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81. 发明授权

US07985426B1 Nanoparticles for targeting hepatoma cells and delivery means 失效
标题翻译：用于靶向肝癌细胞的纳米颗粒和递送装置
公开(公告)号：US07985426B1
公开(公告)日：2011-07-26
申请号：US11975279
申请日：2007-10-18
申请人： Hsing-Wen Sung , Mei-Chin Chen , Hosheng Tu
发明人： Hsing-Wen Sung , Mei-Chin Chen , Hosheng Tu
IPC分类号： A61K9/14
CPC分类号： A61K51/1255 , A61K9/5153 , A61K31/7008 , A61K31/704 , A61K33/24 , A61K45/06 , A61K47/549 , A61K47/6921 , A61K47/6935 , A61K49/0041 , A61K49/0093 , A61K51/0491 , A61K2300/00
摘要： The invention discloses a system, method and pharmaceutical composition of nanoparticles for lodging in a target tissue cell in situ of an animal subject, the nanoparticles comprising PGA-PLA block copolymers that are conjugated with a ligand, wherein the ligand has ligand-receptor binding affinity for the ligand to bind a surface receptor of the tissue cell.
摘要翻译：本发明公开了纳米颗粒的系统，方法和药物组合物，用于在动物受试者的原位靶向组织细胞中沉积，所述纳米颗粒包含与配体缀合的PGA-PLA嵌段共聚物，其中配体具有配体 - 受体结合亲和力用于配体结合组织细胞的表面受体。

82. 发明申请

US20110091373A1 PAA NANOPARTICLES FOR ENHANCEMENT OF TUMOR IMAGING 有权
标题翻译： PAA纳米颗粒增强肿瘤成像
公开(公告)号：US20110091373A1
公开(公告)日：2011-04-21
申请号：US12909573
申请日：2010-10-21
申请人： Ravindra K. Pandey , Raoul Kopelman , Anurag Gupta , Munawwar Sajjad
发明人： Ravindra K. Pandey , Raoul Kopelman , Anurag Gupta , Munawwar Sajjad
IPC分类号： A61K51/00 , A61K49/06 , A61K49/00 , C07D487/22 , B82Y5/00
CPC分类号： A61K41/0071 , A61K47/60 , A61K47/64 , A61K49/0002 , A61K49/0032 , A61K49/0052 , A61K49/0093 , A61K51/0451 , A61K51/1255 , B82Y15/00
摘要： A composition comprising PAA nanoparticles containing a post loaded tetrapyrollic photosensitizer and an imaging agent and methods for making and using same.
摘要翻译：一种包含PAA纳米颗粒的组合物，其包含后载荷的四光镜光敏剂和成像剂及其制备和使用方法。

83. 发明申请

US20100272638A1 RADIOLABELLED MICROPARTICLES, PROCESSES FOR THE PREPARATION THEREOF AND THE USE THEREOF 审中-公开
标题翻译：放射性微球，其制备方法及其用途
公开(公告)号：US20100272638A1
公开(公告)日：2010-10-28
申请号：US12706363
申请日：2010-02-16
申请人： Mareke HARTIG , Michael Trunk , Thomas Weuthen
发明人： Mareke HARTIG , Michael Trunk , Thomas Weuthen
IPC分类号： A61K51/12 , A61P11/00
CPC分类号： A61K9/0075 , A61K9/1611 , A61K51/1217 , A61K51/1255
摘要： The invention relates to microparticles radioactively labelled with the technetium isotope 99m Tc, a process for the preparation thereof and their use for preparing powdered inhalants—suitable for deposition studies, for example—which contain the labelled microparticles as active substances.
摘要翻译：本发明涉及用锝同位素99m Tc放射性标记的微粒，其制备方法及其制备粉末吸入剂的用途 - 适用于沉积研究，例如含有标记的微粒作为活性物质。

