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1. 发明申请

US20120288865A1 METHOD AND APPARATUS FOR GENERATING THERMAL MELTING CURVES IN A MICROFLUIDIC DEVICE 审中-公开
标题翻译：用于在微流体装置中产生热熔融曲线的方法和装置
公开(公告)号：US20120288865A1
公开(公告)日：2012-11-15
申请号：US13444502
申请日：2012-04-11
申请人： Steven A. Sundberg , Michael R. Knapp , Ivor T. Knight , Deborah J. Boles , Aaron J. Rulison , Wesley B. Dong , Edward P. Donlon , Robert J. Moti , Andrew G. Fabans , Allen R. Boronkay , Michael Slater
发明人： Steven A. Sundberg , Michael R. Knapp , Ivor T. Knight , Deborah J. Boles , Aaron J. Rulison , Wesley B. Dong , Edward P. Donlon , Robert J. Moti , Andrew G. Fabans , Allen R. Boronkay , Michael Slater
IPC分类号： G01N25/04
CPC分类号： G01N25/04 , B01L3/5027 , B01L3/502715 , B01L3/50273 , B01L7/52 , B01L7/525 , B01L2200/10 , B01L2300/0627 , B01L2300/0816 , B01L2300/14 , B01L2300/18 , B01L2300/1833 , B01L2400/0409 , B01L2400/0415 , B01L2400/0487 , C12Q1/68 , C12Q1/6844 , C12Q1/686 , C12Q1/6862 , G01N21/33 , G01N21/6428 , Y10T436/143333 , C12Q2565/629 , C12Q2565/101 , C12Q2527/107 , C12Q2527/101
摘要： The present invention provides novel methods and devices that employ microfluidic technology to generate molecular melt curves. In particular, the devices and methods in accordance with the invention are useful in providing for the analysis of PCR amplification products.
摘要翻译：本发明提供了采用微流体技术产生分子熔融曲线的新颖方法和装置。特别地，根据本发明的装置和方法可用于提供PCR扩增产物的分析。

2. 发明授权

US08900811B2 Method and apparatus for generating thermal melting curves in a microfluidic device 有权
标题翻译：用于在微流体装置中产生热解曲线的方法和装置
公开(公告)号：US08900811B2
公开(公告)日：2014-12-02
申请号：US11352452
申请日：2006-02-09
申请人： Steven A. Sundberg , Michael R. Knapp , Ivor T. Knight , Deborah J. Boles , Aaron J. Rulison , Wesley B. Dong , Andrew G. Fabans , Allen R. Boronkay , Edward P. Donlon , Robert J. Moti , Michael Slater
发明人： Steven A. Sundberg , Michael R. Knapp , Ivor T. Knight , Deborah J. Boles , Aaron J. Rulison , Wesley B. Dong , Andrew G. Fabans , Allen R. Boronkay , Edward P. Donlon , Robert J. Moti , Michael Slater
IPC分类号： C12Q1/68 , C12M1/34 , C12M3/00 , B01L3/00 , B01L7/00 , C07H21/02 , C07H21/04
CPC分类号： G01N25/04 , B01L3/5027 , B01L3/502715 , B01L3/50273 , B01L7/52 , B01L7/525 , B01L2200/10 , B01L2300/0627 , B01L2300/0816 , B01L2300/14 , B01L2300/18 , B01L2300/1833 , B01L2400/0409 , B01L2400/0415 , B01L2400/0487 , C12Q1/68 , C12Q1/6844 , C12Q1/686 , C12Q1/6862 , G01N21/33 , G01N21/6428 , Y10T436/143333 , C12Q2565/629 , C12Q2565/101 , C12Q2527/107 , C12Q2527/101
摘要： The present invention provides novel methods and devices that employ microfluidic technology to generate molecular melt curves. In particular, the devices and methods in accordance with the invention are useful in providing for the analysis of PCR amplification products.
摘要翻译：本发明提供了采用微流体技术产生分子熔融曲线的新颖方法和装置。特别地，根据本发明的装置和方法可用于提供PCR扩增产物的分析。

