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81. 发明申请

US20120288865A1 METHOD AND APPARATUS FOR GENERATING THERMAL MELTING CURVES IN A MICROFLUIDIC DEVICE 审中-公开
标题翻译：用于在微流体装置中产生热熔融曲线的方法和装置
公开(公告)号：US20120288865A1
公开(公告)日：2012-11-15
申请号：US13444502
申请日：2012-04-11
申请人： Steven A. Sundberg , Michael R. Knapp , Ivor T. Knight , Deborah J. Boles , Aaron J. Rulison , Wesley B. Dong , Edward P. Donlon , Robert J. Moti , Andrew G. Fabans , Allen R. Boronkay , Michael Slater
发明人： Steven A. Sundberg , Michael R. Knapp , Ivor T. Knight , Deborah J. Boles , Aaron J. Rulison , Wesley B. Dong , Edward P. Donlon , Robert J. Moti , Andrew G. Fabans , Allen R. Boronkay , Michael Slater
IPC分类号： G01N25/04
CPC分类号： G01N25/04 , B01L3/5027 , B01L3/502715 , B01L3/50273 , B01L7/52 , B01L7/525 , B01L2200/10 , B01L2300/0627 , B01L2300/0816 , B01L2300/14 , B01L2300/18 , B01L2300/1833 , B01L2400/0409 , B01L2400/0415 , B01L2400/0487 , C12Q1/68 , C12Q1/6844 , C12Q1/686 , C12Q1/6862 , G01N21/33 , G01N21/6428 , Y10T436/143333 , C12Q2565/629 , C12Q2565/101 , C12Q2527/107 , C12Q2527/101
摘要： The present invention provides novel methods and devices that employ microfluidic technology to generate molecular melt curves. In particular, the devices and methods in accordance with the invention are useful in providing for the analysis of PCR amplification products.
摘要翻译：本发明提供了采用微流体技术产生分子熔融曲线的新颖方法和装置。特别地，根据本发明的装置和方法可用于提供PCR扩增产物的分析。

82. 发明授权

US08147775B2 Self-cleaning and mixing microfluidic elements 有权
标题翻译：自清洁和混合微流体元件
公开(公告)号：US08147775B2
公开(公告)日：2012-04-03
申请号：US12552914
申请日：2009-09-02
申请人： Sivaramakrishnan Krishnamoorthy , Jianiun Feng
发明人： Sivaramakrishnan Krishnamoorthy , Jianiun Feng
IPC分类号： B01F15/00
CPC分类号： B08B7/0064 , B01F13/0079 , B01F13/0081 , B01L3/5027 , B01L99/00 , B01L2300/1833 , B01L2400/0415 , B01L2400/0442 , B01L2400/0493 , B08B9/00 , F04B19/006 , F04B19/24 , Y10S366/04 , Y10T137/0329 , Y10T137/034 , Y10T137/0391
摘要： Apparatus and methods are disclosed for mixing and self-cleaning elements in microfluidic systems based on electrothermally induced fluid flow. The apparatus and methods provide for the control of fluid flow in and between components in a microfluidic system to cause the removal of unwanted liquids and particulates or mixing of liquids. The geometry and position of electrodes is adjusted to generate a temperature gradient in the liquid, thereby causing a non-uniform distribution of dielectric properties within the liquid. The dielectric non-uniformity produces a body force and flow in the solution, which is controlled by element and electrode geometries, electrode placement, and the frequency and waveform of the applied voltage.
摘要翻译：公开了用于基于电热诱导流体流动的微流体系统中的混合和自清洁元件的装置和方法。该装置和方法提供了在微流体系统中的组件之间和之间的流体流动的控制，以便除去不期望的液体和微粒或混合液体。调节电极的几何形状和位置，以在液体中产生温度梯度，从而导致液体内介电性质的不均匀分布。电介质非均匀性在溶液中产生体力和流动，其由元件和电极几何形状，电极布置以及施加电压的频率和波形控制。

