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1. 发明申请

US20080047833A1 Microfluidic device, measuring apparatus, and microfluid stirring method 审中-公开
标题翻译：微流体装置，测量装置和微流体搅拌方法
公开(公告)号：US20080047833A1
公开(公告)日：2008-02-28
申请号：US11802419
申请日：2007-05-22
申请人： Shuzo Hirahara , Kentaro Tani , Haruyuki Minamitani
发明人： Shuzo Hirahara , Kentaro Tani , Haruyuki Minamitani
IPC分类号： G01N27/26
CPC分类号： G01N33/49 , B01L3/502715 , B01L2300/1833
摘要： Conventionally, it has been difficult to effectively and promptly stir and mix fluids together by use of a microfluidic device having a simple flow path structure. Additionally, there has been no means for keeping a particulate sample floating in a fluid in a flow path for a long time without precipitating the particulate sample. Additionally, there has been no method for measuring the true size of a flowing and floating particulate sample by use of a microscope. The present invention solves these problems by using a microfluidic device in which an electrode pair having a wide electrode-to-electrode gap is formed in a flow path or in a chamber, and by applying an AC voltage to this electrode pair, and by generating an eddy by which a fluid is swirled in a torus manner. The accurate size of the particulate sample that crosses the in-focus plane can be measured especially by setting an in-focus plane (53) of an objective lens (52) of a microscope at a position through which a swirling flow (41) vertically passes.
摘要翻译：通常，通过使用具有简单流路结构的微流体装置，难以有效地并且迅速地将流体混合在一起。此外，没有使颗粒样品在流动路径中长时间漂浮在流体中而不使颗粒样品沉淀的方法。另外，没有使用显微镜测量流动和浮动的颗粒样品的真实尺寸的方法。本发明通过使用微流体装置来解决这些问题，其中在流路或室内形成具有宽的电极间电极间隙的电极对，并且通过向该电极对施加AC电压，并且通过产生流体以环形方式旋转的涡流。可以通过将显微镜的物镜（52）的聚焦平面（53）设置在垂直于旋转流（41）的位置上来测量穿过对焦平面的颗粒样品的精确尺寸通过

2. 发明申请

US20110284375A1 Microfluidic device and analyzing device using the same 有权
标题翻译：微流体装置及分析装置采用相同的方法
公开(公告)号：US20110284375A1
公开(公告)日：2011-11-24
申请号：US13067005
申请日：2011-05-02
申请人： Shuzo Hirahara , Tomoyuki Tsuruta , Haruyuki Minamitani
发明人： Shuzo Hirahara , Tomoyuki Tsuruta , Haruyuki Minamitani
IPC分类号： G01N27/447 , B81B1/00
CPC分类号： B01F13/0076 , B01L3/5027 , B01L2300/088 , B01L2300/0887 , F04B19/006
摘要： The conventional micropump and the conventional micromixer have the following problems. In a mechanical or hydrodynamic method, the structure of the inside of a flow path is complex so as to easily cause clogging, and manufacturing cost is high, and dead volume is large. Additionally, in an electrical method, the conventional micropump or the conventional micromixer was incapable of operating with a liquid having the concentration of a physiological saline that is important in the medical or biological field although the structure of the flow path is simple. These problems are solved by applying an AC voltage to a pair of electrodes in which an electrode-to-electrode gap between the pair of electrodes is vertically arranged and by generating the flow of a fluid in the direction opposite to gravity along the electrode-to-electrode gap. A micropump (43, 44) can be realized especially by forming a micro-sized flow path (11) in the vertical direction along the electrode-to-electrode gap, and a micromixer (41) can be realized by forming a micro-sized flow path (11) in the horizontal direction to cross at right angle to the electrode-to-electrode gap.
摘要翻译：传统的微型泵和传统的微混合器具有以下问题。在机械或流体动力学方法中，流路内部的结构复杂，容易引起堵塞，制造成本高，死体积大。此外，在电气方法中，传统的微型泵或常规微混合器不能用具有在医学或生物领域中重要的生理盐水浓度的液体进行操作，尽管流动路径的结构简单。通过对一对电极施加AC电压来解决这些问题，在该对电极中，一对电极之间的电极间电极垂直排列，并且沿与电极相反的方向产生与重力相反的方向的流体 - 电极间隙。特别是通过在电极间电极间沿垂直方向形成微小流路（11），能够实现微型泵（43,44），通过形成微型混合器（41）流动路径（11）在水平方向上与电极间电极交叉成直角。

