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1. 发明申请

WO1992002203A1 MICROCRYSTALLINE INSERTS FOR MEGAFILLED COMPOSITE DENTAL RESTORATIONS 审中-公开
标题翻译：用于混合复合牙齿修复的微晶插入物
公开(公告)号：WO1992002203A1
公开(公告)日：1992-02-20
申请号：PCT/US1991005468
申请日：1991-08-01
申请人： AMERICAN DENTAL ASSOCIATION HEALTH FOUNDATION
发明人： AMERICAN DENTAL ASSOCIATION HEALTH FOUNDATION , BOWEN, Rafael, L.
IPC分类号： A61K06/08
CPC分类号： A61C5/00 , A61K6/0005 , A61K6/0067 , A61K6/0091 , A61K6/0215 , A61K6/023 , A61K6/0235 , A61K6/024 , A61K6/025 , A61K6/083 , C08L33/10 , A61K6/093 , C08L83/04
摘要： Means to decrease the effects of polymerization shrinkage, increase stiffness, decrease the coefficient of thermal expansion to a greater extent than previously possible, and improve the durability of composite restorations by use of improved microcrystalline glass inserts. Shaped pieces of assorted sizes within the range of one-half to 10 millimeters are heat treated to produce microcrystallinity in which the crystalline phases, such as for example stuffed beta quartz, beta-eucryptite, beta-spodumene solid solutions, and keatite and/or other phases, give the microcrystalline glass pieces exceptionally low coefficients of thermal expansion and other desirable properties. Compositions and heat treatment conditions are given to provide the insert pieces with the desired translucencies/opacities, colors, and shades, to match a range of those properties found in teeth. Treatment of the inserts with an organofunctional silane with or without an additional resin coating provides for chemical bonding with composite resins. Cavities in teeth are partially filled with unhardened composite material, and microcrystalline glass inserts of appropriate size, shape and appearance are pressed into the cavity so that the insert constitutes as much as possible of the finished restoration. The composite containing the insert is polymerized either by light, chemical, or combined cure mechanisms, and contoured and polished.
摘要翻译：降低聚合收缩效果，增加刚度，减少热膨胀系数比以前更大的方法，并通过使用改进的微晶玻璃插入物来提高复合材料修复体的耐久性。热处理在一半至10毫米范围内的各种尺寸的成形片，以产生微晶，其中结晶相，例如填充的β石英，β-锂钇石，β-锂辉石固溶体和酮钙石和/或其他相，给予微晶玻璃片特别低的热膨胀系数和其它所需的性能。给出组合物和热处理条件以提供具有期望的透光性/不透明度，颜色和色调的插入片，以匹配在牙齿中发现的那些性质的范围。用有机官能硅烷处理带有或不带有附加树脂涂层的插入物提供与复合树脂的化学键合。齿中的腔部分地填充有未硬化的复合材料，并且具有适当尺寸，形状和外观的微晶玻璃插入件被压入空腔中，使得插入件尽可能地构成完成的修复体。包含插入物的复合材料通过光，化学或组合固化机理聚合，并进行轮廓和抛光。

2. 发明申请

WO2006057727A1 COMPOSITIONS AND METHODS FOR WHITENING, MINERALIZING AND/OR FLUORIDATING CALCIFIED TISSUES 审中-公开
标题翻译：白化，矿化和/或氟化计算的组织的组合物和方法
公开(公告)号：WO2006057727A1
公开(公告)日：2006-06-01
申请号：PCT/US2005/036870
申请日：2005-10-13
申请人： AMERICAN DENTAL ASSOCIATION HEALTH FOUNDATION , TUNG, Ming, S.
发明人： TUNG, Ming, S.
IPC分类号： A61K8/21 , A61K8/22 , A61K8/30 , A61K8/38 , A61C5/00 , A61C15/00 , A61B19/02 , A61B19/10 , B65D25/08
CPC分类号： A61K8/19 , A61K8/20 , A61K8/22 , A61K8/23 , A61K8/24 , A61K8/36 , A61K8/365 , A61K8/42 , A61K2800/31 , A61K2800/88 , A61Q11/00
摘要： Kits and methods that combine whitening/stain removal of teeth with remineralization are disclosed. These kits advantageously comprise separate compositions comprising a soluble calcium salt, a soluble orthophosphate salt, and a soluble peroxide, in order to optimize the stability of these components for stor ge and/or the activity of these components upon use. The active ingredients may also be separated in a solid composition (e.g., a powder) or in a stable dispersion comprising a no -aqueous dispersion medium.
摘要翻译：公开了将美白/去除牙齿与再矿化的组合和方法。这些试剂盒有利地包含分离的组合物，其包含可溶性钙盐，可溶性正磷酸盐和可溶性过氧化物，以便优化用于储存的这些组分的稳定性和/或这些组分在使用时的活性。活性成分也可以在固体组合物（例如粉末）中或在包含无水分散介质的稳定分散体中分离。

