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81. 发明申请

US20100028441A1 COMPOSITIONS AND METHODS FOR TREATING MULTIPLE SCLEROSIS 有权
标题翻译：用于治疗多发性硬化症的组合物和方法
公开(公告)号：US20100028441A1
公开(公告)日：2010-02-04
申请号：US12430728
申请日：2009-04-27
申请人： Richard L. Watson , Anthony B. Wood , Gregory J. Archambeau
发明人： Richard L. Watson , Anthony B. Wood , Gregory J. Archambeau
IPC分类号： A61K9/14 , A61K33/00 , A61P25/00
CPC分类号： C12N13/00
摘要： Provided are electrokinetically-altered fluids (gas-enriched electrokinetic fluids) comprising an ionic aqueous solution of charge-stabilized oxygen-containing nanostructures in an amount sufficient to provide modulation of at least one of cellular membrane potential and cellular membrane conductivity, and therapeutic compositions and methods for use in treating inflammatory neurodegenerative condition or disease or at least one symptom thereof. The electrokinetically-altered fluids or therapeutic compositions and methods include electrokinetically-altered ioinic aqueous fluids optionally in combination with other therapeutic agents. Particular aspects provide for regulating or modulating intracellular signal transduction associated with said inflammatory responses by modulation of at least one of cellular membranes, membrane potential, membrane proteins such as membrane receptors, including but not limited to G-Protein Coupled Receptors (GPCR), and intercellular junctions (e.g., tight junctions, gap junctions, zona adherins and desmasomes). Other embodiments include particular routes of administration or formulations for the electrokinetically-altered fluids (e.g., electrokinetically-altered gas-enriched fluids and solutions) and therapeutic compositions.
摘要翻译：提供了电动改变的流体（富含气体的电动液体），其包含足以提供细胞膜电位和细胞膜电导率中的至少一种的调节的电荷稳定的含氧纳米结构的离子水溶液，以及治疗组合物和用于治疗炎症性神经变性疾病或疾病或其至少一种症状的方法。电动改变的流体或治疗组合物和方法包括任选与其它治疗剂组合的电动改变的碘代水性流体。特定方面提供调节或调节与所述炎症反应相关的细胞内信号转导，通过调节细胞膜，膜电位，膜蛋白如膜受体（包括但不限于G-蛋白偶联受体（GPCR））和细胞间连接（例如，紧密连接，间隙连接，zona adherins和desmasomes）。其他实施方案包括用于电动改变的流体（例如，电动改变的富含气体的流体和溶液）和治疗组合物的特定给药途径或制剂。

