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1. 发明申请

US20060009839A1 Composite vascular graft including bioactive agent coating and biodegradable sheath 审中-公开
标题翻译：复合血管移植物包括生物活性剂涂层和可生物降解护套
公开(公告)号：US20060009839A1
公开(公告)日：2006-01-12
申请号：US10889432
申请日：2004-07-12
申请人： Sharon Tan
发明人： Sharon Tan
IPC分类号： A61F2/06
CPC分类号： A61F2/06 , A61F2/07 , A61F2002/072 , A61F2210/0004 , A61F2250/0067
摘要： A composite vascular graft incorporates bioactive agents to deliver therapeutic materials and/or inhibit or reduce bacterial growth during and following the introduction of the graft to the implantation site in a vascular system. A composite vascular graft includes a porous tubular graft member. One or more biodegradable, bioactive agent coating layers are disposed over the graft member, the coating layer including at least one bioactive agent. A biodegradable sheath is disposed over the coating layer. The sheath has a rigidity greater than the flexible tubular graft member and is biodegradable to expose the coating layer so as to re-establish the flexibility of the tubular graft member.
摘要翻译：复合血管移植物包含生物活性剂以递送治疗材料和/或在将移植物引入血管系统中的植入部位期间和之后抑制或减少细菌生长。复合血管移植物包括多孔管状移植物。一种或多种可生物降解的生物活性剂涂层设置在移植物上方，该涂层包括至少一种生物活性剂。可生物降解的护套设置在涂层上。鞘具有大于柔性管状接枝部件的刚性，并且是可生物降解的以暴露涂层，以便重新建立管状接枝部件的柔性。

2. 发明申请

US20050085777A1 Medical device having anti-microbial properties and a false lumen and method of making the same 有权
标题翻译：具有抗菌性和假腔的医疗装置及其制造方法
公开(公告)号：US20050085777A1
公开(公告)日：2005-04-21
申请号：US10688224
申请日：2003-10-15
申请人： Sharon Tan
发明人： Sharon Tan
IPC分类号： A61L29/16 , A61L31/16 , A61M25/00
CPC分类号： A61L29/16 , A61L31/16 , A61L2300/106 , A61L2300/404 , A61M25/0017
摘要： A medical device with anti-microbial properties to prevent infections. This medical device, such as an in-dwelling catheter, has a portion that is insertable into the body of a patient and accessible from outside the body once the portion is inserted. The portion has an outer wall, a first active lumen within the outer wall, and a false lumen within the outer wall in which the false lumen has a distal portion and a proximal portion. The false lumen contains an anti-microbial agent that provides the outer wall with anti-microbial properties. The distal portion of the false lumen is sealed. The false lumen may be adjacent to the first active lumen. The medical device may also contain a second active lumen, wherein the first active lumen is an inlet lumen and the second active lumen is an outlet lumen. Alternatively, the false lumen may surround the first active lumen.
摘要翻译：具有抗微生物特性的医疗器械，以防止感染。这种医疗装置，例如住宅导管，具有可插入患者体内的部分，一旦该部分被插入，该部分可从外部进入身体。该部分具有外壁，外壁内的第一活动内腔和外壁内的假腔，其中假腔具有远侧部分和近端部分。假腔含有抗微生物剂，为外壁提供抗微生物特性。假腔的远端被密封。假腔可以与第一活动管腔相邻。医疗装置还可以包含第二活动腔，其中第一活动腔是入口腔，而第二活动腔是出口腔。或者，假腔可围绕第一活动腔。

3. 发明申请

US20050256502A1 Anti-infective central venous catheter with diffusion barrier layer 有权
标题翻译：具有扩散阻隔层的抗感染性中心静脉导管
公开(公告)号：US20050256502A1
公开(公告)日：2005-11-17
申请号：US11170235
申请日：2005-06-28
申请人： Kristian DiMatteo , Sharon Tan
发明人： Kristian DiMatteo , Sharon Tan
IPC分类号： A61M25/00
CPC分类号： A61M25/0017
摘要： A catheter extending from a distal end which, when in an operative position is inserted within a body of a patient, to a proximal end, the catheter comprising a charge holding cavity to which a therapeutic compound is to be supplied and a wall including inner and outer portions, an inner surface of the inner portion surrounding the charge holding cavity with an outer portion surrounding at least a portion of an outer surface of the inner portion, wherein the inner portion is formed so that a first diffusion rate of the therapeutic compound therethrough is different from a second diffusion rate through the outer portion.
摘要翻译：从远端延伸的导管，其在操作位置被插入到患者的身体内时到达近端，所述导管包括电荷保持腔，供给治疗化合物的导管和包括内部和/ 所述内部部分的内表面围绕所述电荷保持腔，外部包围所述内部部分的外表面的至少一部分，其中所述内部部分形成为使得所述治疗化合物通过其中的第一扩散速率与通过外部的第二扩散速度不同。