3. 发明申请

WO2002062721A1 PREMIXED CALCIUM PHOSPHATE CEMENT PASTES 审中-公开
标题翻译：优质磷酸钙水泥浆
公开(公告)号：WO2002062721A1
公开(公告)日：2002-08-15
申请号：PCT/US2002/001991
申请日：2002-01-24
申请人： AMERICAN DENTAL ASSOCIATION HEALTH FOUNDATION
发明人： CHOW, Laurence, C. , TAKAGI, Shozo
IPC分类号： C04B12/02
CPC分类号： A61K6/0038 , A61K6/033 , A61K6/0643 , A61K6/0668 , A61K6/097 , A61L24/02 , A61L27/12 , C04B28/34 , C04B28/344 , C04B2111/00836 , C04B14/28 , C04B22/16 , C04B24/02 , C04B24/383 , C04B40/0608 , C04B22/064 , C08L1/284
摘要： A bone or dental implant material in the form of a paste includes a mixture of calcium phosphate powders, that are capable of forming hydroxyapatite, with liquid glycerol and hydroxypropyl methylcellulose and Na 2 HPO 4 . The paste will harden upon exposure to water with the time to harden controlled by the choice and ratio of constituents.
摘要翻译：糊状形式的骨或牙植入材料包括能够形成羟基磷灰石的磷酸钙粉末与液体甘油和羟丙基甲基纤维素和Na 2 HPO 4的混合物。糊剂会在暴露于水中时硬化，随着时间的推移，可以通过选择和成分比例进行控制。

4. 发明申请

WO2010124110A1 DUAL-PHASE CALCIUM PHOSPHATE CEMENT COMPOSITION 审中-公开
标题翻译：双相磷酸钙水泥组合物
公开(公告)号：WO2010124110A1
公开(公告)日：2010-10-28
申请号：PCT/US2010/032084
申请日：2010-04-22
申请人： AMERICAN DENTAL ASSOCIATION FOUNDATION , CHOW, Laurence C. , SHOZO, Takagi
发明人： CHOW, Laurence C. , SHOZO, Takagi
IPC分类号： A61K33/42 , C01B25/37
CPC分类号： C04B28/34 , A61L24/001 , A61L24/0063 , A61L24/043 , C04B40/065 , C04B2111/00836 , C04B22/16 , C04B24/06 , C04B2103/12 , C04B2103/44 , C04B24/383 , C04B38/10
摘要： Disclosed are dual-phase cement precursor systems and associated methods and kits. The cement precursor systems comprises at least first and second phases each containing a calcium phosphate compound. When mixed, the first and second cement precursor phases form a biocompatible cement. The disclosed systems include an organic acid in an amount effective to enhance the working time of the cement precursor composition, and also include a setting accelerator. In some embodiments, one or more of the calcium phosphate compounds is provided in the form of particles with a nonmonomial particle sized distribution.
摘要翻译：公开了双相水泥前体体系及相关方法和试剂盒。水泥前体体系至少包含含有磷酸钙化合物的第一相和第二相。当混合时，第一和第二水泥前体相形成生物相容的水泥。所公开的系统包括有效提高水泥前体组合物的工作时间的有机酸，还包括凝固促进剂。在一些实施方案中，一种或多种磷酸钙化合物以非单调粒度分布的颗粒形式提供。

