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81. 发明专利

AU725091B2 Process for the preparation of platelet growth factors extract for wound healing compositions 未知
公开(公告)号：AU725091B2
公开(公告)日：2000-10-05
申请号：AU2019597
申请日：1997-03-19
申请人： THERATECHNOLOGIES INC
发明人： BRAZEAU PAUL , ABRIBAT THIERRY , IBEA MICHEL , BOUSHIRA MICHELE
IPC分类号： A61K35/14 , A61K35/19

82. 发明专利

BR9710483A 未知
公开(公告)号：BR9710483A
公开(公告)日：1999-08-17
申请号：BR9710483
申请日：1997-06-18
申请人： THERATECHNOLOGIES INC
发明人： VILLENEUVE LUC , MILLER GERARD , BERNIER ROBERT , LAURENDEAU CLAUDE , PAL PRABIR KUMAR
IPC分类号： A61N5/10 , A61B17/00 , A61N5/01 , A61N5/06
摘要： An apparatus for irradiating a biological substance with a substantially uniform quantity of radiation energy comprises a radiation-generating device for producing radiation energy, a support structure for receiving the biological substance, and a motorized mechanism for reciprocating the radiation-generating device along a given path whereby the biological substance receives radiation energy from the radiation-generating device at each passage of the radiation-generating device. A series of sensors lie into a given plane and are subjected to radiation energy from the radiation-generating device upon each passage of that radiation-generating device for sensing and measuring the quantity of radiation energy by surface unit passing through the given plane and reaching the biological substance. Finally the radiation-generating device and the motorized mechanism are de-energized when the measured quantity of radiation energy by surface unit has reached a predetermined value.

83. 发明专利

AU697119B2 Chimeric fatty body-pro-GRF analogs with increased biological potency 未知
公开(公告)号：AU697119B2
公开(公告)日：1998-09-24
申请号：AU5683396
申请日：1996-05-22
申请人： THERATECHNOLOGIES INC
发明人： IBEA MICHEL , ABRIBAT THIERRY , BRAZEAU PAUL
IPC分类号： A61K38/00 , A61K38/22 , A61P3/02 , A61P5/02 , A61P43/00 , C07K14/60 , C07K19/00 , G01N33/68 , A61K38/25
摘要： The present invention relates to chimeric fatty body-pro-GRF analogs with increased biological potency, their application as anabolic agents and in the diagnosis and treatment of growth hormone deficiencies. The chimeric fatty body-pro-GRF analogs include an hydrophobic moiety (tail), and can be prepared, either by anchoring one or several hydrophobic tails to the GRF, or by substituting one or several amino-acids by a pseudomicellar residue in the chemical synthesis of GRF. The GRF analogs of the present invention are biodegradable, non-immunogenic and exhibit an improved anabolic potency with a reduced dosage and prolonged activity.

84. 发明专利

CA2260217A1 IRRADIATING APPARATUS USING A SCANNING LIGHT SOURCE FOR PHOTODYNAMIC TREATMENT 未知
公开(公告)号：CA2260217A1
公开(公告)日：1998-01-29
申请号：CA2260217
申请日：1997-06-18
申请人： MILLER GERARD , VILLENEUVE LUC , BERNIER ROBERT , LAURENDEAU CLAUDE , THERATECHNOLOGIES INC
发明人： MILLER GERARD , VILLENEUVE LUC , PAL PRABIR KUMAR , BERNIER ROBERT , LAURENDEAU CLAUDE
IPC分类号： A61N5/10 , A61B17/00 , A61N5/01 , A61N5/06
摘要： An apparatus for irradiating a biological substance with a substantially uniform quantity of radiation energy comprises a radiation-generating device for producing radiation energy, a support structure for receiving the biological substance, and a motorized mechanism for reciprocating the radiation-generating device along a given path whereby the biological substance receives radiation energy from the radiation-generating device at each passage of the radiation-generating device. A series of sensors lie into a given plane and are subjected to radiation energy from the radiationgenerating device upon each passage of that radiation-generating device for sensing and measuring the quantity of radiation energy by surface unit passing through the given plane and reaching the biological substance. Finally the radiation-generating device and the motorized mechanism are de-energized when the measured quantity of radiation energy by surface unit has reached a predetermined value.

85. 发明专利

BR112013027150A2 thera 未知
公开(公告)号：BR112013027150A2
公开(公告)日：2017-06-06
申请号：BR112013027150
申请日：2012-04-17
申请人： THERATECHNOLOGIES INC
发明人： ABDELKRIM HABI , KRISHNA G PERI
IPC分类号： A61K38/25 , C07K14/60
摘要： resumo da patente de invenção para: análogos de fator de liberação de hormônio de crescimento (grf) e usos dos mesmos. são descritos aqui análogos de fator de liberação de hormônio de crescimento (grf) em que lisina-21, leucina-22 e leucina-23 são deletadas nos mesmos. estes análogos retêm atividade de grf. os usos dos ditos análogos, por exemplo, como um agonista de receptor de grf, por exemplo, para induzir secreção de hormônio de crescimento em um sujeito ou sistema biológico são também descritos.