3. 发明授权

US09376718B2 Method and apparatus for generating thermal melting curves in a microfluidic device 有权
标题翻译：用于在微流体装置中产生热解曲线的方法和装置
公开(公告)号：US09376718B2
公开(公告)日：2016-06-28
申请号：US13444502
申请日：2012-04-11
申请人： Steven A. Sundberg , Michael R. Knapp , Ivor T. Knight , Deborah J. Boles , Aaron J. Rulison , Wesley B. Dong , Edward P. Donlon , Robert J. Moti , Andrew G. Fabans , Allen R. Boronkay , Michael Slater
发明人： Steven A. Sundberg , Michael R. Knapp , Ivor T. Knight , Deborah J. Boles , Aaron J. Rulison , Wesley B. Dong , Edward P. Donlon , Robert J. Moti , Andrew G. Fabans , Allen R. Boronkay , Michael Slater
IPC分类号： C12Q1/68 , B01L3/00 , B01L7/00
CPC分类号： G01N25/04 , B01L3/5027 , B01L3/502715 , B01L3/50273 , B01L7/52 , B01L7/525 , B01L2200/10 , B01L2300/0627 , B01L2300/0816 , B01L2300/14 , B01L2300/18 , B01L2300/1833 , B01L2400/0409 , B01L2400/0415 , B01L2400/0487 , C12Q1/68 , C12Q1/6844 , C12Q1/686 , C12Q1/6862 , G01N21/33 , G01N21/6428 , Y10T436/143333 , C12Q2565/629 , C12Q2565/101 , C12Q2527/107 , C12Q2527/101
摘要： The present invention provides novel methods and devices that employ microfluidic technology to generate molecular melt curves. In particular, the devices and methods in accordance with the invention are useful in providing for the analysis of PCR amplification products.
摘要翻译：本发明提供了采用微流体技术产生分子熔融曲线的新颖方法和装置。特别地，根据本发明的装置和方法可用于提供PCR扩增产物的分析。

4. 发明授权

US06510197B1 Method and apparatus for osteoporosis screening 有权
公开(公告)号：US06510197B1
公开(公告)日：2003-01-21
申请号：US09481299
申请日：2000-01-11
申请人： Christopher R. Mitchell , Joseph R. Rimsa , Edward P. Donlon , Gregory A. Sprehn
发明人： Christopher R. Mitchell , Joseph R. Rimsa , Edward P. Donlon , Gregory A. Sprehn
IPC分类号： G01N2304
CPC分类号： A61B6/505 , A61B6/0421 , A61B6/4042 , A61B6/4216 , A61B6/463 , A61B6/482
摘要： A method and apparatus for forming and reading a radiation image of an object is provided. The method is performed by placing an object of which a radiation image is to be taken adjacent a platform that is positioned between a storage layer radiation screen and an electromagnetic wave radiation source such that radiation from the electromagnetic wave radiation source which traverses the object is absorbed by the storage layer radiation screen; forming a latent radiation image of the object on the storage layer radiation screen by causing the electromagnetic wave radiation source to emit radiation, a portion of the emitted radiation traversing the object and being absorbed by the storage layer radiation screen; and reading the latent radiation image of the object from the storage layer radiation screen.

5. 发明授权

US06492654B1 Scanning system with flexible drive assembly 失效
标题翻译：具有灵活驱动装置的扫描系统
公开(公告)号：US06492654B1
公开(公告)日：2002-12-10
申请号：US09782923
申请日：2001-02-13
申请人： Edward P. Donlon , Joseph R. Rimsa , Louis Hlousek
发明人： Edward P. Donlon , Joseph R. Rimsa , Louis Hlousek
IPC分类号： G01N2304
CPC分类号： G01N23/046 , A61B6/14 , G01N2223/419
摘要： A system is provided for scanning an object, the system comprising: a drive shaft having a proximal portion and a longitudinal axis; a motor including a motor shaft having a rotational axis, the motor serving to rotate the motor shaft about the rotational axis; a flexible joint coupling the drive shaft to the motor shaft by the proximal portion of the drive shaft, the flexible joint having a range of motion which allows the longitudinal axis of the drive shaft to move relative to the rotational axis of the motor shaft; and an object attached to the drive shaft which is movable along the longitudinal axis of the drive shaft in response to the drive shaft being rotated by the motor. This system may be used in a drum scanner system and may be used to read storage layer radiation screens.
摘要翻译：提供一种用于扫描物体的系统，该系统包括：具有近端部分和纵向轴线的驱动轴; 包括具有旋转轴线的马达轴的马达，所述马达用于使所述马达轴绕所述旋转轴线旋转; 柔性接头通过驱动轴的近侧部分将驱动轴连接到电动机轴，柔性接头具有允许驱动轴的纵向轴线相对于电动机轴的旋转轴线移动的运动范围; 以及附接到所述驱动轴的物体，所述物体响应于所述驱动轴由所述马达旋转而沿着所述驱动轴的纵向轴线移动。该系统可以用于鼓式扫描器系统中，并且可以用于读取存储层辐射屏幕。