5. 发明申请

WO2006057857A2 COMPOSITIONS AND METHODS FOR WHITENING, MINERALIZING AND/OR FLUORIDATING CALCIFIED TISSUES 审中-公开
标题翻译：白化，矿化和/或氟化计算的组织的组合物和方法
公开(公告)号：WO2006057857A2
公开(公告)日：2006-06-01
申请号：PCT/US2005/041319
申请日：2005-11-15
申请人： AMERICAN DENTAL ASSOCIATION FOUNDATION , TUNG, Ming, S.
发明人： TUNG, Ming, S.
IPC分类号： A61K8/22
CPC分类号： A61K8/19 , A61K8/20 , A61K8/22 , A61K8/23 , A61K8/24 , A61K8/36 , A61K8/365 , A61K8/42 , A61K2800/31 , A61K2800/88 , A61Q11/00
摘要： Kits and methods that combine whitening/stain removal of teeth with remineralization are disclosed. These kits advantageously comprise separate compositions comprising a soluble calcium salt, a soluble orthophosphate salt, and a soluble peroxide, in order to optimize the stability of these components for storage and/or the activity of these components upon use. The active ingredients may also be separated in a solid composition (e.g., a powder) or in a stable dispersion comprising a non-aqueous dispersion medium.
摘要翻译：公开了将美白/去除牙齿与再矿化的组合和方法。这些试剂盒有利地包含分离的组合物，其包含可溶性钙盐，可溶性正磷酸盐和可溶性过氧化物，以便在使用时优化这些组分用于储存和/或这些组分的活性的稳定性。活性成分也可以在固体组合物（例如粉末）中或在包含非水分散介质的稳定分散体中分离。

6. 发明申请

WO1998007448A1 ANTI-CARIOUS CHEWING GUMS, CANDIES, GELS, TOOTHPASTES AND DENTIFRICES 审中-公开
标题翻译：抗龋牙膏，糖果，凝胶，牙膏和牙釉质
公开(公告)号：WO1998007448A1
公开(公告)日：1998-02-26
申请号：PCT/US1997014519
申请日：1997-08-19
申请人： AMERICAN DENTAL ASSOCIATION HEALTH FOUNDATION
发明人： AMERICAN DENTAL ASSOCIATION HEALTH FOUNDATION , CHOW, Laurence, C. , TAKAGI, Shozo , VOGEL, Gerald, L.
IPC分类号： A61K47/00
CPC分类号： A61Q11/00 , A23G3/362 , A23G4/064 , A61K8/19 , A61K8/24 , A61K9/0058
摘要： The invention relates to anticarious delivery vehicles, specifically chewing-gums, candies, confectioneries, toothpastes, dentifrices and gels. The invention specifically provides chewing gums, candies, confectioneries, toothpastes, dentifrices and gels containing non-toxic sparingly soluble calcium and phosphate compounds as additives, causing the release of calcium and phosphate ions into the oral cavity gradually and persistently for a period no less than 5 minutes. The invention provides released calcium phosphate ions that diffuse into partially demineralized tooth enamel or dentin, leading to remineralization and repair of caries lesions, dental plaque, open dentinal tubules and exposed dentin. The invention thus provides agents and methods for remineralization of teeth and for reducing or eradicating cariogenic challenge in plaque following sucrose intake. The formulations of the invention can thereby produce effective anticaries actions without the use of fluoride. In addition, the formulations of the invention can be used to desensitize hypersensitive teeth.
摘要翻译：本发明涉及抗转运载体，特别是口香糖，糖果，糖果，牙膏，洁齿剂和凝胶。本发明专门提供口香糖，糖果，糖果，牙膏，洁牙剂和含有无毒性微溶钙和磷酸盐化合物作为添加剂的凝胶，导致钙和磷酸根离子逐渐持续持续一段时间不间断 5分钟。本发明提供了释放的磷酸钙离子，其扩散到部分去矿物质的牙釉质或牙本质中，导致龋齿病变，牙斑，开口牙质小管和暴露牙本质的再矿化和修复。因此，本发明提供了用于牙齿再矿化的药剂和方法，并且用于在蔗糖摄入之后减少或消除斑块中的致龋性攻击。因此，本发明的制剂可以在不使用氟化物的情况下产生有效的防龋作用。此外，本发明的制剂可用于使过敏性牙齿脱敏。

