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81. 发明公开

EP1407257A1 MICROFABRICATED SEPARATION DEVICE EMPLOYING A VIRTUAL WALL FOR INTERFACING FLUIDS 审中-公开
标题翻译：与虚拟墙作为表面液体的TO微加工的分离装置
公开(公告)号：EP1407257A1
公开(公告)日：2004-04-14
申请号：EP02744571.7
申请日：2002-06-20
申请人： Cytonome, Inc.
发明人： BÖHM, Sebastian , GILBERT, John
IPC分类号： G01N27/26 , G01N27/447
CPC分类号： G01N27/44791 , B01D57/02 , B01J19/0093 , B01J2219/00274 , B01L3/0241 , B01L3/0244 , B01L3/502753 , B01L2200/027 , B01L2200/143 , B01L2200/147 , B01L2300/089 , B01L2400/0421 , B01L2400/0439 , C12Q1/00 , G01N27/447 , G01N27/44743 , G01N27/44782 , G01N2035/1037
摘要： A fluid interface port (15) in a separation device for separating a sample into different components is provided. The separation device includes an array of separation channels (500) and the fluid interface port (17) comprises an opening formed in the side wall of a separation channel (500) sized and dimensioned to form a virtual wall (15) when the separation channel is filled with a separation medium (20). The fluid interface port (17) is utilized to introduce a liquid sample (19a) into the separation medium (20). The interface ports (17) formed in the array of separation channels (500) are organized into one or more sample injectors. A cathode reservoir is multiplexed with one or more separation channels. To complete an electrical path, an anode reservoir which is common to some or all separation channels (500) is also provided.

82. 发明公开

EP1325311A2 FIBER OPTIC APPARATUS AND USE THEREOF IN COMBINATORIAL MATERIAL SCIENCE 审中-公开
标题翻译：光纤设备和它们在组合材料研究
公开(公告)号：EP1325311A2
公开(公告)日：2003-07-09
申请号：EP01986763.9
申请日：2001-10-10
申请人： Symyx Technologies, Inc.
发明人： KUEBLER, Sigrid, C. , BENNETT, James
IPC分类号： G01N21/49 , G01N15/02
CPC分类号： B01D15/08 , B01D15/26 , B01D15/265 , B01D15/325 , B01D15/34 , B01J19/0046 , B01J19/26 , B01J2219/00274 , B01J2219/00315 , B01J2219/00585 , B01J2219/00587 , B01J2219/00707 , B01J2219/00722 , C40B40/14 , C40B60/14 , G01N15/0205 , G01N21/253 , G01N21/51 , G01N21/532 , G01N30/02 , G01N30/16 , G01N30/24 , G01N30/30 , G01N30/461 , G01N30/466 , G01N30/54 , G01N30/60 , G01N30/6052 , G01N30/88 , G01N33/44 , G01N33/442 , G01N35/085 , G01N35/1097 , G01N2015/0288 , G01N2015/0294 , G01N2030/324 , G01N2030/625
摘要： Methods, systems and devices are described for rapid characterization and screening of liquid samples to determine properties (e.g., particle size, particle size distribution, molar mass and/or molar mass distribution) thereof with static light scattering and/or dynamic light scattering. The liquid samples can be solutions, emulsions, suspensions or dispersions. One method, includes providing a vessel containing a liquid sample having an exposed surface that defines a gas-liquid sample interface, and analyzing the sample by light scattering methods that include transmitting light through the gas-liquid sample interface into the sample, and detecting light scattered from the sample or from a component thereof. Additional methods are directed to characterizing a plurality of liquid samples or components thereof. The methods, systems, and devices have applications in high-throughput screening, and particularly, in combinatorial materials research and in industrial process control.