83. 发明申请

US20090317918A1 METHOD OF HEATING LIQUID MEDIUM USING MICROWAVES AND ANIONS 审中-公开
标题翻译：使用微波和阴离子加热液体介质的方法
公开(公告)号：US20090317918A1
公开(公告)日：2009-12-24
申请号：US12553402
申请日：2009-09-03
申请人： Kyu-youn Hwang , Joon-ho Kim , Koong-kak Nam , Won-seok Chung , Hee-kyun Lim
发明人： Kyu-youn Hwang , Joon-ho Kim , Koong-kak Nam , Won-seok Chung , Hee-kyun Lim
IPC分类号： G01N1/00 , G01N33/48 , C12M1/00
CPC分类号： B01L3/502715 , B01L2200/16 , B01L2300/0806 , B01L2300/0816 , B01L2300/087 , B01L2300/1833 , B01L2300/1866 , B01L2400/0409 , Y10T436/25125
摘要： Provided is a method comprising adding anions having a high charge density to a liquid medium; the liquid medium comprising molecules that hydrogen bond with one another; the anions interacting with the molecules of the liquid medium with a force that is stronger than the forces that produce hydrogen bonding between the molecules of the medium; and heating the liquid medium by irradiating it with microwaves.
摘要翻译：提供了一种方法，包括向液体介质中加入具有高电荷密度的阴离子; 所述液体介质包含彼此氢键合的分子; 阴离子与液体介质的分子相互作用，其力比在介质分子之间产生氢键的力更强; 并通过用微波照射来加热液体介质。

84. 发明申请

US20080047833A1 Microfluidic device, measuring apparatus, and microfluid stirring method 审中-公开
标题翻译：微流体装置，测量装置和微流体搅拌方法
公开(公告)号：US20080047833A1
公开(公告)日：2008-02-28
申请号：US11802419
申请日：2007-05-22
申请人： Shuzo Hirahara , Kentaro Tani , Haruyuki Minamitani
发明人： Shuzo Hirahara , Kentaro Tani , Haruyuki Minamitani
IPC分类号： G01N27/26
CPC分类号： G01N33/49 , B01L3/502715 , B01L2300/1833
摘要： Conventionally, it has been difficult to effectively and promptly stir and mix fluids together by use of a microfluidic device having a simple flow path structure. Additionally, there has been no means for keeping a particulate sample floating in a fluid in a flow path for a long time without precipitating the particulate sample. Additionally, there has been no method for measuring the true size of a flowing and floating particulate sample by use of a microscope. The present invention solves these problems by using a microfluidic device in which an electrode pair having a wide electrode-to-electrode gap is formed in a flow path or in a chamber, and by applying an AC voltage to this electrode pair, and by generating an eddy by which a fluid is swirled in a torus manner. The accurate size of the particulate sample that crosses the in-focus plane can be measured especially by setting an in-focus plane (53) of an objective lens (52) of a microscope at a position through which a swirling flow (41) vertically passes.
摘要翻译：通常，通过使用具有简单流路结构的微流体装置，难以有效地并且迅速地将流体混合在一起。此外，没有使颗粒样品在流动路径中长时间漂浮在流体中而不使颗粒样品沉淀的方法。另外，没有使用显微镜测量流动和浮动的颗粒样品的真实尺寸的方法。本发明通过使用微流体装置来解决这些问题，其中在流路或室内形成具有宽的电极间电极间隙的电极对，并且通过向该电极对施加AC电压，并且通过产生流体以环形方式旋转的涡流。可以通过将显微镜的物镜（52）的聚焦平面（53）设置在垂直于旋转流（41）的位置上来测量穿过对焦平面的颗粒样品的精确尺寸通过

85. 发明申请

US20080003690A1 Prevention of Precipitate Blockage in Microfluidic Channels 有权
公开(公告)号：US20080003690A1
公开(公告)日：2008-01-03
申请号：US11764756
申请日：2007-06-18
申请人： Andrea Chow
发明人： Andrea Chow
IPC分类号： G01N1/38
CPC分类号： B01F13/0059 , B01F5/0471 , B01F2015/0221 , B01J19/0093 , B01J2219/00247 , B01J2219/00783 , B01J2219/0086 , B01L3/5027 , B01L3/502746 , B01L7/52 , B01L2200/10 , B01L2200/14 , B01L2300/0816 , B01L2300/0867 , B01L2300/1805 , B01L2300/1822 , B01L2300/1833 , B01L2300/1838 , B01L2300/1861 , B01L2400/0415 , B01L2400/0487 , Y10T137/0329 , Y10T137/0357 , Y10T436/11 , Y10T436/117497 , Y10T436/13 , Y10T436/25625 , Y10T436/2575
摘要： The present invention provides novel microfluidic devices and methods for preventing/ameliorating formation of precipitate blockages in microfluidic devices. In particular, the devices and methods of the invention utilize microchannels of specific cross-sectional configuration and of specific arrangement as well as application of AC current orthogonal to the direction of fluid flow, in order to prevent/ameliorate formation of precipitate blockages in microfluidic devices.