7. 发明申请

WO1996020693A1 CONTROL OF CALCIUM FLUORIDE FORMATION IN MOUTH RINSES, DENTIFRICES AND GELS 审中-公开
标题翻译：氟盐溶液中的氟化物形成的控制，牙釉质和凝胶
公开(公告)号：WO1996020693A1
公开(公告)日：1996-07-11
申请号：PCT/US1996000162
申请日：1996-01-05
申请人： AMERICAN DENTAL ASSOCIATION HEALTH FOUNDATION
发明人： AMERICAN DENTAL ASSOCIATION HEALTH FOUNDATION , CHOW, Laurence, C. , TAKAGI, Shozo
IPC分类号： A61K07/16
CPC分类号： A61Q11/00 , A61K8/21 , A61K8/24 , A61K8/365 , A61K8/44 , A61K8/55 , A61K2800/88
摘要： Specific compositions and methods are disclosed employing calcium fluoride inhibitors in two-component fluoride delivery systems to produce an initial delay in calcium fluoride formation and to control the rate of reactions that precipitate calcium fluoride in order to achieve enhanced fluoride deposition in the oral environment. In the two-component fluoride delivery system, one component contains a source of calcium ions and the other a source of fluoride ions. An inhibitor of calcium fluoride formation is present in one or both phases such that when one or both components are mixed the formation of calcium fluoride precipitate does not occur until at least about five seconds after mixing. The system may be employed in the form of mouth rinses, dentifrices, or chewable tablets.
摘要翻译：公开了在双组分氟化物递送系统中使用氟化钙抑制剂以产生氟化钙形成的初始延迟并控制沉淀氟化钙的反应速率以在口腔环境中实现增强的氟化物沉积的具体组合物和方法。在双组分氟化物递送系统中，一个组分含有钙离子源，另一个组分含有氟离子源。在一个或两个相中存在形成氟化钙的抑制剂，使得当将一种或两种组分混合时，在混合后至少约五秒钟之后，不会形成氟化钙沉淀物。该系统可以以漱口剂，洁牙剂或咀嚼片的形式使用。

8. 发明申请

WO1995020937A1 A METHOD AND COMPOSITION FOR PROMOTING IMPROVED ADHESION TO SUBSTRATES 审中-公开
标题翻译：用于促进改进粘合剂到基材的方法和组合物
公开(公告)号：WO1995020937A1
公开(公告)日：1995-08-10
申请号：PCT/US1995001063
申请日：1995-01-31
申请人： THE UNITED STATES OF AMERICA, represented by THE SECRETARY, DEPARTMENT OF COMMERCE , AMERICAN DENTAL ASSOCIATION HEALTH FOUNDATION
发明人： THE UNITED STATES OF AMERICA, represented by THE SECRETARY, DEPARTMENT OF COMMERCE , AMERICAN DENTAL ASSOCIATION HEALTH FOUNDATION , ANTONUCCI, Joseph, M. , BENNETT, Patricia, S.
IPC分类号： A61K06/00
CPC分类号： A61K6/0029 , A61K6/0052 , A61K6/0023 , C08L33/08 , C08L33/10
摘要： An etchant/primer composition is provided which includes (a) a compound having the formula (I): RN(CH2YCO2M)2, wherein R = R or R ; R = an aromatic group; R = a conjugated aliphatic group; Y = a single bond, CH2, CHCH3 or C=CH2; and each M is independently H, an alkali metal, an alkaline earth metal, aluminum, a transition or redox metal or an alkyl group having 1 to 18 carbon atoms, with the proviso that when both M groups are alkyl groups, the compound corresponding to formula (I) be capable of being easily hydrolyzed, displaced or exchanged with other reagents present in the etchant/primer composition and (b) a polar solvent system. An etchant/primer/adhesive monomer composition is also provided which includes the etchant/primer composition and an adhesive monomer system. One and two step simplified methods for adhering and for preparing a substrate surface, such as a dental substrate surface, to a polymeric material are also provided. Kits which may be used with these compositions and methods are also provided.
摘要翻译：提供了一种蚀刻剂/底漆组合物，其包括（a）具有式（I）的化合物：RN（CH 2 YCO 2 M）2，其中R = R 1或R 2; R 1 =芳族基团; R 2 =共轭脂族基团; Y =单键，CH2，CHCH3或C = CH2; 每个M独立地为H，碱金属，碱土金属，铝，过渡金属或氧化还原金属或具有1至18个碳原子的烷基，条件是当两个M基团都是烷基时，对应于式（I）能够容易地与蚀刻剂/底漆组合物中存在的其它试剂水解，取代或交换，和（b）极性溶剂体系。还提供了包括蚀刻剂/底漆组合物和粘合剂单体体系的蚀刻剂/底漆/粘合剂单体组合物。还提供了一种和两步简单的方法，用于粘合和制备基材表面，例如牙科基材表面，聚合物材料。也可提供可与这些组合物和方法一起使用的试剂盒。