3. 发明申请

US20080237046A1 Microfluidic device and analyzing device using the same 审中-公开
标题翻译：微流体装置及分析装置采用相同的方法
公开(公告)号：US20080237046A1
公开(公告)日：2008-10-02
申请号：US12000897
申请日：2007-12-18
申请人： Shuzo Hirahara , Tomoyuki Tsuruta , Haruyuki Minamitani
发明人： Shuzo Hirahara , Tomoyuki Tsuruta , Haruyuki Minamitani
IPC分类号： B01J19/08
CPC分类号： B01F13/0076 , B01L3/5027 , B01L2300/088 , B01L2300/0887 , F04B19/006
摘要： The conventional micropump and the conventional micromixer have the following problems. In a mechanical or hydrodynamic method, the structure of the inside of a flow path is complex so as to easily cause clogging, and manufacturing cost is high, and dead volume is large. Additionally, in an electrical method, the conventional micropump or the conventional micromixer was incapable of operating with a liquid having the concentration of a physiological saline that is important in the medical or biological field although the structure of the flow path is simple. These problems are solved by applying an AC voltage to a pair of electrodes in which an electrode-to-electrode gap between the pair of electrodes is vertically arranged and by generating the flow of a fluid in the direction opposite to gravity along the electrode-to-electrode gap. A micropump (43, 44) can be realized especially by forming a micro-sized flow path (11) in the vertical direction along the electrode-to-electrode gap, and a micromixer (41) can be realized by forming a micro-sized flow path (11) in the horizontal direction to cross at right angle to the electrode-to-electrode gap.
摘要翻译：传统的微型泵和传统的微混合器具有以下问题。在机械或流体动力学方法中，流路内部的结构复杂，容易引起堵塞，制造成本高，死体积大。此外，在电气方法中，传统的微型泵或常规微混合器不能用具有在医学或生物领域中重要的生理盐水浓度的液体进行操作，尽管流动路径的结构简单。通过对一对电极施加AC电压来解决这些问题，在该对电极中，一对电极之间的电极间电极垂直排列，并且沿与电极相反的方向产生与重力相反的方向的流体 - 电极间隙。特别是通过沿着电极间电极形成沿着垂直方向的微小流路（11），可以实现微型泵（43,44），通过形成微型混合器（41）流动路径（11）在水平方向上与电极间电极交叉成直角。

4. 发明授权

US08313626B2 Microfluidic device and analyzing device using the same 有权
标题翻译：微流体装置及分析装置采用相同的方法
公开(公告)号：US08313626B2
公开(公告)日：2012-11-20
申请号：US13067005
申请日：2011-05-02
申请人： Shuzo Hirahara , Tomoyuki Tsuruta , Haruyuki Minamitani
发明人： Shuzo Hirahara , Tomoyuki Tsuruta , Haruyuki Minamitani
IPC分类号： G01N27/26 , B81B1/00
CPC分类号： B01F13/0076 , B01L3/5027 , B01L2300/088 , B01L2300/0887 , F04B19/006
摘要： The conventional micropump and the conventional micromixer have the following problems. In a mechanical or hydrodynamic method, the structure of the inside of a flow path is complex so as to easily cause clogging, and manufacturing cost is high, and dead volume is large. Additionally, in an electrical method, the conventional micropump or the conventional micromixer was incapable of operating with a liquid having the concentration of a physiological saline that is important in the medical or biological field although the structure of the flow path is simple. These problems are solved by applying an AC voltage to a pair of electrodes in which an electrode-to-electrode gap between the pair of electrodes is vertically arranged and by generating the flow of a fluid in the direction opposite to gravity along the electrode-to-electrode gap. A micropump (43, 44) can be realized especially by forming a micro-sized flow path (11) in the vertical direction along the electrode-to-electrode gap, and a micromixer (41) can be realized by forming a micro-sized flow path (11) in the horizontal direction to cross at right angle to the electrode-to-electrode gap.
摘要翻译：传统的微型泵和传统的微混合器具有以下问题。在机械或流体动力学方法中，流路内部的结构复杂，容易引起堵塞，制造成本高，死体积大。此外，在电气方法中，传统的微型泵或常规微混合器不能用具有在医学或生物领域中重要的生理盐水浓度的液体进行操作，尽管流动路径的结构简单。通过对一对电极施加AC电压来解决这些问题，在该对电极中，一对电极之间的电极间电极垂直排列，并且沿与电极相反的方向产生与重力相反的方向的流体 - 电极间隙。特别是通过在电极间电极间沿垂直方向形成微小流路（11），能够实现微型泵（43,44），通过形成微型混合器（41）流动路径（11）在水平方向上与电极间电极交叉成直角。

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