86. 发明申请

US20070231799A1 METHOD AND APPARATUS FOR APPLYING CONTINUOUS FLOW AND UNIFORM TEMPERATURE TO GENERATE THERMAL MELTING CURVES IN A MICROFLUIDIC DEVICE 有权
标题翻译：用于连续流动和均匀温度在微流体装置中生成热熔融曲线的方法和装置
公开(公告)号：US20070231799A1
公开(公告)日：2007-10-04
申请号：US11381896
申请日：2006-05-05
申请人： Ivor T. Knight , Deborah J. Boyles
发明人： Ivor T. Knight , Deborah J. Boyles
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6813 , B01L3/502715 , B01L7/525 , B01L2300/1805 , B01L2300/1827 , B01L2300/1833 , B01L2400/0415 , B01L2400/043 , B01L2400/0487 , B01L2400/06
摘要： The present invention provides a method for performing thermal melt analysis using a microfluidic device, the method comprising providing a microfluidic device having at least one microfluidic channel, introducing fluid comprising into the at least one microfluidic channel, continuously flowing the fluid through the at least one microfluidic channel while varying the temperature of the entire fluid stream as it moves through the at least one microfluidic channel by uniformly heating the entire fluid stream, and measuring, while continuously flowing the fluid through the at least one microfluidic channel, a detectable property emanating from the fluid,
摘要翻译：本发明提供一种使用微流体装置进行热熔融分析的方法，所述方法包括提供具有至少一个微流体通道的微流体装置，将包含至少一个微流体通道的流体引入至少一个流体微流体通道，同时通过均匀加热整个流体流来改变整个流体流的温度，同时在流体连续流过至少一个微流体通道的过程中测量可检测的特性，流体，

87. 发明申请

US20070099200A1 High throughput mobility shift 有权
标题翻译：高吞吐量移动性
公开(公告)号：US20070099200A1
公开(公告)日：2007-05-03
申请号：US11412055
申请日：2006-04-25
申请人： Andrea Chow , John Owicki , J. Parce
发明人： Andrea Chow , John Owicki , J. Parce
IPC分类号： C12Q1/68 , C12M3/00 , G01N33/557
CPC分类号： G01N33/557 , B01L3/50273 , B01L3/502753 , B01L7/52 , B01L2200/10 , B01L2300/0816 , B01L2300/1822 , B01L2300/1833 , B01L2400/0415 , B01L2400/0421 , B01L2400/0487 , G01N27/44791 , G01N33/5306
摘要： The present invention provides novel microfluidic devices and methods for performing pulsed field mobility shift assays in microfluidic devices. In particular the devices and methods of the invention utilize differences between electrophoretic mobilities (e.g., as between reactants and products, especially in non-fluorogenic reactions) in order to separate the species and thus analyze the reaction.
摘要翻译：本发明提供了用于在微流体装置中进行脉冲场迁移率变动测定的新型微流体装置和方法。特别地，本发明的装置和方法利用电泳迁移率之间的差异（例如，在反应物和产物之间，特别是在非荧光反应中），以便分离物种并因此分析反应。