83. 发明公开

EP1323465A1 Flexible high density array print head with systems and methods for aligning pin plate, reservoir and substrate with respect to each other 审中-公开
标题翻译：柔性印刷头用于在销板，容器的Ausrrichtung高密度的装置和方法的基体和基板彼此
公开(公告)号：EP1323465A1
公开(公告)日：2003-07-02
申请号：EP01403393.0
申请日：2001-12-31
申请人： Corning Incorporated
发明人： Dannoux, Thierry Luc Alain , Lerebouillet, Jean-Pierre , Ramel, Ramain , Tellier, Xavier
IPC分类号： B01J19/00 , B01L3/02 , G01N33/52
CPC分类号： B01L3/0244 , B01J2219/00274 , B01J2219/00369 , B01J2219/00387 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00621 , B01J2219/00659 , B01J2219/00693 , B01L2200/025 , B01L2300/0819 , Y10T436/11 , Y10T436/2575
摘要： Systems and methods for aligning High Density Array ("HDA") pin plates, substrates and reservoirs with respect to each other. The system includes a flexure (38) having a flexible print head (30), elongated members flexibly connected off-axis to the system and a pin plate support assembly (36) detachably connected to the flexure allowing the pin plate assembly to adapt its position during a printing operation. The pin plate has alignment ball receptacles on its surface and the reservoir (34) has alignment balls (40) on its surface facing the pin plate. The pin plate (32) is positioned with respect to the reservoir (34) such that each of the alignment balls (40) is located within one of the alignment ball receptacles to achieve the alignment. Once the pin plate is aligned, it is secured to a supporting assembly such as a vacuum bridge, and inking and printing operations are performed.
摘要翻译：系统和用于对准高密度阵列（“HDA”）销板，衬底和水库相对于海誓山盟方法。该系统包括具有柔性印刷头的挠曲（38）（30）的长形构件柔性连接的离轴对系统和一个销板支撑组件（36）可拆卸地连接到挠性件允许销板组件，以适应其位置在打印操作期间。销板在其表面上的对准球容器和贮存器（34）在其表面面向所述销板上的对准球（40）。销板（32）被定位相对于所述贮存器（34）检测做每个对准滚珠（40）位于所述对准球容器中的一个内，以实现对准。一旦销板对准，它被固定到一个支撑组件，包括：如真空桥，并进行着墨和打印操作。

84. 发明公开

EP1310789A2 Rapid characterization of polymers with temperature control in a mixing zone 审中-公开
标题翻译： Schlerle Charakterisierung von Polymeren mittels in der MischzonedurchgeführterTemperaturregelung
公开(公告)号：EP1310789A2
公开(公告)日：2003-05-14
申请号：EP03003138.9
申请日：1999-04-02
申请人： Symyx Technologies, Inc.
发明人： Carlson, Eric , Safir, Adam , Petro, Miroslav , Nielson, Ralph, B., , Lee, Thomas, S. , Frechet, Jean, M.J., , Dales, G., Cameron, , Kuebler, Sigrid, C., , Bennett,James
IPC分类号： G01N30/30 , G01N30/34
CPC分类号： G01N35/1097 , B01D15/12 , B01D15/14 , B01D15/26 , B01D15/265 , B01D15/325 , B01D15/34 , B01J19/26 , B01J20/28078 , B01J2219/00119 , B01J2219/00274 , G01N15/0205 , G01N30/16 , G01N30/30 , G01N30/60 , G01N30/6052 , G01N33/44 , G01N33/442 , G01N35/085 , G01N2015/0288 , G01N2015/0294 , G01N2030/347 , G01N2030/885 , G01N2030/8886
摘要： A method for characterizing a non-biological polymer sample, the method comprising injecting a polymer sample into a mobile-phase of a liquid chromatography system, the mobile-phase being supplied to a liquid chromatography column from a mixing zone, the mixing zone being in fluid communication with a first reservoir containing a first mobile phase fluid at a first temperature, and with a second reservoir containing a second mobile phase fluid at a second temperature, controlling the temperature of the mobile-phase in the mixing zone to vary over time by varying the relative amounts of the first and second mobile-phase fluids supplied to the mixing zone, separating one or more sample components of the polymer sample in the chromatography column, and detecting a property of at least one of the separated sample components.
摘要翻译：一种用于表征非生物聚合物样品的方法，所述方法包括将聚合物样品注入到液相色谱系统的流动相中，将流动相从混合区域供应到液相色谱柱，混合区域与在第一温度下含有第一流动相流体的第一储存器以及在第二温度下含有第二流动相流体的第二储存器流体连通，控制混合区中流动相的温度随时间变化随时间变化改变供应到混合区的第一和第二流动相流体的相对量，分离色谱柱中的聚合物样品的一个或多个样品组分，并检测至少一个分离的样品组分的性质。

