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81. 发明申请

US20130281916A1 SONOSENSITIVE NANOPARTICLES 审中-公开
标题翻译：苯基纳米粒子
公开(公告)号：US20130281916A1
公开(公告)日：2013-10-24
申请号：US13885565
申请日：2011-11-17
申请人： Sarah Jayne Wagstaffe , Heiko Alexander Schiffter-Weinle , Michael Bernard Molinari , Manish Arora , Coussios Constantin-Cassios
发明人： Sarah Jayne Wagstaffe , Heiko Alexander Schiffter-Weinle , Michael Bernard Molinari , Manish Arora , Coussios Constantin-Cassios
IPC分类号： A61K41/00 , A61K49/22
CPC分类号： A61K41/0033 , A61K9/0009 , A61K9/5115 , A61K9/5153 , A61K41/0028 , A61K49/222 , Y10T428/2982 , Y10T428/2998
摘要： A method of delivering a therapeutic substance to tissue comprises delivering the therapeutic substance and nanoparticles to the tissue, the nanoparticles having a diameter in the range from 10 to 1000 nm and surface features having a depth in the range from 5 to 50 nm, and insonating the tissue with pressure waves. Corresponding particles, and associated methods of controlling and imaging the treatment and delivery are also disclosed.
摘要翻译：将治疗物质递送到组织的方法包括将治疗物质和纳米颗粒递送到组织中，纳米颗粒的直径在10至1000nm范围内，表面特征具有5至50nm的深度，并且，带有压力波的组织。还公开了相应的颗粒以及控制和成像治疗和递送的相关方法。

82. 发明申请

US20130129799A1 TUMOR PROLIFERATION INHIBITOR CONTAINING ULTRASOUND-SENSITIVE SUBSTANCE AND METHOD FOR INHIBITING TUMOR PROLIFERATION BY USING TUMOR PROLIFERATION INHIBITOR AND LOW-INTENSITY PULSED ULTRASOUND WAVES 审中-公开
标题翻译：包含超声敏感物质的肿瘤增殖抑制剂和通过使用肿瘤增生抑制剂和低强度脉冲超声波抑制肿瘤增生的方法
公开(公告)号：US20130129799A1
公开(公告)日：2013-05-23
申请号：US13812922
申请日：2011-08-30
申请人： Hirotomo Shibaguchi , Hirofumi Tsuru
发明人： Hirotomo Shibaguchi , Hirofumi Tsuru
IPC分类号： A61K41/00
CPC分类号： A61K41/0047 , A61K31/409 , A61K31/7135 , A61K41/0033
摘要： Provided are a tumor proliferation inhibitor and a method for inhibiting tumor proliferation both of which can be applied to a minimally invasive cancer treatment using low-intensity pulsed ultrasound. The present invention provides a tumor proliferation inhibitor containing an ultrasound-sensitive substance and an acoustic cavitation phenomenon-enhancing substance, and provides a method for inhibiting tumor proliferation that can exhibit a tumor proliferation-inhibitory effect using the tumor proliferation inhibitor in combination with low-intensity pulsed ultrasound of a degree that is used in ultrasound diagnosis, and that can be applied to a minimally invasive cancer treatment using low-intensity pulsed ultrasound.
摘要翻译：提供了肿瘤增殖抑制剂和抑制肿瘤增殖的方法，其都可以应用于使用低强度脉冲超声的微创癌症治疗。本发明提供了含有超声敏感性物质和声空穴现象增强物质的肿瘤增殖抑制剂，提供了可以使用肿瘤增殖抑制剂与低分子量组合物显示出肿瘤增殖抑制作用的抑制肿瘤增殖的方法，强度脉冲超声波用于超声诊断，可应用于使用低强度脉冲超声的微创癌症治疗。

83. 发明申请

US20120226139A1 METHOD AND COMPOSITION FOR HYPERTHERMALLY TREATING CELLS 有权
标题翻译：用于超细处理细胞的方法和组合
公开(公告)号：US20120226139A1
公开(公告)日：2012-09-06
申请号：US13455237
申请日：2012-04-25
申请人： Gholam A. Peyman
发明人： Gholam A. Peyman
IPC分类号： A61N2/02 , A61N5/02 , A61N2/00 , A61B6/00 , A61B5/055 , A61B8/00 , A61N7/00 , A61N5/00 , B82Y5/00
CPC分类号： A61K41/0028 , A61K9/0009 , A61K41/0033 , A61K41/0052 , A61K49/0021 , A61K49/0084 , A61K49/227 , Y10S977/911 , Y10S977/912 , Y10S977/931
摘要： A method and composition for hyperthermally diagnosing and monitoring treatment of cells with photoacoustic sound and nanoparticles.
摘要翻译：用于光声和纳米颗粒的高温诊断和监测细胞治疗的方法和组合物。

