersch
IPC分类号： B05D1/04
CPC分类号： D01D5/0084 , A01M7/00 , A01N25/10 , A01N25/34 , B82Y30/00 , D01D5/0092 , D01D5/34 , Y10T428/298
摘要： The invention relates to supports consisting of nanoscalar polymer fibres, polymer tubes or hollow fibres for the application and targeted and/or delayed release of ingredients, in particular, agricultural active ingredients. The invention also relates to a method and a device for the production of supports of this type in a charged or empty state. The method and device use electrospinning technology.
摘要翻译：本发明涉及由纳米级聚合物纤维，聚合物管或中空纤维组成的载体，用于成分，特别是农业活性成分的施用和靶向和/或延迟释放。本发明还涉及一种用于在带电或空状态下制造这种类型的支撑件的方法和装置。该方法和装置采用静电纺丝技术。

6. 发明申请

US20210169363A1 DEVICE AND METHOD FOR DETERMINING THE IMPEDANCE ON A TOOTH 有权
公开(公告)号：US20210169363A1
公开(公告)日：2021-06-10
申请号：US16762753
申请日：2018-11-09
申请人： Philipps-Universitat Marburg
发明人： Michael Gente , Matthias Willamowski
IPC分类号： A61B5/0534 , A61B5/00 , A61C17/06
摘要： The present invention relates to an apparatus and a method for determining impedance (AC resistance) on a tooth. The impedance is determined by measuring the voltage at a given current intensity or by measuring the current intensity at a given voltage. Determining the impedance on a tooth is used for diagnosing tooth decay.

7. 发明申请

US20120083037A1 Non-Viral Transfection Agent 审中-公开
标题翻译：非病毒转染剂
公开(公告)号：US20120083037A1
公开(公告)日：2012-04-05
申请号：US13145756
申请日：2010-01-29
申请人： Joachim H. Wendorff , Achim Aigner , Ronald Dersch , Sabrina Höbel , Markus Rudisile
发明人： Joachim H. Wendorff , Achim Aigner , Ronald Dersch , Sabrina Höbel , Markus Rudisile
IPC分类号： C12N15/85 , B29C47/00
CPC分类号： A61K48/0041 , A61K47/6935 , A61K47/6937 , B82Y5/00 , C12N15/111 , C12N15/87 , C12N2310/14 , C12N2320/32
摘要： The invention relates to a non-viral transfection agent comprising polymer/nucleic acid complexes and nanofibers, wherein the polymer/nucleic acid complexes are composed of at least one nucleic acid and at least one cationic polymer. The nanofibers carry the polymer/nucleic acid complexes, wherein the non-viral transfection agent is advantageously produced by means of electrospinning. The cationic polymer is favorably a polyimine or polyethyleneimine and can be modified with one or more hydrophilic polymers coupled thereto. It can also be advantageous to couple the cationic polymer with one or more carbohydrates and/or with a receptor-specific ligand. The nucleic acid is a DNA or an RNA, or a DNA or RNA derivative, advantageously a therapeutically active nucleic acid. The nanofibers are composed of biodegradable, biocompatible polymers. The nanofibers or the entire transfection agent can be provided with a polymer coating. A method for producing a non-viral transfection agent comprises the following steps: providing the polymer/nucleic acid complex, producing a spinning solution containing the polymer/nucleic acid complexes, and electrospinning.
摘要翻译：本发明涉及包含聚合物/核酸复合物和纳米纤维的非病毒转染剂，其中所述聚合物/核酸复合物由至少一种核酸和至少一种阳离子聚合物组成。纳米纤维携带聚合物/核酸复合物，其中非病毒转染剂有利地通过静电纺丝制备。阳离子聚合物有利地是聚亚胺或聚乙烯亚胺，并且可以与一种或多种与其偶联的亲水性聚合物进行改性。将阳离子聚合物与一种或多种碳水化合物和/或与受体特异性配体偶联也是有利的。核酸是DNA或RNA，或DNA或RNA衍生物，有利地是治疗活性核酸。纳米纤维由可生物降解的生物相容性聚合物组成。纳米纤维或整个转染剂可以提供聚合物涂层。制备非病毒转染剂的方法包括以下步骤：提供聚合物/核酸复合物，产生含有聚合物/核酸复合物的纺丝溶液和静电纺丝。