85. 发明公开

EP1308722A2 Rapid characterization of polymers with heated injection probe 审中-公开
标题翻译： on onde onde onde onde onde onde onde onde onde onde onde onde onde onde onde onde onde onde onde onde onde onde onde
公开(公告)号：EP1308722A2
公开(公告)日：2003-05-07
申请号：EP03003137.1
申请日：1999-04-02
申请人： Symyx Technologies, Inc.
发明人： Carlson, Eric , Safir, Adam , Petro, Miroslav , Nielson, Ralph, B., , Lee, Thomas, S. , Frechet, Jean, M.J., , Dales, G., Cameron, , Kuebler, Sigrid, C., , Bennett,James
IPC分类号： G01N30/30 , G01N30/16
CPC分类号： G01N35/1097 , B01D15/12 , B01D15/14 , B01D15/26 , B01D15/265 , B01D15/325 , B01D15/34 , B01J19/26 , B01J20/28078 , B01J2219/00119 , B01J2219/00274 , G01N15/0205 , G01N30/16 , G01N30/30 , G01N30/60 , G01N30/6052 , G01N33/44 , G01N33/442 , G01N35/085 , G01N2015/0288 , G01N2015/0294 , G01N2030/347 , G01N2030/885 , G01N2030/8886
摘要： A method for characterising a polymer sample, the method comprising withdrawing a sample from a sample container into an injection probe of an auto-sampler, the injection probe being heated to maintain the withdrawn sample at a temperature of not less than about 75 °C while resident in the injection probe, the heated injection probe residing in a first environment maintained at about ambient temperature while withdrawing the polymer sample, loading at least a portion of the withdrawn sample into an injection port or a loading port of a liquid chromatography system or a flow injection analysis system, the injection port or loading port being adaptable for fluid communication with a chromatographic column or a flow injection analysis system, the chromatographic column residing in a heated second environment maintained at a temperature of not less than about 75 °C, injecting the loaded 5 ample into a mobile phase of the liquid chromatography system or a flow injection analysis system chromatographically separating the injected sample, as in the case of using liquid chromatography, detecting a property of the sample or of a component thereof and, maintaining the sample at a temperature of not less than about 75 °C during a period of time including from when the sample is withdrawn from the sample container to when the sample is within the heated second environment or when the property of the sample or of a component thereof is detected.
摘要翻译：用于表征聚合物样品的方法，所述方法包括将样品从样品容器中取出到自动进样器的注射探针中，所述注射探针被加热以将抽出的样品保持在不低于约75℃的温度，同时驻留在注射探针中，加热的注射探针位于保持在大约环境温度的第一环境中，同时抽出聚合物样品，将至少一部分抽出的样品加载到液相色谱系统的注入口或装载端口流动注射分析系统，注射口或装载口适用于与色谱柱或流动注射分析系统的流体连通，色谱柱位于保持在不低于约75℃的加热的第二环境中，注入将5荷载入液相色谱系统的流动相或流动注射分析系统色谱分离注入的样品，如在使用液相色谱法的情况下，检测样品或其组分的性质，并在一段时间内将样品保持在不低于约75℃的温度，包括当样品从样品容器中取出到样品处于加热的第二环境中或当检测到样品或其组分的性质时。