84. 发明申请

US20100158816A1 GAS BUBBLE-GENERATING AGENT 审中-公开
标题翻译：气体发泡剂
公开(公告)号：US20100158816A1
公开(公告)日：2010-06-24
申请号：US12716891
申请日：2010-03-03
申请人： Kenichi Kawabata , Koji HIRATA , Kazuaki Sasaki
发明人： Kenichi Kawabata , Koji HIRATA , Kazuaki Sasaki
IPC分类号： A61B8/00
CPC分类号： A61K41/0033 , A61B5/4839 , A61B8/481
摘要： This invention provides a gas bubble-generating agent that can be used as a contrast medium or a blocking agent in vivo. Such gas bubble-generating agent is produced by a method for producing a gas bubble-generating agent comprising the following steps of: (a) preparing a mixed solution of an amphiphilic substance, an amphiphilic substance comprising a water-soluble polymer chemically bound thereto, a hardly water-soluble substance having a boiling point of lower than 60° C. at atmospheric pressure, and a physiologically acceptable isotonic solution; (b) pressurizing the mixed solution; and (c) centrifuging the mixed solution after the step of pressurization, wherein a molar concentration of the amphiphilic substance in the mixed solution prepared in step (a) is 10 times or more higher than that of the amphiphilic substance comprising a water-soluble polymer chemically bound thereto.
摘要翻译：本发明提供了可用作造影剂或封闭剂的气泡产生剂。这种气泡生成剂是通过气泡发生剂的制造方法制造的，其特征在于，包括以下步骤：（a）制备两亲物质，包含化学键合的水溶性聚合物的两亲物质，在大气压下沸点低于60℃的几乎不溶于水的物质，以及生理上可接受的等渗溶液; （b）对混合溶液加压; 和（c）在加压步骤之后离心混合溶液，其中在步骤（a）中制备的混合溶液中的两亲物质的摩尔浓度比包含水溶性聚合物的两亲物质的摩尔浓度高10倍或更多化学结合。

85. 发明申请

US20080262349A1 Ultrasonic Cancer Treatment Enhancer and Cell Killer 有权
标题翻译：超声波治疗增强剂和细胞杀伤剂
公开(公告)号：US20080262349A1
公开(公告)日：2008-10-23
申请号：US11883208
申请日：2006-10-26
申请人： Koki Kanehira , Shuji Sonezaki , Yumi Ogami , Toshiaki Banzai
发明人： Koki Kanehira , Shuji Sonezaki , Yumi Ogami , Toshiaki Banzai
IPC分类号： A61N7/00
CPC分类号： A61K33/30 , A61K9/0019 , A61K9/19 , A61K33/24 , A61K41/0033 , B82Y5/00
摘要： There is provided an ultrasonic cancer treatment enhancer and cell killer that can significantly improve the effect of treating cancer by ultrasonic irradiation while ensuring a high level of safety. The ultrasonic cancer treatment enhancer and cell killer comprise metal semiconductor particles and can be activated upon ultrasonic irradiation to kill or destruct cancer cells.
摘要翻译：提供超声波治疗增强剂和细胞杀伤剂，其可以通过超声波照射显着改善治疗癌症的效果，同时确保高水平的安全性。超声波治疗增强剂和细胞杀伤剂包含金属半导体颗粒，并且可以在超声波照射下被激活以杀死或破坏癌细胞。

86. 发明申请

US20060100568A1 Ultrasound-activated anti-infective coatings and devices made thereof 有权
标题翻译：超声激活的抗感染涂层及其制成的装置
公开(公告)号：US20060100568A1
公开(公告)日：2006-05-11
申请号：US10896193
申请日：2004-07-21
申请人： Sharon Tan
发明人： Sharon Tan
IPC分类号： A61N1/30 , A61M31/00
CPC分类号： A61K41/0042 , A61K41/0033 , A61L29/085 , A61L29/16 , A61L31/10 , A61L31/16 , A61L2300/404 , A61L2300/416 , A61L2300/602
摘要： An implantable medical device is provided including a vascular access device and a coating on at least one of an inner surface and an outer surface of the vascular access device. The coating includes: (a) a polymeric component including at least one of a light reactive moiety and a sound reactive moiety; and (b) at least one therapeutic agent releasably associated with the polymeric component, wherein a rate of release of the therapeutic agent is controlled by in situ exposure of the medical device to at least one of a light energy source and an ultrasound energy source.
摘要翻译：提供了一种植入式医疗装置，其包括血管通路装置和在血管通路装置的内表面和外表面中的至少一个上的涂层。涂层包括：（a）包含光反应性部分和声反应部分中的至少一种的聚合物组分; 和（b）可释放地与聚合物组分相关联的至少一种治疗剂，其中通过将医疗装置原位暴露于光能源和超声能量源中的至少一种来控制治疗剂的释放速率。