9. 发明申请

WO1995008319A1 SELF-SETTING CALCIUM PHOSPHATE CEMENTS AND METHODS FOR PREPARING AND USING THEM 审中-公开
标题翻译：自制磷酸钙化合物及其制备和使用方法
公开(公告)号：WO1995008319A1
公开(公告)日：1995-03-30
申请号：PCT/US1994010819
申请日：1994-09-23
申请人： AMERICAN DENTAL ASSOCIATION HEALTH FOUNDATION
发明人： AMERICAN DENTAL ASSOCIATION HEALTH FOUNDATION , CHOW, Laurence, C. , TAKAGI, Shozo
IPC分类号： A61K06/033
CPC分类号： A61L24/02 , A61F2310/00293 , A61K6/0038 , A61K6/0067 , A61K6/033 , A61K6/0643 , A61K6/0668 , A61K6/0675 , A61L27/12 , C08L89/00 , A61K6/087
摘要： The invention includes methods and compositions relating to calcium phosphate cements, which self-harden substantially to hydroxyapatite at ambient temperature when in contact with an aqueous medium. More specifically the cements comprise a combination of one or more sparingly soluble calcium phosphates other than tetracalcium phosphate with an aqueous solution adjusted with a base to maintain a pH of about 12.5 or above and having sufficient dissolved phosphate salt to yield a solution mixture with phosphate concentration equal to or greater than about 0.2 mol/L.
摘要翻译：本发明包括与磷酸钙水泥相关的方法和组合物，当与水性介质接触时，其在环境温度下自身硬化成羟基磷灰石。更具体地说，水泥包括除磷酸四钙之外的一种或多种微溶磷酸钙与用碱调节的水溶液以保持约12.5或更高的pH并具有足够溶解的磷酸盐以产生具有磷酸盐浓度的溶液混合物的组合等于或大于约0.2mol / L。

10. 发明申请

WO1995007685A1 COMPLEX CALCIUM AND FLUORIDE CONTAINING MOUTH RINSES, DENTIFRICES, AND CHEWABLE TABLETS 审中-公开
标题翻译：复合钙和氟化物含有的润滑剂，透明质酸和可清洗的片剂
公开(公告)号：WO1995007685A1
公开(公告)日：1995-03-23
申请号：PCT/US1994010302
申请日：1994-09-12
申请人： AMERICAN DENTAL ASSOCIATION HEALTH FOUNDATION
发明人： AMERICAN DENTAL ASSOCIATION HEALTH FOUNDATION , CHOW, Laurence, C. , TAKAGI, Shozo
IPC分类号： A61K07/16
CPC分类号： A61Q11/00 , A61K8/0216 , A61K8/19 , A61K8/21 , A61K2800/51
摘要： The present invention relates to compositions and methods for fluoridating teeth. More specifically, the invention is a reactive, multi-component composition consisting of an admixture of a stable, non-toxic soluble calcium salt and a soluble calcium complexing (chelating) agent, with a stable, non-toxic soluble fluoride compound, a buffer, and one or more non-interfering carriers. The components of this admixture are mixed in a aqueous environment, resulting in a controlled precipitation of calcium fluoride, and then promptly applied to the tooth surfaces. The invention contemplates mouth rinses, dentifrices, gels, and chewable tablets for application of these compositions and methods.
摘要翻译：本发明涉及用于氟化牙齿的组合物和方法。更具体地，本发明是一种反应性多组分组合物，其由稳定的无毒可溶性钙盐和可溶性钙络合剂（螯合剂）与稳定的无毒可溶性氟化物混合物，缓冲液，以及一个或多个非干扰载波。将该混合物的组分在水性环境中混合，导致氟化钙的受控沉淀，然后迅速施加到牙齿表面。本发明考虑了用于这些组合物和方法的漱口剂，洁牙剂，凝胶和咀嚼片。

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