82. 发明申请

US20100021464A1 METHODS OF WOUND CARE AND TREATMENT 失效
标题翻译：治疗方法和治疗方法
公开(公告)号：US20100021464A1
公开(公告)日：2010-01-28
申请号：US12431704
申请日：2009-04-28
申请人： Gregory J. Archambeau , Richard L. Watson , Anthony B. Wood
发明人： Gregory J. Archambeau , Richard L. Watson , Anthony B. Wood
IPC分类号： A61K33/00 , A61K39/395 , A61P17/02
CPC分类号： A61K9/0048 , A61K9/0014 , A61K33/00 , A61K45/06 , A61L15/44 , A61L26/0066 , A61L2300/404 , A61L2300/412 , A61L2300/426 , B01F3/04531 , B01F3/0807 , B01F3/0853 , B01F7/00816 , B29D11/00038 , A61K2300/00
摘要： Provided are electrokinetically-altered fluids (e.g., gas-enriched electrokinetic fluids) comprising an ionic aqueous solution of charge-stabilized oxygen-containing nanostructures in an amount sufficient to provide modulation of at least one of cellular membrane potential and cellular membrane conductivity, and therapeutic compositions and methods for use in treating a wound to a surface tissue or a symptom thereof. The electrokinetically-altered fluids or therapeutic compositions and methods include electrokinetically-altered ionic aqueous fluids optionally in combination with other therapeutic agents. Particular aspects provide for regulating or modulating intracellular signal transduction associated with said inflammatory responses by modulation of at least one of cellular membranes, membrane potential, membrane proteins such as membrane receptors, including but not limited to G-Protein Coupled Receptors (GPCR), and intercellular junctions (e.g., tight junctions, gap junctions, zona adherins and desmasomes). Other embodiments include particular routes of administration or formulations for the electrokinetically-altered fluids (e.g., electrokinetically-altered gas-enriched fluids and solutions) and therapeutic compositions.
摘要翻译：提供了电动改变的流体（例如，富含气体的电动液），其包含电荷稳定的含氧纳米结构的离子水溶液，其量足以提供细胞膜电位和细胞膜电导率中的至少一种的调节，以及治疗用于治疗伤口至表面组织或其症状的组合物和方法。电动改变的流体或治疗组合物和方法包括任选与其它治疗剂组合的电动改变的离子水性流体。特定方面提供调节或调节与所述炎症反应相关的细胞内信号转导，通过调节细胞膜，膜电位，膜蛋白如膜受体（包括但不限于G-蛋白偶联受体（GPCR））和细胞间连接（例如，紧密连接，间隙连接，zona adherins和desmasomes）。其他实施方案包括用于电动改变的流体（例如，电动改变的富含气体的流体和溶液）和治疗组合物的特定给药途径或制剂。

83. 发明申请

US20090274771A1 COMPOSITIONS AND METHODS FOR TREATING ASTHMA AND OTHER LUNG DISORDERS 审中-公开
标题翻译：用于治疗哮喘和其他肺功能障碍的组合物和方法
公开(公告)号：US20090274771A1
公开(公告)日：2009-11-05
申请号：US12259101
申请日：2008-10-27
申请人： Richard L. Watson , Anthony B. Wood , Gregory J. Archambeau
发明人： Richard L. Watson , Anthony B. Wood , Gregory J. Archambeau
IPC分类号： A61K33/00 , A61P11/00
CPC分类号： A61K33/00 , A61K31/43 , A61K31/431 , A61K45/06 , A61K2300/00
摘要： Provided are compositions and methods for treating or preventing lung or respiratory disorders or conditions characterized by airflow obstruction or limitation, or a symptom thereof (e.g., asthma, rhinitis, allergic rhinitis (e.g. nose respiratory tract), and chronic obstructive pulmonary disease (COPD) and COPD-associated conditions (e.g., bronchitis, emphysema, asthma), emphysema, pneumonia, bronchitis, influenza, SARS, tuberculosis, and whooping cough (pertussis), and the like) in a subject in need thereof by administering a therapeutic composition comprising at least one electrokinetically generated fluid (including gas-enriched electrokinetically generated fluids) as disclosed herein, the electrokinetically altered aqueous fluid suitable to alter cellular membrane structure or function sufficient to provide for modulation of intracellular signal transduction, wherein treating a lung disorder or a symptom thereof is thereby afforded. Additional aspects relate to therapeutic compositions, and combination treatment methods comprising administration of at least one electrokinetically generated fluid in combination with at least one additional therapeutic agent.
摘要翻译：提供用于治疗或预防肺或呼吸系统疾病或由气流阻塞或限制或其症状（例如，哮喘，鼻炎，过敏性鼻炎（例如鼻呼吸道）和慢性阻塞性肺病（COPD））的症状的组合物和方法，和COPD相关的病症（例如，支气管炎，肺气肿，肺气肿，肺炎，支气管炎，流行性感冒，SARS，肺结核和百日咳（百日咳）等）在有需要的受试者中通过施用治疗组合物，至少一种电动产生的流体（包括富含气体的电动产生的流体），如本文所公开的，电动改变的水性流体适于改变足以提供细胞内信号转导调节的细胞膜结构或功能，其中治疗肺病或症状由此得到。另外的方面涉及治疗组合物和组合治疗方法，其包括与至少一种另外的治疗剂组合施用至少一种电动产生的流体。