87. 发明授权

US07011817B2 Hydrophilic cyanine dyes 失效
公开(公告)号：US07011817B2
公开(公告)日：2006-03-14
申请号：US09757332
申请日：2001-01-09
申请人： Samuel I. Achilefu , Raghavan Rajagopalan , Richard B. Dorshow , Joseph E. Bugaj
发明人： Samuel I. Achilefu , Raghavan Rajagopalan , Richard B. Dorshow , Joseph E. Bugaj
IPC分类号： A61B10/00 , A61B5/00 , A61B8/00
CPC分类号： A61K49/0056 , A61K41/0033 , A61K41/0057 , A61K49/0032 , C09B23/0016 , C09B23/0025 , C09B23/0066 , C09B23/0075 , C09B23/086
摘要： Cyanine dye bioconjugates useful for diagnostic imaging and therapy are disclosed. The conjugates include several cyanine dyes with a variety of bis- and tetrakis (carboxylic acid) homologues. The compounds may be conjugated to bioactive peptides, carbohydrates, hormones, drugs, or other bioactive agents. The small size of the compounds allows more favorable delivery to tumor cells as compared to larger molecular weight imaging agents. The various dyes are useful over the range of 350-1300 nm, the exact range being dependent upon the particular dye. Use of dimethylsulfoxide helps to maintain the fluorescence of the compounds. The inventive compounds are useful for diagnostic imaging and therapy, in endoscopic applications for the detection of tumors and other abnormalities, for localized therapy, for photoacoustic tumor imaging, detection and therapy, and for sonofluorescence tumor imaging, detection and therapy.

88. 发明申请

US20050271592A1 Optical diagnostic and therapeutic agents and compositions 有权
标题翻译：光学诊断和治疗剂及组合物
公开(公告)号：US20050271592A1
公开(公告)日：2005-12-08
申请号：US11146377
申请日：2005-06-06
申请人： Samuel Achilefu , Raghavan Rajagopalan , Richard Dorshow , Joseph Bugaj , Muthunadar Periasamy
发明人： Samuel Achilefu , Raghavan Rajagopalan , Richard Dorshow , Joseph Bugaj , Muthunadar Periasamy
IPC分类号： A61K41/00 , A61K49/00 , A61K51/00 , C07D209/12 , C07D405/14 , C07F5/00 , C07K14/47 , C07K16/46 , C09B23/01 , C09B23/08
CPC分类号： A61K49/0032 , A61K41/0033 , A61K41/0057 , A61K49/0056 , C07D209/12 , C07D405/14 , C09B23/0066 , C09B23/0075 , C09B23/08 , C09B23/086
摘要： Cyanine and indocyanine dye compounds and bioconjugates are disclosed. The present invention includes several cyanine and indocyanine dyes, including bioconjugates of the same, with a variety of bis- and tetrakis (carboxylic acid) homologues. The compounds of the invention may be conjugated to bioactive peptides, carbohydrates, hormones, drugs, or other bioactive agents. The small size of compounds of the invention allows favorable delivery to tumor cells as compared to larger molecular weight imaging agents. Further, use of a biocompatible organic solvent such as dimethylsulfoxide may be said to assist in maintaining the fluorescence of compounds of the invention. The compounds and bioconjugates herein disclosed are useful in a variety of medical applications including, but not limited to, diagnostic imaging and therapy, endoscopic applications for the detection of tumors and other abnormalities, localized therapy, photoacoustic tumor imaging, detection and therapy, and sonofluorescence tumor imaging, detection and therapy.
摘要翻译：公开了花青和靛蓝染料化合物和生物共轭物。本发明包括几种花青和靛蓝染料，其包括与其各种双和四（羧酸）同系物的生物缀合物。本发明的化合物可以与生物活性肽，碳水化合物，激素，药物或其他生物活性剂缀合。与较大的分子量成像剂相比，本发明化合物的小尺寸允许有利地递送到肿瘤细胞。此外，使用生物相容性有机溶剂如二甲基亚砜可以说有助于维持本发明化合物的荧光。本文公开的化合物和生物缀合物可用于各种医学应用，包括但不限于诊断成像和治疗，用于检测肿瘤和其他异常的内窥镜应用，局部治疗，光声肿瘤成像，检测和治疗以及声发射肿瘤成像，检测和治疗。