86. 发明公开

EP1304162A2 Chemical arrays and method for their production 审中-公开
标题翻译： Chemische Arrays und Verfahren zu ihrer Herstellung
公开(公告)号：EP1304162A2
公开(公告)日：2003-04-23
申请号：EP02257236.6
申请日：2002-10-18
申请人： Agilent Technologies, Inc.
发明人： Lefkowitz, Steven M. , Kanemoto, Roy H. , Schembri, Carol T. , Perbost, Michel G.M.
IPC分类号： B01J19/00 , G06F19/00 , C12Q1/68
CPC分类号： B82Y30/00 , B01J19/0046 , B01J2219/00274 , B01J2219/00378 , B01J2219/00497 , B01J2219/00518 , B01J2219/00527 , B01J2219/00547 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00626 , B01J2219/00637 , B01J2219/00659 , B01J2219/00675 , B01J2219/00677 , B01J2219/00689 , B01J2219/00695 , C40B50/14 , C40B60/14 , C40B70/00 , G01N35/00009 , G01N2035/00158
摘要： Methods, apparatus, and computer program products to form arrays (12) of polymers each having a pattern of features on a surface (11a) of a flexible elongated web (10). In a method polymers or their precursor units are applied at an application station to the surface. Multiple features (16) are covered at a reagent station (384) with a continuous volume of reagent which chemically reacts with precursors or the web (10). The flexible elongated web (10) is driven in a lengthwise direction through the application station. This sequence may be repeated as needed to form the arrays along the web. Also provided is a method preparing a surface of a flexible elongated web (10) to receive a biopolymer array (12).
摘要翻译：方法，装置和计算机程序产品以形成聚合物阵列（12），每个聚合物在柔性细长网（10）的表面（11a）上具有特征图案。在一种方法中，将聚合物或其前体单元在施用站施加到表面。多个特征（16）用试剂站（384）覆盖有连续体积的试剂，其与前体或网（10）发生化学反应。柔性细长网（10）沿长度方向驱动通过施工台。可以根据需要重复该序列以沿着网形成阵列。还提供了制备柔性细长网（10）的表面以接收生物聚合物阵列（12）的方法。

87. 发明公开

EP1302241A2 Apparatus and method for evaluating a test fluid 审中-公开
标题翻译：装置和方法用于评估测试液体
公开(公告)号：EP1302241A2
公开(公告)日：2003-04-16
申请号：EP02028571.4
申请日：2001-04-30
申请人： Symyx Technologies, Inc.
发明人： Mansky, Paul , Tiede, Richard , Havadtoy, Steve
IPC分类号： B01J19/00 , B01L3/00 , G01N33/36
CPC分类号： B01L3/5023 , B01J19/0046 , B01J2219/00274 , B01J2219/00315 , B01J2219/00484 , B01J2219/00585 , B01J2219/00659 , B01J2219/00704 , B01L3/50255 , B01L2400/0481 , B01L2400/049 , G01N33/36 , G01N33/367 , G01N35/028
摘要： A method for evaluating a fluid as a fabric-care composition or as component thereof, the method comprising providing a test sheet of fabric comprising a plurality of test regions, simultaneously contacting the test regions with a fluid.

88. 发明公开

EP1281439A1 Device for receiving a chip shaped carrier and process for assembling a plurality of such devices 审中-公开
标题翻译：装置，用于接收一个芯片形载体和工艺组装多个这样的装置的
公开(公告)号：EP1281439A1
公开(公告)日：2003-02-05
申请号：EP01118247.4
申请日：2001-07-30
申请人： F. HOFFMANN-LA ROCHE AG , Roche Diagnostics GmbH
发明人： Vischer, Peter
IPC分类号： B01L3/00 , B01L9/00 , C12Q1/68 , B01J19/00 , G01N21/00
CPC分类号： H01L21/67144 , B01J2219/00274 , B01J2219/00529 , B01J2219/00596 , B01J2219/00608 , B01J2219/00612 , B01J2219/00637 , B01J2219/00659 , B01J2219/00707 , B01J2219/00722 , B01L3/508 , B01L9/52 , B01L9/527 , B01L2200/0689 , B01L2300/0636 , B01L2300/0809 , B01L2400/0677 , C40B40/06 , H01L21/67121 , Y10S435/809
摘要： A device for receiving a chip shaped carrier (21) having an active surface (28) which is adapted to be read by an electro-optical reading device, e.g. a surface which carries an array (32) of DNA oligonucleids. The device comprises: a cartridge having an opening for receiving a liquid sample and including casing parts (14); a casing part (14) having an inner surface (17) and outer surface (16), a first cavity for receiving a chip shaped carrier (21), and means (22) which provide access to that first cavity and thereby to the active surface of the chip shaped carrier; a sealing material (26) which is at least once reversibly liquidifiable; the shape and dimensions of first cavity, chip shaped carrier (21), and sealing material (26), being chosen that the chip shaped carrier (21) fits into the space delimited by the sealing material (26). The process for mounting the carrier (21) in the cartridge essentially consists in placing the carrier (21) in the first cavity and liquidifying the sealing material (26). In the liquid state, the sealing material closes any gap between the side walls (24) of the first cavity and the carrier (21), and after solidification, the sealing material constitutes a strong and liquid-tight bond.
摘要翻译：一种用于接收具有芯片形载体（21）在有源表面（28），所有这些是angepasst装置通过在电光学读取装置被读取，E.G. 一个表面上的DNA oligonucleids的阵列（32），其承载。该装置包括：具有开口的盒，用于接收液体样品并包括壳体部分（14）; 具有内表面（17）和外表面（16）上的壳体部件（14），用于接收芯片形载体（21）的第一腔，和装置（22）为其提供访问做第一腔，并由此到有源芯片形载体的表面上; 密封材料（26），其至少一次可逆liquidifiable; 的形状和第一空腔，芯片形载体（21）和密封材料（26）的尺寸被选择DASS裸芯片形载体（21）装配到由密封材料（26）限定的空间。在盒安装在载体（21）的方法，从本质上讲besteht在将载体放置（21）在所述第一腔和liquidifying密封材料（26）。在液体状态下，密封材料封闭第一空腔的侧壁（24）和所述载体（21）之间的任何间隙，并凝固后，密封材料构成强和液密结合。