6. 发明授权

US07008788B2 Containers for supports comprising biopolymers 失效
公开(公告)号：US07008788B2
公开(公告)日：2006-03-07
申请号：US09919062
申请日：2001-07-30
申请人： Donald J. Schremp , Richard O. Hilson , Edward P. Donlon
发明人： Donald J. Schremp , Richard O. Hilson , Edward P. Donlon
IPC分类号： C12M3/00
CPC分类号： B01L9/52 , B01F11/0014 , B01F11/0022 , B01F13/0059 , B01F13/02 , B01F13/0272 , B01F2005/0017 , B01F2215/0454 , B01F2215/0468 , B01L3/502 , B01L3/508 , B01L2300/0636 , B01L2300/0822 , B01L2300/0851 , C12M23/04 , C12Q1/6834 , Y10S436/809 , Y10S436/823
摘要： Devices and methods are disclosed for containing and processing samples on the surface of supports. Biopolymer features are attached to the surfaces of the supports. A device in accordance with the invention comprises a housing and a support confined by the housing. The housing comprises a well having walls and at least one wall extending from the edge of the well. The height of the walls of the well is at least great enough, and the design of the at least one wall is such, that liquid contained in the well is not drawn out of the well to any substantial degree by surface tension or small movements or small mechanical vibrations. In one embodiment, the at least one wall is designed such that corners thereof are curved or are distant from the edge of the well to substantially eliminate wicking of liquid from the well. Also disclosed are methods for mixing materials on the surface of a support. A sample is incubated with the surface of the support of the aforementioned device. The sample is removed from the surface, a residual amount of the sample remaining on the surface. The surface is contacted with a wash solution. A stream of gas is directed at the surface of the support. The pressure of the stream and the angle of the stream create a vortex on the surface sufficient to mix the sample and the wash solution. The wash solution is then removed from the surface. Also disclosed are methods for conducting binding reactions using the devices of the invention.

7. 发明授权

US06859584B2 Methods and apparatuses for bonding in athermal optical fiber packages 有权
公开(公告)号：US06859584B2
公开(公告)日：2005-02-22
申请号：US10335629
申请日：2002-12-31
申请人： Alan E. Johnson , Frank D. Braun , Edward P. Donlon
发明人： Alan E. Johnson , Frank D. Braun , Edward P. Donlon
IPC分类号： G02B6/02 , G02B6/34
CPC分类号： G02B6/0218
摘要： An athermal package for fiber photonic devices includes a ferrule to attach the optical fiber to the package. The ferrule has an opening to receive the optical fiber. The ferule is collapsed to attach the optical fiber to the athermal package. Alternatively, the athermal package uses adhesive bonds disposed in pockets of the package. The pockets have a narrow end and a wide end, with the narrow ends facing each other. The adhesive bonds are disposed in the pockets in contact the narrow ends of the pockets but not with the wide ends. The narrow ends physically confine the adhesive bonds so that if the bonds expand or contract due to environmental conditions (or the curing process), the adhesive either expands or contracts near the wide ends of the pockets. This allows the strain on the optical fiber segment between the bonds to remain substantially constant.

8. 发明授权

US06490339B2 Method and apparatus for osteoporosis screening 有权
标题翻译：用于骨质疏松筛查的方法和装置
公开(公告)号：US06490339B2
公开(公告)日：2002-12-03
申请号：US10007815
申请日：2001-11-09
申请人： Christopher R. Mitchell , Joseph R. Rimsa , Edward P. Donlon , Gregory A. Sprehn
发明人： Christopher R. Mitchell , Joseph R. Rimsa , Edward P. Donlon , Gregory A. Sprehn
IPC分类号： G01N2304
CPC分类号： A61B6/505 , A61B6/0421 , A61B6/4042 , A61B6/4216 , A61B6/463 , A61B6/482
摘要： A method and apparatus for forming and reading a radiation image of an object is provided. The method is performed by placing an object of which a radiation image is to be taken adjacent a platform that is positioned between a storage layer radiation screen and an electromagnetic wave radiation source such that radiation from the electromagnetic wave radiation source which traverses the object is absorbed by the storage layer radiation screen; forming a latent radiation image of the object on the storage layer radiation screen by causing the electromagnetic wave radiation source to emit radiation, a portion of the emitted radiation traversing the object and being absorbed by the storage layer radiation screen; and reading the latent radiation image of the object from the storage layer radiation screen.
摘要翻译：提供了一种用于形成和读取物体的辐射图像的方法和装置。该方法通过将放射线图像的对象放置在与位于存储层辐射屏和电磁波辐射源之间的平台附近来实现，使得来自穿过物体的电磁波辐射源的辐射被吸收通过存储层辐射屏; 通过使电磁波辐射源发射辐射，发射的辐射的一部分穿过物体并被存储层辐射屏幕吸收，在存储层辐射屏上形成物体的潜在辐射图像; 以及从存储层辐射屏幕读取物体的潜在辐射图像。