8. 发明申请

US20110312873A1 N-TERMINALLY MODIFIED TETRAPEPTIDE DERIVATIVES HAVING A C-TERMINAL ARGININE MIMETIC 有权
标题翻译：具有C-末端蛋白质的N-末端修饰的四肽衍生物
公开(公告)号：US20110312873A1
公开(公告)日：2011-12-22
申请号：US13126504
申请日：2009-10-29
申请人： Torsten Steinmetzer , Gero Becker , Wolfgang Garten
发明人： Torsten Steinmetzer , Gero Becker , Wolfgang Garten
IPC分类号： A61K38/07 , C07K1/02 , C07K1/06 , C07K1/10 , A61P31/12 , A61P31/04 , A61P3/10 , A61P9/10 , A61P35/00 , A61P25/28 , A61P3/04 , A61P31/18 , A61P31/16 , A61P31/14 , C12N9/99 , A61P35/04 , C07K5/10
CPC分类号： C07K5/0808 , A61K38/00 , C07K5/0815 , C07K5/0817
摘要： The invention refers to multibasic, N-terminally modified tetrapeptide mimetics with a C-terminal P1-arginine mimetic, methods for their production and use for therapy and prophylaxis of diseases, caused by bacterial pathogens or viruses, as well as for therapy and prophylaxis of diabetes, arteriosclerosis, cancer, Alzheimer's or the onset of obesity, as well as the use of these compounds as inhibitors of the proprotein convertases which cleave behind basic P1 residues, especially for inhibition of the protease furin.
摘要翻译：本发明涉及具有C-末端P1-精氨酸模拟物的多碱性N-末端修饰的四肽模拟物，其生产方法和用于治疗和预防由细菌性病原体或病毒引起的疾病，以及用于治疗和预防糖尿病，动脉硬化，癌症，阿尔茨海默氏症或肥胖症的发生，以及这些化合物作为在基本P1残基之后切割的前蛋白转化酶的抑制剂的用途，特别是用于抑制蛋白酶弗林蛋白酶。

9. 发明授权

US08865865B2 N-terminally modified tetrapeptide derivatives having a C-terminal arginine mimetic 有权
标题翻译：具有C-末端精氨酸模拟物的N-末端修饰的四肽衍生物
公开(公告)号：US08865865B2
公开(公告)日：2014-10-21
申请号：US13126504
申请日：2009-10-29
申请人： Torsten Steinmetzer , Gero Becker , Wolfgang Garten
发明人： Torsten Steinmetzer , Gero Becker , Wolfgang Garten
IPC分类号： C07K5/10 , A61K38/07 , C07K5/083 , C07K5/09 , A61K38/00
CPC分类号： C07K5/0808 , A61K38/00 , C07K5/0815 , C07K5/0817
摘要： The invention refers to multibasic, N-terminally modified tetrapeptide mimetics with a C-terminal P1-arginine mimetic, methods for their production and use for therapy and prophylaxis of diseases, caused by bacterial pathogens or viruses, as well as for therapy and prophylaxis of diabetes, arteriosclerosis, cancer, Alzheimer's or the onset of obesity, as well as the use of these compounds as inhibitors of the proprotein convertases which cleave behind basic P1 residues, especially for inhibition of the protease furin.
摘要翻译：本发明涉及具有C-末端P1-精氨酸模拟物的多碱性N-末端修饰的四肽模拟物，其生产方法和用于治疗和预防由细菌性病原体或病毒引起的疾病，以及用于治疗和预防糖尿病，动脉硬化，癌症，阿尔茨海默氏症或肥胖症的发生，以及这些化合物作为在基本P1残基之后切割的前蛋白转化酶的抑制剂的用途，特别是用于抑制蛋白酶弗林蛋白酶。

10. 发明申请

US20110300383A1 NANOSCALED POLYMER FIBERS 失效
标题翻译：纳米聚合物纤维
公开(公告)号：US20110300383A1
公开(公告)日：2011-12-08
申请号：US13204778
申请日：2011-08-08
申请人： Andreas GREINER , Hans E. Hummel , Joachim H. Wendorff , Mathias Becker , Roland Dersch
发明人： Andreas GREINER , Hans E. Hummel , Joachim H. Wendorff , Mathias Becker , Roland Dersch
IPC分类号： D02G3/00
CPC分类号： D01D5/0084 , A01M7/00 , A01N25/10 , A01N25/34 , B82Y30/00 , D01D5/0092 , D01D5/34 , Y10T428/298
摘要： The invention relates to supports consisting of nanoscalar polymer fibres, polymer tubes or hollow fibres for the application and targeted and/or delayed release of ingredients, in particular, agricultural active ingredients. The invention also relates to a method and a device for the production of supports of this type in a charged or empty state. The method and device use electrospinning technology.
摘要翻译：本发明涉及由纳米级聚合物纤维，聚合物管或中空纤维组成的载体，用于成分，特别是农业活性成分的施用和靶向和/或延迟释放。本发明还涉及一种用于在带电或空状态下制造这种类型的支撑件的方法和装置。该方法和装置采用静电纺丝技术。

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