84. 发明授权

US07731648B2 Magnetic nanoscale particle compositions, and therapeutic methods related thereto 失效
标题翻译：磁性纳米粒子组合物及其相关治疗方法
公开(公告)号：US07731648B2
公开(公告)日：2010-06-08
申请号：US11264680
申请日：2005-11-01
申请人： Robert Ivkov
发明人： Robert Ivkov
IPC分类号： A61N2/00
CPC分类号： A61K41/0052 , A61K47/6923 , A61K47/6929 , A61K49/1818 , A61K49/1887 , A61K51/1255 , A61N1/406 , A61N2/002 , A61N2/02 , A61N5/1001 , B82Y5/00 , Y10S977/904
摘要： Disclosed are thermotherapeutic compositions for treating disease material, and methods of targeted therapy utilizing such compositions. These compositions comprise a) stable single domain magnetic particles; b) magnetic nanoparticles comprising aggregates of superparamagnetic grains; or c) magnetic nanoparticles comprising aggregates of stable single magnetic domain crystals and superparamagnetic grains. These compositions may also comprise a radio isotope, potential radioactive isotope, chemotherapeutic agent. These methods comprise the administration to a patient's body, body part, body fluid, or tissue of bioprobes (energy susceptive materials attached to a target-specific ligand), and the application of energy to the bioprobes so as to destroy, rupture, or inactivate the target in the patient. Energy forms, such as AMF, are utilized to provide the energy. The disclosed methods may be useful in the treatment of a variety of indications, including cancers, diseases of the immune system, central nervous system and vascular system, and pathogen-borne diseases.
摘要翻译：公开了用于治疗疾病材料的热治疗组合物，以及利用这种组合物的靶向治疗方法。这些组合物包含a）稳定的单畴磁性颗粒; b）包含超顺磁性颗粒聚集体的磁性纳米颗粒; 或c）包含稳定的单磁畴晶体和超顺磁性晶粒的聚集体的磁性纳米颗粒。这些组合物还可以包含放射性同位素，潜在的放射性同位素，化学治疗剂。这些方法包括向患者的身体，身体部位，体液或生物探针的组织（连接到靶特异性配体的能量敏感材料）的施用，以及向生物探针施加能量以破坏，破裂或灭活患者的目标。能量形式，如AMF，被用来提供能量。所公开的方法可用于治疗各种适应症，包括癌症，免疫系统疾病，中枢神经系统和血管系统以及病原体传播疾病。

85. 发明授权

US07691285B2 Magnetic nanoparticles having improved magnetic properties 失效
标题翻译：具有改善磁性能的磁性纳米颗粒
公开(公告)号：US07691285B2
公开(公告)日：2010-04-06
申请号：US10564228
申请日：2004-07-09
申请人： Joachim Teller , Fritz Westphal , Cordula Gruettner
发明人： Joachim Teller , Fritz Westphal , Cordula Gruettner
IPC分类号： H01F1/00
CPC分类号： A61K33/26 , A61K47/60 , A61K47/61 , A61K47/6849 , A61K47/6923 , A61K47/6929 , A61K49/186 , A61K49/1863 , A61K49/1875 , A61K51/1255 , B82Y5/00 , B82Y25/00 , H01F1/0054 , H01F1/445 , Y10S977/811 , Y10S977/83 , Y10S977/838
摘要： The invention relates to a method for producing magnetic nanoparticles which are made of metal oxide-polymer composites and are provided with an increased magnetic mobility, among other things, due the high metal oxide content and the morphological structure thereof. High-pressure homogenization has proven to be a reliable technique for producing the inventive magnetic nanoparticles. According to said technique, the components metal oxide and polymer are processed in a carrier medium. Water is used in most cases at pressures ranging from 500 bar to 1200 bar while using great shearing forces. High pressure homogenization creates a colloidally stable magnetic particle population having a diameter ranging below 200 nm while also resulting in the produced magnetic nanoparticles being provided with greater magnetic moments than the metal oxide used as an initial material at low magnetic field strengths. The inventive particles are particularly suitable for applications in the bioanalytical and diagnostic field, in bioseparation processes, and as a carrier material in high throughput screening.
摘要翻译：本发明涉及一种由金属氧化物 - 聚合物复合材料制成的磁性纳米颗粒的制造方法，其特征在于由于高的金属氧化物含量及其形态结构而具有增加的磁性迁移率。已经证明高压均质化是生产本发明磁性纳米颗粒的可靠技术。根据所述技术，组分金属氧化物和聚合物在载体介质中加工。大多数情况下，在500 bar至1200 bar的压力下使用水，同时使用极大的剪切力。高压均质化产生直径在200nm以下的胶体稳定的磁性粒子群，同时还使得所制备的磁性纳米粒子具有比在低磁场强度下用作初始材料的金属氧化物更大的磁矩。本发明的颗粒特别适用于生物分析和诊断领域，生物分离过程中的应用，以及高通量筛选中的载体材料。