89. 发明公开

EP1268052A2 HIGH THROUGHPUT SCREENING ARRAY CONTAINING POROUS MATERIAL 审中-公开
标题翻译：多孔材中含有矩阵高通量分析
公开(公告)号：EP1268052A2
公开(公告)日：2003-01-02
申请号：EP01920717.4
申请日：2001-03-24
申请人： Lyles, Mark B.
发明人： Lyles, Mark B.
IPC分类号： B01J19/00 , G01N33/50 , C12Q1/68 , C07K1/04
CPC分类号： C07K1/1077 , B01J2219/00274 , B01J2219/00457 , B01J2219/00527 , B01J2219/00587 , B01J2219/00596 , B01J2219/00605 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/00617 , B01J2219/00621 , B01J2219/00626 , B01J2219/00637 , B01J2219/00641 , B01J2219/00659 , B01J2219/00707 , B01J2219/0072 , B01J2219/00722 , B01J2219/00725 , B01J2219/00731 , C07B2200/11 , C07H15/00 , C07H21/00 , C40B40/06 , C40B40/10 , C40B40/12 , G01N33/551
摘要： Two dimensional arrays of molecules on a porous material are disclosed. Combinatorial arrays of molecules may include peptides, oligosaccharides, proteins, oligonucleotides, RNA, DNA, antibodies, and small organic molecules. The arrays can be used in high throughput screening methods to identify targets, receptors, hybridizing sequences, antibody epitopes, and other chemical and biological molecule-molecule interactions. The porous material preferably comprises alumina and silica.

90. 发明授权

EP1171230B1 MATRIX STORAGE AND DISPENSING SYSTEM 有权
标题翻译：矩阵系统保存和销售
公开(公告)号：EP1171230B1
公开(公告)日：2002-11-27
申请号：EP00908647.1
申请日：2000-02-15
申请人： PE Corporation (NY)
发明人： VANN, Charles, S. , COX, David, M.
IPC分类号： B01J19/00
CPC分类号： B01J4/02 , B01J19/0046 , B01J2219/00274 , B01J2219/00306 , B01J2219/00308 , B01J2219/0031 , B01J2219/00322 , B01J2219/00333 , B01J2219/00351 , B01J2219/00409 , B01J2219/00459 , B01J2219/00461 , B01J2219/00463 , B01J2219/00466 , B01J2219/00468 , B01J2219/005 , B01J2219/00547 , B01J2219/00596 , B01J2219/00689 , B01J2219/00691 , B01J2219/00693 , C40B60/14 , C40B70/00 , G01N35/0099 , G01N35/025 , G01N35/026 , G01N35/028 , G01N35/1002 , G01N2035/00158 , G01N2035/00752 , G01N2035/042 , G01N2035/0425 , G01N2035/1041 , Y10T436/25375 , Y10T436/255 , Y10T436/2575
摘要： The present invention provides a system and process providing variable access to, as well as quick and accurate dispensing of, numerous selected reagents from a mass storage arrangement. According to one embodiment, an array of reagent dispensers is supported over a movable platform assembly. The platform assembly aligns a designated receiving receptacle under a selected dispenser of the array so that a respective reagent can be dispensed therein. Advantageously, the apparatus and process can be carried out under the control of a programmed computer.

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