84. 发明申请

US20080281001A1 MIXING DEVICE 有权
标题翻译：混合装置
公开(公告)号：US20080281001A1
公开(公告)日：2008-11-13
申请号：US11924595
申请日：2007-10-25
申请人： Anthony B. Wood , Gregory J. Archambeau , Richard L. Watson
发明人： Anthony B. Wood , Gregory J. Archambeau , Richard L. Watson
IPC分类号： B01F3/04 , G05D11/13
CPC分类号： B01F5/0665 , A23L2/54 , A61J3/00 , A61K9/08 , A61K9/10 , A61K33/00 , B01F3/04099 , B01F3/04531 , B01F3/0807 , B01F3/0853 , B01F7/008 , B01F7/00816 , C02F1/727 , C02F3/02 , C09K3/00 , C12M27/00 , Y02W10/15
摘要： Particular aspects provide compositions comprising an electrokinetically altered oxygenated aqueous fluid, wherein the oxygen in the fluid is present in an amount of at least 25 ppm. In certain aspects, the electrokinetically altered oxygenated aqueous fluid comprises electrokinetically modified or charged oxygen species present in an amount of at least 0.5 ppm. In certain aspects the electrokinetically altered oxygenated aqueous fluid comprises solvated electrons stabilized by molecular oxygen, and wherein the solvated electrons present in an amount of at least 0.01 ppm. In certain aspects, the fluid facilitates oxidation of pyrogallol to purpurogallin in the presence of horseradish peroxidase enzyme (HRP) in an amount above that afforded by a control pressure pot generated or fine-bubble generated aqueous fluid having an equivalent dissolved oxygen level, and wherein there is no hydrogen peroxide, or less than 0.1 ppm of hydrogen peroxide present in the electrokinetic oxygen-enriched aqueous fluid.
摘要翻译：具体方面提供了包含电动改变的含氧水溶液的组合物，其中流体中的氧以至少25ppm的量存在。在某些方面，电动改变的含氧水性流体包含以至少0.5ppm的量存在的电动改性或带电的氧物质。在某些方面，电动改变的含氧水性流体包含由分子氧稳定的溶剂化电子，并且其中溶剂化电子以至少0.01ppm的量存在。在某些方面，流体有助于在辣根过氧化物酶（HRP）存在下将连苯三酚氧化成紫罗卜糖苷，其量高于由产生的对照压力罐或具有等效溶解氧水平的微小气泡产生的水性流体所提供的量，并且其中在电动性富氧水溶液中不存在过氧化氢或少于0.1ppm的过氧化氢。

85. 发明申请

US20080146679A1 METHODS OF THERAPEUTIC TREATMENT OF EYES AND OTHER HUMAN TISSUES USING AN OXYGEN-ENRICHED SOLUTION 失效
标题翻译：使用富氧解决方案治疗眼睛和其他人体组织的治疗方法
公开(公告)号：US20080146679A1
公开(公告)日：2008-06-19
申请号：US11924601
申请日：2007-10-25
申请人： Gregory J. Archambeau , Anthony B. Wood , Richard L. Watson
发明人： Gregory J. Archambeau , Anthony B. Wood , Richard L. Watson
IPC分类号： A61K45/00 , A61P27/02 , A61P17/02 , G02C7/04
CPC分类号： A61K9/0014 , A61K9/0048 , A61K33/00 , A61K33/14 , A61K45/06 , B01F3/04531 , B01F3/0807 , B01F3/0853 , B01F7/00816 , B29D11/00038 , B29D11/00096 , A61K2300/00
摘要： Particular embodiments disclosed herein relate to electrokinetically altered gas-enriched fluids, methods of making the same, systems for making the same and/or methods of treatment utilizing the gas-enriched fluids for eye related conditions and/or diseases. In certain embodiments, the electrokinetically altered gas-enriched fluid is oxygen-enriched water. Certain embodiments relate to cosmetic and/or therapeutic fluids and/or methods of treatment utilizing the fluids to treat a cosmetic and/or therapeutic symptom related to eye conditions and/or diseases.
摘要翻译：本文公开的具体实施方案涉及电动改变的富含气体的流体，其制备方法，制备其的系统和/或利用富含气体的流体用于眼睛相关病症和/或疾病的治疗方法。在某些实施方案中，电动改变的富含气体的流体是富氧水。某些实施方案涉及使用流体处理与眼睛条件和/或疾病相关的化妆品和/或治疗症状的化妆品和/或治疗流体和/或治疗方法。