88. 发明授权

US07189578B1 Methods and systems employing electrothermally induced flow for mixing and cleaning in microsystems 有权
标题翻译：在微系统中采用电热诱导流混合和清洗的方法和系统
公开(公告)号：US07189578B1
公开(公告)日：2007-03-13
申请号：US10307907
申请日：2002-12-02
申请人： Jianjun Feng , Sivaramakrishnan Krishnamoorthy , Vinod Bhagwan Makhijani
发明人： Jianjun Feng , Sivaramakrishnan Krishnamoorthy , Vinod Bhagwan Makhijani
IPC分类号： G01N1/00 , G01N1/10 , G01N35/00 , H05F3/00 , B01D57/02
CPC分类号： B08B9/00 , B01F13/0079 , B01F13/0081 , B01L3/5027 , B01L99/00 , B01L2300/1833 , B01L2400/0415 , B01L2400/0442 , B01L2400/0493 , B08B7/0064 , F04B19/006 , F04B19/24 , Y10T29/49 , Y10T29/49002 , Y10T436/11 , Y10T436/25 , Y10T436/2575
摘要： A method and system for controlling flow motion in a channel/cavity in a microfluidic system includes positioning at least one pair of electrodes in and/or proximate to the channel/cavity. A buffer solution is placed in the channel/cavity, the buffer solution having at least one dielectric property that varies in response to changes in temperature of the solution. An AC/DC voltage is applied to the electrodes to generate an electric field in the channel/cavity; the AC voltage having a known magnitude and frequency and the DC voltage having a known magnitude. The magnitude of the AC/DC voltage is adjusted to cause Joule heating of the buffer solution in the channel/cavity. The geometry and position of the electrodes is adjusted to generate a temperature gradient in the buffer solution, thereby causing a non-uniform distribution of the dielectric property within the solution in the channel/cavity. The dielectric non-uniformity produces a body force and flow in the solution. Also, the frequency of the AC voltage is adjusted to generate flow of the buffer solution in the channel/cavity in response to the non-uniform distribution of the dielectric property.
摘要翻译：用于控制微流体系统中的通道/空腔中的流动的方法和系统包括将至少一对电极定位在通道/空腔中和/或接近通道/空腔。将缓冲溶液放置在通道/空腔中，缓冲溶液具有响应于溶液温度变化而变化的至少一种介电特性。 AC / DC电压施加到电极以在通道/空腔中产生电场; AC电压具有已知的幅度和频率，并且DC电压具有已知的幅度。调整AC / DC电压的大小，使通道/腔中的缓冲溶液焦耳加热。调节电极的几何形状和位置以在缓冲溶液中产生温度梯度，从而导致溶液中的介电性质在通道/空腔中的不均匀分布。电介质非均匀性会在溶液中产生体力和流动。此外，响应于介电性质的不均匀分布，调节AC电压的频率以产生通道/空腔中的缓冲溶液的流动。

89. 发明授权

US07150814B1 Prevention of surface adsorption in microchannels by application of electric current during pressure-induced flow 有权
公开(公告)号：US07150814B1
公开(公告)日：2006-12-19
申请号：US10214961
申请日：2002-08-08
申请人： J. Wallace Parce , Andrea W. Chow
发明人： J. Wallace Parce , Andrea W. Chow
IPC分类号： G01N27/453 , G01N30/02
CPC分类号： B08B17/00 , B01L3/50273 , B01L2300/0816 , B01L2300/1833 , B01L2400/0409 , B01L2400/0415 , B01L2400/0487 , G01N27/44704 , G01N27/44752
摘要： Methods and apparatus for reducing adsorption in microscale devices are provided. In the methods and apparatus, an electrical current such as an alternating current is applied to materials under pressure-induced flow. Integrated systems for simultaneous control of current and pressure in a channel are also provided.

90. 发明申请

US20060081600A1 Method and apparatus for performing rapid thermo cycling as well as micro fabricated system 审中-公开
标题翻译：执行快速热循环的方法和装置以及微制造系统
公开(公告)号：US20060081600A1
公开(公告)日：2006-04-20
申请号：US11226637
申请日：2005-09-13
申请人： Martin Kopp , Emad Sarofim
发明人： Martin Kopp , Emad Sarofim
IPC分类号： F27D11/04
CPC分类号： G05D23/19 , B01L7/52 , B01L2300/1822 , B01L2300/1833
摘要： A method to adjust a temperature of a fluid is disclosed, the method comprising the steps of providing a heat sink taking effect on the fluid, heating the fluid by Joule heating, and adjusting the heat provided by Joule heating in order to reach a desired temperature of the fluid. Furthermore, an apparatus to carry out the method is also disclosed. Therewith, a very efficient temperature change of the fluid can very quickly be obtained since the temperature of the surrounding is not substantially changed by heat diffusion. While a temperature increase is carried out by Joule heating, a temperature decrease is carried out by simply deactivating Joule heating. As soon as Joule heating is deactivated, the heat is extracted from the fluid by the heat sink, thereby initiating a high speed temperature change towards lower temperatures.
摘要翻译：公开了一种调节流体温度的方法，该方法包括以下步骤：提供散热器对流体的作用，通过焦耳加热加热流体，并调节由焦耳加热提供的热量以达到所需温度的流体。此外，还公开了一种执行该方法的装置。因此，由于通过热扩散基本上不改变周围的温度，所以可以非常快速地获得流体的非常有效的温度变化。当通过焦耳加热进行温度升高时，通过简单地停用焦耳加热来进行温度降低。一旦焦耳加热被停用，热量通过散热器从流体中提取，从而开始向较低温度的高速温度变化。

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