9. 发明授权

US5777325A Device for time lag focusing time-of-flight mass spectrometry 失效
标题翻译：时差聚焦飞行时间质谱仪的设备
公开(公告)号：US5777325A
公开(公告)日：1998-07-07
申请号：US643708
申请日：1996-05-06
申请人： Scot R. Weinberger , Edward P. Donlon , Yevgeny Kaplun , Tor C. Anderson , Liang Li , Larry Russon , Randy Whittal
发明人： Scot R. Weinberger , Edward P. Donlon , Yevgeny Kaplun , Tor C. Anderson , Liang Li , Larry Russon , Randy Whittal
IPC分类号： H01J49/02 , H01J49/40
CPC分类号： H01J49/40 , H01J49/025
摘要： A laser desorption ionization instrument for and method of measuring the molecular weight of large organic molecules includes a time of flight mass spectrometer (TOF MS). The TOF MS instrument provides optimized optic design for both DC and TLF modes. The invention further provides dynamic resolution enhancement for a given ejection pulse, along with optimized ion ejection pulses relative to the ion optic elements. The invention also provides means for compensating for difference in total kinetic energy among ions of different mass; high resolution detection means for improved sensitivity for large molecular weight species. The invention further provides x-y-z stage for sample presentation of both standard MALDI and gel or membrane based samples.
摘要翻译：用于测量大型有机分子分子量的激光解吸电离仪及其测定方法包括飞行时间质谱仪（TOF MS）。 TOF MS仪器为DC和TLF模式提供优化的光学设计。本发明还提供了对于给定的喷射脉冲的动态分辨率增强以及相对于离子光学元件的优化的离子喷射脉冲。本发明还提供了补偿不同质量离子之间总动能差异的方法; 高分辨率检测手段，用于提高大分子量物种的灵敏度。本发明还提供用于标准MALDI和基于凝胶或膜的样品的样品呈现的x-y-z级。

10. 发明授权

US06881579B2 Sample processing apparatus and methods 失效
标题翻译：样品处理设备和方法
公开(公告)号：US06881579B2
公开(公告)日：2005-04-19
申请号：US09919073
申请日：2001-07-30
申请人： Richard O. Hilson , Edward P. Donlon , Donald J. Schremp , Laurence R. Shea , Carol T. Schembri , Joseph P. Fredrick
发明人： Richard O. Hilson , Edward P. Donlon , Donald J. Schremp , Laurence R. Shea , Carol T. Schembri , Joseph P. Fredrick
IPC分类号： G01N35/00 , G01N35/04 , G01N35/02 , G01N33/50
CPC分类号： G01N35/04 , G01N35/00029 , G01N2035/00158 , G01N2035/0444 , Y10T436/11 , Y10T436/113332 , Y10T436/114998 , Y10T436/142222 , Y10T436/143333
摘要： Apparatus and methods are disclosed for processing samples on the surface of supports that are contained in support housings. Biopolymer features are attached to the surfaces of the supports. An apparatus comprises an input element, a holding device for holding a plurality of support housings, one or more fluid dispensing stations, and an output element. Each of the support housings contains a support having attached thereto a plurality of biopolymer features. The holding device is movably mounted with respect to other components of the apparatus. The holding device is adapted to receive a support housing from the input element. The output element is adapted to receive a support housing from the holding device. The apparatus is adapted to index each support housing for a predetermined operation. In use, each of the support housings is moved to one or more processing stations by means of the movable holding device. The location and identity of each of the support housings is indexed. Fluid is applied to the surface of each of the supports at the processing stations to process the samples. Each of the support housings is moved away from the fluid dispensing stations, and fluid is physically removed from each of the supports within the support housings.
摘要翻译：公开了用于在载体表面上包含在支撑壳体中的样品进行处理的装置和方法。生物聚合物特征附着在支撑体的表面上。一种装置包括输入元件，用于保持多个支撑壳体的保持装置，一个或多个流体分配站以及输出元件。每个支撑壳体包含附着有多个生物聚合物特征的支撑体。保持装置相对于装置的其它部件可移动地安装。保持装置适于从输入元件接收支撑壳体。输出元件适于从保持装置接纳支撑壳体。该装置适于为每个支撑壳体索引预定的操作。在使用中，通过可移动保持装置将每个支撑壳体移动到一个或多个处理站。每个支撑壳体的位置和身份被索引。将流体施加到处理站处的每个支撑件的表面以处理样品。每个支撑壳体移动离开流体分配站，并且流体物理地从支撑壳体内的每个支撑件移除。

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