4. 发明申请

US20050090785A1 Catheter with a sidearm for delivery of antimicrobial agents to prevent infection 审中-公开
标题翻译：导管用侧臂递送抗菌剂以防止感染
公开(公告)号：US20050090785A1
公开(公告)日：2005-04-28
申请号：US10690436
申请日：2003-10-22
申请人： Sharon Tan
发明人： Sharon Tan
IPC分类号： A61M25/00 , A61M39/10
CPC分类号： A61M25/00
摘要： An apparatus and method for management of nosocomial infections associated with indwelling catheters, in which an antimicrobial agent-based infection intervention device, such as an iodine-bearing flexible rod, may be inserted, dwell within the catheter lumen, and be removed through a side arm tube extending from the side of the catheter. The apparatus and method minimize interference with the use of the catheter lumen for other medical procedures, eliminates undesired exposure of the proximal end of the catheter lumen to the atmosphere, and/or prevents back-bleeding of fluids from the proximal end of the catheter lumen during insertion or removal of the antimicrobial agent-based intervention device.
摘要翻译：用于管理与留置导管相关的医院内感染的装置和方法，其中可以插入基于抗微生物剂的感染介入装置，例如含碘柔性杆，并置于导管内腔内，并通过侧面臂管从导管侧延伸。该装置和方法使对使用导管腔的干扰最小化用于其它医疗过程，消除了导管内腔的近端不期望的暴露于大气中，和/或防止流体从导管内腔的近端反向渗出在插入或移除基于抗微生物剂的干预装置期间。

5. 发明申请

US20070106261A1 Anti-infective central venous catheter with diffusion barrier layer 有权
标题翻译：具有扩散阻隔层的抗感染性中心静脉导管
公开(公告)号：US20070106261A1
公开(公告)日：2007-05-10
申请号：US11642453
申请日：2006-12-19
申请人： Kristian DiMatteo , Sharon Tan
发明人： Kristian DiMatteo , Sharon Tan
IPC分类号： A61M25/00
CPC分类号： A61M25/0017
摘要： A catheter includes a wall surrounding a lumen. The wall has an inner portion forming an outer surface of the lumen and an outer portion surrounding at least a portion of an outer surface of the inner portion. A first diffusion rate of materials from the lumen through the inner portion is different from a second diffusion rate through the outer portion. A durometer hardness of the inner portion is lower than a durometer hardness of the outer portion.
摘要翻译：导管包括围绕管腔的壁。壁具有形成内腔的外表面的内部部分和围绕内部部分的外表面的至少一部分的外部部分。从内腔到内部的材料的第一扩散速率不同于通过外部的第二扩散速率。内部部分的硬度计硬度低于外部部分的硬度计硬度。

6. 发明申请

US20070004973A1 Tissue treatment methods 审中-公开
标题翻译：组织治疗方法
公开(公告)号：US20070004973A1
公开(公告)日：2007-01-04
申请号：US11154106
申请日：2005-06-15
申请人： Sharon Tan
发明人： Sharon Tan
IPC分类号： A61B5/00
CPC分类号： A61K41/0028 , A61K9/0009 , A61K9/5036
摘要： Methods of treating tissue are disclosed. The methods can include disposing a plurality of particles including a therapeutic agent within tissue of a subject. The plurality of particles can be exposed to energy to release at least some of the therapeutic agent from the particles. The methods can also include exposing a plurality of particles disposed in a subject to multiple intervals of energy. The energy can release therapeutic agent from at least some of the particles.
摘要翻译：公开了治疗组织的方法。所述方法可以包括在受试者的组织内设置包括治疗剂的多个颗粒。多个颗粒可以暴露于能量以从颗粒中释放至少一些治疗剂。所述方法还可以包括将设置在受试者中的多个颗粒暴露于多个能量间隔。能量可以从至少一些颗粒释放治疗剂。