89. 发明申请

US20040241095A1 Receptor-avid exogenous optical contrast and therapeutic agents 有权
标题翻译：受体 - 狂热的外源性光学对比和治疗剂
公开(公告)号：US20040241095A1
公开(公告)日：2004-12-02
申请号：US10800531
申请日：2004-03-15
申请人： Mallinckrodt Inc.
发明人： Samuel Achilefu , Raghavan Rajagopalan , Richard B. Dorshow , Joseph Bugaj , Muthunadar P. Periasamy
IPC分类号： A61K049/00 , C07K014/705
CPC分类号： A61K49/0032 , A61K41/0033 , A61K41/0057 , A61K49/0056 , C07D209/12 , C07D405/14 , C09B23/0066 , C09B23/0075 , C09B23/08 , C09B23/086
摘要： Cyanine dye bioconjugates useful for diagnostic imaging and therapy are disclosed. The conjugates include several cyanine dyes with a variety of bis- and tetrakis (carboxylic acid) homologes. The compounds are be conjugated to bioactive peptides, carbohydrates, hormones, drugs, or other bioactive agents. The small size of the compounds allows more favorable delivery to tumor cells as compared to larger molecular weight imaging agents. The various dyes are useful over the range of 350 to 1,300 nm, the exact range being dependent upon the particular dye. The use of a biocompatible organic solvent such as dimethylsulfoxide helps to maintain the fluorescence of the compounds. The inventive compounds are useful for diagnostic imaging and therapy, in endoscopic applications for the detection of tumors and other abnormalities, for localized therapy, for photoacoustic tumor imaging, detection and therapy, and for sonofluorescence tumor imaging, detection and therapy.
摘要翻译：公开了可用于诊断成像和治疗的花青染料生物缀合物。缀合物包括几种具有多种双和四（羧酸）同系物的花青染料。化合物与生物活性肽，碳水化合物，激素，药物或其他生物活性剂缀合。与较大的分子量成像剂相比，化合物的小尺寸允许更有利于肿瘤细胞的递送。各种染料在350至1,300nm的范围内是有用的，精确的范围取决于特定的染料。使用生物相容性有机溶剂如二甲基亚砜有助于维持化合物的荧光。本发明化合物可用于诊断成像和治疗，用于检测肿瘤和其他异常的内窥镜应用，局部治疗，光声肿瘤成像，检测和治疗以及用于声发射肿瘤成像，检测和治疗。

90. 发明申请

US20040141920A1 Tumor-targeted optical contrast agents 失效
标题翻译：肿瘤靶向光学造影剂
公开(公告)号：US20040141920A1
公开(公告)日：2004-07-22
申请号：US10654033
申请日：2003-09-03
申请人： MALLINCKRODT INC.
发明人： Samuel I. Achilefu , Raghavan Rajagopalan , Richard B. Dorshow , Joseph E. Bugaj , Muthunadar P. Periasamy
IPC分类号： C07D417/14 , C07D413/14 , A61K049/00
CPC分类号： A61K49/0032 , A61K41/0033 , A61K49/0056 , C07D209/14 , C07D405/06 , C07K1/13 , C07K14/655
摘要： Cyanine dye bioconjugates useful for diagnostic imaging and therapy are disclosed. The conjugates include several cyanine dyes with a variety of bis- and tetrakis (carboxylic acid) homologs. The compounds may be conjugated to bioactive peptides, carbohydrates, hormones, drugs, or other bioactive agents. The small size of the compounds allows more favorable delivery to tumor cells as compared to larger molecular weight imaging agents. The various dyes are useful over the range of 350 to 1300 nm, the exact range being dependent upon the particular dye. The use of dimethylsulfoxide helps to maintain the fluorescence of the compounds. The inventive compounds are useful for diagnostic imaging and therapy, in endoscopic applications for the detection of tumors and other abnormalities, for localized therapy, for photoacoustic tumor imaging, detection and therapy, and for sonofluoresence tumor imaging, detection and therapy.
摘要翻译：公开了可用于诊断成像和治疗的花青染料生物缀合物。缀合物包括几种具有多种双和四（羧酸）同系物的花青染料。化合物可以与生物活性肽，碳水化合物，激素，药物或其他生物活性剂缀合。与较大的分子量成像剂相比，化合物的小尺寸允许更有利于肿瘤细胞的递送。各种染料在350至1300nm的范围内是有用的，精确的范围取决于特定的染料。使用二甲基亚砜有助于维持化合物的荧光。本发明化合物可用于诊断成像和治疗，用于检测肿瘤和其他异常的内窥镜应用，局部治疗，光声肿瘤成像，检测和治疗以及用于声波荧光肿瘤成像，检测和治疗。

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