86. 发明申请

US20090220418A1 MULTIMODAL IMAGING USING A THREE COMPARTMENT POLYMER NANOPARTICLE WITH CELL SPECIFICITY 有权
标题翻译：使用具有细胞特异性的三层间聚合物纳米颗粒的多模式成像
公开(公告)号：US20090220418A1
公开(公告)日：2009-09-03
申请号：US12279695
申请日：2007-02-19
申请人： Ulrich Pison , Bernd-Reiner Paulke , Silvia Pietschmann , Regis Cartier , Lutz Kaufner
发明人： Ulrich Pison , Bernd-Reiner Paulke , Silvia Pietschmann , Regis Cartier , Lutz Kaufner
IPC分类号： A61K51/00 , A61K49/00 , A61K49/06 , A61K49/04
CPC分类号： A61K49/0404 , A61K49/0002 , A61K49/0041 , A61K49/0093 , A61K49/0423 , A61K49/0485 , A61K49/1878 , A61K51/1255 , B82Y5/00
摘要： The present invention pertains to a three compartment structured polymer nanoparticle (core-shell-corona) for multimodal imaging with specificity for cells or cellular components, thus enabling more advanced diagnostic approaches and targeted therapy on the cellular level without the use of additional biologically active materials.
摘要翻译：本发明涉及用于对细胞或细胞成分具有特异性的多模式成像的三室结构聚合物纳米颗粒（核 - 壳 - 电晕），从而使得能够在细胞水平上进行更先进的诊断方法和靶向治疗而不使用额外的生物活性物质。

87. 发明申请

US20080233048A1 Oral Preparation Useful in Measurement Capacity to Metabolize Pyridine 有权
标题翻译：口服制剂可用于代谢吡啶的测定能力
公开(公告)号：US20080233048A1
公开(公告)日：2008-09-25
申请号：US11989286
申请日：2006-07-24
申请人： Yoshiharu Inoue , Tadashi Mukai
发明人： Yoshiharu Inoue , Tadashi Mukai
IPC分类号： A61K49/00
CPC分类号： A61K49/0004 , A61K9/145 , A61K9/1623 , A61K9/2018 , A61K51/1255
摘要： An object of the present invention is to provide an oral preparation that can be used to diagnose the existence or degree of pyridine metabolic capacity disorder, pyrimidine metabolic rate, etc., with high accuracy and with little variation due to individual differences. The oral preparation is prepared using a powder material obtained by mixing and pulverizing (a) an isotope-labeled compound and/or a pyrimidine metabolite compound and (b) a sugar and/or a sugar alcohol.
摘要翻译：本发明的目的是提供一种口服制剂，其可用于以高精度诊断吡啶代谢能力障碍，嘧啶代谢率等的存在或程度，并且由于个体差异而几乎没有变化。使用通过混合和粉碎（a）同位素标记的化合物和/或嘧啶代谢物化合物和（b）糖和/或糖醇获得的粉末材料来制备口服制剂。