86. 发明专利

BRPI0812947A2 未知
公开(公告)号：BRPI0812947A2
公开(公告)日：2014-12-23
申请号：BRPI0812947
申请日：2008-07-04
申请人： THERATECHNOLOGIES INC
发明人： PERI KRISHNA , HABI ABDELKRIM
IPC分类号： C07K19/00 , A61K38/22 , A61P9/12 , A61P13/12 , C07K14/575 , C07K14/58 , C07K14/685
摘要： A bifunctional hormone exhibiting an alpha-MSH activity and a natriuretic peptide activity is described. The bifunctional hormone comprises for example a first domain having alpha-MSH related hormonal activity covalently linked to a second domain having natriuretic peptide related hormonal activity. The bifunctional hormone of the present invention is useful for example for the prevention and/or treatment of renal related diseases or conditions, such as acute renal failure (ARF) or acute kidney injury (AKI).

87. 发明专利

AR087727A1 ANALOGOS DEL FACTOR DE LIBERACION DE LA HORMONA DE CRECIMIENTO (GRF) Y SUS USOS 未知
公开(公告)号：AR087727A1
公开(公告)日：2014-04-16
申请号：ARP120101345
申请日：2012-04-19
申请人： THERATECHNOLOGIES INC
IPC分类号： C07K14/61 , A61K38/27
摘要： En la presente se describen análogos del GRF nóveles con actividad de GRF como así también los usos de los mismos, por ejemplo como receptores agonistas del GRF, p. ej., para inducir la secreción de la hormona de crecimiento en un sujeto o sistema biológico. Reivindicación 1: Un análogo del factor liberador de la hormona de crecimiento (GRF) que comprende un dominio de la fórmula (1) (SEQ ID Nº 1): X¹-X²-Asp-Ala-Ile-Phe-Thr-X⁸-X⁹-Tyr-X¹¹-X¹²-X¹³-Leu-X¹⁵-GIn-Leu-X¹⁸-X¹⁹-Arg-GIn-X²²-X²³-X²⁴-X²⁵-X²⁶-X²⁷-X²⁸-X²⁹-X³⁰-X³¹-X³²-X³³ (1) donde: X¹ es Tyr o His; X² es Ala, D-Ala, Ser, Leu, ácido a-aminoisobutirico (Aib), Val o Gly; X⁸ es Asn, Asp, Ala, Gln, Ser o Aib; X⁹ es Ser, Asp o Ala; X¹¹ es Arg o L-Homoarginina (HoArg); X¹² es Lys, L-Ornitina (Orn) o HoArg; X¹³ es Val o Ile; X¹⁵ es Gly o Ala; X¹⁸ es Lys, L-Ornitina, L-2,4-ácido diaminobutírico, L-2,3-ácido diaminobutírico, o Ser; X¹⁹ es Ala o Leu; X²² es Asp o Glu; X²³ es Ile o Leu; X²⁴ es Met, Ile, Nle o Leu; X²⁵ es Ser, Asn, Aib o Ala; X²⁶ es Arg, D-Arg, HoArg o Lys; X²⁷ es Ala o está ausente; X²⁸ es Ala o está ausente; X²⁹ es Arg o está ausente; X³⁰ es Ala o está ausente; X³¹ es Ala o está ausente; X³² es Arg o está ausente; X³³ es L-Homoserina (HoSer) o está ausente; y donde si X¹⁸ es Ser, X²⁷ a X³² o X²⁷ a X³³ están presentes, o una sal de los mismos farmacéuticamente aceptable.

88. 发明专利

CA2852594A1 PEPTIDE COMPOUNDS DERIVED FROM MELANOTRANSFERRIN AND USES THEREOF 未知
公开(公告)号：CA2852594A1
公开(公告)日：2013-04-25
申请号：CA2852594
申请日：2012-10-18
申请人： THERATECHNOLOGIES INC
发明人： BELIVEAU RICHARD , MICHAUD-LEVESQUE JONATHAN , PERI KRISHNA G , HABI ABDELKRIM , BOUSQUET-GAGNON NATHALIE
IPC分类号： C07K14/705 , A61K38/10 , A61K38/40 , A61P35/00 , C07K7/08 , C07K14/79
摘要： Peptide compounds derived from human melanotransferrin, and compositions thereof, are described. Uses of these peptide compounds, for example to modulate angiogenesis and/or cell migration, and/or to treat angiogenesis-related disorders (e.g., cancer), are also described.

89. 发明专利

ES2393462T3 Péptido útil para inhibir la actividad del receptor de prosta-glandina F2X 未知
公开(公告)号：ES2393462T3
公开(公告)日：2012-12-21
申请号：ES03735223
申请日：2003-06-11
申请人： THERATECHNOLOGIES INC , UNIV MONTREAL
发明人： PERI KRISHNA , POLYAK FELIX , LUBELL WILLIAM , THOUIN ERYK , CHEMTOB SYLVAIN
IPC分类号： C07K7/00 , A61K38/00 , A61K38/08 , C07K7/06
摘要： Peptido que consiste en la secuencia ilgh(cit)dyk, en el que todos los aminoacidosson D-aminoacidos y (cit) es D-citrulina.

90. 发明专利

PT1511764E PEPTÍDEO ÚTIL PARA INIBIR A ACTIVIDADE DO RECEPTOR DE PROSTAGLANDINA F2ALFA 未知
公开(公告)号：PT1511764E
公开(公告)日：2012-11-15
申请号：PT03735223
申请日：2003-06-11
申请人： THERATECHNOLOGIES INC , UNIV MONTREAL
发明人： LUBELL WILLIAM , PERI KRISHNA G , POLYAK FELIX , THOUIN ERYK , CHEMTOB SYLVAIN
IPC分类号： C07K7/00 , A61K38/00 , A61K38/08 , C07K7/06

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