86. 发明授权

US07084864B1 Computer display with switched capacitor power supply 失效
标题翻译：带切换电容电源的电脑显示器
公开(公告)号：US07084864B1
公开(公告)日：2006-08-01
申请号：US08758425
申请日：1996-11-29
申请人： Anthony B. Wood
发明人： Anthony B. Wood
IPC分类号： G09G5/00
CPC分类号： H05B41/16
摘要： A computer (80) includes a display assembly 10 which uses a backlight power supply 40 to power a fluorescent tube 18 for backlighting purposes. The power supply generates voltages necessary to power the tube 18, generally in the range of 250-450 for steady-state operation, using a bank 41 of switched capacitors 52. The switched capacitors are charged in parallel and switched to a serial configuration to produce the voltage necessary to power the tube 18.
摘要翻译：计算机（80）包括显示组件10，显示组件10使用背光源40为荧光管18提供背光源。使用开关电容器52的组41，电源产生为管18供电所需的电压，通常在250-450的范围内用于稳态操作。开关电容器并联充电并切换到串行配置以产生为管18供电所需的电压。

87. 发明授权

US06386751B1 Diffuser/emulsifier 失效
标题翻译：扩散器/乳化剂
公开(公告)号：US06386751B1
公开(公告)日：2002-05-14
申请号：US08957530
申请日：1997-10-24
申请人： Norman L. Wootan , Anthony B. Wood
发明人： Norman L. Wootan , Anthony B. Wood
IPC分类号： B01F716
CPC分类号： A01K63/042 , B01F3/04531 , B01F3/04539 , B01F3/0807 , B01F3/0853 , B01F3/0857 , B01F7/00758 , B01F7/00783 , B01F7/008 , B01F7/00825 , B01F13/06 , B01F2003/04546 , B01F2003/04695 , B01F2003/04872 , B01F2003/04879 , B01F2003/0842 , B01F2215/0052 , B01F2215/0088 , B01J19/008 , C02F1/34 , C02F1/685 , C02F1/727 , C02F1/74 , C02F1/78 , C02F3/20 , C02F2101/322 , Y02W10/15
摘要： A diffuser for incorporating one or more infusion materials into a host material. The diffuser includes a rotor 12 and stator 30 rotating relative to one another. The infusion materials are drawn through openings in the rotor and stator. During movement of the rotor, the openings cause cavitation of the host material in the channel 32 resulting in diffusion of the infusion materials through the openings and into the host material. The opening patterns in the rotor and stator can be designed to operate at a single frequency or a multiple frequencies. The frequencies of operation may affect bonding between the infusion materials and the host material and may also be effective in breakdown of complex molecular structures.
摘要翻译：用于将一种或多种输注材料并入主体材料的扩散器。扩散器包括相对于彼此旋转的转子12和定子30。输液材料通过转子和定子中的开口抽吸。在转子运动期间，开口引起主体材料在通道32中的空化，导致输注材料通过开口扩散并进入主体材料。转子和定子中的开口图案可以设计成在单个频率或多个频率下工作。操作频率可能会影响浸泡材料与宿主材料之间的粘合，也可能有效地分解复合分子结构。

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