7. 发明申请

US20060020328A1 Composite vascular graft having bioactive agent 审中-公开
标题翻译：复合血管移植物具有生物活性剂
公开(公告)号：US20060020328A1
公开(公告)日：2006-01-26
申请号：US10898102
申请日：2004-07-23
申请人： Sharon Tan
发明人： Sharon Tan
IPC分类号： A61F2/06
CPC分类号： A61F2/06 , A61F2/07 , A61F2002/072 , A61F2210/0004 , A61F2250/0067
摘要： A composite vascular graft incorporates bioactive agents to deliver therapeutic materials and/or inhibit or reduce bacterial growth during and following the introduction of the graft to the implantation site in a vascular system. A composite vascular graft includes a porous tubular graft member. A flexible ePTFE sheath is disposed over the tubular graft member. The sheath includes the bioactive agents incorporated therein.
摘要翻译：复合血管移植物包含生物活性剂以递送治疗材料和/或在将移植物引入血管系统中的植入部位期间和之后抑制或减少细菌生长。复合血管移植物包括多孔管状移植物。柔性ePTFE护套设置在管状移植件上。护套包括并入其中的生物活性剂。

8. 发明申请

US20060292300A1 Methods and systems for coating particles 有权
标题翻译：涂覆颗粒的方法和系统
公开(公告)号：US20060292300A1
公开(公告)日：2006-12-28
申请号：US11165949
申请日：2005-06-24
申请人： Sharon Tan
发明人： Sharon Tan
IPC分类号： B05D7/00 , B05D3/00
CPC分类号： B01J2/003 , A61K9/0039 , A61K9/5036 , A61K9/5089 , B01J2/06 , B01J13/04
摘要： Methods and systems for coating particles are disclosed.
摘要翻译：公开了涂覆颗粒的方法和系统。

9. 发明申请

US20060100568A1 Ultrasound-activated anti-infective coatings and devices made thereof 有权
标题翻译：超声激活的抗感染涂层及其制成的装置
公开(公告)号：US20060100568A1
公开(公告)日：2006-05-11
申请号：US10896193
申请日：2004-07-21
申请人： Sharon Tan
发明人： Sharon Tan
IPC分类号： A61N1/30 , A61M31/00
CPC分类号： A61K41/0042 , A61K41/0033 , A61L29/085 , A61L29/16 , A61L31/10 , A61L31/16 , A61L2300/404 , A61L2300/416 , A61L2300/602
摘要： An implantable medical device is provided including a vascular access device and a coating on at least one of an inner surface and an outer surface of the vascular access device. The coating includes: (a) a polymeric component including at least one of a light reactive moiety and a sound reactive moiety; and (b) at least one therapeutic agent releasably associated with the polymeric component, wherein a rate of release of the therapeutic agent is controlled by in situ exposure of the medical device to at least one of a light energy source and an ultrasound energy source.
摘要翻译：提供了一种植入式医疗装置，其包括血管通路装置和在血管通路装置的内表面和外表面中的至少一个上的涂层。涂层包括：（a）包含光反应性部分和声反应部分中的至少一种的聚合物组分; 和（b）可释放地与聚合物组分相关联的至少一种治疗剂，其中通过将医疗装置原位暴露于光能源和超声能量源中的至少一种来控制治疗剂的释放速率。

10. 发明申请

US20050025800A1 Latex medical articles for release of antimicrobial agents 有权
标题翻译：用于释放抗菌剂的乳胶医药制品
公开(公告)号：US20050025800A1
公开(公告)日：2005-02-03
申请号：US10631871
申请日：2003-07-31
申请人： Sharon Tan
发明人： Sharon Tan
IPC分类号： A61L29/04 , A61L29/16 , A61L31/04 , A61L31/16 , A61M29/00 , A61F2/00 , A61K35/60
CPC分类号： A61L29/16 , A61L29/042 , A61L31/049 , A61L31/16 , A61L2300/10 , A61L2300/104 , A61L2300/404 , A61L2300/622
摘要： According to an aspect of the present invention, a medical article is provided which comprises a latex antimicrobial region. The latex antimicrobial region can constitute the entirety of the medical article, or it can constitute only a portion of the medical article. The latex antimicrobial region comprises release-modulating microparticles, which are dispersed within a latex polymer. The release-modulating microparticles further comprise an antimicrobial agent, and the microparticles are adapted to release the antimicrobial agent. Examples of medical articles that can be produced in accordance with the present invention are gloves, finger cots, supply and drainage tubes, catheters, condoms, and contraceptive diaphragms. Also described are methods for forming such articles.
摘要翻译：根据本发明的一个方面，提供一种包含胶乳抗微生物区域的医疗用品。胶乳抗微生物区域可以构成整个医疗制品，或者它可以构成医疗用品的一部分。胶乳抗微生物区域包含分散在胶乳聚合物中的释放调节微粒。释放调节微粒还包含抗微生物剂，并且微粒适于释放抗微生物剂。可以根据本发明生产的医疗制品的实例是手套，手指套，供排水管，导管，避孕套和避孕膜。还描述了形成这种制品的方法。

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