88. 发明授权

US07316644B2 Method for preparing particles of radioactive powder containing Cesium-131 for use in brachytherapy sources 有权
标题翻译：制备用于近距离放射治疗源的含有铯-131的放射性粉末颗粒的方法
公开(公告)号：US07316644B2
公开(公告)日：2008-01-08
申请号：US11198873
申请日：2005-08-05
申请人： Lane Allan Bray
发明人： Lane Allan Bray
IPC分类号： A61M36/00
CPC分类号： G21G4/08 , A61K51/1255 , A61K51/1268 , A61N2005/1019 , B82Y5/00
摘要： The present invention provides a method of preparing Cesium-131 (Cs-131) as a dispersed radioisotope. Uses of the dispersed Cs-131 prepared by the method include cancer research and treatment, such as for the use in brachytherapy. Cs-131 is particularly useful in the treatment of faster growing tumors.
摘要翻译：本发明提供了制备作为分散的放射性同位素的铯-131（Cs-131）的方法。通过该方法制备的分散Cs-131的使用包括癌症研究和治疗，如用于近距离放射治疗。 Cs-131在治疗生长较快的肿瘤中特别有用。

89. 发明申请

US20070218009A1 LANTHANIDE RICH NANOPARTICLES, AND THEIR INVESTIGATIVE USES IN MRI AND RELATED TECHNOLOGIES 有权
标题翻译：兰州纳米纳米粒子及其在MRI及相关技术中的研究用途
公开(公告)号：US20070218009A1
公开(公告)日：2007-09-20
申请号：US11627273
申请日：2007-01-25
申请人： Franciscus van Veggel , Robert Prosser , Cunhai Dong
发明人： Franciscus van Veggel , Robert Prosser , Cunhai Dong
IPC分类号： A61K49/10
CPC分类号： A61K41/009 , A61K49/0002 , A61K49/0428 , A61K49/1833 , A61K49/1836 , A61K49/1842 , A61K51/025 , A61K51/1244 , A61K51/1255 , B82Y5/00
摘要： An aqueous soluble, lanthanide rich nanoparticle for investigative use, such as NMR, MRI, CT, PET, and GdNCT is provided. The nanoparticle is synthesized from a mixture comprising lanthanide ions and coated with a suitably selected organic ligand such that the resultant nanoparticle is soluble in aqueous solutions. A method of collecting nuclear magnetic resonance information on a sample or a subject is also provided.
摘要翻译：提供了一种用于调查用途的水溶性富含镧系元素的纳米颗粒，如NMR，MRI，CT，PET和GdNCT。纳米颗粒由包含镧系元素离子的混合物合成，并涂覆有适当选择的有机配体，使得所得纳米颗粒可溶于水溶液。还提供了收集样品或受试者的核磁共振信息的方法。

90. 发明申请

US20070053830A1 Particulate materials and compositions for radio therapy 有权
标题翻译：用于放射治疗的颗粒材料和组合物
公开(公告)号：US20070053830A1
公开(公告)日：2007-03-08
申请号：US10531996
申请日：2005-03-07
申请人： Yongren Peng , Xingye Lei
发明人： Yongren Peng , Xingye Lei
IPC分类号： A61K51/00
CPC分类号： A61K51/1217 , A61K51/1251 , A61K51/1255 , A61L27/425 , A61L27/427 , A61L27/54 , A61L27/58 , A61L2300/44
摘要： Timed-bioresorbable particulates, particularly microspheres or fibers, may be used as a vehicle for delivery of radioisotopes, such as Y-90 and Pd-103 for localized radiotherapy, or as an embolic device. These particulates may also be embedded in polymers, or dispersed in injectable gels or other injectable media for the treatment of various cancers. The benefit of bioresorption, the ability to control the ratio of radioisotopes in the particulate, especially the gamma and beta ratios such as In-111/Y-90 ratio in a particulate, and the benefit of non-conductive implants are disclosed.
摘要翻译：定时生物可再吸收的颗粒，特别是微球或纤维，可用作递送放射性同位素的载体，例如用于局部放射治疗的Y-90和Pd-103，或作为栓塞装置。这些颗粒也可以嵌入聚合物中，或者分散在可注射的凝胶或其它注射介质中用于治疗各种癌症。公开了生物再吸收的优点，控制颗粒中放射性同位素比例的能力，特别是颗粒中的In-111 / Y-90比例的γ和β比率以及非导电植入物的益处。

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